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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Efektivitas terapi komplementer propolis telaah terhadap SGHT dan IL-33 sekret hidung penderita rinitis alergi Yunis Sucipta Ibnu; Dwi Reno Pawarti; Mansyur Siddiq Wiyadi
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.286

Abstract

Latar belakang: Rinitis alergi (RA) adalah inflamasi mukosa hidung yang diperantarai oleh IgE. Gejala dapat dinilai dengan Skor Gejala Hidung Total (SGHT). Patofisiologi dan manifestasi klinis RA dipengaruhi oleh berbagai sitokin diantaranya interleukin 33 (IL-33). Efektivitas propolis maupun flavonoid dalam menurunkan SGHT dan kadar IL-33 sekret hidung masih kontroversi. Tujuan: Membuktikan bahwa penambahan propolis pada terapi komplementer RA lebih efektif menurunkan SGHT dan kadar IL-33 sekret hidung. Metode: Penelitian double blind randomized clinical trial (RCT), dilakukan di Unit Rawat Jalan (URJ) Divisi Alergi Imunologi, Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher (THT-KL) RSUD Dr. Soetomo, dan Institute of Tropical Disease, Universitas Airlangga, Surabaya pada bulan September 2018-Januari 2019. Pasien RA yang memenuhi kriteria inklusi diperiksa SGHT dan kadar IL-33 sekret hidung. Terapi diberikan selama 14 hari, evaluasi SGHT dan kadar IL-33 dilakukan hari ke-15. Hasil: Sepuluh sampel mendapat propolis dan terapi standar (kelompok A), sepuluh sampel mendapat terapi standar (kelompok B). Perbandingan SGHT antar kelompok setelah terapi rerata kelompok A=1,6 (SD 1,7), kelompok B=5,2 (SD 1,6). Uji Mann-Whitney satu arah p=0,001 menunjukkan SGHT antar kelompok setelah terapi berbeda signifikan (p<0,005). Rerata kadar IL-33 setelah terapi kelompok A=0,051 (SD 0,005), kelompok B=0,051 (SD 0,013). Uji t nilai p=0,881 menunjukkan kadar IL-33 sekret hidung antar kelompok setelah terapi berbeda tidak signifikan (p>0,005). Kesimpulan: Penambahan propolis sebagai terapi komplementer lebih efektif dalam menurunkan SGHT dibandingkan dengan terapi standar saja, namun tidak efektif dalam menurunkan kadar IL-33 sekret hidung penderita RA. Background: Allergic rhinitis (AR) is a nasal mucosa inflammation mediated by IgE. The symptoms severity is determined by total nasal symptom score (TNSS). The pathophysiology and clinical manifestations of AR are affected by several cytokines, one of which is interleukin 33 (IL-33). Efficacy of propolis or flavonoid in reducing TNSS and IL-33 level in nasal secretion is still a controversy. Purpose: To find out whether propolis addition to standard therapy could be more effective in reducing TNSS and IL-33 level of nasal secretion. Method: Double blind randomized clinical trial (RCT). The study was conducted at Outpatient unit of Department of Allergic and Immunology, Dr. Soetomo General Hospital, Surabaya and Institute of Tropical Disease (ITD) Universitas Airlangga. Allergic rhinitis patients who met inclusion criteria were examined for TNSS and IL-33 nasal secretion level. Therapy was given for 14 days, after which TNSS and IL-33 levels were evaluated on day 15th. Ten samples received propolis and standard therapy (group A), ten samples received standard therapy only (group B). Result: The comparison of TNSS groups after treatment: mean group A=1.6 (SD 1.7), and mean group B=5.2 (SD 1.6). One way Mann-Whitney test showed p=0.001 indicating the TNSS after treatment was significantly different (p<0.005). The comparison of IL-33: mean group A=0.051(SD=0.005) and mean group B=0.051(SD=0.013), t-test p=0.0881 indicating the IL-33 level of nasal secretion after treatment was not significantly different (p>0.005). Conclusion: Propolis as a complementary therapy was more effective reducing TNSS compared to standard therapy only, but it was not effective in reducing IL-33 level of nasal secretion.
Hubungan kadar CA 125 dengan karakteristik klinis Diffuse Large B cell Lymphoma Agung Dinasti Permana; Igor Hutabarat; Thaufiq Boesoirie; Bethy S. Hernowo; Rovina Ruslami
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.287

