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INDONESIA
Indonesian Journal of Cardiology
Published by Indonesian Heart Association
ISSN : 28303105     EISSN : 29647304     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies. Subjects suitable for publication include but are not limited to the following fields: Acute Cardiovascular Care Arrhythmia / Cardiac Electrophysiology Cardiovascular Imaging Cardiovascular Pharmacotherapy Cardiovascular Public Health Policy Cardiovascular Rehabilitation Cardiovascular Research General Cardiology Heart Failure Hypertension Interventional Cardiology Pediatric Cardiology Preventive Cardiology Vascular Medicine
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 12 Documents
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Search results for , issue "Vol. 28, No. 3 Mei 2007" : 12 Documents clear
Penyakit Jantung Pada Perempuan Anna Ulfah Rahajoe
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.237

Abstract

Penyakit kardiovaskular diklaim sebagai penyebab kematian nomor satu bagi perempuan diatas usia 65 tahun di benua Europa, masalah ini dikemukakan secara lengkap oleh Angela H.E.M. Maas, MD, PhD dan Harry Suryapranata, MD, PhD dari Isala Klinieken, Zwolle -The Netherlands, dalam jurnal edisi ketiga ini. Menurut survai di negeri kincir angin itu, perempuan kurangmemahami ancaman penyakit kardiovaskular, umumnya mereka lebih jarang menjalani uji latih jantung, apalagi angiografi diagnostik dan intervensi.Hormon estrogen berperan melindungi perempuan dari PJK, oleh karenanya infark miokard akut terjadi pada usia yang lebih tua dibanding laki-laki. Mereka juga mempunyai risiko kematian lebih tinggi dan komorbiditas faktor risiko penyakit jantung koroner (PJK) yang lebih besar. Estrogen berperan dalam pengaturan faktor metabolisme, seperti lipid, petanda inflamasi, sistim trombotik, vasodilatasi reseptor adan ß. Oleh karena itu, terjadinya menopause berpengaruh terhadap kejadian PJK.
Apakah Lp(a) Merupakan Prediktor Kejadian Kardiovaskular Pasca Infark Miokard Akut dengan Elevasi Segmen ST? Nisa Ike Rini; Manoefris Kasim; Santoso Karo Karo
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.238

Abstract

Background. The role of lipoprotein (a)/Lp(a) as a risk factor for coronary artery disease has abundantly observed in various prospective and retrospective studies. However there is still lack of evidence about its role in thrombotic process, particularly acute coronary syndrome. Hence, this study was conducted to observe the role of high Lp(a) level on cardiovascular event in post acute ST elevation myocardial infarction (STEMI) patients.Methods and results.A cohort study was conducted by enrolling 110 STEMI patients (mean age 53.3 ± 8 years) eligible for fibrinolytic therapy. Respondents were observed from January 2003 to May 31st 2005 (average observation period was 432 days). Recurrent angina, reinfarction, revascularization within 6 months after admission and death were defined as end points of the study. Lp(a) measurement were done from blood sample taken within 24 hours after onset of infarction. Respondents were divided into three groups according to level of Lp(a) percentiles. The highest percentile (> 75%) was (Lp(a) level of > 26.4 mg/dL) and the lowest percentile (<25%) was (Lp(a) level of < 7.2 mg/dL Survival analysis of composite cardiovascular events showed that the highest percentile group failed to show lower cumulative survival compared to the lowest percentile group; hazard ratio of 0.69 (95% CI 0. 29-1.63; p=0. 40). This phenomena was also observed in survival analysis of death; hazard ratio of 0.92 (95% CI 0.13-6.58; p=0.190).Conclusions. It was concluded that high level of Lp(a) was not a predic-tor of cardio-vascular event following acute STEMI.
Efek Ekstrak Daun Kelor (Moringa Oleifera) Dalam Menghambat Aktifasi NFkB, Ekspresi TNF-adan ICAM-1 pada HUVECS yang Dipapar LDL Teroksidasi Titin Andri Wihastuti; Djanggan Sargowo; M Saifur Rohman
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.239

