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Articles 283 Documents
ANTIBACTERIAL ACTIVITY OF FRACTIONATED SANDALWOOD OILS A. T. Karossi; H. Agustina; L. Sutedja
Jurnal Kimia Terapan Indonesia Vol 3, No 1 (1993)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2688.792 KB) | DOI: 10.14203/jkti.v3i1.299

Abstract

Sandalwood oil was prepared through water distillation of sandalwood (Sansalum album L) sawdust. The inhibitory activity of the oil was tested against Staphylococcus aureus and Bacillus cereus. This antibacterial active oil was further fractionated through column chromatography into five fractions. Larger antibacterial activity, expressed as inhibitory diameter ( ID ), was observed in the prepared sandalwood oil and its fractions compared to sandalwood oil originated from Kupang and sanialol from International Flavors and Fragrance ( IFF ). The inhibitory diameter of the isolated sandalwood oil against S. aureus and B. cereus were 8.75 and 8.20 mm respectively. While the IV of sandalwood oil from Kupang and santalol IFF against S aureus were 7.20 and 7.23 mm, and against B. cereus 6.62 and 7.35 mm respectively. The ID of the sandalwood oil fractions against S aureus ranged between 7.32 - 9.93 mm, and the largest inhibition was shown by fraction -2. Against Bicereus the IV ranged between 7.64 - 11.12 mm., and the largest inhibition was shown by fraction - 1. Suggested possible structures for sandalwood oil fractions were based on the infra red spectra of the oils and sandalwood oil components.
Nickel Supported Natural Zeolite as a Bifunctional Catalysts for Conversion of Citronella Oil Crude to Menthols Ralentri Pertiwi; Silvester Tursiloadi; Indri Badria Adilina; Kiky Corneliasari Sembiring; Yuya Oaki
Jurnal Kimia Terapan Indonesia Vol 18, No 02 (2016)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.308 KB) | DOI: 10.14203/jkti.v18i02.78

Abstract

Characterization and catalytic activity of modified natural zeolite for the conversion of citronella oil to menthol was investigated. In this research, natural zeolite was prepared by acid activation with HCl and impregnated with Ni metal. The addition of Ni metal of around 12.5 nm in diameter provided a bifunctional catalyst for two steps of citronella oil conversion i.e. cyclization and hydrogenation. The process was performed in a one-pot reaction system by stirring at 200oC with pressure of 20 bar H2 for 3h. The reaction products changed slightly with varieties of reaction temperature and amount of catalysts employed. Results showed that Ni/NZB-HT catalyst was the best catalyst which was able to convert citronella oil to menthol with a selectivity of 50% menthol and 100% conversion of citronellal.
PREPARATION OF LEAD ZIRCONATE TITANATE FILM BY SOL-GEL METHOD AND ITS CHARACTERIZATION Silvester Tursiloadi; Hiroaki Imai; Hiroshi Hirashima
Jurnal Kimia Terapan Indonesia Vol 6, No 1-2 (1996)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5139.688 KB) | DOI: 10.14203/jkti.v6i1-2.232

Abstract

A ferroelectric material film of Lead Zirconate Titanate, Pb(Zr,Ti)O3 (PZT), was produced by sol-gel method from alkoxide and acetate precursors in a normal propanol solvent system. The excess amount of Pb was 10 mole % more than stoichiometrically used for preparing the solution. The concentration of PZT in coating solution was 0.7 M, and pH of the solution was 4.5. The films was prepared by dip-coating onto slide glass, silica glass and Pt/Ti/SiO2/Si substrate. In order to avoid cracking TiO2 was coated on the glasses as a barrier layer. The asdried PZT film was amorphous from X-ray diffraction. The amount of pyrochlore and perovskite phase depended on the heating temperature and kind of barrier layer. Single perovskite phase was found for coated films on TiO2/SiO2 and Pt/Ti/SiO2/Si heated at 600° C or higher, but it was never found for coated films on SiO2 substrate without barrier layers. Crystallization of perovskite PZT film was retarded when deposited on amorphous substrates as compared to crystalline substrate. The coated film on Pt/Til/SiO2/Si was thicker and smaller in particle size than that of coated film on Ti02/SiO2. A columnar structure with a diameter around 6.5 nm, was observed and no boundary was observed between layers in 9 time dipcoated film on Pt/Ti/SiO2/Si.
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Jurnal Kimia Terapan Indonesia Vol 11, No 2 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v11i2.168

