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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
 128   129   130   131   132 
Total Mercury (THg) Concentration in Indian Scad (Decapterus russelli) and Torpedo Scad (Megalaspis cordyla) from Southern Waters of Binuangeun, Banten Suratno Suratno; Zahriza Purnadayanti; Hilda Novianty; Selvia Oktaviyani
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56967

Abstract

The high level of fish consumption was the main factor in the vulnerability of Hg exposure to the human body. The preliminary information of the total mercury (THg) concentration of Indian scad (Decapterus russelli) and Torpedo scad (Megalaspis cordyla) from Binuangeun fish auction in Lebak, Banten, Indonesia, was presented in this research. The objective of this research was to understand the distribution of THg in each organ of D. russelli (muscle, gut tissues, gonad, and eggs) and M. cordyla (muscle, liver, and gut contents). The results showed that THg in all samples were below the National Regulation limit from the National Agency of Drug and Food in mg/kg ww. THg gonad from D. russelli was showed highly significant (P < 0.01) lower compare THg in muscle, gut tissues, and eggs. Pearson’s correlation from THg in each organ of D. russelli compare to total weight and total length showed that concentration of THg in gonad highly significantly (p < 0.01) correlated with total body weight (r2 = 0.97) and total length (r2 = 0.96). M. cordyla was showed no correlation of THg in muscle compare to total length and total weight. The present study showed that D. russelli could accumulate higher mercury compare to M. cordyla and need caution while consuming this fish.
Design of New Quinazoline Derivative as EGFR (Epidermal Growth Factor Receptor) Inhibitor through Molecular Docking and Dynamics Simulation Herlina Rasyid; Bambang Purwono; Harno Dwi Pranowo
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.57012

Abstract

Erlotinib, Afatinib, and WZ4002 are quinazoline derivative compounds and classified as first, second, and third-generation EGFR inhibitor. All inhibitors have been given directly to cancer patients for many years but find some resistance. These three compounds are candidates as the lead compound in designing a new inhibitor. This work aims to design a new potential quinazoline derivative as an EGFR inhibitor focused on the molecular docking result of the lead compound. The research method was started in building a pharmacophore model of the lead compound then used to design a new potential inhibitor by employing the AutoDock 4.2 program. Molecular dynamics simulation evaluates the interaction of all complexes using the Amber15 program. There are three new potential compounds (A1, B1, and C1) whose hydrogen bond interaction in the main catalytic area (Met769 residue). The Molecular Mechanics Generalized Born Surface Area (MM-GBSA) binding energy calculation shows that B1 and C1 compounds have lower binding energies than erlotinib as a positive control, which indicates that B1 and C1 are potential as EGFR inhibitor.
Synthesis and Characterization of 2,3-Diaminomaleonitrile Derivatives by One-Pot Schiff Base Reaction and Their Application in Dye Synthesized Solar Cells Saifaldeen Muwafag Abdalhadi; Asmaa Yahya Al-Baitai; Hazim Abdulrazzaq Al-Zubaidi
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.57535

Abstract

In a one-pot reaction, three new 2,3-diaminomaleonitrile (DAMN) derivative dyes were prepared by simple Schiff base reaction. The compounds were designed as a sensitizer in dye synthesizes solar cells (DSSCs). Many conditions have been used to provide the methodology to get the best yield. The prepared dyes were characterized by melting point, elemental microanalysis, mass spectroscopy, FT-IR, 1H-NMR, and UV-Vis spectroscopy. A computational study was carried out to support our results. The DSSC data was shown the best performance for SA3 dye with 0.38% efficiency at AM 1.5 then SA2 with 0.22% and the last dye is SA1 with 0.09%, compared to control cell (N719) 5.4%.
Synthesis, Molecular Docking, and Evaluation of Some New Curcumin Analogs as Antimalarial Agents Endang Astuti; Tri Joko Raharjo; Putra Boang Manalu; Ilham Satria Putra; Stephanus Satria Waskitha; Junita Solin
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.57646

