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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
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Preparation, Electronic Properties, and Powder-XRD Structure Analysis of 3,5-Bis(pyridin-2-yl)-H-1,2,4-triazoledichloridocopper(II) Kristian Handoyo Sugiyarto; Isti Yunita; Harold Andrew Goodwin
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.55600

Abstract

Salt of [Cu(bptrzH)Cl2], (bptrzH = 3,5-bis(pyridin-2-yl)-H-1,2,4-triazole) has been prepared and characterized its electronic spectral and magnetic properties. This salt is paramagnetic with magnetic moment, μs, being 1.77–1.78 BM at 293 K, but decreased significantly with decreasing temperature to be 0.60–0.63 BM at 90 K, indicating antiferromagnetic nature. This is associated with Cu–Cu magnetic interactions at low temperatures, and suggests that the salt adopt an octahedrally polymeric structure. The electronic spectrum of this salt reveals a strong ligand field band centered at about 13,000 cm–1 and a very strong charge transfer absorption at about 23,000–24,000 cm–1. The spectrum is better resolved at lower temperature and this is parallel to the slight change in color from yellowish-green at room temperature to bright green at low temperature (90 K). The powder XRD of this complex was refined by Le Bail method of Rietica program and found to be fit as triclinic symmetry of space group PĪ with the figure of merit: Rp = 5.02; Rwp = 7.95; Rexp = 5.40; Bragg R-Factor = 0.05; and GOF = 2.166.
Microwave-Assisted Preparation of Zinc-Doped β-Tricalcium Phosphate for Orthopedic Applications Ali Taha Saleh; Dheyaa Alameri
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.55931

Abstract

A novel two-step methodology delivering zinc into the structure of β-tricalcium phosphate (β-TCP) has been investigated. Incorporating wet precipitation of calcium-deficient apatite [Ca9-xZnx(HPO4)(PO4)5(OH)] (x = 0.00–1.00 mol) using a microwave-assisted process followed by two-hour calcination at 1000 °C has been conducted to generate a ratio of 1.48 of Zn doped β-TCP. The products were characterized by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectrometer, and field emission scanning electron microscope (FESEM). Our results confirmed that the product was crystalline Zn2+-doped β-tricalcium phosphate. The incorporation of Zn+2 into the β-TCP lattice resulted in a shifting of diffraction peaks to higher 2θ values, which were attributed to the substitution of larger-sized Ca+2 ions with smaller-sized Zn2+ ions. A reduction in the intensity of the XRD peaks was also observed due to the reduction in the degree of crystallinity of the samples. Lattice parameters along the a and c-axis showed a gradual decrease in length with an increase in the amount of Zn2+ doping. This decrease was attributed to the replacement of Ca+2 ion by the smaller-sized Zn2+ ions. The microstructure of the powders consisted of microscale aggregates fused together. EDX analysis of all samples showed that the Zn2+ doping had successfully taken place and the amount of Zn2+ present in the samples was in good agreement with the theoretical values.
Nicotiana tabacum Mediated Green Synthesis of Silver Nanoparticles and Ag-Ni Nanohybrid: Optical and Antimicrobial Efficiency Anuoluwa Abimbola Akinsiku; Joseph Adeyemi Adekoya; Enock Olugbenga Dare
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56072

Abstract

A sustainable method was considered for the preparation of nanosilver and its allied nanoparticles. Nicotiana tabacum, an abused plant, has found an application as a bio-chemical instead of lethal chemical in the synthesis of nanoparticles. As part of green chemistry implementation, double distilled water was the solvent used for extraction. The phytochemicals present were analyzed using standard procedures. Nanoparticle synthesis was carried out at varying precursor concentrations, and the reaction was monitored with a UV-visible spectrophotometer. Another optical characterization was also achieved with photoluminescence. Other characterization involved: X-ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersive X-ray (EDS), and Fourier transform infrared spectroscopy techniques (FTIR). A matched phase identification of nanosilver resembled a face-centered cubic of Ag with a mean size of 11.68 nm, and a lattice constant of 4.0862 Å. The Ag NPs displayed activity against clinical isolates of fungi, Gram-positive, and Gram-negative bacteria as the growth inhibition was significant at P < 0.05. Ag NPs obtained from the Nicotiana tabacum proved to be an antibacterial and antifungal candidate, unlike the Ag NPs derived using chemical and physical methods, which were harmful for this purpose. Both the Ag NPs and Ag-Ni NPs displayed optical activity, which qualifies them for application in visual materials.
Stability, Hydrogen Bond Occupancy Analysis and Binding Free Energy Calculation from Flavonol Docked in DAPK1 Active Site Using Molecular Dynamic Simulation Approaches Adi Tiara Zikri; Harno Dwi Pranowo; Winarto Haryadi
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56087

