cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 2,006 Documents
 194   195   196   197   198 
Design, Synthesis, In-Silico Study of Novel Benzofuran Thiazolyl Hydrazones as Anticancer Agents Targeting EGFR Kinase Shinde, Sonali Sandeep; Kilbile, Jaydeo Tirthraj; Bhusari, Sachin Shivling; Wakte, Pravin Shridhar
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106097

Abstract

In the current investigation, a series of new benzofuran-thiazolyl hydrazones 5(a–h) were synthesized, characterized, and tested for anticancer activity against selected cancer cell lines, including A549, MCF-7, and DU-145, using MTT and EGFR enzymatic assays. The synthesized compounds 5g and 5h showed considerable anticancer activity, with IC₅₀ values ranging from 9.05 to 18.09 μM and 12.03 to 13.09 μM, respectively. Doxorubicin and osimertinib were used as the standard drugs for comparison of activity. Compounds 5g and 5h also showed significant antioxidant activity as measured by the DPPH method. The molecular docking investigation was conducted against the EGFR (PDB: 1M17) to learn about the interactions of synthesized compounds with binding pockets. Furthermore, an ADME research and molecular dynamics simulation study was conducted to provide insight into drug-likeness and conformational stability. The results show a good match between reported anticancer effects and computational analyses. Compounds 5g and 5h exhibited significant cytotoxicity against lung, breast, and prostate cancer cell lines. These findings underscore the potential of benzofuran-thiazolyl hydrazone derivatives as promising candidates for the development of novel anticancer therapeutics.
Free Radical Scavenging Activity of Chlorochalcones: An Integrated Computational and Experimental Study Puspitasari, Anita Dwi; Ulfah, Maria; Hartati, Indah; Vifta, Rissa Laila; Hermawan, Faris; Ekasari, Munifilia; Marlina, Lala Adetia
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106221

Abstract

Chlorochalcone derivatives (chalcones 1–3) were synthesized using ultrasound-assisted Claisen-Schmidt condensation, yielding > 80%. Antioxidant activity was evaluated through DPPH and ABTS assays, demonstrating strong activity with IC50 values ranging from 61.52 ± 0.97 to 98.27 ± 1.42 ppm. Chalcones 1 and 2 show SPF potential at 40 ppm and chalcone 3 at 20 ppm (SPF 19.47 ± 0.46). ADMET analysis using the pkCSM tool confirmed favorable pharmacokinetic profiles and low toxicity, supporting their safety for potential applications. Additionally, density functional theory calculations provided more profound insights into molecular stability and reactivity, including electronic properties such as HOMO-LUMO gaps, further corroborating their pharmacological efficacy. These results collectively indicate that chalcones 1–3 exhibit potent antioxidant activity, adequate UV protection, and promising pharmacokinetic properties. Integrating in vitro, in silico, and DFT analyses underscores their potential as multifunctional compounds for antioxidant and sunscreen applications.
Unveiling the Bioactive Compound Potential of Red Mariposa Christia vespertilionis Using Chemometric and ATR-FTIR Spectroscopy Mohamad Tahier, Soraya Shafawati; Jaafar, Nurfirzana Liyana Abdul
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106329

Abstract

Red Mariposa Christia vespertilionis (MCV) is a medicinal plant containing potential bioactive compounds of interest; however, these have not been fully investigated. This work focuses on the antioxidant properties of red MCV, as evaluated by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy with chemometric methods of analysis such as principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA).The highest total phenolic levels (15.91 ± 0.04 mg GAE/mL) were found in the leaf of aqueous extracts, and total flavonoid content, 15.7 ± 0.04 mg QE/mL, in hexane extracts, compared to other solvents, which is linked to better DPPH radical scavenging activity (74.24 ± 0.00%). The FTIR spectra demonstrated the presence of hydroxyl (O−H) and carbonyl (C=O) functional groups, indicating a significant abundance of polyphenols and flavonoids. The bioactive composition of the red MCV was definitively confirmed through chemometric techniques. The chemometric analysis revealed that methanol and aqueous extracts offer maximum antioxidant and optimum solvent profiles. These results show that red MCV is a feasible source for pharmaceutical and nutraceutical applications dealing with oxidative stress.
Recent advances in Blue-Emitting Iridium(III) Complexes Featuring 2-(2,4-Difluorophenyl)pyridine as the Cyclometalating Ligand Zulkarnaen, Nur Khaliesa; Ali, Noorshida Mohd
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106512