Abstract

Background. Atherosclerosis is a chronic inflammation process of vascu-lar endothelial cells. Increased oxydized LDL(OxLDL) is one of the most potent inducer of atherogenesis. OxLDL induces an increased ROS (Reac-tive Oxigen Species) and also acts as cytotoxic and chemotaxis factor for monocytes result in accumulation of inflammatory cells. Nuclear Factor Kappa Beta(NFkB) is a transcription factor that plays an important role in this inflammatory proces. NFkB compose of heterodimer molecules of p50 and p65, which bind to its inhibitor, IkB, leading to its inactive form in cytoplasm. OxLDL activates NFkB complex by phosphorylate IkB resulting in released p50-p65-IkB binding and translocation of p50-p65 into the nucleus. p50-p65 then binds to promoter and activates transcription of target genes. NFkB activation therefore increase gene and protein expressions of target molecules such TNF-a, ICAM-1, VICAM, etc. This study aimed to examine whether Moringa oleiferainhibits activation of NFkB dan expression of cytokine TNF-aand adhesion molecule ICAM-1.Methods and results.Human umbilical vein endothelial cells (HUVECs) treated with OxLDL were used as model of atherosclerosis. The increased NFkB activity was measured by indirect method using p50 subcellular lo-calization by immunohistochemistry. 40ug/mL OxLDL, 0.01 gr/mL and 0.005 gr/mL Moringa oleiferawere used based on preliminary study.Conclusions. This study showed that OxLDL significantly induce NFkB activation and increase protein expression of TNF-aand (ICAM-1). This study also observed that Moringa oleiferasignificantly inhibit NFkB activa-tion, and prevent an increased TNF-aand ICAM-1 expression at protein level in OxLDL-treated HUVECs as compare to the controls. Moringa oleifera dose of 0.01mg/mL has a better inhibition effect as compare to that of 0.005 gr/mL.
Penilaian Kualitas Hidup Pasien Pasca Bedah Pintas Koroner Yang Menjalani Rehabilitasi Fase III Kiki Abdurachim; Harmani Kalim; Basuni Radi
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.240

Abstract

Background. Coronary artery bypass graft surgery (CABG) is one of the management for coronary artery disease. Cardiovascular rehabilitation usually conducted for recovery and improved quality of life. Questionnaire was used to evaluate quality of life. One of the quality of life instrument most commonly used is Questionnaire SF-36. So far there isn’t any study to evaluate quality of life in patients post CABG who wish to follow rehabilitation program phase III in Indonesia.Methods and results.This is a cross sectional study conducted in the National Cardiovascular Centre (NCC) - Rehabilitation Division to patients post CABG in phase III rehabilitation program during 2004-2005. Subject was taken in consecutive sampling manner. Questionnaire SF-36 was handed directly or via mail. Validity and reliability test was done for the questionnaire form in Indonesia language. There were 112 patients, 34 patients did rehabilitation program in hospital and 78 were home-based. The characteristics between two groups were similar. Validity test using r product moment from Pearson to every questions in SF-36 showed r = 0,53-0.83 > 0,51 (r table) and Cronbach a= 0,855. SF-36 scoring was not significantly different among the two groups (in hospital rehab vs home-based rehab) and also control group (healthy). Conclusions. There were no difference in quality of life and aerobic ca-pacity in patients who performed rehabilitation program phase III in hospi-tal and home-based.
Risiko Bedah pada Pasien Dewasa dengan Tetralogi Fallot Karina V Wilamarta; Dicky Fakhri; Jusuf Rachmat
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.241