Abstract

Latar belakang: Kadar serum CA 125 telah diketahui mengalami peningkatan pada kasus limfoma non Hodgkin. Kegunaannya dalam menentukan prognosis, tingkat keparahan penyakit, dan follow up pasca terapi limfoma non Hodgkin telah banyak diteliti dan masih didapatkan hasil yang bervariasi. Saat ini belum diketahui mengenai kadar serum CA 125 pada kasus diffuse large B cell lymphoma (DLBCL) yang bermanifestasi di regio kepala dan leher. Tujuan: Mengetahui hubungan kadar serum CA 125 dengan karakteristik klinis pada kasus DLBCL regio kepala dan leher. Metode: Penelitian ini merupakan penelitian potong lintang yang melibatkan 31 subjek penelitian dengan diagnosis DLBCL regio kepala dan leher. Dilakukan pencatatan karakteristik klinis dan penentuan kadar serum CA 125 dengan pemeriksaan Immunoasai dan kemudian dilakukan analisis statistik untuk menentukan hubungan antar variabel. Hasil: Didapatkan peningkatan kadar serum CA 125 pada stadium lanjut dengan p<0,001. Analisis statistik terhadap kadar serum CA 125 dan Kadar Lactic Dehydrogenase (LDH) menunjukkan hubungan yang signifikan (p=0,018) demikian juga hubungannya dengan skorEastern Cooperative Oncology Group (ECOG) dengan nilai p=0,001. Pada penelitian ini tidak terdapat hubungan yang bermakna antara kadar serum CA 125 dengan skor Prognostic International Index (IPI). Kesimpulan: Kadar serum CA 125 berhubungan bermakna dengan stadium klinis, kadar LDH dan Skor ECOG pada DLBCL yang bermanifestasi di regio kepala dan leher. Dengan demikian CA 125 dapat digunakan sebagai marker untuk memprediksi prognosis dan mendekati stadium lanjut kasus limfoma non Hodgkin. Background: Serum CA 125 level has been known to increase in Non-Hodgkin Lymphoma cases.Many studies had elaborately researched the prognosis, disease severity and the follow up of Non Hodgkin Lymphoma cases using CA 125, yet the results had been varied. Up to now, serum CA 125 levels in cases of diffuse large B cell lymphoma (DLBCL) which manifest in the head and neck region, is still unclear. Purpose: To find out the correlation of serum CA 125 levels with clinical manifestations of DLBCL cases in the head and neck region. Method: A cross-sectional study involving 31 subjects diagnosed with DLBCL in the head and neck region. The clinical manifestations were recorded and serum CA 125 levels were obtained by Immunoassay examination. Statistical analysis was performed to determine the correlation between variables. Results: An increase in serum CA 125 levels at an advanced stage with p <0.001. The statistical result of CA 125 serum levels and LDH levels showed a significant correlation (p=0.018), as well as its significant correlation with the Eastern Cooperative Oncology Group (ECOG) score, with p=0.001. In this study there was no significant correlation between CA 125 serum levels and Prognostic International Index (IPI) scores. Conclusion: Serum CA 125 levels were significantly correlated with clinical stage, LDH level and ECOG score of DLBCL which manifested in the head and neck region. Therefore, CA 125 might be used as a marker to predict prognosis and to detect advanced disease in Non-Hodgkin Lymphoma cases.
Tatalaksana karsinoma sel skuamosa kanalis akustikus eksternus Ratna Dwi Restuti; Iman Pradana Maryadi; Rangga Rayendra Saleh
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.289

