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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 8 Documents
 1 
Search results for , issue "Vol 8, No 2 (2023)" : 8 Documents clear
Prescribing Pattern of Vitamins in Dermatologic Disorders at Tertiary Care Teaching Hospital in Western India Patel, Zankrut J.; Prajapati, Akanksha; Thaker, Vidhi; Patel, Sumit
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.40973

Abstract

Skin ailments are a major burden in society. It is thought that Vitamins may help in improving skin health and appearance, but their deficiency may cause disease. The data regarding vitamin usage patterns in dermatologic practice in India is lacking. Therefore, the present study has been planned to analyze the prescribing pattern of vitamins. A cross-sectional, observational study was carried out at the outpatient department of dermatology at GCSMCH and RC, Ahmedabad, for 12 months from October 2019 to September 2020. Prescriptions of 500 patients were analyzed for common skin conditions and prescribing patterns.  All the data were compiled into Microsoft Office Excel, and a descriptive statistical analysis was conducted. Out of 500 patients, males and females were 226(45%) and 274 (55%), respectively. Most of them had skin appendage-related diseases (28%). Out of the total of 1935 prescribed drugs, 619(31.98%) vitamins were prescribed in 500 patients with an average of 1.23 per prescription, in which the majority of drugs were as fixed-dose combination (FDC). Of 1211 prescribed vitamins, vitamin A was the most commonly prescribed vitamin 197 (39.4%). There is no association between prescribed vitamins and the prevalence of diseases. (p>0.05). However, the P-value is highly significant, suggesting an association between prescribed vitamins and different age groups. (p<0.05). Skin appendage-related diseases are commonest skin ailments. The use of vitamins in skin conditions is very common, particularly in oral formulations, among which the majority were prescribed as FDCs.
Effects of Centella Asiatica (L) Urb. on Cognitive Function in Hypothyroid Mice Offspring Khairinisa, Miski A.; Alfaqeeh, Mohammed; Patricia, Vinda M.
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.48162

Abstract

Centella asiatica (C. asiatica) is widely used in traditional medicine due to its numerous health benefits. Among its reputed advantages are improved memory, intelligence, and neural protection. Impairment of cognitive function as a center for memory processing occurs due to perinatal hypothyroidism. Although several studies have shown that C. asiatica extract may improve memory function, the effectiveness of its extract as a memory enhancer for patients with perinatal hypothyroid is less unknown. Therefore, this study aimed to determine the effects of ethanol extract of C. asiatica (EEC) leaf as a memory enhancer in perinatal hypothyroid mice model. C. asiatica leaves were extracted by the decoction method, and the ethanol extract was administered to mice. the hypothyroid mouse model was developed by administering antithyroid agents to pregnant mice from gestational day (GD) 18 to postnatal day (PND) 21. The hypothyroid mice were administered either donepezil 5 mg/kg BW/mL (positive control) or treatment group (EEC 2 mg/kg BW/mL) from PND 21 to PND 35 (14 days). The light-dark test (LDT) and memory tests of offspring were conducted on PND 36. We found that EEC improved the cognition and memory of perinatal hypothyroidism mice. This study contributes to the foundational research for developing memory-enhancing supplement preparations, mainly targeting children with perinatal hypothyroidism.
Pharmacokinetic Changes and Dosage Adjustment of Digoxin in Elderly Patients with Atrial Fibrillation: A Narrative Review Alfaqeeh, Mohammed; Permatasari, Lanny I.; Khairinisa, Miski A.; Rusdiana, Taofik
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.48284