Abstract

Stability and hydrogen bond occupancy analysis of flavonol derivative docked in DAPK1 have been carried out using molecular dynamics simulation approach. Six flavonol derivatives were docked in DAPK1 as protein target, then continued with molecular dynamics simulation. NVT and NPT ensembles were used to equilibrate the system, followed by 20 ns sampling time for each system. Structural stability and hydrogen bond occupancy analyses were carried out at the NVT ensemble, while free binding energy analysis was done at NPT ensemble. From all compounds used in this work, compound B (5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one) has a similar interaction with reference ligands (quercetin, kaempferol, and fisetin), and the most stable complex system has the maximum RMSD around 2 Å. Compound C complex has -48.06 kJ/mol binding free energy score, and it was slightly different from quercetin, kaempferol, and fisetin complexes. Even though complex C has similar binding free energy with the reference compound, complex B shows more stable interactions due to their hydrogen bond and occupancy.
Virtual Screening of the Indonesian Medicinal Plant and Zinc Databases for Potential Inhibitors of the RNA-Dependent RNA Polymerase (RdRp) of 2019 Novel Coronavirus Muhammad Arba; Andry Nur-Hidayat; Ida Usman; Arry Yanuar; Setyanto Tri Wahyudi; Gilbert Fleischer; Dylan James Brunt; Chun Wu
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56120

Abstract

The novel coronavirus disease 19 (Covid-19) which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a pandemic across the world, which necessitate the need for the antiviral drug discovery. One of the potential protein targets for coronavirus treatment is RNA-dependent RNA polymerase. It is the key enzyme in the viral replication machinery, and it does not exist in human beings, therefore its targeting has been considered as a strategic approach. Here we describe the identification of potential hits from Indonesian Herbal and ZINC databases. The pharmacophore modeling was employed followed by molecular docking and dynamics simulation for 40 ns. 151 and 14480 hit molecules were retrieved from Indonesian herbal and ZINC databases, respectively. Three hits that were selected based on the structural analysis were stable during 40 ns, while binding energy prediction further implied that ZINC1529045114, ZINC169730811, and 9-Ribosyl-trans-zeatin had tighter binding affinities compared to Remdesivir. The ZINC169730811 had the strongest affinity toward RdRp compared to the other two hits including Remdesivir and its binding was corroborated by electrostatic, van der Waals, and nonpolar contribution for solvation energies. The present study offers three hits showing tighter binding to RdRp based on MM-PBSA binding energy prediction for further experimental verification.
Determination of Eugenol in Personal-Care Products by Dispersive Liquid-Liquid Microextraction Followed by Spectrophotometry Using p-Amino-N,N-dimethylaniline as a Derivatizing Agent Bahaa Malik Altahir; Omar Abdulazeez; Sarmad Bahjat Dikran; Keith Edward Taylor
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56198

Abstract

Two simple methods for the determination of eugenol were developed. The first depends on the oxidative coupling of eugenol with p-amino-N,N-dimethylaniline (PADA) in the presence of K3[Fe(CN)6]. A linear regression calibration plot for eugenol was constructed at 600 nm, within a concentration range of 0.25-2.50 μg.mL–1 and a correlation coefficient (r) value of 0.9988. The limits of detection (LOD) and quantitation (LOQ) were 0.086 and 0.284 μg.mL–1, respectively. The second method is based on the dispersive liquid-liquid microextraction of the derivatized oxidative coupling product of eugenol with PADA. Under the optimized extraction procedure, the extracted colored product was determined spectrophotometrically at 618 nm. A linear plot within a concentration range of 0.05–1.65 μg.mL–1 (r = 0.9997) was constructed. The LOD and LOQ were 0.053 and 0.177 μg.mL–1, respectively. Both methods were tested for the analysis of eugenol in commercial personal-care products, and the results confirmed that the procedures are accurate, precise, and reproducible (RSD < 1%).
Synthesis, Characterization and Antibacterial Properties of Nickel(II) Complex with 4-Aminoantipyrine Ligand Yusica Amalia Rasyda; Mudhita Kusuma Widowati; Soerya Dewi Marliyana; Sentot Budi Rahardjo
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56552

Abstract

The novel nickel(II) complex has been successfully synthesized through the reaction of Ni(NO3)2·6H2O with 4-aminoantipyrine (AAP) ligand in a 1:3 mole ratio of Ni(II) to AAP. The complex was characterized using UV-Vis, Atomic Absorption Spectroscopy (AAS), Infrared spectrophotometry (IR), Thermogravimetry/Differential Scanning Calorimetry (TG/DSC), conductivity, and magnetic susceptibility. The complex formula was [Ni(AAP)3](NO3)2·5H2O. AAP was a bidentate ligand that coordinated through the primary amine nitrogen and the carbonyl oxygen to the nickel ion. The electronic spectra of the complex displayed two peaks at 646 nm and 385 nm in accordance with the 3A2g(F) → 3T1g(F) and 3A2g(F) → 3T1g(P) transitions, respectively. This complex gave a paramagnetic property with the effective magnetic moment (µeff) of 2.96 BM and the shape of an octahedron. The antibacterial test of this complex showed higher activity than the metal and its free ligand.
Formulation and Characterization of a Kinetically Stable Topical Nanoemulsion Containing the Whitening Agent Kojic Acid Gan Yi Yun; Nur Azzanizawaty Yahya; Roswanira Abdul Wahab; Mariani Abdul Hamid
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56587

Abstract

The research was carried out to synthesize a stable kojic acid (KA) encapsulated nanoemulsion as a whitening agent for topical skin usage. In this study, the oil-in-water (O/W) KA nanoemulsion was formulated using integrated low and high energy methods that combined ultrasonic and hot temperature inversion methods. Several different combinations of parameters were screened, viz. xanthan gum amount (1.0 to 2.0 g), kojic acid (KA) amount (0.5 to 1.5 g), and surfactant-to-water ratio (1:10.75 to 1:4.875), to prepare a stable KA nanoemulsion. The identified best parameters to design the O/W KA nanoemulsion were then subjected to different stability tests: storage and pH stability (freeze-thaw and centrifugal tests). Results revealed that the Trial 6 formulation, with the highest ratio of Tween 80 to water (1:4.875 v/v), yielded the best polydispersity index at 0.255 ± 0.006 with an average particle size of 90.57 ± 1.401 nm. The formulation retained the recommended pH range (pH 4.95–5.18) for topical skin applications within six-week storage under room condition. The nanoemulsions were also kinetically stable as proven by the absence of phase separation after the centrifugation, freeze-thaw cycle, and storage temperature (2 and 25 °C) tests, except at the 37 °C three-week extended storage. The results collectively showed that the formulated O/W KA nanoemulsion is suitable for topical application on human skin.
Development of a Simple Fe(II) Ion Colorimetric Sensor from the Immobilization of 1,10-Phenanthroline In Alginate/Pectin Film Nindya Tri Muliawati; Dwi Siswanta; Nurul Hidayat Aprilita
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56759

Abstract

An optical analytical sensor was proposed based on the complexation reactions of 1,10-phenanthroline derivative in aqueous solutions. This study aims to synthesize a metal ion sensor for detecting Fe(ll) ion from the immobilization of 1,10-phenanthroline compound in alginate/pectin film. This was carried out by characterizing the films using the Fourier-transform infrared spectrometry (FT-IR) and scanning electron microscope (SEM). The determination of the optimal condition for Fe(II) ion detection and validation of the parameters was conducted by measuring the absorbance of the films using a UV-Vis spectrophotometer. After the addition of Fe(II) ion, the color of the alginate/pectin-phenanthroline film changed from transparent yellow to orange-red, showing its potential as a visual colorimetric sensor for iron(II) ion. It was found that the optimum condition for Fe(II) ion sensing was at 513 nm after 2 min of detection at pH 2. The alginate/pectin-phenanthroline film had good linearity, precision, selectivity, and accuracy with a detection limit as low as 0.446 mg L–1, which was remarkable.
High Reusability of NiAl LDH/Biochar Composite in the Removal Methylene Blue from Aqueous Solution Aldes Lesbani; Neza Rahayu Palapa; Rabelia Juladika Sayeri; Tarmizi Taher; Nurlisa Hidayati
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.56955

Abstract

Ni/Al layered double hydroxide was used as a starting material for composite formation with biochar as a matrix. The materials were characterized using X-ray, FTIR, nitrogen adsorption-desorption, thermal, and morphology analyses. The NiAl LDH/Biochar material is then used as an adsorbent of methylene blue from an aqueous solution. The factor that was influencing adsorption such as pH, time, methylene blue concentration, and temperature adsorption was studied systematically. The regeneration of adsorbent was performed to know the stability of NiAl LDH/Biochar under several cycle adsorption processes. The results showed that NiAl LDH/Biochar has a specific diffraction peak at 11.63° and 22.30°. NiAl LDH/Biochar has more than ten-fold surface area properties (438,942 m2/g) than biochar (50.936 m2/g), and Ni/Al layered double hydroxide (92.682 m2/g). The methylene blue adsorption on NiAl LDH/Biochar follows a pseudo-second-order kinetic adsorption model and classify as physical adsorption. The high reusability properties were found for NiAl LDH/Biochar, which was largely different from biochar and Ni/Al layered double hydroxide.

Page 129 of 196 | Total Record : 1956

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