Abstract

Latar belakang: Keganasan pada kanalis akustikus eksternus (KAE) merupakan kasus yang jarang terjadi, kurang dari 0,2 % dari seluruh keganasan pada regio kepala dan leher. Secara histologis, karsinoma sel skuamosa merupakan jenis karsinoma terbanyak, terjadi pada 80% kasus. Karsinoma sel skuamosa KAE masih menjadi tantangan bagi praktisi medis dalam mendiagnosis dan menatalaksana. Tujuan: Hingga saat ini, belum ada algoritma yang spesifik dalam menatalaksana kasus ini, sehingga membutuhkan pengetahuan yang mendalam mengenai anatomi dan teknik pembedahan, serta ditunjang dengan adanya tim multidisiplin dalam menangani kasus keganasan KAE. Laporan kasus: Tulisan ini melaporkan 4 kasus pasien karsinoma sel skuamosa KAE yang menjalani bermacam modalitas tatalaksana dengan keluaran yang bervariasi. Metode: Telaah literatur berbasis bukti mengenai tatalaksana karsinoma sel skuamosa KAE melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan satu jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Karsinoma sel skuamosa liang telinga terutama ditatalaksana dengan terapi pembedahan. Modalitas tambahan yang dapat diberikan adalah kemoterapi dan radioterapi. Terapi pembedahan seringkali meninggalkan defek yang besar sehingga memerlukan tindakan rekonstruksi. Kesimpulan: Tatalaksana karsinoma sel skuamosa KAE seringkali membutuhkan pendekatan multidisiplin dan kompleks terutama pada kasus stadium lanjut. Angka harapan hidup yang lebih baik akan dicapai dengan mendiagnosis dan menatalaksana kasus ini secara dini. Background: Cancer of the external auditory canal (EAC) is a rare tumor, representing less than 0.2% of all head and neck cancers. Histologically, squamous cell carcinoma comprises more than 80% of cases. Squamous cell carcinoma (SCC) of the EAC is still a therapeutic challenge for medical specialists in its diagnosis and management. Purpose: Up to date, there is no specific treatment guidelines available due to SCC low incidence. The attending physician must have asubstantial knowledge of literatures as well as anatomy and surgical techniques, supported by an appropriate cancer center with adequate multidisciplinary team to offer the best therapy in accordance with the needs of the cancer clinical stages. Cases: This paper reports 4 cases of squamous cell carcinoma of the EAC which underwent various treatment modalities, and yielded also various outcomes. Method: Evidence based literature study about squamous cell carcinoma of EAC was performed through Cochrane and Pubmed Medline database. Based on inclusion and exclusion criteria, one study was found relevant to these cases. Results: The particular choice of SCC management of EAC is surgery, yet SCC of the EAC requires additional modalities such as chemotherapy and radiotherapy. Surgery often leaves a large defect which requires a reconstructive procedure. Conclusion: Cancer of EAC management requires a multidisciplinary approach, especially it is more complex in the advanced stage of SCC. An early stage diagnosis and prompt management will lead to a better survival rate. 
The correlation between plasma reactive oxygen species and hearing threshold levels in presbycusis patients Nyilo Purnami; Anita Nuraini; Bakti Surarso
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.291

