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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
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Design, Synthesis, In-Silico Study of Novel Benzofuran Thiazolyl Hydrazones as Anticancer Agents Targeting EGFR Kinase Shinde, Sonali Sandeep; Kilbile, Jaydeo Tirthraj; Bhusari, Sachin Shivling; Wakte, Pravin Shridhar
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106097

Abstract

In the current investigation, a series of new benzofuran-thiazolyl hydrazones 5(a–h) were synthesized, characterized, and tested for anticancer activity against selected cancer cell lines, including A549, MCF-7, and DU-145, using MTT and EGFR enzymatic assays. The synthesized compounds 5g and 5h showed considerable anticancer activity, with IC₅₀ values ranging from 9.05 to 18.09 μM and 12.03 to 13.09 μM, respectively. Doxorubicin and osimertinib were used as the standard drugs for comparison of activity. Compounds 5g and 5h also showed significant antioxidant activity as measured by the DPPH method. The molecular docking investigation was conducted against the EGFR (PDB: 1M17) to learn about the interactions of synthesized compounds with binding pockets. Furthermore, an ADME research and molecular dynamics simulation study was conducted to provide insight into drug-likeness and conformational stability. The results show a good match between reported anticancer effects and computational analyses. Compounds 5g and 5h exhibited significant cytotoxicity against lung, breast, and prostate cancer cell lines. These findings underscore the potential of benzofuran-thiazolyl hydrazone derivatives as promising candidates for the development of novel anticancer therapeutics.
Free Radical Scavenging Activity of Chlorochalcones: An Integrated Computational and Experimental Study Puspitasari, Anita Dwi; Ulfah, Maria; Hartati, Indah; Vifta, Rissa Laila; Hermawan, Faris; Ekasari, Munifilia; Marlina, Lala Adetia
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106221

Abstract

Chlorochalcone derivatives (chalcones 1–3) were synthesized using ultrasound-assisted Claisen-Schmidt condensation, yielding > 80%. Antioxidant activity was evaluated through DPPH and ABTS assays, demonstrating strong activity with IC50 values ranging from 61.52 ± 0.97 to 98.27 ± 1.42 ppm. Chalcones 1 and 2 show SPF potential at 40 ppm and chalcone 3 at 20 ppm (SPF 19.47 ± 0.46). ADMET analysis using the pkCSM tool confirmed favorable pharmacokinetic profiles and low toxicity, supporting their safety for potential applications. Additionally, density functional theory calculations provided more profound insights into molecular stability and reactivity, including electronic properties such as HOMO-LUMO gaps, further corroborating their pharmacological efficacy. These results collectively indicate that chalcones 1–3 exhibit potent antioxidant activity, adequate UV protection, and promising pharmacokinetic properties. Integrating in vitro, in silico, and DFT analyses underscores their potential as multifunctional compounds for antioxidant and sunscreen applications.
Unveiling the Bioactive Compound Potential of Red Mariposa Christia vespertilionis Using Chemometric and ATR-FTIR Spectroscopy Mohamad Tahier, Soraya Shafawati; Jaafar, Nurfirzana Liyana Abdul
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106329

Abstract

Red Mariposa Christia vespertilionis (MCV) is a medicinal plant containing potential bioactive compounds of interest; however, these have not been fully investigated. This work focuses on the antioxidant properties of red MCV, as evaluated by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy with chemometric methods of analysis such as principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA).The highest total phenolic levels (15.91 ± 0.04 mg GAE/mL) were found in the leaf of aqueous extracts, and total flavonoid content, 15.7 ± 0.04 mg QE/mL, in hexane extracts, compared to other solvents, which is linked to better DPPH radical scavenging activity (74.24 ± 0.00%). The FTIR spectra demonstrated the presence of hydroxyl (O−H) and carbonyl (C=O) functional groups, indicating a significant abundance of polyphenols and flavonoids. The bioactive composition of the red MCV was definitively confirmed through chemometric techniques. The chemometric analysis revealed that methanol and aqueous extracts offer maximum antioxidant and optimum solvent profiles. These results show that red MCV is a feasible source for pharmaceutical and nutraceutical applications dealing with oxidative stress.
Recent advances in Blue-Emitting Iridium(III) Complexes Featuring 2-(2,4-Difluorophenyl)pyridine as the Cyclometalating Ligand Zulkarnaen, Nur Khaliesa; Ali, Noorshida Mohd
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106512