Abstract

This research involves the synthesis, antimalarial evaluation, and molecular docking of several curcumin analogs. A total of six curcumin analog compounds were synthesized using aldol condensation using hydrochloric acid and sodium hydroxide catalysts. The synthesized compounds were elucidated using FTIR, 1H-NMR, 13C-NMR, and LC-MS/MS. Subsequently, all curcumin analogs were tested as an antimalarial agent against Plasmodium falciparum 3D7 strain, and their mechanism of action was evaluated through a molecular docking study. Six curcumin analogs, i.e. 2,6-bis(2-hydroxybenzylidene)cyclohexanone; 2,6-bis(2-hydroxybenzylidene)cyclopentanone; 1.5-bis(2-hydroxyphenyl)penta-1,4-diene-3-one; 2,6-bis(3-hydroxybenzylidene)cyclo-hexanone; 2,6-bis(3-hydroxybenzylidene)cyclopentanone; and 1,5-bis(3-hydroxy-phenyl)penta-1,4-diene-3-one have been successfully synthesized. In addition, 2,6-bis(2-hydroxybenzylidene) cyclopentanone demonstrated the lowest IC50 value and binding affinity of 0.04 µM and -7.6 kcal/mol, respectively. Based on molecular docking studies, this compound also showed the most potent antimalarial activity targeted at PfATP6.
Study of Mangosteen Peel (Garcinia mangostana L.) Waste Capability to Recover Au(III) and Ag(I) in Aqueous Solution Mellia Harumi; Rian Kurniawan; Agustiwandina Saputri; Dian Hanna Saraswati; Meissha Ayu Ardini; Sri Sudiono
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.57670

Abstract

Electronic waste (e-waste) has been confirmed containing some precious metals such as gold and silver. Mangosteen peel waste as eco-friendly adsorbent has been studied to recover Au(III) and Ag(I) successfully. Recovery was started through adsorbent preparation, consisting of soxhlet extraction and maceration. About 100 mg of adsorbent was dispersed into Au(III) and Ag(I) solutions in various pH conditions (2–6). The result proves that the optimum adsorptions of Au(III) and Ag(I) are at pH 2 and pH 6, respectively. Au(III) adsorption follows the isotherm model of Langmuir with a maximum capacity of 0.580 mmol/g (114.27 mg/g). Ag(I) adsorption follows the isotherm model of Freundlich with a maximum capacity of 0.511 mmol/g (55.10 mg/g).
Study of the Electrochemical Behavior of Merocyanine and Merocarbocyanine Salts and Their Transformation into Π-Electron Donor Molecules, Namely Tetrathiatetraazafulvalenes Manel Khiat; Fatima-Zohra Zradni; Souad Kasmi-Mir; Alejandro Baeza
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58132

Abstract

An electrochemical study using the cyclic voltammetry method was carried out on some previously prepared merocyanines salts, namely thiazolideniumsulfonate salts 5a-b, and thiazolidenium chloride salts 6a-b, and merocarbocyanines salts, namely alkylidenthiazolidenium sulfonate salt 5c, and alkylidenthiazolidenium chloride salt 6c. These salts are transformed by dimerization in situ in a voltammetric cell into tetrathiatetraazafulvalenes (TTTAFs) 7a-b, 7’a-b, 8c, and 8'c supposed to be π-electron donor molecules due to the existing conjugation in their structure. The structure of all new chemically synthesized molecules was confirmed by IR, 1H-NMR, 13C-NMR, and MS. The transformation of salts into TTTAF was confirmed by a reversible voltammogram curve and the variation of observed potentials.
Spatial Distribution of Heavy Metals in Al-Zarqa, Jordan Reem Naser Dabaibeh
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58304

Abstract

Al-Zarqa is experiencing challenges in industry conversion and extensive urbanization. The environmental quality of soil in the Al-Zarqa region was analyzed by Spatial analysis for the identification of sources and estimation of the concentration of heavy metals, which helped in the assessment of soil quality and heavy metal pollution. The reason for the elevation of heavy metal pollution is increased urbanization, industrialization, traffic, oil refinery emissions, and mixed anthropogenic sources in that region. The main objective of this research was to assess the ecological impact of heavy metals pollutants in the Al-Zarqa region. The concentrations of (Cd, Cr, Cu, Mn, Ni, Pb, Zn, and Fe) were estimated and compared with the existing literature. The distribution pattern of each metal was identified by spatial distribution analysis. Results revealed that metals concentration (Cd, Cr, and Ni) is higher, and the concentration of Pb, Zn, and Cu is less than the maximum allowed limits. Factor analysis identified the potential sources of heavy metals in the investigated area, and spatial distribution showed the geographical distribution of heavy metals over the study area. Consequently, it is better than showing only the individual point concentration without identifying their potential sources and their geographical variations.
Flavonoids as Antidiabetic Agents Yana Cahyana; Tsani Adiyanti
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58439