Abstract

Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To find out the correlation between ROS levels in plasma and hearing threshold levels in presbycusis patients. Method: The design was cross sectional and conducted at the Outpatient Clinic of Neurotology Division, Geriatric Clinic, Clinical Pathology Installation, and Central Installation of Biomaterials Network Bank of Dr. Soetomo Hospital. Samples were taken by consecutive sampling for audiometric examination and measurement of ROS levels in plasma. Results: Fifty samples were collected, ROS levels in plasma were found with mean (SD) of 2.46 ng/ml (0.84). The mean hearing threshold level was 47.70 dB (12.42). The Pearson statistical test revealed a significant correlation between ROS levels in plasma and hearing threshold levels, with p=0.003 (p<0.05), and the correlation coefficient (r) 0.41. Conclusion: There was a correlation between ROS in plasma and hearing threshold levels in presbycusis patients, with a significant moderate-positive correlation pattern. It indicated that the higher the ROS levels in plasma, the higher the hearing threshold levels in presbycusis patients. Latar belakang: Presbikusis adalah gangguan pendengaran akibat proses degenerasi yang dijumpai pada usia 65 tahun atau lebih, ditandai oleh penurunan kepekaan pendengaran pada kedua telinga. Reactive oxygen species (ROS) diduga mempunyai peran penting pada patogenesis  presbikusis. Tujuan: Untuk mengetahui hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis. Metode: Penelitian ini adalah cross sectional, dilakukan di Unit Rawat Jalan (URJ) THT-KL Divisi Neurotologi, URJ Geriatri, Instalasi Patologi Klinik, dan Instalasi Pusat Biomaterial Bank Jaringan RSUD Dr. Soetomo. Sampel diambil secara consecutive sampling. Diperoleh 50 sampel untuk dilakukan pemeriksaan audiometri dan pengukuran kadar ROS dalam plasma. Hasil: Kadar ROS dalam plasma didapatkan hasil rerata (SD) 2,46 ng/ml (0,84). Nilai ambang dengar didapatkan hasil rerata (SD) 47,70 dB (12,42). Hasil uji statistik dengan korelasi Pearson terhadap kadar ROS dalam plasma dan nilai ambang dengar didapatkan hasil koefisien korelasi (r) sebesar 0,41 dan p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis dengan pola hubungan bersifat positif-sedang yang signifikan, yang berarti semakin tinggi kadar ROS dalam plasma, semakin tinggi nilai ambang dengar.
ABR profile in children with congenital rubella syndrome at Hasan Sadikin General Hospital Wijana Wijana; Alfira Ulfa
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.292

Abstract

Background: Congenital Rubella Syndrome (CRS) refer to a condition of variable birth defects, such as hearing impairment, congenital heart defects, cataract or congenital glaucoma, and others. In Indonesia, the incidence rate of rubella infection in 2015 was 3.2 per 100.000 live birth and increasing to 5.6 per 100.000 live birth in 2017. Rubella vaccination can decrease the incidence of CRS, however it has not been implemented in many developing country. Hearing impairment is the most common clinical manifestation among CRS cases. Purpose: This study was performed to know the hearing profile on CRS from January until December 2018, at Hasan Sadikin Hospital. Methods: A retrospective descriptive study design was conducted. Data was obtained from medical records and Auditory Brainstem Response (ABR) results, between January until December 2018, at Dr. Hasan Sadikin General Hospital, Bandung. Results: There were 60 CRS patients, 53 of them (88%) had hearing loss. Profound Sensorineural Hearing Loss (SNHL) in 27 patients (45%), severe SNHL in 18 patients (30%), 3 of them were unilateral, moderate unilateral SNHL in 3 patients (5%), mild SNHL in 5 patients (8%) consisted of 2 unilateral SNHL and 3 bilateral SNHL. Normal hearing in 7 patients (12%). Conclusion: Eighty eight percent of CRS patients had hearing loss, 75% with bilateral SNHL. Follow-up and management for these patients required multidisciplinary approach such as paediatrics, ophthalmologic, physical medicine and rehabilitation, and parental support. Latar belakang: Sindrom Rubella Kongenital (SRK) mengacu pada berbagai kondisi cacat lahir, seperti gangguan pendengaran, cacat jantung kongenital, katarak atau glaukoma kongenital, dan lain-lain. Di Indonesia, tingkat kejadian infeksi rubella pada tahun 2015 adalah 3,2 per 100,000 kelahiran hidup dan meningkat menjadi 5,6 per 100,000 kelahiran hidup pada tahun 2017. Vaksinasi rubella dapat mengurangi kejadian SRK, namun belum diterapkan di banyak negara berkembang. Gangguan pendengaran adalah manifestasi klinis paling umum di antara kasus SRK. Tujuan: Penelitian ini dilakukan untuk mengetahui profil pendengaran pada SRK, dari Januari sampai dengan Desember 2018, di Rumah Sakit Hasan Sadikin. Metode: Penelitian ini adalah deskriptif retrospektif. Data diperoleh dari rekam medis dan hasil Auditory Brainstem Response (ABR) antara Januari hingga Desember 2018 di Rumah Sakit Umum Dr. Hasan Sadikin, Bandung. Hasil: Didapatkan 60 pasien SRK, 53 pasien (88%) mengalami gangguan pendengaran. Gangguan pendengaran sensorineural (GPSN) sangat berat terdapat pada 27 pasien (45%), GPSN berat pada 18 pasien (30%), 3 di antaranya adalah GPSN unilateral. GPSN unilateral sedang pada 3 pasien (5%), GPSN ringan pada 5 pasien (8%) terdiri dari 2 gangguan pendengaran unilateral dan 3 GPSN bilateral. Pendengaran normal pada 7 pasien (12%). Kesimpulan: Delapan puluh delapan persen pasien SRK mengalami gangguan pendengaran, 75% dengan GPSN bilateral. Tindak lanjut dan penatalaksanaan untuk pasien ini memerlukan pendekatan multidisiplin: spesialis THT, spesialis anak, spesialis mata, spesialis kedokteran fisik dan rehabilitasi, serta dukungan orang tua.
Hubungan Derajat Kolesteatoma dengan Keberhasilan Mastoidektomi Radikal pada Otitis Media Supuratif Kronis dengan Kolesteatoma Edi Handoko; Dyah Indrasworo; Akhmad Harun Nursalim
Oto Rhino Laryngologica Indonesiana Vol. 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i20.302