Abstract

The significance of blue emitters in the realization of cutting-edge organic light-emitting diode (OLED) displays cannot be overstated, leading to considerable efforts aimed at synthesizing intense blue phosphorescent Ir(III) complexes that are stable for use as dopants. Nevertheless, the quest for highly effective blue phosphorescent Ir(III) complexes remains fraught with challenges. Bis(2-(4,6-difluorophenyl)pyridinato-C2,N)(picolinato)iridium(III) (FIrpic), which employs 2-(2,4-difluorophenyl)pyridine (F2ppy) as the cyclometalating ligand and picolinic acid as the ancillary ligand, serves as a benchmark for blue phosphorescent Ir(III) complexes because of its outstanding performance in OLED devices, yet it still exhibits several limitations. Consequently, the pursuit of more effective blue phosphorescent iridium complexes remains a priority. In recent years, advancements in the field have focused on blue phosphorescent Ir(III) complexes utilizing a variety of cyclometalated ligands in conjunction with bidentate ancillary ligands, leading to extensive investigation. This discussion will highlight and analyze the most recent progress in designing and preparing those complexes, particularly utilizing F2ppy alongside diverse bidentate ancillary ligands. Future studies are encouraged to focus on structural modification of the F2ppy cyclometalating ligand, particularly with the combination of suitable ancillary ligands, to improve further color purity of blue-emitting Ir(III) complexes and their photophysical performance.
Detecting Hesperidin in Pharmaceutical Forms via Sensitive and Eco-Friendly Cloud Point Extraction Method Utilizing Spectrophotometry Salman, Ali Mohammed; Abed, Sadeem Subhi
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106702

Abstract

A spectrophotometric method was developed for the determination of hesperidin (HSP) in pharmaceutical preparations and bulk powder, characterized by sensitivity, simplicity, and ecofriendliness. The method involves diazotization of p-chloroaniline (PCA), followed by coupling with HSP in an alkaline medium. The resulting azo product is extracted using the cloud point extraction (CPE) with Triton X-114, and the absorbance was measured at 437 nm. Two approaches were used, i.e., the batch spectrophotometric method and the CPE technique. The batch method showed a detection limit of 0.409 μg/mL, while the CPE method achieved a significantly lower detection limit of 0.023 µg/mL. The linearity ranges were 3–40 and 1–8.5 μg/mL of HSP for the batch and CPE methods. Both methods demonstrated high precision (RSD < 1.17%) and excellent recovery rates, 99.18 to 102.27% for the batch method and 97.32 to 104.28% for CPE, with an enrichment factor of 4.7 using CPE. The methods were successfully applied to the analysis of HSP in supplement formulations and spiked urine samples without significant interference. A greenness evaluation using AGREE software confirmed its environmentally friendly nature. The proposed method offers a reliable, green, low-cost analytical approach suitable for routine pharmaceutical quality control in laboratories to analyze HSP in dosage forms.
Prolonged Release of Anti-inflammatory Diclofenac Sodium from In Situ Loaded Thermosensitive Chitosan Hydrogels for Localized Applications Do, Nga Hoang Nguyen; Le, Ha Vu; Nguyen, Khoa Dang; Ha, Anh Cam
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.106833

Abstract

Previous work developed a thermosensitive hydrogel from chitosan (CS) and β-glycerophosphate (GP) loaded with diclofenac sodium (DIC) using a post-loading method. The hydrogel as a wound dressing exhibited burst release of DIC within 5 h, rendering it suitable for immediate anti-inflammatory treatment. For the first time, the in situ loading method has been applied to synthesize an injectable CS/GP hydrogel for prolonged DIC release. The optimal synthesis condition is at 1.0 w/v% CS (high molecular weight of 324 kDa) and 4.0 w/v% GP, yielding the hydrogel capable of sol-gel transition at 37 °C. The porous structure of the hydrogels is filled with DIC, ensuring efficient drug entrapment. The hydrogels demonstrate prolonged DIC release over 7 days, achieving a cumulative drug release (CDR) ranging from 62.39 to 80.51%. At an initial DIC loading of 3000 µg/mL, the hydrogel maintains a drug concentration above 10 µg/mL after 6 days of release. DIC release kinetics are temperature-dependent, with a higher CDR at 39 °C (simulating an inflammatory condition) than 37 °C (normal body temperature), and governed by drug diffusion and hydrogel network swelling. This study provides a novel approach for synthesizing an injectable temperature-responsive CS hydrogel for local anti-inflammatory DIC delivery.
Chemical Constituents and Antifeedant Activity of Essential Oils from Four Selected Malaysian Local Plants against the Invasive Red Palm Weevil Larvae Tay, Karh Yan; Mehamod, Faizatul Shimal; Azmi, Wahizatul Afzan; Harun, Nor Omaima; Adnan, Azila; Zakeri, Hazlina Ahamad
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.97509

Abstract

Red palm weevil, a significant pest affecting oil palm cultivation, necessitates eco-friendly control strategies due to the environmental and health risks posed by synthetic insecticides. This study explores the efficacy of essential oils from lemongrass, gelam, pandan, and beach vitex as sustainable alternatives. Employing hydrodistillation for oil extraction, this study assessed the total phenolic content (TPC) and total flavonoid content (TFC) using gallic acid and quercetin standards, respectively. GC-MS analysis was conducted to identify the chemical constituents. The antifeedant activity was evaluated through food consumption, larval weight changes, and the feeding deterrent index (FDI) in sago food substrate experiments. Findings show oil yields of 0.42, 0.24, 0.04, and 0.03% w/w for lemongrass, gelam, beach vitex, and pandan, respectively, with gelam exhibiting the highest TPC and TFC (12.3 ± 0.36 and 10.8 ± 0.03). Significant constituents identified include beta-citral and citral in lemongrass, terpinolene in gelam, alpha-pirene in vitex, and phytol in pandan. Lemongrass and gelam displayed notable antifeedant effects, with FDI ranging from 24 to 28%, suggesting their potential as alternatives for managing the red palm weevil. This research highlights the potential of lemongrass and gelam oils as environmentally friendly and effective alternatives to synthetic insecticides in combating the invasive red palm weevil.
Potential of Favipiravir Analogs as SARS-CoV-2 RdRp Inhibitors: Synthesis and In Silico Studies Alni, Anita; Lokitha, Angela; Maulana, Yusuf Eka; Hermawati, Elvira; Danova, Ade
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.98538

Abstract

The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for causing the lethal infectious disease known as COVID-19. The RNA-dependent RNA polymerase (RdRp) is a pivotal component that facilitates the translation of viral RNA into viral proteins. Therefore, our study aimed to synthesize new inhibitors from favipiravir (FVP) analogs by modifying the hydrophobicity through a nucleophilic aromatic substitution at the C-6 position of the pyrazine ring with alkoxy groups under acidic conditions. Moreover, the synthesized FVP analogs were investigated for their antiviral potency against SARS-CoV-2 RdRp through in silico studies. Five FVP analogs (3–7), including four known (3, 4, 5, 7) and one new (6), were successfully synthesized with yields ranging from 2.3 to 32.7%. All favipiravir analogs could be drug-likeness with inactive hepatotoxicity and carcinogenicity. The docking study showed that compound 5 exhibited a strong binding affinity with a binding score of −7.00 kcal/mol by interacting with the catalytic site residues of Asp618 and Asp760 of SARS-CoV-2 RdRp. Furthermore, the molecular dynamics simulation revealed that the compound 5 was stable, as indicated by RMSD, Rg, solute H-bonds, RMSF, and binding energy calculations. Thus, these results suggest that the FVP-RTP analog (5) may have antiviral potency by targeting SARS-CoV-2 RdRp.
Development of a Low-Cost Spectrophotometer for Protein Determination Using the Lowry Method Salsabilla, Lestha Aurel; Hermawan, Dadan; Diastuti, Hartiwi; Anggraeni, Mekar Dwi; Fatoni, Amin
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99361

Abstract

Affordable and accessible laboratory equipment is increasingly crucial, particularly in resource-limited settings. This research presents the development of a cost-effective spectrophotometer using an Arduino microcontroller and a TSL2591 light sensor to quantify protein concentration via the Lowry method. The device employs a 750 nm LED and a 3D-printed PLA case to house the components. Casein was used for calibration, yielding a linear detection range of 100–700 ppm with a high correlation coefficient (r = 0.9991). The limit of detection (LOD) and limit of quantification (LOQ) were 18.05 and 60.16 ppm, respectively. Precision was confirmed with a HORRAT value of 0.982. Accuracy was validated using the Wilcoxon Signed-Rank test, which showed no significant difference between the fabricated device and a commercial UV-vis spectrophotometer (p = 0.779). These findings support the reliability and reproducibility of the device for protein quantification. The project’s open-source nature encourages further development and application in educational, clinical, and field settings. This innovation supports the development of accessible, low-cost biochemical analysis tools.
Regeneration of Spent Bleaching Earth by Calcination and Its Morphological Enhancement via KOH Impregnation Nugraheni, Ika Kusuma; Jaya, Jaka Darma; Nuryati, Nuryati; Sunardi, Sunardi; Irawati, Utami; Faiza, Putri Iis; Saputra, Dita Adi
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99600

