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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 7 Documents
 1 
Search results for , issue "Vol. 1 No. 1 (2013)" : 7 Documents clear
Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug Goswami, D. S.; Uppal, N.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.
Preparation and characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers Goswami, Dhruba; Sharma, M.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

Purpose of this research was to study mucoadhesive tablets of Amoxicillin trihydrate using Neem gum as mucoadhesive natural polymer. The conventional oral dosage form of this drug has low half life and high dosing frequency. Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Azadirachta indica as mucoadhesive polymer. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC K4M, carbopol 934P and sodium alginate) and natural (neem gum) polymers have been made to prepare total ten formulations. Further, different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing neem gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that neem gum is suitable for preparation of mucoadhesive tablets
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
Phyto-pharmacological review of Portulaca quadrifida Linn. Das, Mrinmay; D., Ashok Kumar
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

Portulaca quadrifida Linn. (Family: Portuleacea), commonly known as “Chicken Weed”, a traditional medicinal plant has been used in the Ayurvedic system of medicine for centuries, valued for its benefits in the management of urinary and inflammatory disorders. The juice of leaves is applied to abscesses and decoction is given in dysentery. The decoction of the plant can act as anthelminthic and used in the treatment of stomach complaints and gonorrhoea. Portulaca quadrifida has been reported to possess antifungal activity. The effect of ethanolic extract of Portulaca quadrifida on central and peripheral nervous system were studied by using spontaneous motor activity, in vivo muscle relaxant activity (Grip strength) and anticonvulsant activity and it is also found to have good effect on central nervous system. In this review, we have explored the Phyto-pharmacological properties of the Portulaca quadrifida plant and compiled its vast pharmacological applications to comprehend and synthesize the subject of its potential image of multipurpose medicinal agents.
Pharmacological activities of pyrazolone derivatives Parajuli, Rishi Ram; Pokhrel, Priyanka; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

Pyrazoline is a five member heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The review of the literature shows that the pyrazoline derivatives are quite stable and has inspired the chemists to synthesize the new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various pharmacological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc. and the pharmacological activities of different synthesized compound are reviewed in the present article.
Development of reverse phase high performance liquid chromatographic method and method validation of paracetamol by using economical single mobile phase Saha, S.; Dey, B. K.; Chakrabotry, S.; Choudhury, T.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The computerization of method development and validation are useful in analysis of pharmaceuticals in pharmaceutical industry. In this article a simple, sensitive, and precise high performance liquid chromatographic (HPLC) method for the analysis of Paracetamol with ultraviolet detection at 257 nm has been developed, validated, and used for the determination of compounds in commercial pharmaceutical products. Paracetamol tablet dosage form (two brands) was purchased from market and was from Glaxo Smith Kline (Calpol) and from IPCA (Pacimol) respectively. The compounds were well separated on a Hypersil ODS C18 reversed-phase column by use of a mobile phase consisting of methanol and water (90:10v/v at a flow rate of 1.0 ml.min). The linearity ranges were 20- 100µg/ ml for Paracetamol. Limits of detection (LOD) obtained 3.298g/ml limit of quantitation (LOQ) were 9.875g/ml Paracetamol. The study showed that reversed-phase liquid chromatography is sensitive and selective for the determination of Paracetamol using single mobile phase.
Pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Sharma, U.; Nandi, R. P.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

The aim of the study is to cover the pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Stephania hernandifolia (Willd.) Walp. belonging to the family Menispermaceae is a natural taxon. The plant was collected from the Darjeeling district of West Bengal, India, during summer and was authenticated by the botanist. Pharmacognostical study included macroscopical characters, microscopical characters, physico-chemical constants and fluorescence analysis. Preliminary phytochemical screening includes phytochemical extraction, phytochemical testing and thin layer chromatography (TLC). In macroscopical studies of the corm, it was found that, it’s shape was spherical, size was about 8 to 20 cm in length and 10 to 20 cm broad, colour was brown (Rusty), surface was rough, odour was not specific, taste was bitter, direction of growth was vertical, the surface has many circular and slightly raised spots. In microscopical studies of corm, it were found that it has periderm, vascular bundles, thin phelloderm cells, ground parenchymatous cells, dense masses of starch grains and wide circular secretory cavities were seen. In powder microscopy, sclereids and vessel elements have been observed with short sclerenchyma. Physico-chemical parameters like total ash value (13 % w/w), acid insoluble ash value (2.66 %w/w), water-soluble ash value (2.50 %w/w) and sulphated ash value (3.33 %w/w) were observed. Alcohol soluble extractive value (7.23 %w/w), water-soluble extractive value (10.84 %w/w) were also observed and loss on drying was observed as 2.50 %w/w. The foaming index was found to be 111.11. Preliminary phytochemical studies show the presence of alkaloids, carbohydrates, Steroids, Saponin, tannin and phenolic compounds flavanoids, and lignin in ethanolic extract and carbohydrates, Saponin, tannin and phenolic compounds flavanoids, and lignin in aqueous extract. Performing TLC of ethanolic extract using chloroform: ethanol (30:70) and methanol: water (70: 30) as solvent system, few spots were identified. The study helps in the correct identification of the plant. The presence of alkaloids and flavanoids explains that the plant must have valuable medicinal properties which must be explored.

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