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INDONESIA
Indonesian Journal of Obstetrics & Gynecology Science
Published by Universitas Padjadjaran
ISSN : 2615496X     EISSN : 2615496X     DOI : -
Core Subject : Health,
Health Professions Public Health
OBGYNIA (Indonesian Journal of Obstetrics & Gynecology Science ) adalah jurnal dalam bidang ilmu Obstetri & Ginekologi yang diterbitkan resmi oleh Departemen Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran. OBGYNIA menerbitkan artikel penelitian tentang kemajuan ilmiah, manajemen klinis pasien, teknik bedah, kemajuan pengobatan dan evaluasi pelayanan, manajemen serta pengobatan dalam bidang obstetri & ginekologi.
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Articles 432 Documents
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Correlation Between First-Trimester Anemia in Pregnancy and the Incidence of Preeclampsia: A Retrospective Cohort Study Muhammad Hairul Umam; Marta Isyana Dewi; M. Rizkar Arev Sukarsa
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 2 July 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i2.1176

Abstract

Introduction: Preeclampsia affects 2 – 4% of pregnancies worldwide and is a leading cause of maternal and perinatal morbidity and mortality. Anemia in pregnancy—defined as hemoglobin <11 g/dL in the first or third trimester—remains prevalent, affecting 48.9% of Indonesian pregnant women (Riskesdas 2018). First-trimester anemia may contribute to preeclampsia through oxidative stress, endothelial dysfunction, and impaired placentation.Objective: To analyze the association between first-trimester anemia and preeclampsia at Prof. Dr. Margono Soekarjo Regional General Hospital (January – December 2023).Methods: This retrospective cohort study used total sampling of pregnant women treated at the hospital from January to December 2023. Variables included first-trimester hemoglobin and preeclampsia status. Logistic regression analysis was performed using SPSS 27.0.Results: The model showed good fit (Hosmer–Lemeshow = 2.491, p=0.778; Nagelkerke R²=0.367). First-trimester hemoglobin was significantly associated with preeclampsia (p<0.001; OR=0.884, 95% CI: 0.849–0.921). Each 1 g/dL increase in hemoglobin was associated with an 11.6% reduction in the odds of preeclampsia.Conclusion: First-trimester anemia was significantly associated with preeclampsia. Adequate early hemoglobin levels were associated with lower odds of preeclampsia, underscoring the importance of early hematologic monitoring and iron–folate supplementation in antenatal care.Korelasi antara Anemia Trimester-Pertama pada Kehamilan dan Kejadian Preeklampsia: Studi Kohort RetrospektifAbstrakPendahuluan: Preeclampsia memengaruhi 2 – 4% kehamilan di seluruh dunia dan merupakan penyebab utama morbiditas serta mortalitas maternal dan perinatal. Anemia pada kehamilan—didefinisikan sebagai hemoglobin <11 g/dL pada trimester pertama atau ketiga—masih banyak terjadi, memengaruhi 48,9% ibu hamil Indonesia (Riskesdas 2018). Anemia trimester pertama dapat berkontribusi terhadap preeclampsia melalui oxidative stress, disfungsi endotel, dan gangguan plasentasi.Tujuan: Penelitian ini bertujuan menganalisis korelasi antara anemia trimester pertama dan preeclampsia di Rumah Sakit Umum Daerah Prof. Dr. Margono Soekarjo (Januari – Desember 2023).Metode: Penelitian ini merupakan studi retrospektif bersifat kohort dengan teknik total sampling terhadap ibu hamil yang dirawat di rumah sakit dari Januari hingga Desember 2023. Variabel yang diteliti meliputi hemoglobin trimester pertama dan status preeclampsia. Analisis logistic regression dilakukan menggunakan SPSS 27.0.Hasil: Model menunjukkan kecocokan yang baik (Hosmer–Lemeshow = 2.491, p=0.778; Nagelkerke R²=0.367). Hemoglobin trimester pertama berhubungan signifikan dengan preeclampsia (p<0.001; OR=0.884, 95% CI: 0.849–0.921). Kenaikan hemoglobin sebesar 1 g/dL berhubungan dengan penurunan peluang preeclampsia sebanyak 11,6%.Kesimpulan: Anemia trimester pertama berhubungan secara signifikan dengan preeclampsia. Kadar hemoglobin awal yang memadai berhubungan dengan penurunan peluang terjadinya preeclampsia, sehingga menekankan pentingnya pemantauan hematologi dini dan suplementasi zat besi–folat dalam pelayanan antenatal.  
Mosaic Turner Syndrome and Hypogonadotropic Hypogonadism in a 17-Year-Old Female: A Diagnostic Dilemma with Possible Kallmann Syndrome Muhammad Alif; Artha Falentin Putri Susilo; Hanom Husni Syam; Dian Tjahyadi; Anita Rachmawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 9s Number 2 July 2026 Special Issue Case Report & Systematic Review
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i2.1085

Abstract

Introduction: Primary amenorrhea, defined as the absence of menstruation by age 15, has a broad differential diagnosis, including anatomical, endocrine, hypothalamic-pituitary, and genetic causes. Turner syndrome and Kallmann syndrome are two distinct etiologies with different pathophysiological mechanisms. Turner syndrome is characterized by hypergonadotropic hypogonadism due to gonadal dysgenesis, whereas Kallmann syndrome results from gonadotropin-releasing hormone (GnRH) deficiency and is often associated with anosmia.Case Presentation: A 17-year-old female was referred with primary amenorrhea and absent secondary sexual development. Physical examination revealed Tanner Stage I breast and pubic hair development, with no reported olfactory disturbances. Hormonal assays indicated hypogonadotropic hypogonadism, with low FSH, LH, and estradiol levels. Pelvic ultrasonography revealed a hypoplastic uterus and non-visualized ovaries. Cranial MRI showed pituitary hypoplasia and bilateral agenesis of the olfactory bulbs, suggestive of Kallmann syndrome. However, karyotype analysis revealed a mosaic 45,X/46,XX pattern, consistent with Turner syndrome. This combination of clinical, hormonal, imaging, and cytogenetic findings posed a unique diagnostic dilemma.Discussion: The overlapping features of Turner and Kallmann syndromes make this case highly unusual. Turner syndrome typically presents with hypergonadotropic hypogonadism, whereas Kallmann syndrome is characterized by hypogonadotropic hypogonadism, often with anosmia. Comprehensive evaluation, including cytogenetic analysis and MRI, was essential for accurate diagnosis. Management focused on pubertal induction with hormone replacement therapy and appropriate genetic and systemic evaluation.Conclusion: This case underscores the diagnostic complexity of primary amenorrhea with overlapping features of Turner and Kallmann syndromes. Accurate diagnosis requires integrated hormonal, imaging, and cytogenetic evaluation, with management focused on hormonal correction and long-term supportive care. 

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