Abstract

Background. The beneficiaries of successful pediatric cardiac surgery and cardiology increases surgical treatment in the adult population with congenital heart disease. Adults patient with Tetralogy of Fallot (TOF) will need surgery either reoperative, palliative or more commonly reparative by the time they come. Many of them face the prospect of further operations, arrhythmias, complications and if managed inappropriately will increase risk of heart failure and premature death. This study presents the early surgical results of adult TOF.Methods and results.Data were reviewed retrospectively related to the hospital course of TOF adult patients (age > 17 years) from June 1, 1998 to December 30, 2006 who require surgical treatment in National Cardiac Center - Harapan Kita, Indonesia. Most of the operations were corrective procedures (20 patients, 66.7%), followed by palliative procedures (6 patients, 20%), and reoperations (4 patients, 13.3%). Mean age at surgery was 20.87+5.49 years. There were no hospital mortality in the primary corrective group, one death (16.7) in the palliative group related to poor left ventricular function, and one death (25%) in the reoperation group related to perioperative bleeding. Follow up data of 11.73+17.68 months duration were available in 28 of 30 patients (93%) who were discharged home. Overall survival probability is higher for corrective procedures than palliative and reoperative procedures.Conclusions. Surgical treatment of TOF in adult patients proved quite save and beneficial.
Nilai Prediktif Distorsi QRS pada Infark Miokard Akut Anterior Budhi Setianto; Nur Haryono
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.242

Abstract

Background. The initial ECG at patients with Acute Coronary Syndrome, especially STEMI can predict size of infarction, response to reperfusion therapy and long term prognosis. A new classification, the QRS distortion have increased mortality rates and larger infarct size and less limitation of their infarct size by thrombolytic therapy. QRS distortion is the emergence of J point = 50% of R wave in leads with qR configuration (I, aVL, V4-V6), or disappearance of the S wave in leads with Rs configuration (V1-V3). Methods and results.This study is cohort-retrospective to patients with anterior IMA treated by thrombolytic at National Cardiovascular Centre – Harapan Kita, Jakarta, Indonesia, during January 2003 – September 2004, that fulfill inclusion and exclusion criterias. They were divided into two group, with QRS distortion (+) and without QRS distortion (-); each group consist of 30 patients. Correlation between the two groups were ana-lyzed by t test, chi-square test, Mann Whitney u test and logistic regres-sion. Patients age range is 40 – 69 years, and mostly man. There is no difference between baseline characteristic in the two groups, except cho-lesterol LDL which is higher in the group with QRS distortion. Patients with QRS distortion have a higher tendency of thrombolytic therapy fail-ure compare to patients without QRS distortion, (p=0,003). As the con-sequence they also have a higher rate of arrhythmia events, low ejection fraction and re-hospitalization due to congestive heart failure.Conclusions. The prognosis of patients with anterior IMA associated with QRS distortion is worse than without QRS distortion.
Peran Pembedahan Pada Sindroma Vena Cava Superior Akibat Tumor Mediastinum: Pengalaman Di RS. Persahabatan Januari 1995 – Maret 2005 Ronald W Kartika; Ismid D.I. Busro; Agung Wibawanto; Frans B Busro; Marsono Tabrani
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.243

Abstract

Sindroma Vena Cava Superior (SVCS) adalah kumpulan gejala (sulit bernafas/nafas pendek, batuk, pembengkakan muka wajah, leher, bagian atas tubuh dan lengan) yang dapat terjadi akibat penekanan vena cava superior oleh tumor mediastinum, baik tumor yang ganas maupun yang jinak. Tindakan yang dilakukan untuk mengurangi komplikasi yang semakin sering dijumpai ini, adalah dengan kemoterapi, radioterapi maupun pembedahan. Akhir-akhir ini semakin banyak sentra pendidikan yang melakukan bedah pintas vena cava, dari daerah sebelum sumbatan (vena jugularis interna) ke vena cava dibawah sumbatan atau ke atrium kanan. Walaupun prosedur bedah tersebut merupakan terapi paliatif, tetapi dapat memperpanjang umur dan meningkatkan kualitas hidup pasien. Namun demikian, pada akhirnya prognosis pasien tergantung pada perangai tumor penyebabnya.Laporan ini bertujuan untuk mengevaluasi tindakan bedah paliatif dalam penanganan SVCS di Rumah Sakit Persahabatan, Jakarta.
Cardiac Resynchronization Therapy: Kapan dapat kita lakukan? Andria Priyana
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.244

