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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 12 Documents

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Search results for , issue "Vol 16, No 1 (2021)" : 12 Documents clear

Isolation, Characterization and Application of Humin From Sumatran Peat Soils as Adsorbent for Naphtol Blue Black and Indigosol Blue Dyes Maya Rahmayanti; Indah Nurhikmah; Feni Larasati
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Isolation, characterization and application of humin as adsorbent for naphtol blue black (NBB) and indigosol blue (IB) dyes has been carried out. Humin application in this study aims to obtain the optimum pH conditions and kinetics model for adsorption NBB and IB dyes onto humin. Humin was isolated from peat soils originating from Riau, Sumatra. The isolation method used was the alkaline extraction method and the characterization of humin using FTIR spectrophotometer. The total acidity, carboxylic groups and –OH phenolic groups of humin were determined quantitatively using the acid-base titration method. FTIR characterization indicated the presence of an –OH group which was indicated by the appearance of absorption at a wavelength of 3425.3 cm-1 and a stretching vibration of C=O from the –COOH group at a wavelength of 1705 cm-1. The quantitative calculation of the total acidity value, the content of the carboxylic group and the -OH group phenolics of humin were 508.47 cmol kg-1, 289.42 cmol kg-1 and 219.05 cmol kg-1, respectively. The optimum pH conditions for adsorption NBB and IB onto humin occurred at pH 5 and pH 2, respectively. The adsorption kinetics model of NBB and IB on humin followed the Ho kinetics model.

Purification of Carbon-Based Magnetic Nanoparticles (CMNs) Produced by Submerged Arc Discharge in Liquid Ethanol/Ethylenediamine Oktaviana Dyah Mayasari; Dielsa Eka Kuswari; Witri Wahyu Lestari; Teguh Endah Saraswati
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Surface modification of covalently amine-attached carbon-based magnetic nanoparticles (CMNs) can be produced quite simply in submerged arc discharge using the amine-containing liquid medium ethylenediamine (ED), resulting in CMNs-ED. However, after the arc discharge processing, the resulting nanoparticles possibly contain physically absorbed amine-containing molecules from a liquid medium on the particle surface. To remove the non-covalently bound molecules, a purification process is required. In this study, the purification was conducted using polar and non-polar solvents following the synthesis process. The surface property was initially characterized by a dispersion test in water, showing that CMNs-ED purified by water have better dispersion than CMNs produced in ethanol alone, CMNs-ED before purification, and CMNs-ED after purification by immersion in toluene. Before and after purification, the diffraction pattern showed definitive peaks corresponded to the crystal planes of C(002), Fe3C(220), and Fe3O4(311) at 26.51°, 44.65°, and 35.42°, respectively. The amine functional group on the nanoparticles before purification thought to come from decomposed ethylenediamine assigned by the vibration peaks appeared at a wavenumbers ~3400 cm-1 and 1020-1220 cm-1, which corresponds to N-H and C-N, respectively. After purification, the vibration peaks of amine groups were still observable, indicating that the amine groups were still covalently attached to the nanoparticles. Magnetic analysis showed that CMNs before and after purification have superparamagnetic properties, with the magnetic saturation value around 10-17 emu/g. The electron microscope images show that the CMNs-ED before purification have a spherical form with a diameter larger than CMNs-ED after purification.

The Influence of ZnCl2 Activation on Macronutrient NPK Adsorption Simultaneously Using Coconut Shell Biochar for Soil Fertility Improvement Candra Purnawan; Christina Candra Dewi; Syafrudin syafrudin; Bimastyaji Surya Ramadan; Mochamad Arief Budihardjo; Agus Jatnika Effendi; Syarif Hidayat
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

The influence of ZnCl2 activation on macronutrient Nitrogen, Phosphor, Potassium (NPK) adsorption simultaneously using Coconut Shell Biochar for soil fertility improvement has been conducted. Biochar formation is carried out at temperature up to 500 oC using variation in the concentration of ZnCl2 0,5; 1,0; 1,5; 2,0; dan 2,5 M. The biochar formed was characterized using Fourier Transform InfraRed (FTIR) spectroscopy and Surface Area Analyzer (SAA). Whereas NPK analysis has used the Indonesian standard method (SNI 7763: 2018). Based on this research, it was concluded that the greater the concentration of ZnCl2 activator, indicated that the higher intensity of the spectra of –OH and –NH2 at wave number 3400 cm-1 and 1600 cm-1. It showed that biochar activation was higher and a more active functional group was opened. Increasing the concentration of ZnCl2 activator has increased Biochar adsorption of NPK macronutrients. The optimum condition for activation of coconut shell Biochar was activation with ZnCl2 2.5 M. The addition of activated Biochar was increased soil adsorption on NPK macronutrients. Biochar addition had increased Nitrogen (N) adsorption up to 23.53%, Phosphor (P) up to 200%, and Potassium (K) up to 41.24%.

Equilibrium and Kinetic Study of Removal Copper(II) from Aqueous Solution Using Chicken Eggshells: Low Cost Sorbent Mohammad Jihad Madiabu; Joko Untung; Imas Solihat; Andi Muhammad Ichzan
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

The research aims to investigate feasibility eggshells as potential adsorbent to remove copper(II) ions from aqueous solution. Eggshells powder was characterized using X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. Effect of copper(II) initial concentration, adsorbent dosage, and contact time have conducted. The optimum adsorption condition obtained when 0.7 g eggshells applied to 50 mg/L copper(II) solution for 50 minutes. The maximum percentage of copper(II) removal was exceeded more than 85%. Langmuir and Freundlich isotherm model were applied to describe the equilibrium adsorption. Copper(II) kinetics sorption process was fitted to pseudo-second order model with a rate constant equal to 0.516 g/mg.min. The results clearly exhibit that eggshells powder can be effectively used to remove copper(II) ions from aqueous solutions.

Enhanced Expression and Purification Strategy for Recombinant Bacterially-Expressed Human Hexokinase II Fazia Adyani Ahmad Fuad; Suriyea Tanbin
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Dengue virus hijacks the host cellular mechanism to propagate and survive during viral infection, in which the central carbon mechanism plays a crucial role to upregulate DENV infection through the increase of human hexokinase II (HKII) activity. Since the enzyme governs the glycolytic pathway, it has potentials as a target for anti-dengue (DENV) drug development. In this study, the production of human hexokinase II protein has been enhanced by using bacterial system for anti-dengue therapeutic purpose. The HKII gene was cloned into pET28b vector and transformed into the E. coli strain BL21 (DE3) for HKII expression. In order to obtain soluble recombinant HKII in an active form, we optimized protein expression under specific conditions at 18°C for 19 hours using Terrific Broth media, in the presence of 0.5 mM isopropyl-2-D-thiogalactopyranoside (IPTG). The pET28b-HKII construct expressed in BL21(DE3) system exhibited adequate protein expression, thus, this construct was subsequently proceeded to purification process. The expressed protein was purified to homogeneity by a combination of Immobilized Metal Ion Affinity Chromatography (IMAC)and size exclusion chromatography (SEC), resulting in pure, active bacterially-expressed HKII with a specific activity of 56. 67U.mg-1. The amount of HKII obtained from 2 L culture is 80 mg, with a yield percentage of 10.5%. Hence in this study, human HKII has successfully been cloned and expressed as a soluble protein that can be utilized for further therapeutic studies.

Characterization of Antioxidant Compound from Syzygium polyanthum Leaves Fraction Using UHPLC-HRMS Muhammad Ana Syabana; Nancy Dewi Yuliana; Irmanida Batubara; Dedi Fardiaz
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

The leaves of Syzygium polyanthum is widely used in Indonesia as a spice. It has been reported to have significant antioxidant activity. However, the reports on compounds responsible for the activity are very scarce. The purpose of this research was to characterize the chemical profile of S. polyanthumfractions which showed the highest antioxidant activity. The dried leaves of S. polyanthum were fractionated using the different combination of non-polar to polar solvent, those are n-hexane, acetone, water. Fourteen fractions were collected and analyzed for their DPPH antioxidant activity. The chemical profile of selected fractions was characterized using UHPLC-HRMS to identify compounds that might associate with the antioxidant activity of S. polyanthum. The results showed that at the dose of 500 μg/ml, four fractions showed the highest antioxidant activity with the following order: F9 (acetone:water=80:20), F10 (acetone:water=60:40), F1 (hexane 100%) andF3 (hexane:aceton=80:20). UHPLC-HRMSanalysis successfully identified several compounds in F9 and F10. Gallic acid, pyrogallol, and myricetin were identified in F9. Aconitic acid was identified in F10. All of the identified compounds were previously reported to have antioxidant activity

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Fatoni, Amin
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents)

Physical, Thermal Stability, and Mechanical Characteristics of New Bioplastic Elastomer from Blends Cassava and Tannia Starches as Green Material Christwardana, Marcelinus; Ismojo, I.; Marsudi, Sidik
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

This paper presents the study results of the morphology, physical properties, thermal stability, and mechanics of bioplastic blends made from tannia and cassava starch, with a varying weight from 0 to 95%. The addition of tannia to the cassava starch-based bioplastic composition has the ability to reduce the number of pores, density, and water absorption with an average thickness of 0.21-0.29 mm. It also increased moisture content due to its nature, which is more hydrophilic than cassava starch. The result showed that the tensile strength of bioplastic ranged from 0.81-1.33 MPa and elongated from 31-35%. In addition, the thermal analysis data showed that the glass transition temperature shifted marginally due to intermolecular activity. This shows that tannia starch has promising potential as an alternative raw material for bioplastics to replace cassava starch which is more dominantly used as a food source.

Characterization of Glucomannan Extracted from Fresh Porang Tubers Using Ethanol Technical Grade Nurlela Nurlela; Nina Ariesta; Dwi Sutari Laksono; Edi Santosa; Tjahja Muhandri
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Glucomannan is a polysaccharide consisting of β-1.4-linked D-mannose and D-glucose monomers, which have many benefits especially in the food and pharmaceutical industry. It has been widely reported that one of the main sources of glucomannan is porang tuber (Amorphophallus muelleri Blume). Generally, glucomannan extracted or purified from porang flour. However, the drying process causes other compounds than glucomannan stick strongly, resulting low levels of glucomannan. This study was to obtain glucomannan extract in an easy, effective, and inexpensive method, by direct extraction from fresh porang tubers using ethanol technical grade. We performed two extraction methods. The first is a fixed concentration method, the sample was repeatedly extracted using 50% ethanol (FC50) and 96% ethanol (FC96) 3 times, respectively. The second is a multilevel concentration method, the sample was repeatedly extracted using ethanol 60% (first step), 80% (second step), and 96% (third step), one replication each step. The highest glucomannan content (66.56%) was obtained by a multilevel concentration method. Moisture, lipid, protein, crude fiber, calcium oxalate level significantly reduce to 13.58%, 0.07%, 4.03%, 4.95%, 0.56% respectively. FTIR spectra confirmed the presence of functional groups (O-H, C=O, C-O, C-H), that compose the glucomannan compound. SEM image showed that the granules form of glucomannan were round and oval, began to change its phase from amorphous to crystalline, related to XRD data. The results showed that the direct extraction from fresh porang tuber using ethanol technical grade with a multilevel concentration method was an effective method to extract the glucomannan

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Backmatter (Instruction for author and back cover)

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Amin Fatoni

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Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

Abstract

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Abstract

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Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA