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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 5 Documents

Search results for , issue "Vol 12, No 1 (2016)" : 5 Documents clear

CBIA-DIARRHEA FOR IMPROVING KNOWLEDGE, ATTITUDE AND BEHAVIOR OF MOTHER IN INFANT DIARRHEA TREATMENT FOR BINA KELUARGA BAHAGIA (BKB) BANGUNTAPAN, BANTUL Ajeng Padma Kumala; Sri Suryawati
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Diarrhea in infants becomes emerged issue in Indonesia (MOH, 2010). The role of mother as a 'key person' is expected to have a level of knowledges, attitudes, and behaviors that qualified for the treatment of diarrhea. CBIA shown to improve knowledge, attitudes and maternal behavior in choosing a drug (Suryawati, 1995). CBIA-Diarrhea adopted from CBIA is expected to gain the knowledge, attitudes, and behavior of the mother in the management of diarrhea so as to reduce morbidity and infant mortality. For improving knowledge, attitudes, and behavior of the mother in the prevention of diarrhea in infants with CBIA-Diarrhea method and to develop methods from CBIA into CBIA-Diarrhea. This type of research is quasi-experimental design with pre-test to post-test control group design. There are 40 respondents to the treatment group and 40 respondents to the control group. Selected respondents has entered inclusion criteria, and selected randomly. CBIA-Diarrhea intervention and readings of diarrhea in infants by the experimental group, and in the control group performed conventional lectures with material non-diarrhea. relationship between variables was analyzed by Wilcoxon and Man-Whiteney with a confidence level of 95 %. There are a significant difference between pre and post intervention of CBIA which developed a new module CBIA-Diarrhea. The knowledge, attitudes and maternal behavior increased after intervention by the method of CBIA-Diarrhea. The development of CBIA to CBIA-Diarrhea shown to improve knowledge, attitudes and maternal behavior for the treatment ofdiarrhea in infants.

IRRITATION TEST AND PHYSICAL PROPERTIES OF UNGUENTUM VOLATILE OIL OF Syzygium aromaticum IN HYDROCARBON BASE Neneng Rachmalia Izzatul Mukhlishah; Nining Sugihartini; Tedjo Yuwono
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Essential oil of clove (Syzygium aromaticum) with the active compound eugenol has been widely studied and well known efficacious as antiinflammatory, and advanced research related to the formulation continues. Formula in this study was the topical dosage form an ointment using a hydrocarbon base (Vaseline album and Paraffin liquidum). Aim of this study was to know the physical properties and the power of irritation from ointment of clove essential oil (MABC) hydrocarbon base. The ointment was made by the melting method with concentration of MABC 5% (F1), 10% (FII) and 15% (FIII). Then the ointment of the third formula was evaluated its physical properties (spreadibility, adhesivity and pH). It was also evaluated the irritation’s properties on the skin by using a male guinea pigs test animals by the method of Draize test. The data were analyzed statistically with a confidence level of 95%. The statistical shows that were method significant differences between the formula. The increasing concentration of MABC, causes the greater of spreadibility (p<0,05) and adhesivity (p <0.05 between F 1 and FIII). On the other hand, the Kruskal Wallis test of pH shows there was no significant difference (p> 0.05). The results of irritation Draize test shows that an ointment base MABC hydrocarbon with concentration of 5%, 10% and 15% does not cause irritation.

THE EFFECT OF COMBINATION OF PEARLITOL® 400DC AND CROSCARMELLOSE SODIUM ON THE PHYSICAL PROPERTIES OF FAST DISINTEGRATING TABLET HIDROKLOROTIAZID Margareta Anindya Christianti; T.N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Hydrochlorothiazide is commonly used as first-line antihypertensive drugs. Hydrochlorothiazide is available in tablet dosage forms which has disadvantages such as taking long time to be absorbed, low bioavailability, and inconvenience for geriatric patients. Fast Disintegrating Tablet (FDT) is an alternative dosage form that can overcome the disadvantages of conventional tablets. This study aims to determine the effect of combination of Pearlitol® 400DC and croscarmellose sodium on the physical properties of FDT hydrochlorothiazide. Five runs of FDT hydrochlorothiazide are made using direct compression method, with the combination of Pearlitol® 400 DC and croscarmellose sodium are Run 1 (70%: 2%), Run 2 (68%: 4%), Run 3 (66%: 6%), Run 4 (64% : 8%), and Run 5 (62%: 10%). Evaluations of the FDT physical properties include hardness, friability, disintegration time, wetting time, water absorption ratio, and drug dissolution. Results are analyzed using simplex lattice design method with Design-Expert® software to obtain the optimum formula. Results show that the combination of Pearlitol® 400DC and croscarmellose sodium take effects to the physical properties of FDT hydrochlorothiazide. Increasing proportion of Pearlitol® 400DC may improve wetting time and friability, meanwhile increasing proportion of croscarmellose sodium may increase hardness, water absorption ratio, disintegration time, and reducing drug dissolution.

THE EFFECT OF SWEETENER TO THE FORMULATION OF LOZENGES TABLET FROM CITRUS FRUIT PEELS PONTIANAK’S ESSENTIAL OILS Ella Sriasih; Wintari Taurina; Rafika Sari
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pontianak orange (Citrus nobilis Lour. var. microcarpa) has good benefit for health. Adding value of peel waste, it can be the waste of Pontianak citrus it can be formulated into lozenges contains essential oils. The lozenges were made by direct compress method with variation of manitol-sukrose ratio as sweetening agent. Formula 1 uses sucrose as sweetener, formula 2 employs combination of manitol-sukrose (1:1). Meanwhile, formula 3 uses manitol as sweetening agent. Based on the research, it showed that variations of the sweetener affect the physical properties of lozenges. Friability test of the tablet performed significant difference between formula 1 and formula 2 which formula 1 is better than formula 2 in friability. Taste test and preference of the respondent showed formula 1 as the most preferred with score of 124 in flavor aspect and texture with score of 113.

EVALUATION OF GOOD DISTRIBUTION PRACTICE (GDP) IMPLEMENTATION IN DRUG STORE AT MLATI, SLEMAN, YOGYAKARTA Isna Sugih Hartini; Marchaban Marchaban
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Drug distribution is an important process in maintaining efficacy, safety, and quality of a drug after manufacturing process. Good Distribution Practices (GDP) should be implemented in distribution facilities included pharmacies. Drug quality should be main concern until the drug is administered to patients. This study is intended to determine GDP implementation and follow-up steps that should be implemented to pharmacies in Mlati, Sleman, Yogyakarta. It is a descriptive qualitative study conducted on pharmacies by reviewing the application of GDP upon the profile aspects of facilities, buildings and equipment, procurement, reception and storage, distribution, handling of product returns and expire date, etc. Primary data obtained by interviewing head of pharmacists (APA) or vice of head pharmacists using the check-list form. Subsequently, the data are analyzed qualitatively to determine the follow-up steps which should be taken to pharmacies that are not eligible to operate. The results showed that no one of pharmacy absolutely follows the GDP rule, 88.89% of pharmacies should be warned seriously, and 11,11% of pharmacies should be suspended temporarily.

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