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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 27 Documents

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Search results for , issue " Volume. 4, No. 2, April 2016" : 27 Documents clear

Postplacental IUD Insertion Using Ring Forceps versus Push and Push Technique Tjahjanto, Hary; Rizal, Rahmad
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare IUD-endometrium (ED) distance and the incident of malposition postplacental CuT-380A IUD insertion in vaginal delivery between ring forceps technique and push and push technique. Method: This study was a double-blind randomized control trial, performed in September 2014 until March 2015 at Dr. Kariadi Hospital. Ring forceps and push and push insertion technique groups consisted of 25 subjects in each group. Follow-up was performed at 1-2 weeks, 6-8 weeks and >12 weeks after insertion. Result: The mean of IUD-ED distance in push and push group was shorter (but not statistically significant) than ring forceps group. The IUD-ED distance was at 1-2-week follow-up 4.1 (2.2) vs. 4.9 (3.4) mm; p=0.208, at 6-8-week follow-up: 2.6 (1.8) vs. 3.2 (3.7) mm; p=0.452, and at > 12-week follow-up: 0.9 (0.8) vs. 1.0 (0.9) mm; p=0.427, respectively. Malposition was found in 1-2-week follow-up, but the IUD was changed to the normal position (sagital position in uterine fundus) at 6-8-week and >12-week follow-up. Up to 3 months of follow-up, there was no occurrence of perforation, expulsion or pregnancy in both groups. Most of subjects (56% in the ring forceps, 68% in push and push groups) did not feel painful during IUD insertion. Conclusion: Push and push insertion technique clinically tends to produce IUD-ED distance shorter than ring forceps technique. Both techniques are comfortable, safe and effective. [Indones J Obstet Gynecol 2016; 4-2: 78-87] Keywords: immediate postplacental IUD insertion technique, IUDendometrium distance, IUD malposition, push and push technique, ring forceps technique

Ovarian Tissue Vitrification as a Method for Ovarian Preservation in Women with Cancer: an Analysis of Granulose Cell Apoptosis Wiweko, Budi; Andriyana, Huthia; Aulia, Achmad
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To obtain the effective method of ovarian function preservation with granulose cell apoptosis assessment. Ovarian tissue vitrification became a method for ovarian function preservation in women with cancer. This technique can be done anytime without delay on cancer therapy both in prepubertal and unmarried patient. It can also store many primordial follicles. Ovarian tissue vitrification study is still limited to animal test and there are no data about apoptosis assessment after ovarian vitrification in human ovary. Method: This quasi experimental study was held in Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia - Dr. Cipto Mangunkusumo General Hospital and Fatmawati Hospital Jakarta from March 2012 to May 2015. Ovaries from thirteen women between 31 and 37 years old who underwent oophorectomy with gynecological indication were examined. Result: There was no morphological difference between follicles from fresh and warmed-vitrified ovaries. The mean protein Bax expression on the fresh ovaries assessed in the form of H-score was 1.66 (SD 0.14) compared with 1.68 (SD 0.13) on the warmedvitrified group (p=0.165). The mean protein Bcl-2 expression on the fresh ovaries examined in the form of H-score was 1.73 (SD 0.10) compared with 1.71 (SD 0.10) on the warmed-vitrified group (p=0.068). Conclusion: Ovarian tissue vitrification does not affect the Bax and Bcl-2 expression on human ovary. [Indones J Obstet Gynecol 2016; 4-2: 88-92] Keywords: apoptosis, bax, Bcl-2, ovarian tissue vitrification

Impact of Ethinyl Estradiol to Human Telomerase Reverse Transcriptase Activity on Complete Hydatidiform Mole Culture Nurseta, Tatit; Wijasa, Arsana; Sitompul, Barlian
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To prove the effect of ethinyl estradiol as an activator on human Telomerase Reverse Transcriptase (hTERT). Method: The experimental study was conducted in vitro by using culture of complete hydatidiform mole trophoblast cell. We exposed the culture to ethinyl estradiol in varied doses and measured the concentration of hTERT through RT-PCR quantitative. There were 40 specimens as control group and 20 specimens exposed to ethinyl estradiol in different doses (10, 20, 40 and 80 mcg) as experimental group. The activity of hTERT was measured by RT-PCR and the concentration of it was assessed by ELISA. We analyzed the variables using ANOVA, Turkey post hoc and Pearson correlation test. Result: In control group, the concentration of hTERT was not detected. Meanwhile, the concentration among different doses of ethynil estradiol (10, 20, 40, 80 mcg) was 113,117.5; 114,507.6; 102,193.9; 127.546.1 amoles/ml, respectively. Among experimental group, they were significantly different both using F test (ANOVA) (p=0.001) and Turkey post hoc test (p=0.005). The correlation among group was 0.84 which meant higher level of ethinyl estradiol was correlated with higher activity of hTERT. Conclusion: Ethinyl estradiol impacts to the increase of hTERT activity on complete hydatidiform mole cell culture. [Indones J Obstet Gynecol 2016; 4-2: 93-96] Keywords: complete hydatidiform mole, ethinyl estradiol, human Telomerase Reverse Transcriptase (hTERT)

Bladder Function after Hysterectomy Wijaya, Johanna; Tendean, Hermie; Laihad, Bismarck J
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the effect of hysterectomy on bladder function pre- and post-radical hysterectomy in early stage of cervical cancer. Method: This study was a pre-post intervention study. Data were collected through questionnaires from women who had radical hysterectomy and total hysterectomy in Prof. Dr. R. D. Kandou Manado general hospital and other networking hospitals since January 1st, 2014 to November 31st, 2014. We analyzed the data using Wilcoxon and Mann-Whitney statistical test. Result: There were each 18 respondents for the radical and total hysterectomy group in Prof. Dr. R. D. Kandou general hospital and networking hospitals. The age distribution of radical hysterectomy was 41-45 years old for 44.4%. The parity was dominated by second parity for 38.8%. In pre- and post-surgery, there were significant differences for urinary incontinence disorder (p=0.003), emptying disorder (p=0.008), urinary pain (p=0.034), and total urinary disorder (p=0.001). While, between radical and total hysterectomy, there was no significant difference in bladder function (p>0.05). Conclusion: There is an association before and after surgery to urinary function. However, there is no association between the radical and total hysterectomy group. [Indones J Obstet Gynecol 2016; 4-2: 97-100] Keywords: bladder function, cervical cancer, radical hysterectomy

Epidemiology Data of Ovarian Cancer in Dr. Cipto Mangunkusumo Hospital, Jakarta Noela, Fransisca; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To describe the incidence of ovarian cancer and its characteristic in Dr. Cipto Mangunkusumo Hospital in the last 5 years. Method: This was cross sectional study design. The data was collected from Gynecology Oncology Division Cancer Registry and Dr. Cipto Mangunkusumo Hospital medical record from January 2009 to December 2013; follow up was performed to know the 4-years survival rate. Result: There were 98 subjects in this study. The majority incidence of ovarian cancer was 45-54 years old (33.6%); the incidence of ovarian cancer decreased with the increased number of parity; the majority histotype was epithelial (76.5%); and most of them were diagnosed on advanced stage (55.1%). The 4-year survival rate for epithelial type was 77%; germinal type was 83.3%; and stromal type was 100%. Based on therapy, the 4-year survival rate was 84.1% for surgical only; 83.3% in adjuvant chemotherapy group; and 68.4% in neoadjuvant chemotherapy. In the group of adjuvant chemotherapy, there was 63% patients with complete response and 41.2% patients with complete response in neoadjuvant chemotherapy. Conclusion: The highest incidence of ovarian cancer in Dr. Cipto Mangunkusumo Hospital belongs to the age of reproductive women (≤ 55 years old) with the highest incidence occurs in nulliparity women. Most of the ovarian cancer cases are diagnosed in advanced stage (stage III-IV). [Indones J Obstet Gynecol 2016; 4-2: 101-106] Keywords: age, histotype, ovarian cancer, parity, response, stage, survival, treatment

Mesothelin versus Ca125 in Screening the Ovarian Malignancy Jayasaputra, Meliana; Wagey, Freddy W; Rarung, Max R
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the sensitivity and specificity of mesothelin compared with Ca-125 as a tumor marker in predicting ovarian malignancy. Method: The cross sectional study design with diagnostic tests was conducted in 30 samples of patients undergoing elective laparotomy due to ovarian tumor. We compared the sensitivity and specificity between mesothelin and Ca-125, then the data were analyzed using SPSS software version 22.0. Result: According to the ROC curve analysis, optimal sensitivity and specificity value of mesothelin was 63.2% and 54.5% at a cut-off point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55 pg/ml. While the value of both optimal sensitivity and specificity of Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml. Conclusion: Mesothelin and Ca-125 are not different significantly for the AUC value of 50%. Due to higher sensitivity and specificity of Ca-125 than mesothelin, Ca-125 is still used as tumor marker for screening the ovarian malignancy. [Indones J Obstet Gynecol 2016; 4-2: 107-110] Keywords: Ca-125, mesothelin, ovarian malignancy

The Outcomes of Primary Debulking Surgery and Neoadjuvant Chemotherapy in Advanced Ovarian Cancer Rinaldy, Dino; Andrijono, Andrijono; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the outcomes and survival rate of primary debulking surgery with neoadjuvant chemotherapy. Method: We selected advanced ovarian cancer patients from medical records. Subjects were allocated into groups of primary debulking surgery and neoajuvant chemotherapy by considering the inclusion and exclusion criteria. We analyzed the data using T test, Fisher’s exact, and chi-square. The survival rate was presented in Kaplan Meier curve, whereas the significance was tested with Logrank. We managed the data using STRATA software version 12. Result: We obtained 32 cases of primary debulking surgery group and 20 cases of the neoadjuvant chemotherapy group. Most of the subjects (44.2%) were 40-49 years old and 80.8% had delivered more than twice. The mean value of Ca-125 at admission was 3,594.8 u/ml (range 66.6 to 73,000 u/ml). Total of 31 subjects showed the serous histologic type (59.6%). There was no association between primary debulking surgery and neoadjuvant chemotherapy for the parameter of operative time, blood loss, organs injury, ICU stay, and hospital stay (p>0.05). Primary debulking surgery had a survival rate similar to neoadjuvant chemotherapy group (p=0.95). Conclusion: The perioperative outcomes of advanced ovarian cancer patients has similar result between primary debulking surgery and neoadjuvant chemotherapy. Primary debulking surgery has a survival rate similar to neoadjuvant chemotherapy group. [Indones J Obstet Gynecol 2016; 4-2: 111-115] Keywords: advanced ovarian cancer, neoadjuvant chemotherapy, primary debulking surgery

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
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Journal Mail Official
support@inajog.com

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Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA