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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats reddi, Padmavathi; Keerthana, K. B; Lalitha Devi, A.; Sree Hari, Y.; Samad, Abdul
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.15.24

Abstract

Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.
Recent advancement in the method of transdermal drug delivery system: A review Halder, Sudip; Chakraborty, Prodipta; Pradhan, Darshan; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.06.09

Abstract

A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.
Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate Shoaeba, Shaikh; Sharav, Desai; Jain, Hitesh; Sahu, Asit; Meshram, D. B.
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.25.29

Abstract

The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for pH, drug content, viscosity, gelling time, gelling strength spreadability and sterility testing. In vitro drug release study was carried by using diffusion cell with dialysis membrane. The drug content and pH of the formulation were found to be satisfactory. The gelling strength was found to be in the range of 34 seconds to 91 seconds. The viscosity and spredability of the formulations were found to be satisfactory. Formulation F5 containing 0.3 % carobopol 940 and 0.6 % HPMC K4M showed highest drug release of 80.30 %. The developed formulations showed sustained release of drug up to 8 hrs. From in-vitro drug release studies, it could be concluded that the developed in-situ gelling systems were thus a better alternative to conventional eye drops.
Rising Indian Clinical Trials Industry and Career Opportunities Biswas, Arghya
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.8-13

Abstract

The Indian clinical trials industry has seen stable growth over the past decades and especially since 2014 there has been a significant rise. With the current expected market growth rate, India has the potential to become one of the largest clinical trial hubs. The ministry of health had a very positive outlook towards the growth of the Indian clinical trial market; with the constant reformation of the regulatory guidance, the confidence of pharma companies to do trials in India is growing. The Covid-19 pandemic has caused mass public awareness about clinical trials and drug development process, this will increase acceptance and help to further promote the industry. This article provides an insight into the various drivers for the fast growth of the Indian clinical trials industry and at the same time discusses the numerous career opportunities the industry offers.
Current developments in prevention and treatment of candidiasis: A review Chakraborty, Prodipta; Pradhan, Darshan; Halder, Sudip; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.21-25

Abstract

Invasive fungus infection affects about six people out of every 100,000 people each year. Only half of these infections are detected throughout the patient's lifetime, making it one of the most common causes of death among intensive-care patients. The low detection rate is due to the diagnostic work's complexity, which comprises clinical, radiographic, and microbiological results. Antimycotic drug-resistant fungi are on the rise all over the world. Guidelines for identifying and treating invasive fungous infections caused by Candida spp., Aspergillus spp., Mucorales, and Fusarium spp. are the topic of this review. In typical hospital care, intrusive fungous infections are frequently ignored. They must include it as a necessary component of antimicrobial stewardship programmes. There is also a great need for novel antimycotic medication classes to be developed
An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system Pradhan, Darshan; Chakraborty, Prodipta; Halder, Sudip; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.1-7

Abstract

FDTs are defined by the United States Food and Drug Administration (FDA) as a solid dosage form containing the therapeutic substance or when applied on the tongue, the active ingredient disintegrates quickly, usually within seconds. The goal of this study is to create a fast-dissolving tablet that uses natural disintegrants. Fast dissolving tablets have grown in popularity in the pharmaceutical industry in recent years. They have a quick disintegration activity that dissolves with saliva without the use of water when placed within the mouth. Furthermore, FDT aims to provide quick medication absorption, reduced toxicity, and higher drug bioavailability, and it is especially popular among geriatric and paediatric patients. Natural disintegrants, which are obtained from natural sources, have a number of advantages, including low cost, nontoxicity, biodegradability, environmental friendliness, and less adverse effects. As a result, it has been established that natural disintegrants are often safer than synthetic disintegrants. Natural disintegrants includes Chitin and chitosan, Guar gum, Gum karaya, Agar and treated agar, Fenugreek seed mucilage, Soy polysaccharide, Gellan gum, Mango peel pectin, Lepidium sativum mucilage, Plantago seed mucilage, Agele marmelos gum, Locust bean gum, Mangifera indica gum, Hibiscus rosa sinensis mucilage, Dehydrated banana powder.
Plants as pharmaceutical excipients in oral sustained drug delivery systems: A review Uwah, T O; Akpabio, E I; Effiong, Daniel
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.26-38

Abstract

Plants and their derivatives have contributed immensely to drug development for their application as medicinal agents or as excipients in preparation of new drug delivery systems. Their use keeps increasing by the day. The rich, yet-to-be fully tapped vegetation available in the African sub-region puts it with great potential to be the next global destination as sources for pharmaceutical excipient. This work reviews published articles on plants and derivatives that have been employed so far in modifying drug delivery. Published articles from databases of PubMed, science direct and google scholar were sourced. Obtained manuscripts were screened for relevance to the topic and currency from reading through the abstract and scanning the body of the work. Gums and mucilages as plant derivatives in their natural form or as changed forms have been well investigated for use in controlled drug delivery. Some of these have been as functional in modifying drug release as many commercially employed excipients in drug delivery. Many plants and plant-derived polymers are generally regarded as safe, easily cultivated, show good functionality as drug additives and can be modified to improve on any less desirable property. Taking advantage of these positive factors will open doors for optimal use of these naturally endowed pharmaceutical excipients
A brief review on colon-specific drug delivery system for targeting to colonic region Ghosh, Soumyadip; Majumdar, Subhabrota; Ganguly, Debgopal
Journal of Applied Pharmaceutical Research Vol. 9 No. 4 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.9.15

Abstract

Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have been covered.
An emerging technique of medicated chewing gum in drug delivery system: a review Khatiwara, Deepika; Ranabhat, Priyanka; Paul, Moumita; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 4 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.1.8

Abstract

Many advances in research and technology have been made in the oral route of drug delivery system in recent years. Because of increased patient compliance not only in geriatric and paediatric patients, but also in the general population, the oral channel of drug delivery system- medicated chewing gum has received worldwide recognition throughout the year. Chewing gum can be used as a mobile medication delivery device for both local and systemic drug administration via the oral route. Because of its ease and ability to be administered without water, it is an exceptional drug delivery device for self-medication. The production technique, advantages, disadvantages, factors impacting the release of medicament, assessment parameter, difficulty related with chewing gum manufacture, and future trends have all been examined in this review paper
A review on using an alcohol-based sanitizer as a prophylactic measure against microorganisms Ranabhat, Priyanka; Khatiwara, Deepika; Paul, Moumita; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 4 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.23.28

Abstract

Because of the COVID 19 pandemic, we now utilise hand sanitizer in our daily lives. Hand hygiene has become a legal requirement. Infection control is becoming a requirement. Hand hygiene is widely regarded as the most practical and effective way of infection prevention. Hand sanitizer is thought to have played a significant role in reducing illness transmission to patients. Because it is more cost-effective and efficient. The efficiency of hand sanitizer is totally determined by how it is used. There are two sorts of hand sanitizers on the market. 1) Hand sanitizer with alcohol 2) Hand sanitizer that isn't alcohol-based. Most effective hand sanitizers contain 70 percent to 95 percent alcohol, which has the potential to denature microbial protein and inactivate viruses. The impact of hand sanitizer on human health care is significant, and this review article will provide you with information on several elements of hand sanitizer

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