Abstract

Gagal jantung (GJ) merupakan penyebab utama perawatan pasien di rumah sakit Amerika Serikat, dan merupakan kasus yang memakan biaya terbanyak per tahunnya. Sekitar 500.000 kasus baru ditemukan setiap tahun, dan tak kurang dari 5 juta orang kini di Amerika menderita GJ.Studi mengenai terapi neurohormonal telah mencapai puncaknya, tambahan terapi selain penghambat renin-angiotensin-aldosteron dan adrenergik, belum terbukti memberi tambahan manfaat yang signifikan. Sementara itu, laporan studi mengenai device therapy(pacemakers, implantabledefibrillators, danventricular assist devices)pada GJbanyak yang memberi hasil positif. Khusus mengenai cardiac resynchronization therapy(CRT), telah banyak studi yang melaporkan manfaatnya pada GJ, dan telah pula dimasukkan dalam guideline Heart Failure sebagai salah satu terapi GJ. Meski demikian hasil pemasangan CRT masih ber variasi, dan membawa risiko komplikasi. Oleh karenanya, pemasangan CRT memerlukan kriteria seleksi pasien yang ketat dan tepat, sehingga rasio keuntungan-risiko dapat optimal.Laporan kasus ini menguraikan tentang sebuah kasus pemasangan CRT. Akan dibahas mengenai kapan sebaiknya pemasangan CRT dilakukan, tatalaksana GJ, prediksi adanya disinkroni ventrikel, dan prognosis CRT berdasarkan elektrokardiogram (EKG) dan ekokardiogram.
Ablasi Konvensional Kepak Atrium Atipikal Yoga Yuniadi; Chaerul Achmad; Muhammad Munawar
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.245

Abstract

Kepak atrium (KA, atrial flutter) merupakan jenis aritmia tersering kedua setelah firbrilasi atrium dalam praktek klinik. KA saat ini dibedakan berdasarkan keterlibatan ismus kavotrikuspid (IKT) dalam sirkuit reentry-nya. Di antara KA yang melibatkan IKT, KA tipikal dan tipikal terbalik merupakan jenis yang paling sering ditemukan. Semua KA yang tidak melibatkan IKT disebut sebagai KA atipikal. Pada KA atipikal sirkuit reentrykepak dapat berada di atrium kanan atau kiri. Kepak atrium atipikal termasuk sulit di atasi baik secara medikamentosa maupun dengan ablasi frekuensi radio (AFR). AFR KA atipikal umumnya mem-butuhkan teknik pemetaan canggih yaitu sistem pemetaan 3 dimensi (3D). Pemetaan 3D diperlukan untuk mengidentifikasi sirkuit kepak secara tepat sehingga lokasi ismus sebagai target ablasi dapat ditentukan dengan akurat.Teknik pemetaan konvensional umumnya tidak memadai untuk melakukan ablasi KA atipikal. Akan dilaporkan satu kasus KA atipikal yang berhasil diablasi dengan teknik pemetaan konvensional.
Women Make the Difference in Heart Disease Angela H.E.M. Maas; Harry Suryapranata
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.246

Abstract

Cardiovascular disease develops 10 to15 years later in women than in men and is the major cause of death in women older than 65 years of age. The risk of heart disease in women however is still underestimated and many women are not aware of their own risk factors.In a recent report from the European Heart Survey on stable angina pectoris it was found that women are less likely to be referred for functional testing for ischemia, with a lower rate of diagnostic angiograms and interventional procedures.The under-recognition of heart disease and differences in clinical presentation in women lead to less aggressive treatment strategies and a lower representation of women in clinical trials. In the current review we summarize the major issues that are important in the diagnosis and treatment of coronary heart disease (CHD) in women.

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