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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 6 Documents
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Search results for , issue "Vol. 3 No. 1 (2015)" : 6 Documents clear
Statistical optimization of compression coated ketoprofen tablet using amylose/ethyl cellulose mixture for colonic delivery Devi, Nirmala; Sharma, Manju
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

In the present study the effect of two independent factors (amount of ethyl cellulose in coating layer and coating level) on ketoprofen release from compression coated tablet in order to optimize coated tablet for colonic delivery. 3 2 factorial design was used for designing coated formulation. Amount of ethyl cellulose (X1) and coating level (X2) were selected as independent variables. The studied responses were drug release at 5 hr (Y1) and drug release at 10 hr (Y2). The core tablets were compression coated with different ratio of amylose and ethylcellulose. In vitro drug release study was carried out in pH1.2 for 2 hr, pH 7.4 for 3 hr and goat caecal medium for 5 hr. Drug release revealed that amount of ethyl cellulose and coating level have antagonistic effect on drug release. Multiple regression analysis was used for generation of polynomial equation and optimization of formulation. The optimized formulation consisted of ethyl cellulose (14.33 %) and coating level (318 mg) provided a release profile that is closed to estimated values. The model is found to be accurate and robust for optimization of compression-coated tablet for colonic delivery of ketoprofen
Clock gene variation in type 2 diabetes: a review Parveen, Nushrat; Satapathy, Trilochan; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone. Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clocks
Development of stability indicating, validated single dissolution method for simultaneous estimation of clopidogrel bisulfate and rivaroxaban in tablet dosage formulation by RP-HPLC method Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

A dissolution method was developed for combination of two drugs which are already marketed as an individual product, Clopidogrel Bisulfate Tablets USP 75 mg and another is Rivaroxaban Tablets 10 mg & 20 mg. It was emphasized that both products have several advantages when given as combination therapy. Hence, the preference was given to develop a single dissolution method for the analysis of both the active components. This article presents a single dissolution method to accommodate both drugs. The method uses USP Type II Apparatus (paddles) at 75 rpm in 1000 mL of Acetate buffer (pH 4.5) medium containing 1% Sodium Lauryl Sulfate as surfactant at 37 °C± 0.5°C . This dissolution methodology provides good dissolution profiles for both Clopidogrel Bisulfate and Rivaroxaban and is able to discriminate the changes in composition, manufacturing process and stability for the combination tablets. To quantitate both drugs simultaneously, a rapid isocratic reversed-phase liquid chromatographic method was developed and validated.
Cucumis sativus (cucumber): a review on its pharmacological activity Sahu, Tripti; Sahu, Jyoti
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

Medicinal plants have been used for centuries, and numerous cultures still rely on plants for their primary health care needs. In the recent past there has been a tremendous increase in the use of plant based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. The present article gives an account of such a medicinally important of Cucumis sativus belonging to family Cucurbitaceae which comprise both wild and cultivated species and is consumed in different ways like vegetable and salads, but less is known about its medicinal importance. Phytochemical analysis of these plants confirms the presence of various phytochemicals like tannins, cardiac glycosides, terpenoides, carbohydrates, resins, Saponins and phytosterols. While other phtochemicals like alkaloids, flavonoids, glycosides, steroidal terpenes and phylobatamins were found to be cucumber fruits. The plant exhibits various pharmacological activities such as anti-bacterial activity, antifungal activity, cytotoxic activity, Antacid & Carminative activity, Activity against ulcerative colitis ,Hepetoprotective activity, Hypoglycemic and Hypolipidemic activity, Wound healing activity etc. A study on safety profile suggests the plant to be safe for its therapeutic uses.
Inspection of a novel penetration enhancer for transungual drug delivery system: Pelargonium hortorum Singh, Vikram; Chandrul , Kaushal Kishore
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

This study was to search some natural penetration enhancer and formulate them in a transungual drug delivery formulation. This natural penetration enhancer helps to overcome the main problem in front of success of transungual drug delivery system. We selected to formulate fluconazole as a model drug for the nail fungal infection treatment with extracted penetration enhancer (PE). Model drug i.e. fluconazole was formulated with the natural extracted penetration enhancer with different deigned formula. The solvent for PE extraction was methanol and that extracts were air dried. The cadaver human nail plates were used for penetration study, were collected from the same volunteer for negligence in the thickness and chemical composition concentration in the nail plate. The extracted PE (pelargonium hortorum) was selected for formulation on the basis of ethanopharmaceutical history. The human cadaver nail plates were treated with the formulation with and without the extracted PEs. Ex - vivo drug penetration was evaluated by Franz diffusion cells using cadaver human nail plate upto 36 hours. The drug filmability was found to be best with the polymer like HPMC K4M, Ethyl cellulose and hydroxyl propyle cellulose in the ratio of 1:1:1, mixture of propanol and butanol in 7:3 as solvent and 30% w/w DBP as plasticizer. The formula FT25AP4 shows total 35.67% drug penetraion i.e. near about two times of drug penetration across the nail plate when compare to the same formulation but without any penetration enhancer. The “p” value (0.0011) of drug penetration was less than 0.05.
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets. The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory

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