Abstract

Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. The aim of this review is to describe the flavonoid's ability as an alternative treatment for diabetes type-II patients. This paper addresses several aspects in which flavonoids may impart a pivotal role in starch digestion, such as the interaction of flavonoids with enzymes involved in starch hydrolysis, the role of flavonoids in inhibiting glucose absorption, as well as the interaction of flavonoids with starch to form a complex resistant to hydrolysis. Further studies, however, are suggested to extensively carry out, particularly the ones dealing with the intervention study using human volunteers to reveal the role of flavonoids in the real applications. The data on human intervention studies are still rare and can further be exploited using meta-analysis to have firmer results. Flavonoids in the food matrix are more realistic to perform to reveal the effect of interaction with other compounds, which may affect the mechanism of flavonoids interaction or their bioavailability.
Multiple Response Optimization of a HPLC Method for Analyzing Resorcinol and 4-n-Butyl Resorcinol in Lipid Nanoparticles Rini Dwiastuti; Dina Christin Ayuning Putri; Maywan Hariono; Florentinus Dika Octa Riswanto
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58537

Abstract

Resorcinol and 4-n-butyl resorcinol have been used to improve skin health. However, these two compounds were unstable due to the oxidation process. Lipid nanoparticle formulation strategies were reported as the solution to overcome the stability problem for both resorcinol and 4-n-butyl resorcinol. Nevertheless, it is important to determine the content of resorcinol and 4-n-butyl resorcinol in lipid nanoparticle formulation. Aiming to develop the analytical method for resorcinol and 4-n-butyl resorcinol determination, a response surface methodology (RSM) was applied in the HPLC optimization stage. An optimized HPLC condition was obtained by generating a Box-Behnken design followed by multiple response analysis. It was obtained that optimized HPLC conditions due to the predictive multiple response optimization were methanol percentage of 50.0%, acetonitrile percentage of 18.1%, and flow rate of 0.6 mL min–1. This optimized condition was successfully applied and met the requirements of the system suitability test. Quantitative estimation was performed and resulted that the resorcinol and 4-n-butyl resorcinol content in lipid nanoparticles were 70.37 ± 0.47 and 95.07 ± 0.80 µg mL–1, respectively.
Separation of Rhodamine B Dye from Aqueous Media Using Natural Pomegranate Peels Zainab Mohammad Saigl; Arwa Mohammed Ahmed
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58592

Abstract

Natural pomegranate peels (PPs) ground powder was proved as effective natural biomass for the separation of RhB from different aqueous media by batch adsorption experiments. Several parameters that affect the maximum adsorption capacity toward RhB dye, e.g., the pH solution, initial dye concentration, adsorbent dosage, shaking time, and solution temperature in the sorption behavior, were studied. Adsorption of RhB dye from aqueous media of pH ≈ 5 reached equilibrium in 10 min and was independent of the initial concentration of RhB. RhB dye sorption followed pseudo-second order kinetic with an overall rate constant (k2) of 0.04 g mg–1 min–1. Furthermore, the sorption isotherm was found 31.95 ± 0.02 mg g–1 for the sorption capacity of RhB onto PPs. The thermodynamic parameters (ΔH, ΔS, and ΔG) of RhB retention by the sorbent were calculated. The positive value of ΔH confirms the endothermic behavior of the adsorption of RhB by PPs from aqueous solution. The positive value of entropy (ΔS = 42.17 J mol–1 K–1) of the sorption of RhB onto the sorbent surface may be attributed to the increase in the degree of freedom of the RhB molecules is more restricted in the PPs structure than in solution.

Page 130 of 196 | Total Record : 1956

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