Abstract

The significance of blue emitters in the realization of cutting-edge organic light-emitting diode (OLED) displays cannot be overstated, leading to considerable efforts aimed at synthesizing intense blue phosphorescent Ir(III) complexes that are stable for use as dopants. Nevertheless, the quest for highly effective blue phosphorescent Ir(III) complexes remains fraught with challenges. Bis(2-(4,6-difluorophenyl)pyridinato-C2,N)(picolinato)iridium(III) (FIrpic), which employs 2-(2,4-difluorophenyl)pyridine (F2ppy) as the cyclometalating ligand and picolinic acid as the ancillary ligand, serves as a benchmark for blue phosphorescent Ir(III) complexes because of its outstanding performance in OLED devices, yet it still exhibits several limitations. Consequently, the pursuit of more effective blue phosphorescent iridium complexes remains a priority. In recent years, advancements in the field have focused on blue phosphorescent Ir(III) complexes utilizing a variety of cyclometalated ligands in conjunction with bidentate ancillary ligands, leading to extensive investigation. This discussion will highlight and analyze the most recent progress in designing and preparing those complexes, particularly utilizing F2ppy alongside diverse bidentate ancillary ligands. Future studies are encouraged to focus on structural modification of the F2ppy cyclometalating ligand, particularly with the combination of suitable ancillary ligands, to improve further color purity of blue-emitting Ir(III) complexes and their photophysical performance.
Detecting Hesperidin in Pharmaceutical Forms via Sensitive and Eco-Friendly Cloud Point Extraction Method Utilizing Spectrophotometry Salman, Ali Mohammed; Abed, Sadeem Subhi
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106702

Abstract

A spectrophotometric method was developed for the determination of hesperidin (HSP) in pharmaceutical preparations and bulk powder, characterized by sensitivity, simplicity, and ecofriendliness. The method involves diazotization of p-chloroaniline (PCA), followed by coupling with HSP in an alkaline medium. The resulting azo product is extracted using the cloud point extraction (CPE) with Triton X-114, and the absorbance was measured at 437 nm. Two approaches were used, i.e., the batch spectrophotometric method and the CPE technique. The batch method showed a detection limit of 0.409 μg/mL, while the CPE method achieved a significantly lower detection limit of 0.023 µg/mL. The linearity ranges were 3–40 and 1–8.5 μg/mL of HSP for the batch and CPE methods. Both methods demonstrated high precision (RSD < 1.17%) and excellent recovery rates, 99.18 to 102.27% for the batch method and 97.32 to 104.28% for CPE, with an enrichment factor of 4.7 using CPE. The methods were successfully applied to the analysis of HSP in supplement formulations and spiked urine samples without significant interference. A greenness evaluation using AGREE software confirmed its environmentally friendly nature. The proposed method offers a reliable, green, low-cost analytical approach suitable for routine pharmaceutical quality control in laboratories to analyze HSP in dosage forms.
Prolonged Release of Anti-inflammatory Diclofenac Sodium from In Situ Loaded Thermosensitive Chitosan Hydrogels for Localized Applications Do, Nga Hoang Nguyen; Le, Ha Vu; Nguyen, Khoa Dang; Ha, Anh Cam
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106833

Abstract

Previous work developed a thermosensitive hydrogel from chitosan (CS) and β-glycerophosphate (GP) loaded with diclofenac sodium (DIC) using a post-loading method. The hydrogel as a wound dressing exhibited burst release of DIC within 5 h, rendering it suitable for immediate anti-inflammatory treatment. For the first time, the in situ loading method has been applied to synthesize an injectable CS/GP hydrogel for prolonged DIC release. The optimal synthesis condition is at 1.0 w/v% CS (high molecular weight of 324 kDa) and 4.0 w/v% GP, yielding the hydrogel capable of sol-gel transition at 37 °C. The porous structure of the hydrogels is filled with DIC, ensuring efficient drug entrapment. The hydrogels demonstrate prolonged DIC release over 7 days, achieving a cumulative drug release (CDR) ranging from 62.39 to 80.51%. At an initial DIC loading of 3000 µg/mL, the hydrogel maintains a drug concentration above 10 µg/mL after 6 days of release. DIC release kinetics are temperature-dependent, with a higher CDR at 39 °C (simulating an inflammatory condition) than 37 °C (normal body temperature), and governed by drug diffusion and hydrogel network swelling. This study provides a novel approach for synthesizing an injectable temperature-responsive CS hydrogel for local anti-inflammatory DIC delivery.

Page 196 of 196 | Total Record : 1956

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