Abstract

Digoxin is a cardiac glycoside medication commonly used to control rapid heart rates in Atrial Fibrillation (AF). However, digoxin has a narrow therapeutic range and can be associated with adverse effects, including increased mortality risk, especially in the elderly. Pharmacokinetic changes occur with aging, affecting the way drugs are absorbed, distributed, metabolized, and eliminated from the body. Thus, this narrative review aimed to assess the optimization of digoxin dosing in elderly patients with AF while considering pharmacokinetic changes due to aging. We performed a comprehensive computerized search of relevant English articles and a manual examination of reference lists from primary sources formed the basis of this scoping review. This involved an extensive computerized search of relevant articles in English and a manual search of the reference lists of original articles. The review highlighted the need to carefully monitor digoxin levels in elderly patients due to changes in body composition, protein binding, hepatic clearance, renal excretion, and other factors affecting drug metabolism. Furthermore, we summarized guidelines and recommendations for optimizing digoxin dosing in elderly patients with AF. By shedding light on the intricacies of optimizing digoxin dosing in the elderly with atrial AF and emphasizing the significance of accounting for age-related pharmacokinetic changes, this review offers valuable insights for healthcare practitioners and researchers in the field. Addressing these aspects is crucial to enhancing therapeutic outcomes and minimizing potential risks associated with digoxin therapy in this vulnerable patient population
Kratom (Mitragyna speciosa) Leaf Ethanol Extract Showed In Vivo Analgesic Activity Prasetya, Rahmad A.; Sudarwati, Tri P.L
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.40727

Abstract

Analgesic drugs like morphine and other opioids exhibit several harmful effects. Thus, the exploration of a new and safer analgesic drug is necessary. Utilizing Indonesia's biodiversity richness, medicinal plants can serve as an alternative source of novel analgesic drugs. Here, we show the analgesic activity of Kratom (Mitragyna speciosa) leaf ethanol extract (KE) in formaldehyde-induced rat (Rattus norvegicus) models. The effect of KE was examined by observing the duration of spontaneous nociceptive behavior such as paw licking or limp leg. The result showed that rats treated with 70 mg/kg KE demonstrated significantly (p<0.01) decreased nociceptive behavior compared to those receiving vehicles. However, a higher KE dose (210 mg/kg) failed to increase the analgesic effect and showed a slight reduction (not significant) compared to the control group. These findings proved that kratom leaf ethanol extract has the potential to alleviate painful conditions.
Pharm-Care Tadulako®: Web-Based Design Application to Improve Pharmaceutical Care Services Rumi, Amelia; Faisal, Muhammad; Syarifuddin, Nuryani; Purwanti, Rani; Natasya, Putri; Serli, Serli; Yusriadi, Yusriadi; A. Khairinisa, Miski
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.45759

Abstract

Pharmaceutical services recently require new ideas and innovation to provide maximum benefit concerning the pharmacological treatments of patients and taking responsibility for the process of monitoring their therapy. One of the efforts proposed to be implemented by pharmacists is the pharmaceutical care program which is designed to ensure pharmacists are able to monitor safe and effective medication use and also to provide timely access to medicines for the population. Moreover, the application of eHealth in terms of technology is expected to be effective, networked, patient-centered, and accessible for patients. Therefore, Pharm-Care Tadulako® which is a personalized eHealth application designed with key features of pharmaceutical care to enhance communication between pharmacists and patients is presented in this study. Some of the services designed to be provided by this application include electronic medical records, drug reminders, pharmaceutical messenger, clinical data monitoring, and medication analysis. The application was designed using Software Development Life Cycle (SDLC) Waterfall, after which a pilot study was conducted at four pharmacies in Palu City, Centre of Sulawesi, Indonesia, using 30 patients who volunteered willingly to participate in the experiment. It was discovered that 65% out of the 30 patients were aged 26-45 years old out of which 36% were observed to be suffering from hypertension. The Pharm-Care Tadulako® application was found to have a good impact on pharmacists during the process of providing pharmaceutical care services to patients while they were able to monitor their treatment through the five main features of the application.
Usability of mHealth in Patient with Type 1 and Type 2 Diabetes Mellitus: A Review Belinda, Andhara M.; Milanda, Tiana
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.50595

Abstract

Diabetes mellitus (DM) is a group of metabolic illnesses identified by elevated blood glucose levels. The glycated hemoglobin (HbA1C) test is used to evaluate a person’s control of their blood glucose levels. According to a recent study, mHealth interventions may be particularly helpful for assisting patients with diabetes mellitus to self-monitor their status on their HbA1c level. Therefore, this systematic review aims to provide an overview of how mHealth affects individuals with diabetes mellitus, concentrating on HbA1c evaluation. A systematic review was conducted by reviewing the PubMed, Google Scholar, and Mendeley databases for randomized control trials published between February 2017 and September 2023. The studies of mHealth on the result of HbA1c were then examined. A drop in HbA1c was seen in all intervention groups. The overall average reduction in HbA1c across all intervention groups was - 0.79%, while the reduction in control groups was - 0.42%. The influence of mHealth could significantly reduce HbA1c levels. Studies show that HbA1c decreased more in patients who underwent a 3 to 6-month intervention. This study discovered 12 papers that discuss health for people with diabetes mellitus type 1 and 2. This study found that mHealth interventions significantly lower HbA1c in DM patients. For further research, bigger sample sizes and data on self-care results are needed. The views and perspectives of patients regarding the physical characteristics and design aspects of different interventions—mobile applications, texts, and phone calls—need to be further investigated.
The Effect of Prebiotic Starch and Pectin from Ambon Banana Peel (musa acuminata aaa) on the Growth of Skin Microbiota Bacteria In Vitro Rusdi, Bertha; Aryani, Ratih; Yuniarni, Umi
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.49261

Abstract

Propionibacterium acnes is a bacteria which causes acne. This bacteria is hypothesized to be inhibited by Staphylococcus epidermidis. Prebiotics have been shown to enhance the number of S. epidermidis and decrease the growth of P. acnes. The prebiotic action of starch and pectin from diverse plant sources is known in the skin microbiome. The prebiotic activity of Ambon banana peel starch and pectin on skin microbiota has not been researched. This study aims to investigate the prebiotic activity of starch and pectin from Ambon banana peels on skin microbiota, represented by S.epidermidis and P.acnes. The results showed that starch, and pectin have a prebiotic activity because they promoted the growth of S. epidermidis while suppressing the growth of P. acnes. P. acnes inhibitor percentages were 1.62% for starch and 65.07% for pectin. Negative inhibition values were -184.95% for starch and -5.80% for pectin suggesting an increase in S. epidermidis proliferation.
Rationality of Antidiabetic in Outpatient with Type 2 Diabetes Mellitus at PKU Muhammadiyah Yogyakarta Hospital, Special Region of Yogyakarta - Indonesia Urfiyya, Qarriy A.; Aisyah, Aisyah
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.41494

Abstract

In the past few decades, the number of people with diabetes mellitus has steadily increased in various countries. Type 2 Diabetes Mellitus (DM) is the most common type of DM. An increase follows this significant increase in the number of patients in the use of antidiabetic drugs and the risk of irrational drug use, where drug use evaluation is one of the strategies to reduce it. This study aims to evaluate the rational use of antidiabetics in outpatients with type 2 DM at PKU Muhammadiyah Yogyakarta Hospital, Special Region of Yogyakarta - Indonesia. This study is a retrospective analytical observational study. The data used as reference is patient medical records from October 2021 to March 2022. Antidiabetic accuracy based on Indonesian Endocrinology Society guidelines and Drug Information Handbook ed. 22. A total of 155 medical records patients were included in this study. The result showed that patients with complications (50,4%) were higher than patients without complications (49,6%), with the most complication was nephropathy (67,9%) and the most comorbidity was hypertension (21,2%). The rationality of antidiabetics includes the right patient (94%), the right medicine (74%), the right dosage (100%), the right time administration (100%), and the right interval administration (97%). The rational drug use is expected to reduce the risk of drug side effects, reduce patient treatment costs, and improve patient life quality.

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