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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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In vitro anti-oxidation activity studies of the whole plant (except flower) of Thunbergia coccinea Damanbhalang Rynjah; Sumit Das
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.45.49

Abstract

An in vitro study of the methanolic extract of the whole plant (except flower) of Thunbergia coccinea was performed to check the anti-oxidant activity by different methods (Reducing power assay, TBA and DPPH scavenging assay) and before starting the study, the plant was extracted by Soxhlet apparatus using methanol as solvent and the marc was evaporated kept under desiccator. From the literature survey it was found that the plant contain flavonoids and tannins which are non-enzymatic antioxidants responsible for scavenging free radicals as reported and based on this, the study for antioxidant was carried out. The methanolic extract of the plant Thunbergia coccinea shows promising result in antioxidant studies when in comparison with the standard (Ascorbic acid). Thus further studies like in vivo evaluation can be performed in the mere future.
Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method Choudhary, Amit; Sinha, Manish; Amar Deep Ankalgi; Goyal, Kamya; Devi, Arti
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.24.32

Abstract

The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug. The UV-Visible method employed was a simultaneous equation method. Ethanol was used as a solvent and therefore the absorption maxima (λ max) was found to be 229 nm and 209 nm for mefloquine hydrochloride and artemether. The linearity ranges of both drugs were 1-6 μg/mL and 100 – 350 μg/mL with a regression coefficient r2 ≥ 0.998 respectively. The method was validated for different parameters according to International Conference on Harmonization ICH Q2B guidelines. The average recovery for mefloquine hydrochloride was found to be 100 per cent and artemether 99.3 per cent. The method was also found precise and robust with a per cent relative standard deviation of less than 2. All the parameters result obtained within the limits. Therefore, the proposed method for the accurate quantitation of mefloquine hydrochloride and artemether in the bulk drug was successfully implemented.
Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives Pathak, Shailesh; Sharma, Sharad; Pathak, Vinay; Prasad, Mahesh
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.50.61

Abstract

1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. This nucleus has various biological activity such as antioxidant, antimicrobial, antifungal, antitumor, antidepressant, anticancer, analgesic etc.  have been reported. A series of 1,3,4-oxadiazoles-2(3H)thione derivative has been synthesized in four steps and the derivative were characterized by FTIR spectral analysis. This article explain the different biological activities associated with 1,3,4-oxadiazole five membered ring are useful for researchers across the world working on this nucleus.
Preparation and evaluation of adipic dihydrazide cross-linked hyaluronic acid microspheres for cephalexin B. Padmasri; R. Kalyani; V. Anilkumar; D. Prasanth; M. Indu
Journal of Applied Pharmaceutical Research Vol. 9 No. 1 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/JOAPR.2021.9.1.30.36

Abstract

Hyaluronic acid also called as Hyaluronan, Sodium Hyaluronate (SA), sodium salt form of Hyaluronic acid is a biodegradable, biocompatible, and viscoelastic linear polysaccharide of a wide molecular weight range (1000 to 10,000,000 Da). In this project, described a method for preparing HA microspheres at different pH conditions by adapting a non-toxic and aqueous based crosslinking chemistry for sustained drug delivery of drugs. The derivatization chemistry of HA utilizing adipic dihydrazide has been used to construct hydrogels, applied for microsphere preparation. ADH was coupled efficiently to carbodimide-activated glucoronic acid residues of hyluronans. These ADH modified hyaluronan can be loaded with drug molecules and then cross linked into hydrogel. The drug was present in the bulk of hydrogel droplets which are present in liquid paraffin are precipitated by IPA. Formulating HA microspheres with this method have several advantages. Preliminary studies were conducted to confirm the better ratio of HA and ADH to show maximum entrapment efficiency and drug release. Then microspheres were prepared at different pH conditions and formulations were subjected to evaluation of various parameters like percentage yield, particle size, drug entrapment efficiency, porosity and bulk density, surface morphology, in vitro drug release among which F2B was optimized as best formulation which showed 74.6% entrapment efficiency and above 90% of drug release in 12 hours indicating Hyaluronic acid microspheres can be used as good carriers for sustained drug delivery of drugs.
Quercetin as an antiviral weapon-A review Kalita, Ramen; Bhattacharya, Kunal; Ali, Amir; Sandilya, Satyasish
Journal of Applied Pharmaceutical Research Vol. 9 No. 1 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/JOAPR.2021.9.1.25.29

Abstract

Antioxidants are substances that can prevent cells from the damage caused by unstable molecules such as free radicals. Quercetin, a plant pigment present in many fruits, vegetables, grains, and one of the most beneficial antioxidants in the diet and plays an important role in helping the body and prevent free radical damage, which is linked to chronic diseases. The antioxidant properties of quercetin may help to reduce inflammation, allergy symptoms, blood pressure. A lot of studies have been done and experiments have been conducted both in vivo and in vitro and it has been found that in cultured cells many respiratory viruses were inhibited by quercetin. At a minimal inhibitory concentration of 0.03 to 0.5μg/ml in WI-38 or Hela cells, Cytopathic effects produced by echovirus type 7,11,12,19, rhinovirus, poliovirus, and coxsackievirus A21 and B1 were inhibited. The plaque formed by DNA and RNA viruses such as Herpes Simplex Virus-1, Polio type 1, and parainfluenza types 3 were effectively reduced demonstrating its anti-replicative properties. This article reviews effect of quercetin on different types of viral infections.
Surface modified receptor mediated delivery systems for site specific treatment of cancer Vanapariya, Fenil; Malviya, Miteshkumar; Nathabhai, Shiroya Milankumar
Journal of Applied Pharmaceutical Research Vol. 9 No. 1 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/JOAPR.2021.9.1.01.07

Abstract

The treatment of the cancer has many challenges now a days due to side effects of the treatment.  However, in the modern formulation development the concept of the site specific drug delivery for disease treatment in the body is considering as continuous challenges. Observing the challenges in convectional technique site specific drug delivery system has good potential to reduce adverse side effects, efficiently improve the human body health with very low toxicity. This review article elaborates the current challenges and prospective of   surface modified drug carrier systems for delivery of protein for site-specific treatment of cancer and anti-cancer drug.
Evaluation of analgesic and anti-inflammatory activity of ethanolic extract of Enhydra fluctuans on male wistar rats Roy, Kishor Kumar; Mollah, Md. Kabirul Islam; Reja, Md. Masud; Shil, Dibyendu; Maji, Ranjan Kumar
Journal of Applied Pharmaceutical Research Vol. 9 No. 1 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/JOAPR.2021.9.1.37.42

Abstract

Enhydra fluctuations an edible semi-aquatic vegetable plant are widely used in the traditional system of medicine. Ethanolic extract of Enhydra fluctuans was screened for analgesic & anti-inflammatory activity. Analgesic activity was evaluated by the hot plate method and anti-inflammatory activity was evaluated by formalin induce paw edema in Wistar rats (male). Ethanolic extract dose of 300 mg/kg reduce formalin induce paw inflammation and also increased the pain threshold in rats evidenced by hot plate method. The experimental results concluded that Enhydra fluctuans have significant analgesic and anti-inflammatory activity may due to flavonoid and phenolic compound content.
Novel approaches in development of cell penetrating peptides Shah, Vatsal R.; Shah, Yamini D.; Athalye, Mansi N.
Journal of Applied Pharmaceutical Research Vol. 9 No. 1 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/JOAPR.2021.9.1.08.24

Abstract

Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the endocytic organelles. Here the CPP mediated endosomal escape and some strategies used to increase endosomal escape of CPP-cargo conjugates are discussed with evidence. Potential benefits can be obtained by peptides such as reduction in side effects, biocompatibility, easier synthesis and can be obtained at lower administered doses. The particular peptide known as cell penetrating peptides are able to translocate themselves across membrane with the carrier drugs with different mechanisms. This is of prime importance in drug delivery systems as they have capability to cross physiological membranes. This review describes various mechanisms for effective drug delivery and associated challenges
Evaluation of analgesic, antioxidant and cytotoxic activities of ethanol extract of Clerodendrum viscosum Vent Das, Sujan Chandra; Kuddus, Md. Ruhul; Qais, Nazmul; Hasan, Choudhury M.
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.10.14

Abstract

Clerodendrum viscosum Vent. is a very common plant in Bangladesh which is locally familiar as “Bhat” or “Ghetu”. Here, the ethanol extract of whole plant part of C. viscosum and its various solvent (petroleum-ether, chloroform and ethyl acetate) fractions were subjected for the appraisal of analgesic, antioxidant and cytotoxic activities. Analgesic activity was tested by acetic acid-induced writhing model in Swiss albino mice. All the plant samples at the oral doses of 100- and 200 mg/kg body weight were found to exhibit significant (p<0.05) pain reducing activity in test animals. Highest inhibition of writhing was 62.38% by the ethyl acetate soluble fraction at dose of 200 mg/kg body weight while the standard drug diclofenac sodium (50 mg/kg) produces 76.14% reduction of abdominal writhing. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical quenching assay was employed to determine the antioxidant potential of the plant samples while cytotoxic activity was checked by brine shrimp lethality bioassay. In DPPH radical scavenging assay, the plant samples showed prominent antioxidant activity. Among all, the ethyl acetate fraction showed maximum antioxidant potential with IC50 value of 28.02±0.53 μg/ml. In cytotoxic assay, the petroleum-ether fraction demonstrated strong cytotoxicity with LC50 value of 1.42±1.12 μg/ml. In summary, C. viscosum extracts possess significant analgesic, antioxidant and cytotoxic activities which rationalize its traditional use in folk medicine.
In India, diabetes mellitus is on the rise at an alarming rate: A review Bagchi, Arnab; Pal, Prosanta
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.01.05

Abstract

The aim of the current review is to acquaint all the covering aspect of dibetes mellitus which can provide awareness to the diabetes patients in india as well as all over the world. The number of diabetic patients in india is increasing at an alarming rate and is therefore a major area for concern. As per the WHO, the diabetes is expected to reach 79.4 million by 2030. The studies have shown that the type II diabetes is 4-6 times higher in urban than in rural areas in india. Development of  diabetes among indians is due to several factors such as age ( Based on NHANES data),waist circumference, hypertention, BMI, smoking habit and total cholestero these variables are important for comparing diabetic and non-diabetic patients

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