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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol. 12 No. 2 (2023): February" : 7 Documents clear
The Difference of Low Density Lipoprotein Cholesterol Levels on Different Severity of Coronary Artery Disease Patients in Siloam Hospital Lippo Village Tanaka, Michael; Santoso, Wilbert; Anggraini, Novita
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7033

Abstract

Background: Coronary artery disease (CAD) is one of the highest causes of death in the world. Hypercholesterolemia, especially low-density lipoprotein (LDL) levels, is a major risk factor, because it is the main precursor of atherosclerosis. Previous studies showed the relationship between LDL level and the number of vessel disease is still inconsistent, therefore it needs to be observed further. The objective of this study was to know the effect of LDL levels on the number of vessel disease in CAD patients who underwent coronary angiography.Methods: It was a cross-sectional and retrospective study, where data were taken from medical records of CAD patients who underwent coronary angiography at Siloam Hospital Lippo Village between January to June 2018. Patients with at least one vessel disease were included. The number of vessel disease was categorized into 3 groups: one-vessel, two-vessels, and multi-vessel. The relationship between LDL levels and the number of vessel disease was analyzed using one way ANOVA.Result: The data includes 90 patients; 70 (77.8%) were male with average age of 56±9 years. There were 32 (35.6%) patients in one-vessel group; 27 (30%) in two-vessel group; and 31 (34.4%) in multi-vessel group with an average LDL levels of 106.43±40.51 mg/dl; 111.15±39.43 mg/dl; and 114.52±32.55 mg/dl respectively. Although it seemed that the increase in LDL cholesterol levels was in line with the number of vessel disease, there was no statistically significant relationship between the two variables (p=0.694).Conclusions: LDL cholesterol level does not affect the number of vessel disease in CAD patients.
Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7034

Abstract

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6 - 7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5%  of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren. 
Relationship of Sexual Violence to Depression in Female Students of Faculty of Medicine, Pelita Harapan University Xaviera, Luqyana Ghina; Kristiani, Erna; Suryadinata, Neneng
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7035

Abstract

Background: Sexual violence can take many forms to anyone. The increase in the number of sexual violence against women in Indonesia is quite significant. These incidents are reported to occur frequently in women in young adulthood. These experiences can have long-term effects, one of which is depression. There are several studies that show an association between sexual violence and the incidence of depression. However, there has not been much quantitative research to look at the relationship on this matter in Indonesia, especially on female students. This study aims to understand the relationship between sexual violence and the incidence of depression in female students of the Faculty of Medicine, Universitas Pelita Harapan.Methods: This study use a cross-sectional study design. The data has been collected using questionnaires filled in by the respondents. This study involved 149 female students of the Faculty of Medicine, Pelita Harapan University. The results of the study were processed and statistically analyzed using SPSS 25.Result: Based on research data, there are 149 respondents from female students of the Faculty of Medicine, Universitas Pelita Harapan. with a mean age of 19.29 (SD = 1.086). The youngest age of the respondent is 17 years old and the oldest is 24 years old. A total of 55 respondents had experienced sexual violence. Based on the results of the Beck's Depression Inventory (BDI) questionnaire, 16% had mild depression, 9% had moderate depression, and 2% had severe depression. Chi-square test showed a significant relationship between experiences of sexual violence and the incidence of depression, with p <0.001.Conclusions: Sexual violence is related to the incidence of depression in female students of the Faculty of Medicine, Pelita Harapan University.
Understanding Tsetse Fly (Glossina morsitans) Behavior through its Genome Marbun, Kristin Talia; Nugroho, Satya; Jo, Juandy
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7036

