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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Thysanolaena maxima (roxb.) kuntze: a therapeutically less explored plant from northeastern India Safal Sharma; Bibhas Pandit; Sushilta Pradhan; Jyochhana Mohanty
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.9.13

Abstract

Thysanolaena maxima is a member of the Poaceae family of medicinal plants, and it is used to cure a variety of ailments, including boils, vomiting, stomach disorders, and infectious diseases like tuberculosis. Thysanolaena maxima has been found to possess a variety of chemicals, including terpenoids, polysaccharides, tannins, flavonoids, saponins, glycosides, phenols, and steroids. The current mini-review analyses its pharmacological profile, chemical components, and phytochemistry, with an emphasis on, cytotoxic, antioxidant and antimicrobial properties, in order to better assess the plant's medicinal potential. Traditional and modern medicine, as well as possible herbal therapy for a number of ailments, have a lot of potential for Thysanolaena maxima. Its active ingredients and pharmacological activities is yet to be thoroughly researched. This brief review has offered up-to-date work on Thysanolaena maxima's phtyochemical and other information, which will serve as a reference for future research
Development and validation of UV-spectrophotometric method for the determination of folic acid in bulk and tablet dosage forms Takreem A. Elkhazein; Tahani A. Abdeljabar; Amal N. Abdelrahman; Mohamed E. Adam; Shaza W. Shantier
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.19.23

Abstract

The purpose of this study was to create and verify a simple and accurate UV-Spectrophotometric technique for determining Folic acid in bulk and tablet dosage form. The approach was based on the measurement of folic acid solution absorbance at 255nm in 0.01M NaOH. In the concentration range of 10-50 g/ml, the constructed calibration curve was found to be linear (R2 = 0.9996). Limits of detection and quantification were 2.73 µg/ml, and 8.27 µg/ml, respectively. The precision of the developed method was confirmed by the obtained low RSD% values. Recoveries percentages were found 98.46%±1.42, 100.0%±0.20, 98.92%±1.12; n=3 for 50%, 100% and 150% levels, respectively indicating the method accuracy and freedom of interference from excipients. Folic acid content percent in the two analyzed brands were found to be equal 96.59%±0.005; n=3, and 97.28%±0.003; n=3 which complies with the official range (90-110%).
New treatment approaches for the management of Alzheimer's disease Abhishek; Sourav Pahwa
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.1.8

Abstract

This assessment is mainly concerned with the new treatment approaches for the management of Alzheimer’s disease and how these procedures can be beneficial for patients suffering from such diseases. With various other brain diseases, the number of Alzheimer’s disease cases is also increasing day by day in the world. So, it has become very important to be aware of the various new methods for the treatment of Alzheimer’s disease. The new treatment methods that are been used for the treatment of such brain disorders are found to be highly beneficial, as various new therapies and methods are being discovered for the treatment of such brain diseases. The various medications that are being used for the treatment of such diseases are beneficial only when taken under proper guidance and amount. Various precautions are very necessary during the treatment of such diseases, which can be helpful in the treatment. These treatment procedures may vary from person to person depending on their age factor and health.
A study on cost analysis of oral antihypertensive drugs available in India AVANTHI E; Allen Joe Rodrigues; Abhishek Achar; Mahesh G K; Anand Koppal
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.14.18

Abstract

The major health care problem in developing world is shifting from communicable diseases to non-communicable disease which causes morbidities more than mortality affecting the personal efficiency. Hypertension is a major health care burden in developing countries like India causing both morbidity and mortality. Few studies shows that the hypertension prevalence has raised from 2% to 15% in rural population and 2% to 25% in urban population in last six decades in India. This research work aims to enumerate the price of commonly available oral antihypertensive drugs in India. It also aims to study the cost variation of oral antihypertensive drugs. The present study was carried out in the department of Pharmacology in a tertiary care medical college in south India. The cost analysis of individual drugs by different manufacturers were done. Percentage of cost variation was analysed. The variation in cost of most of the antihypertensive drugs is more than 100%. It’s found maximum in Amlodipine (5mg) with cost variation of 625%, Atenolol 100 mg with cost variation of 413%. In India there is a wide price variation among antihypertensive drugs. The major gap in the cost variation of antihypertensive drugs to be narrowed for the benefit of the patients. So the government and the prescribing doctors should think about the huge difference in cost and work in the direction of benefitting the patient.
Formulation and evaluation of theophylline sustained release matrix tablets using synthetic polymers Navdeep Kaur; Mohit Kumar
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.24.31