Abstract

Spent bleaching earth (SBE), a waste generated from palm oil bleaching, contains residual oil and organic matter that block its pore structure and pose environmental disposal concerns. Regeneration of SBE is therefore essential to enable its reutilization. In this study, SBE was regenerated by calcination and further modified via KOH impregnation at concentrations of 1.00, 0.10, and 0.01 M. The regenerated materials were characterized using XRF, SEM, TEM, XRD, and BET surface area analysis. Calcination combined with 0.10 M KOH impregnation increased the surface area from 8.70 to 93.81 m2/g, approaching the value of activated bleaching earth (94.29 m2/g), and significantly altered pore volume and pore size distribution. These findings indicate that calcination restores the basic structure of SBE, while subsequent KOH impregnation enhances its morphological properties, highlighting the potential of regenerated SBE as a low-cost adsorbent or catalyst support.

Page 196 of 201 | Total Record : 2006

 194   195   196   197   198 

Filter by Year

2001 2026


Reset
Filter By Issues
All Issue Vol 26, No 2 (2026) Vol 26, No 1 (2026) Vol 25, No 5 (2025) Vol 25, No 4 (2025) Vol 25, No 3 (2025) Vol 25, No 2 (2025) Vol 25, No 1 (2025) Vol 24, No 6 (2024) Vol 24, No 5 (2024) Vol 24, No 4 (2024) Vol 24, No 3 (2024) Vol 24, No 2 (2024) Vol 24, No 1 (2024) Vol 23, No 6 (2023) Vol 23, No 5 (2023) Vol 23, No 4 (2023) Vol 23, No 3 (2023) Vol 23, No 2 (2023) Vol 23, No 1 (2023) Vol 22, No 6 (2022) Vol 22, No 5 (2022) Vol 22, No 4 (2022) Vol 22, No 3 (2022) Vol 22, No 1 (2022) Vol 22, No 2 (2022) Vol 21, No 6 (2021) Vol 21, No 5 (2021) Vol 21, No 4 (2021) Vol 21, No 3 (2021) Vol 21, No 2 (2021) Vol 21, No 1 (2021) Vol 20, No 6 (2020) Vol 20, No 5 (2020) Vol 20, No 4 (2020) Vol 20, No 3 (2020) Vol 20, No 2 (2020) Vol 20, No 1 (2020) Vol 19, No 4 (2019) Vol 19, No 3 (2019) Vol 19, No 2 (2019) Vol 19, No 1 (2019) Vol 18, No 4 (2018) Vol 18, No 3 (2018) Vol 18, No 2 (2018) Vol 18, No 1 (2018) Vol 17, No 3 (2017) Vol 17, No 2 (2017) Vol 17, No 1 (2017) Vol 16, No 3 (2016) Vol 16, No 2 (2016) Vol 16, No 1 (2016) Vol 15, No 3 (2015) Vol 15, No 2 (2015) Vol 15, No 1 (2015) Vol 14, No 3 (2014) Vol 14, No 2 (2014) Vol 14, No 1 (2014) Vol 13, No 3 (2013) Vol 13, No 2 (2013) Vol 13, No 1 (2013) Vol 12, No 3 (2012) Vol 12, No 2 (2012) Vol 12, No 1 (2012) Vol 11, No 3 (2011) Vol 11, No 2 (2011) Vol 11, No 1 (2011) Vol 10, No 3 (2010) Vol 10, No 2 (2010) Vol 10, No 1 (2010) Vol 9, No 3 (2009) Vol 9, No 2 (2009) Vol 9, No 1 (2009) Vol 8, No 3 (2008) Vol 8, No 2 (2008) Vol 8, No 1 (2008) Vol 7, No 3 (2007) Vol 7, No 2 (2007) Vol 7, No 1 (2007) Vol 6, No 3 (2006) Vol 6, No 2 (2006) Vol 6, No 1 (2006) Vol 5, No 3 (2005) Vol 5, No 2 (2005) Vol 5, No 1 (2005) Vol 4, No 3 (2004) Vol 4, No 2 (2004) Vol 4, No 1 (2004) Vol 3, No 3 (2003) Vol 3, No 2 (2003) Vol 3, No 1 (2003) Vol 2, No 3 (2002) Vol 2, No 2 (2002) Vol 2, No 1 (2002) Vol 1, No 3 (2001) Vol 1, No 2 (2001) Vol 1, No 1 (2001) Article in press ARTICLE IN PRESS More Issue