Abstract

Latar belakang: Mastoidektomi radikal merupakan salah satu terapi pembedahan pada OMSK dengan kolesteatoma. Kolesteatom dapat diklasifikasikan melalui sistem TMC (tympanum-mastoid-complication). Telinga yang kering merupakan indikator keberhasilan operasi. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara derajat kolesteatoma pada penderita OMSK dengan kolesteatoma dengan keberhasilan operasi. Metode: Penelitian ini menggunakan desain analitik deskriptif dengan melibatkan 14 penderita OMSK dengan kolesteatoma yang menjalani mastoidektomi radikal di RSUD. Dr Saiful Anwar Malang periode 1 Januari 2017-31 Desember 2018. Derajat kolesteatoma dinilai dari pemeriksaan otoskopi dan atau mikroskop, pemeriksaan foto Schuller, dan temuan operasi. Keberhasilan operasi dilihat dari telinga kering saat evaluasi 2 bulan paska operasi. Analisa statistik  yang digunakan adalah uji Kolmogorov Smirnov dan Mann Whitney. Hasil: Evaluasi hasil mastoidektomi radikal antara derajat kolesteatoma 3 dan 4 memiliki perbandingan frekuensi yang sama dengan p = 1,00 (> 0,05).  Hasil operasi telinga kering adalah 85,6% dan basah 14,4%. Kesimpulan: Tidak terdapat hubungan signifikan antara derajat kolesteatoma pada penderita OMSK dengan kolesteatoma dengan keberhasilan operasi mastoidektomi radikal. Perlu penelitian lebih lanjut dengan sampel yang lebih besar, jenis operasi yang beragam dan periode observasi yang lebih lama untuk mengetahui tingkat rekurensi kolesteatoma.
Hubungan asfiksia perinatal dengan gangguan fungsi sel rambut luar koklea Novi Primadewi; Dewi Pratiwi; Diah Hayustiningsih
Oto Rhino Laryngologica Indonesiana Vol. 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i20.305