Abstract

The aim of present work was to develop theophylline sustained release tablets which could improve patient compliance towards the effective management of asthma The polymers, HPMC (Hydroxy propyl methyl cellulose) K4M, HPMC K100M, Eudragit, Chitosan in blending and granulation stage of processing and evaluate their physico-chemical properties. The precompression limits of the powder blends used for the preparation of sustained-release tablets were in an acceptable range of pharmacopeial specification with excellent flow and good compressibility. Wet granulation method prepared tablets using different grades of polymers HPMC K100, HPMC K4M, Eudragit, Chitosan. The active ingredient, release retardants, diluents, fraction of polymer are mixed to make wet mass for granulation. The in- vitro release was prolonged to 12 hours using HPMC K4M, HPMC K100M, Chitosan, Eudragit. F9 formulation prolonged the theophylline release in 12 hours. The effect of polymer on drug release was studied. Thus, sustained release matrix tablets can promise better patient compliance through reduction in over-all dose and dosage regimen, which can be of excessive support to treat chronic disease.
Perioperative anaesthetic challenges in coronavirus disease associated mucormycosis: A retrospective study Mamta Khandelwal; Sunita Meena; Sanjay Morwal; Priyanka Jain; Yogesh Modi
Journal of Applied Pharmaceutical Research Vol. 10 No. 2 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2022.32.37

Abstract

Background & Aim: Mucormycosis is a life-threatening fungal infection that occurs in immune-compromised patients. There were large number of mucormycosis cases reported during COVID pandemic (2019-21) mainly as post COVID sequelae. In the present retrospective study we aimed to evaluate the perioperative challenges faced in the anaesthetic management of Coronavirus disease associated Mucormycosis (CAM) patients who underwent surgery under general anesthesia. Methods: The perioperative records of CAM patients who underwent surgery from May 2021-July 2021 for mucormycosis were reviewed and evaluated in terms of difficult bag mask ventilation, difficult intubation and other intraoperative and post-operative complications. Observation and Results: The incidence of CAM and its associated surgery was significantly more in males than females and the mean age of the patients was 50 years. In 39.8% patients we encountered difficult bag mask ventilation. and in 17.5% patients more than two attempts for intubation were required. Conclusion: Mucormycosis patients posted for surgery may pose various anesthetic challenges especially in airway management and anesthesiologists must be well prepared for it
A brief review on different plant parts used as immunity boosting agent Debgopal Ganguly; Soumyadip Ghosh; Madhumita Banerjee; Anasuya Mandal; Sarmistha Panja; Ananta Choudhury
Journal of Applied Pharmaceutical Research Vol. 10 No. 1 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/J.JOAPR.2022.1.6

Abstract

A strong immune system is essential to keep a person healthy. Every person should incorporate specific food items into their diet that can strengthen their immune system. Mother Nature has a bag full of plants and trees whose different parts contain different ingredients that can act as immune boosters. Tulsi is a small herb, found in many parts of India and can be grown in our homes too. The leaves of Tulsi have different properties like antimicrobial, antipyretic, anti-inflammatory, and many more. 5-6 leaves of Tulsi daily help to build our immune system. Giloy is an herbaceous vine found in the tropical regions of different Indian subcontinents. The heart-shaped leaves and reddish fruit of Giloy have many active ingredients like alkaloids, glycosides, phytosterols, etc. which help to attain anti-inflammatory, antipyretic, antioxidant properties. 2-3 tablespoons of Giloy juice daily helps to boost our immune system and increase the ability of our body to fight various infectious diseases. Garlic is used in a variety of dishes we cook garlic bulb is a great supplement known to boost the immune system functioning. Active compound present in garlic helps to reduce blood pressure improve cholesterol levels and can also lower the risk of heart diseases. Garlic bulbs can also reduce cold and flu symptoms. The various vitamins present in garlic also add more effect to its immunity-boosting property. Citrus lemon is found primarily in the north-eastern part of India, China or Myanmar, Italy, Spain. It has various phytochemicals such as terpenes, tannins, polyphenols, etc. is considered a rich of all essential vitamins to enrich our immune system and also provide therapeutic benefits
Microwave-assisted single-step synthesis of acid hydrazides from corresponding acids utilizing newly designed apparatus Sabah Mohamad; Shaza Shantier; Elrashied Garalnabi
Journal of Applied Pharmaceutical Research Vol. 10 No. 1 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/J.JOAPR.2020.29.37