Abstract

PENGARUH PENINGKATAN LIPOFILISITAS PADA SENYAWA ANALOG UK-3A DALAM MENGHAMBAT PERTUMBUHAN SEL KANKER P-388 Hanafi M; Y Anita; AMJ. Putra; A. Darmawan; N. Artanti; Linar Z. Udin
Jurnal Kimia Terapan Indonesia Vol 11, No 1 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3926.945 KB) | DOI: 10.14203/jkti.v11i1.173

Abstract

Antibiotic UK-3A contains a 9-membered dilactone ring. It had been isolated as a minor component from the mycelium of 5trepyomyces sp. 51701.The antibiotic was hypothesized to be potential to inhibit the growth of leukemia cancer cell line of P388 and KB with ICso 38 and 20 Dg/mL, respectively. To understand the effect of lipophilicity increase of the analogues on their anticancer activities based on QSAR parameter (Log P) and binding energy to BcL-xL protein. To produce analogues of UK-3A, 3hydroxypicolinyl serine methyl ester (A) was synthesized from 3-hydroxypicolinic acid and L-serine methyl ester. The product was then esterified by pentanoic (1), hexanoic (2), heptanoic (3), and octanoic (4). The final products were confirmed with IHand 13C FT-NMR and FTIR spectra, and also MS spectra. Then they were tested against P388 Murine Leukemia cells. The result of bioassay showed lipophilicity increase of3hydroxypicolinyl serine methyl octhyl ester (PSMOE) correlated positively with their anticancer activity increase, withICso 15.4mg/mL against P388 cell lines.Keywords: Anticancer, Streptomyces sp 517-02, UK-3A, Analog UK-3A and P388
ADSORPSI ZAT WARNA TEKSTIL PADA ZEOLIT ALAM DARI BAYAH Hilyati Hilyati; BAMBANG WIDIHASTONO
Jurnal Kimia Terapan Indonesia Vol 1, No 2 (1991)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3480.237 KB) | DOI: 10.14203/jkti.v1i2.304

Abstract

Adsorption equilibrium of a dye stuff (Basacryl Red X. GRL 300% of BASF) on a natural zeolite from Bayah was investigated by studying the effects of dye concentrations, panicle sizes of adsorbent, agitation rates and adsorption temperatures. The experimental results indicated that adsorption follows the Langmuir and Freundlich equations. Adsorption of dye stuff into the zeolite increased by decreasing the adsorbent panicle size and by increasing both temperature and agitation rate. The adsorption ability of the natural zeolite could be increased up to 5-7 % higher than inactroated zeolite via an aktivation proces by treating it with H2SO4, HCL, HNO3, NaOH or heating seperately. It is found that the maximum adsorption by zeolite occured at the base or acid concentration of 0,05 N, or at temperature of 100°C.
SITOTOKSISITAS XANTHORRHIZOL dari MINYAK ATSIRI RIMPANG Curcuma xanthorrhizaRoxb. terhadap SEL KANKER PAYUDARA YBM-1 Zalinar Udin
Jurnal Kimia Terapan Indonesia Vol 15, No 1 (2013)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4649.3 KB) | DOI: 10.14203/jkti.v15i1.101

Abstract

Curcuma xanthorrhiza Roxb. (temulawak) known hascytotoxic activity against cancel cells. The active compoundofCurcuma xanthorrhizaRoxb., for several cancer cells isxanthorrhizole. This research would assay the cytotoxicactivity of volatile oil from Curcuma xanthorrhizaRoxb. 'srhizome toward YMB-1 breast cancer cell. The method wasdone by in-vitro with alamar blue dyed, and measuredtheabsorbance to observe the viability (%) of cell and IC,ovalue. Xanthorrhizole used in this research was isolate fromethyl acetate fraction of Curcuma xanthorrhizaRoxb. 'srhizome compared the result with pure xanthorrhizol . Thecytotoxic activity assay toward YMB-1 cell showed thatxantorrhizole has highest activity with ICso 2.88 glmL,followed by the volatile oil with IC,o 3.20 glmL.lt meansthatactivity of volatile oil was not significantly different comparedwith that of xanthorrhizole . The lowest activity was found onisolate C27 with ICso 4.80 g/ml, while antimycin as positivecontrol gave IC,o 1.03 glmL..Keywords: Curcumaxanthorrhiza Roxb., volatile oil,xanthorrhizol,breast cancer,YMB-1cell, alamar blue method
PROSES PEMBUATAN SERTA ANALISA BENTON-38 DARI BENTONIT SEBAGAI BAHAN ADITIF PADA CAT Tasrif Tasrif; Nuryatini Nuryatini; Siti Isnijah
Jurnal Kimia Terapan Indonesia Vol 5, No 1 (1995)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3387.126 KB) | DOI: 10.14203/jkti.v5i1.237

Abstract

The production of bentone for paint additive from Cabentonite was carried out by ion exchange process. The process has two steps, i.e. Ca++ ion in Ca-bentonite is exchanged by Na+ ion in saturated solution of NaCl to produce Na-bentonite. Then, Na+ ion in Na-bentonite is exchanged into {(R1)2N(R2)2 + by using alkyl quaternary ammonium salt to produce bentone. lnterms of swelling characteristic the ion exchange using 140 ml of saturated solution of NaCl for 100 g Ca-bentonite produced best product with a swelling characteristic of 15.56. The amount of dimethyl distearyl ammonium salt (DAM) used for production of bentone-38 was 60 g/100 g bentonite. This is based on the ion exchange capacity of bentone-38, i.e. 69 meq for 100 g bentonite. Swelling characteristics of the above bentone-TS-R (reference) and bentone-38-H (experiment) were 24.5 and 39 in Spirit Mineral Terplne (SMT), 55 and 54 in SMT + ethanol (17:3 v/v), and the viscosity of bentone-38-R, and bentone-38-H are 7.2 cps and 6.5 cps respectively.
ISOlASI DAN ELUSIDASI SENYAWA KIMIA DARI KULIT POHON Garcinia tetrandra PIERRE Soleh Kosela; leonardus B. Kardono; M. Hanafi
Jurnal Kimia Terapan Indonesia Vol 10, No 1-2 (2000)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3414.945 KB) | DOI: 10.14203/jkti.v10i1-2.178

Abstract

A preliiminary study was carried out to isolate theconstituents of the stem bark of Garcinia tetran dra Pierre(Guttiferae). Several species of this family had been known asmedicinal herb, some other contain bioactive constituents andnovel compounds. The isolation were carried out by macerationin n-hexane where crude extract was purified usingchromatographic technique on SIG60 coloumn and n- hexane ethylacetate as eluents by gradient. Two pure compunds werefound and their molecular structures were determined on thebasis of combined spectroscopic methods UV, IR, 1H-NMR, l3C-NmR and MS and comparison with literature. The compouridhad been identified as xanton, 15-hydroxy-20, 21, 22, 23-tetramethyl-3H,11H-dipyrano (3, 2-a ; 2'. 3'-i) xanten-17-one(A), known as Thwaitesixanton and a triterpene as Hopenol - a(Hop-(22) (29)-en 3-0 ol) (B).
POTENSI TEMPE PASTA STERIL IRADIASI SEBAGAI NUTRISI ENTERAL PASIEN YANG MENGGUNAKAN ALAT BANTU NASO GASTRIC TUBE (NGT) Zubaidah Irawati; R. S. Adji Koesoemowidodo; Ades Puspita; Swasono R Tamat
Jurnal Kimia Terapan Indonesia Vol 15, No 2 (2013)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6133.892 KB) | DOI: 10.14203/jkti.v15i2.106

Abstract

Food irradiation process has a potential topromote of a safe, adequate and nutritiousfood supply for hospital diets. It has twoapplications that can contribute to thehealth and well being of humanity, i.e. theelimination of foodborne pathogensmicroorganisms, and the preservation offoods by the destruction of pests. Effects ofionizing radiation on tempe pasta selectedas samples for patient food intake throughNaso Gastric Tube (NGT) has beenstudied. Tempe pasta was vacuum packedin a laminate pouch of po lyesteraluminumfoil- linear low densitypolyethylene and gamma irradiated atdoses of 10 kGy and 25 kGy , respectivelyunder cryogenic condition and then storedat room temperature for 6 and 12weeks. Some quality parameters wereobserved. There was no significantdifferences between un irradiated andirradiated tempe pasta on the moisturecontent, pH, protein content and viscosity.Meanwhile isojlavon genestein contentand antioxidant capacity showed anincrease by increasing irradiation dose upto 12 weeks of storage. Malonaldehydecontent in tempe pasta was accelerating byincreasing the irradiation dose andextending the storage period but Peroxidevalue was not detected in all treatedsamples. The irradiated tempe pasta atcertain degree of viscosity and particlesize could be considered as protein basefood intake for immunocompromisedpatients through Naso Gastric Tube(NGT).Keywords: Tempe pasta, food irradiation,isojlavon genestine, nutritious food,immunocompromised patients.

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