Abstract

Latar belakang: Bayi baru lahir dengan asfiksia perinatal dapat mengalami gangguan fungsi sel rambut luar  pada kokleanya. Tujuan:  Mengetahui   hubungan   asfiksia  perinatal  dengan  gangguan   fungsi  sel rambut luar koklea. Metode: Penelitian analitik observasional dengan desain Case control yang dilakukan di bagian perinatologi RSUD Dr. Moewardi Surakarta, RSUD Karanganyar,          RSUD Wonogiri, dan RSUD Sukoharjo dengan waktu penelitian  pada bulan Oktober 2014 – Januari 2015. Sampel penelitian dipilih dengan cara non probability sampling yaitu dengan teknik consecutive sampling, sebanyak 50 orang yang terdiri dari 25 kelompok kasus dan 25 kelompok kontrol. Diagnosis adanya gangguan fungsi sel rambut luar koklea  ditegakkan dari hasil pemeriksaan fisik THT dan pemeriksaan Distortion Product Otoacoustic Emissions  (DPOAE). Asfiksia perinatal dapat dilihat dengan menggunakan  skor APGAR, sedangkan faktor risiko yang lain dapat dilihat dari  catatan  medis pasien. Analisis statistik menggunakan univariat, bivariat, dengan chi square dan multivariat dengan regresi logistik ganda model faktor risiko. Hasil: Dari 25 kelompok kasus dan 25 kelompok kontrol didapatkan hasil bahwa asfiksia perinatal merupakan faktor risiko yang berpengaruh terjadinya gangguan fungsi sel rambut luar koklea.  Bayi baru lahir yang mempunyai  gangguan fungsi sel rambut luar koklea  dengan  asfiksia perinatal mempunyai faktor risiko 29 kali lebih besar daripada bayi dengan bayi baru lahir tanpa gangguan fungsi sel rambut luar koklea, setelah mengontrol pengaruh dari faktor perancu hiperbilirubinemia dan berat  badan lahir rendah. Hasil tersebut didapatkan bermakana secara statitistik (OR=29,614; CI – 95 % = 5,454 - 160,792; p<0,001). Kesimpulan: Terdapat hubungan antara asfiksia perinatal dengan  gangguan fungsi sel rambut luar koklea. Background: Newborn  with  perinatal  asphyxiae can occur disturbance of  function outer hair cell in the cochlea. Objective: was to know the relationship between the degree of perinatal asphyxiae  with impaired  function  of  outer hair cell. Methods: The study was  an analytic observational study with case control design, that  took a place in perinatology department in Doctor Moewardi hospital Surakarta, General hospital  in  Karanganyar,  General hospital in Wonogiri, General hospital in Sukoharjo. The study started from October 2014 until January 2015. The sample study were selected with consecutive sampling method, with total sample of 50 newborns which consist of 25 case group and 25 control group. Impaired function of outer hair cell  has been diagnosed from ENT examination and  examined with Distortion Product Otoacoustic Emissions  (DPOAE). Perinatal asphyxiae were measured with APGAR score and the other risk factor were collected from the medical record of the patients. Data were analyzed with univariat, bivariat (chi square) and multivariat statistic with double logistic regression. Result: From 25 case group and 25 control group, were found that perinatal asphyxiae was the influence risk factor to the occurrence of impaired function of outer hair cell. Newborns have impaired function  of  outer hair cell with   perinatal asphyxiae will have the risk of twenty nine times higher than newborns without perinatal asphyxiae, after controlling of confounding factors low birth weight, and hyperbilirubinemiae. The results  was statistically significant. (OR = 29,614; CI – 95 % = 5,454 - 160,792; p < 0,001). Conclusion: There has corellated between perinatal asphyxiae and impaired function of outer hair cell.
Communication Ability and Related Factors in Children with Hearing Aids rico doloksaribu; Wijana -
Oto Rhino Laryngologica Indonesiana Vol. 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i2.307