Abstract

Acid hydrazides are essential intermediates in organic synthesis. They conventionally require a two-step synthetic pathway; esterification and hydrazine hydrate treatment; to obtain the hydrazide. The microwave-assisted synthetic methodology was utilized as a greener and straightforward single-step approach for their synthesis in highly encouraging yields. Thus, the aim of the present work was to synthesize acid hydrazides of Diclofenac, Indomethacin, Ibuprofen, and Mefenamic acid using microwave radiation with the aid of a newly designed fit-in ice condenser. Esters of the selected compounds were firstly synthesized, and acid hydrazides were then synthesized utilizing both the conventional and the proposed microwave-assisted single-step methods. The developed technique was successfully yielded 86.7%, 40.9%, and 65.5% acid hydrazides of Diclofenac, Indomethacin, and Mefenamic acid in just 3 min., 10 min. and 3 min., respectively. In comparison to the conventional method, the developed method was simpler with a very short reaction time and quantified yields. The structures of the synthesized acid hydrazides were also confirmed using FT-IR and 1H-NMR. The proposed method with the modified fit-in ice condenser proved to be efficient, cost-effective, and time-saving in the synthesis of acid hydrazides understudy in a single step.
Evaluation of wound healing effect of colostrum and curcumin cream in rat excision wound model Sakthibalan M; Aakash R; Mangaiarkkarasi A; Prasad C
Journal of Applied Pharmaceutical Research Vol. 10 No. 1 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/J.JOAPR.2022.15.20

Abstract

Background: Proper wound healing is very crucial for the reconstruction of injured tissues. Compared to the conventional dressings, currently there are many novel biological wound dressings and healing agents containing colostrum which has many advantages. Aim & Objective: This experimental study was done to evaluate the effect of colostrum and curcumin cream dressing and compare it with that of conventional Povidone iodine dressing. Methods: The rats were anesthetized and excision wounds were created. Wounds were then measured with a standard measuring scale on the day of wounding and then subsequently at a time interval of 4 days till day 20, then on alternate days. After tracing the wound area was treated with the Test and Standard drugs on Day 1,4,8,12,16 and 20. The data was then analysed using Chi square, one-way ANOVA and two tailed t test using Graph pad prism software version 5.0. Results: Efficacy of Colostrum 10% &Curcumin 1% cream (test) was equal to that of povidone iodine 10% (standard) cream with respect to wound contraction and wound healing. But, with respect to the rate of wound healing, Colostrum 10% & Curcumin 1% cream treated group was better compared to the povidone iodine 10% cream treated group. Conclusion: Colostrum plus Curcumin cream has shown a better wound healing at a short time span in excisional wound model in rats, when compared to the conventional povidone iodine cream. Thus, the Colostrum plus curcumin cream appear to be an economical and safe alternative to costly therapies like growth factors for wound healing
A brief review on recent advancement of tablet coating technology Debgopal Ganguly; Soumyadip Ghosh; Pubali Chakraborty; Sumit Mitra; Shounak Chatterjee; Sarmistha Panja; Ananta Choudhury
Journal of Applied Pharmaceutical Research Vol. 10 No. 1 (2022)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/J.JOAPR.2022.7.14

Abstract

A tablet can be defined as a solid unit dosage form. There are several reasons for coating of solid dosage form, the most important reason is to control the release profile & also to control the bioavailability parameters of the APIs (Active Pharmaceutical Ingredients). Tablets containing active pharmaceutical ingredients (API) can be coated with thin polymer-based film for various advantages. Generally, horizontal rotating pans are used for coating purposes & coating solution can be spread through the spraying systems over the surface of tablets. Bitter taste masking, odor masking, physical and chemical protection, and also environmental protection are all benefits of the tablet coating. Despite that, Tablet coating also plays an important role in controlling the action site. Sugar-coating, film coating, and enteric coating are some of the conventional tablet coating processes. The primary objective for creating tablet coating technologies is to eliminate the numerous disadvantages of solvent-based coating. Coating solution preferentially applied on the surface of solid dosage forms without the need for any solvent in these novel technologies. This review article provides information regarding the techniques of conventional tablet coating, the recent advancement of tablet coating procedures, and tablet coating components.

Page 24 of 46 | Total Record : 459

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