Abstract

Glossina morsitans (G. morsitans), commonly known as tsetse fly, have caused public health concerns throughout the years. G. morsitans is the vector for Trypanosoma brucei (T. brucei), the parasite responsible for causing the deadly African sleeping disease (African trypanosomiasis). Researchers have searched for ways to contain this disease, but to little avail. Fortunately, new advances in sequencing methods have given researchers a new opportunity to win the war against the disease. The whole-genome sequence of G. morsitans provides essential data regarding involved genes that transmits T. brucei to humans. Information about those unique genes facilitates researchers to create new methods to prevent G. morsitans from becoming the vector of T. brucei, enabling the containment of this disease. With this, we review the unique genes in the G. morsitans genome, such as those that contribute to blood-feeding ability, establish a relationship with symbionts, and G. morsitans unique sensory genes, with an expectation that it would enhance our knowledge of G. morsitans as the vector for parasites causing African trypanosomiasis.
Future Application of Oncolytic Viruses for Cancer Treatment Lesmana, Jevon Aaron; Jo, Juandy
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7037

Abstract

Cancer treatments have developed over the years. A particular improvement is the utilization of oncolytic viruses to treat cancers. Oncolytic viruses are one of the immunotherapeutic tools that potentially could provide good results and benefits to the patients. Oncolytic viruses could mediate antitumor effects. Indeed, the connection between viral infections and cancer treatment have been reported historically. It is known that oncolytic viruses prefer to infect cancer cells rather than normal cells, resulting in the presentation of tumor-associated antigens to the immune system, boosting immunological activity in the tumor microenvironment, as well as assisting in the expression of inflammatory and immunomodulatory cytokines. Oncolytic viruses are a novel regimen in the cancer therapy, in which knowledge and technology of utilizing oncolytic viruses to treat cancer are still evolving. Importantly, clinical trials demonstrated that the viruses were well tolerated by cancer patients. Considering its potency and prospect, oncolytic viral treatments could be a useful additional tool for cancer therapy.
Postoperative Pain Comparison Between Open Hemorrhoidectomy and Stapled Hemorrhoidopexy on Internal Hemorrhoid at Siloam Hospitals Lippo Village Sudirman, Taufik; Wiguna, Alvin Leonard
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7038

Abstract

Background: Hemorrhoids have a prevalence of 4,4%. Surgery is one of the modalities for treating hemorrrhoids. The method accepted as the "golden standard" is open hemorrhoidectomy. Although considered effective, open hemorrhoidectomy is still often associated with a significant rate of morbidity and pain symptoms that are a complaint of most patients. Therefore, another method is an alternative, namely, stapled hemorrhoidopexy. Some studies showed that stapled hemorrhoidopexy has a lower occurrence of postoperative pain, and others offer the opposite.Methods: This study was conducted at Siloam Hospitals Lippo Village between February and March 2019. Samples were taken as many as 70 patients by taking secondary data from medical records. Patients diagnosed with third or fourth degree hemorrhoids and undergoing open hemorrhoidectomy or stapled hemorrhoidopexy will be taken the pain score from the visual analogue scale. Data is then tabulated using Microsoft Excel and analysed using SPSS.Result: the occurrence of postoperative pain in the stapled hemorrhoidopexy and open hemorrhoidectomy group, respectively, are 80% and 97%, with a p-value of 0,055. The average visual analogue scale score for open hemorrhoidectomy and stapled hemorrhoidopexy was 3±1,39 and 2±1,39, respectively, with a p-value of 0.003.Conclusions: the result showed that the occurrence of postoperative pain was not statistically significant. And the average visual analogue scale score was lower in the stapled hemorrhoidopexy group.
Transvaginal Ultrasound as an Indicator of Preterm Birth Wibisono, Jacobus Jeno; Onasis, Serena; Nikendari, Sri Mulyani Rana; Andhika, Aryasena; Wibisono, Maria Georgina
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7039

Abstract

Preterm Birth is delivery that occurs when the mother's gestational age is 20-36 weeks starting from the first day of the last menstrual period with a fetal weight still below 2500 grams. In preterm birth there are regular uterine contractions that cause thinning or dilation of the cervix before 36 weeks of gestation is complete. Approximately 50% of sequelae that occur in children are due to preterm birth. It is known that cervical dilatation in pregnant women is associated with preterm birth, so there are several screening methods that are used to predict preterm birth, including cervical length examination. Transvaginal ultrasound examination is a safe method of examination to measure cervical length objectively. Cervical length less than or equal to 25 mm or cervical dilatation 70% to 100% are expected to have preterm birth.

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