Abstract

Background : Hearing function is very influential on the development of speech and language. Hearing disorders in children can lead to disrupt of communication skills. Hearing aids help provide the development of the ability to hear, talk, and communicate. Some factors such as age, duration of use of hearing aids, and parental activeness in encouraging children to communicate and perform auditory verbal therapy are known have an effect on communication skills.Aim : Knowing the capabilities and related factors of communication  after using of hearing aids in children.Method : Had been done cross sectional study design at the private hearing centre in Bandung in the period January - May 2018. Inclusion criteria for this research is children who use hearing aids which control in the period January-May 2018Result : From  60 subjects that fit with research criteria. There were 35 childrens (58,33%)  who use mix communication, there were 23 childrens (38,33%) in special school. There were 37 childrens (61,67%) who have communication duration more than 6 hours. There were 45 childrens (75%) had routine  frequency of therapy. There were 23 childrens (38,33%) who use AVT&Speech Therapy. A total of 66.67% of subjects had a low PEACH score (< 60), 16.67% had a moderate PEACH score (> 60 - ≤ 75), and 16.66% had a normal PEACH score (> 75). The PEACH score in this study shows an average value of 52.63% with 16.66% had a normal PEACH score (> 75)Conclusion : Caractheristic that have a significant relationship with normal peach score, communication method, educational method, communication duration, frequency of therapy, and type of therapy used (p <0.05 )
Analisis biaya implantasi koklea bilateral simultan dan sekuensial Ratna Dwi Restuti
Oto Rhino Laryngologica Indonesiana Vol. 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i20.313

Abstract

Latar belakang: Implantasi koklea merupakan tatalaksana pasien dengan ketulian sensorineural bilateral derajat berat atau sangat berat yang tidak terbantu dengan alat bantu dengar konvensional. Pemasangan implan dapat bersifat unilateral atau bilateral, baik secara simultan maupun sekuensial, dengan konsekuensi biaya yang berbeda. Di Indonesia pembiayaan implantasi koklea dapat dilakukan secara pribadi, atau jaminan kesehatan baik jaminan pemerintah (BPJS) maupun non pemerintah (swasta). Tujuan: Untuk mengetahui apakah biaya yang dibutuhkan untuk implantasi koklea simultan lebih efisien dibandingkan biaya implantasi secara sekuensial.Metode: Penelitian dilakukan secara retrospektif pada seluruh pasien yang dilakukan implantasi koklea dalam kurun waktu Januari 2015 hingga September 2019. Data rekam medis dan biaya perawatan dikumpulkan serta ditelaah dan dilakukan pengolahan data secara deskriptif dan analitik. Hasil: Pada penelitian ini didapatkan hasil bahwa pada operasi implantasi koklea secara simultan biayanya lebih efisien dibanding dengan operasi secara sekuensial. Sistem paket pasien BPJS tidak membedakan antara paket biaya pemasangan secara simultan maupun sekuensial. Kesimpulan: Berdasarkan perspektif biaya, pasien implantasi koklea secara simultan lebih efisien dibanding dengan pasien implantasi secara sekuensial.Kata kunci: ketulian sensorineural, implantasi koklea, bilateral simultan, bilateral sekuensial, biayaABSTRACT Background: Cochlear implantation is the management of patients with severe or profound bilateral sensorineural deafness whose hearing capacity does not improved by the assistance of conventional hearing aids. Implants can be unilateral or bilateral, either simultaneously or sequentially inserted with different cost consequences. In Indonesia cochlear implantation costs can be covered by private funding and health insurance, both government (BPJS) and non-government (private) insurance company. Purpose: To find out the more efficient cost between simultaneous and sequential cochlear implantation. Methods: The study was conducted retrospectively on all patients undergoing cochlear implantation in the period of January 2015 to September 2019. Medical record data and treatment costs were collected and reviewed, and data were processed descriptively and analytically. Result: This study revealed that simultaneous cochlear implantation surgery costs more efficient compared with sequential surgery, because the BPJS (government) patient package system does not differentiate between simultaneous and sequential package implantation costs. Conclusion: Based on financial perspective, the simultaneous cochlear implantation was more cost-effective than the sequential surgery.Keywords: sensorineural hearing loss, cochlear implantation, bilateral simultaneous, bilateral sequential, costs
Pengaruh mometasone furoate terhadap kadar Interleukin 6 serum padapenderita hipertrofi adenoid Rus Suheryanto; Surya Parlaungan Harahap; Iriana Maharani
Oto Rhino Laryngologica Indonesiana Vol. 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i20.314

Abstract

Latar belakang: Inflamasi adenoid ditandai dengan ditemukannya pembesaran ukuran adenoid atau hipertrofi adenoid. Telah banyak dilakukan penelitian yang mendukung IL-6 merupakan dasar patofisiologi terjadinya hipertrofi adenoid sehingga dibutuhkan terapi yang dapat mengurangi peran IL-6. Saat ini, kortikosteroid intranasal menjadi pilihan terapi pada hipertrofi adenoid karena memiliki efek anti inflamasi. Terdapat penelitian mengenai manfaat penggunaan kortikosteroid intranasal terhadap penderita hipertrofi adenoid, dimana terjadi penurunan kadar IL-6, tetapi pengaruhnya terhadap kadar IL-6 serum tidak diteliti. Tujuan: Mengetahui pengaruh pemberian mometasone furoate semprot hidung terhadap kadar IL-6 serum pada penderita hipertrofi adenoid. Metode: One group pre and post test design ini melibatkan 16 subjek. Dilakukan pemeriksaan foto polos skull lateral soft tissue dan pengambilan darah tepi untuk menghitung kadar IL-6 serum. Diberikan terapi mometasone furoatesemprot hidung selama 6 minggu. Setelah 2 minggu dan 6 minggu dilakukan pengambilan darah tepi untuk menghitung kadar IL-6 serum, serta evaluasi foto polos skull lateral soft tissue setelah 6 minggu. Hasil:Terdapat perbedaan bermakna antara kadar IL-6 serum sebelum dan sesudah perlakuan baik, pada minggu kedua maupun minggu keenam (p=0.00). Terdapat perbedaan bermakna antara nilai foto polos skull lateral soft tissue sebelum dan sesudah perlakuan (p=0.00). Berdasarkan uji Pearson, nilai kadar IL-6 serum darah berkorelasi secara signifikan yang bersifat negatif (p<0,05) dengan foto polos skull lateral sebelum dan sesudah perlakuan dengan hasil -0,819 dan -0,692. Kesimpulan: Mometasone furoatesemprot hidung dapat menurunkan kadar IL-6 serum pada penderita hipertrofi adenoid secara bermakna, disertai dengan mengecilnya ukuran adenoid, penurunan gejala dan keluhan penderita hipertrofi adenoid. Kata kunci: Hipertrofi adenoid, Interleukin 6, Mometasone FuroateABSTRACT Background:Adenoid inflammation is characterized by adenoid hypertrophy (AH). Numerous studies had stated that Interleukin 6 (IL-6) is the pathophysiological basis for the occurrence of AH, thus, a therapy is needed to reduce the role of IL-6. Intranasal corticosteroid (IC) is the drug-of-choice for AH for its anti-inflammatory nature. Previous research had shown a decrease in IL-6 levels in adenoid tissue after IC administration, but its effect on IL-6 serum level had not yet been studied. Purpose: To find out the effect of Mometasone Furoate (MF) on IL-6 serum level in AH patients. Methods: One group pre and post test design, involving 16 subjects, underwent a soft tissue skull lateral plain x-ray, also a peripheral blood examination for IL-6 serum level. Afterwards, subjects were treated with MF nasal spray for 6 weeks. The IL-6 serum level was evaluated after 2 and 6 weeks, and the soft tissue x- ray was assessed after 6 weeks. Results: There were significant differences between IL-6 serum levels before and after treatment both in the second and sixth week (p = 0.00). There were significant differences between the value of soft tissue skull lateral plain x-ray before and after treatment (p = 0.00). Based on the Pearson test, IL-6 serum levels correlated significantly negatively (p <0.05) with soft tissue skull lateral plain x-ray before and after treatment with results -0.819 and -0.692. Conclusion: MF nasal spray significantly reduce IL-6 serum levels in AH patients, reducing adenoid size and decreasing symptoms of AH patients.  

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