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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Caustic esophageal injury in clinical settings Zuleika, Puspa; Saleh, Irsan; Murti, Krisna; Liberty, Iche Andriyani
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i1.606

Abstract

Background: esophageal stricture is loss of esophageal lumen patency and may involve injuries after ingesting caustic substances. This systematic review aims to review clinical presentations, diagnostic modalities involved, treatments and outcomes, and complications of esophageal strictures following caustic injuries.Methods: this systematic review involves original researches conducted between 2002-2022 indexed in PubMed and EuropePMC searched using following MeSH terms: “((caustic injury) OR (caustic burn)) AND (ingestion) AND (inflammation)” following PRISMA algorithm. Biases were assessed using STROBE checklist and presented as narratives.Results: searches yielded 326 results with 16 studies included in this review. Majority of caustic ingestion and strictures involved pediatric population due to accidental ingestion. Alkali ingestion has more severe presentation. Radiological imaging, including CT and MRI, may help in determining damages involved. Degrees of damages are related with mortalities or morbidities, and dilatation may improve quality-of-life in some cases.Conclusion: pediatric patients are at risk for accidental ingestions and alkali ingestion creates more severe damage. Radiological imaging may assist in determining involvement of underlying tissues. 
Vitamin D levels in nasopharyngeal carcinoma of the Minangkabau ethnic group Rahman, Sukri; Ali, Hirowati; Indra, Beni
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i1.613

Abstract

Background: The etiology of nasopharyngeal carcinoma (NPC) is not yet known with certainty, but is suspected to be an interaction of multiple factors. Nasopharyngeal carcinoma is closely related to Epstein-Barr virus (EBV) infection which interacts with genetic susceptibility and environmental factors. Various studies have reported the relationship of vitamin D with the risk of various cancers, but very little research has a relationship with NPC. Objective: This study was conducted to analyze the association of vitamin D levels with nasopharyngeal carcinoma in the Minangkabau ethnic group. Methods: This study was a cross-sectional study comparing plasma levels of vitamin D (25(OH)D) in new patients with NPC of the Minangkabau ethnic who were treated at Dr. M. Djamil Padang with healthy control plasma. Result: This study found that the average vitamin D level in the NPC group was higher than the control group. Vitamin D levels in this study varied in both cases and controls. In the NPC group, vitamin D levels varied from 14.64 to 75.56 ng/ml. Most of the NPC group had normal vitamin D levels (69.6%), and in controls, vitamin D levels also varied from 6.06 to 73. .96 ng/ml, and most of them were also with normal levels (52.2%). There was no statistically significant difference between cases and controls (p>0.05). Conclusion: This study found no association between the level of vitamin D and the incidence of nasopharyngeal carcinoma in the Minangkabau ethnic group.
Korelasi ekspresi LMP-1 dengan ekspresi E-chaderin dan MMP-9 pada mekanisme metastasis penderita KNF WHO tipe 3 Adrian Benediktus; Soehartono Soehartono; Hendradi Surjotomo
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.263

Abstract

Latar belakang: Karsinoma nasofaring (KNF) adalah karsinoma sel skuamosa yang berasal dari epitel nasofaring. Salah satu etiologi KNF adalah infeksi Epstein-Barr virus (EBV). Pada biopsi jaringan KNF sering ditemukan genom EBV. Latent membran protein-1 (LMP-1) merupakan antigen dari EBV diekspresikan pada 65% KNF. Efek LMP-1 pada signaling salah satunya adalah memodulasi E-cadherin dan matrix metalloproteinase 9 (MMP-9) yang berperan pada proses metastasis. Metastasis adalah suatu proses yang kompleks dimana sel-sel kanker meninggalkan lokasi primer dan bermigrasi ke jaringan lain dalam tubuh. E-cadherin berfungsi sebagai mediator utama yang berperan terhadap adhesi sel-sel pada jaringan epitel, sedangkan MMP-9 menyebabkan rusaknya integritas dari matriks ekstraseluler yang merupakan barrier, sehingga memungkinkan sel tumor menginvasi jaringan sekitarnya. Tujuan: Untuk mengetahui korelasi ekspresi LMP-1 dengan ekspresi E-cadherin dan MMP-9 pada penderita KNF WHO tipe 3. Metode: Penelitian observasional analitik dengan desain potong lintang yang melibatkan 11 penderita KNF WHO tipe 3. Pemeriksaan ekspresi LMP-1, MMP-9, dan E-cadherin menggunakan metode pewarnaan imunohistokimia, dan hasilnya dihitung dengan menggunakan software ImmunoRatio. Hasil: Analisis statistik ekspresi LMP-1 dan E-cadherin menunjukkan korelasi negatif yang signifikan (p=0,000) dengan koefisien korelasi r= -0,940 (terdapat korelasi yang sangat kuat). Analisis korelasi ekspresi LMP-1 dan MMP-9 menunjukkan korelasi positif yang signifikan (p=0,000) dengan koefisien korelasi r=0,881 (terdapat korelasi yang sangat kuat). Kesimpulan: Semakin tinggi ekspresi LMP-1, maka ekspresi E-cadherin pada jaringan nasofaring penderita KNF WHO tipe 3 semakin menurun. Semakin tinggi ekspresi LMP-1 maka ekspresi MMP-9 pada jaringan nasofaring penderita KNF WHO tipe 3 semakin meningkat. Background: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from nasopharynx epithel cells. Epstein-Barr virus (EBV) is one of the risk factor of NPC. EBV can often be found in NPC tissue biopsy. Latent membran protein 1 (LMP-1) is an antigen from EBV which is expressed in 65% of NPC. The effect of LMP-1 includes modifying E-cadherin and matrix metalloproteinase 9 (MMP-9) which important in metastasis. Metastasis is a complex series of steps in which cancer cells leave the original tumor site and migrate to other tissues. E-cadherin is a main mediator in adhesion between cells. Decreased of E-cadherin makes tumor cells tend to migrate to other tissues of the body. MMP-9 involved in degradation of collagen IV in basement membranes and extracellular matrix facilitating invasion, metastasis, growth, and angiogenesis. Purpose: To determine the correlation between LMP-1 with E-cadherin and MMP-9 in WHO type 3 nasopharygeal carcinoma. Method: Observational analytic study with cross sectional design involving 11 NPC patients. The expression of LMP-1, E-cadherin, and MMP-9 using immunohistochemistry staining, and the results were calculated with ImmunoRatio software. Result: Statistical analysis showed significant negative correlation between LMP-1 dan E-cadherin (p=0.000) with r= -0.940 (very strong correlation). Statistical analysis showed significant positive correlation between LMP-1 dan MMP-9 (p=0.000) with r= 0.881 (very strong correlation). Conclusion: There was a significant negative correlation between LMP-1 dan E-cadherin in tissue from type 3 NPC patient. There was a significant positive correlation between LMP-1 dan MMP- 9 in tissue from type 3 NPC patient.
Surgical management of preauricular based on plastic-reconstructive algorithm Dini Widiarni Widodo; Hemastia Manuhara Harba'i
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.271

Abstract

Background: Preauricular fistula is a congenital malformation of the six auditory hillocks during the development of auricle, when an imperfect fusion of the first arch tuberculum to other tuberculums occurred and generated a tract. It is characterized by a nodule or a dent located adjacent to the external ear. An infection will create a swollen area in front of ear auricles with pain and suppuration. Fistula extirpation should be carried out after the acute infection subsides. Purpose: To evaluate surgery techniques with the lowest complication and recurrence rate. Case report: Reporting 4 surgical cases of prearicular fistula treated by Plastic-Reconstructive ENT Head and Neck surgery, among 26 cases of preauricular fistula diagnosed between 2015 to 2017 in Cipto Mangunkusumo General Hospital. Methods: Searching literature through Pubmed, Wiley, Proquest and Google Schoolar with keywords of “Preauricular fistula AND surgical treatment”. Further selection through clinical questions. Results: One journal presented a systematic review on the surgical outcome of preauricular sinus excision techniques. Reporting 4 cases treated by plastic-reconstructive surgery based on the systematic review above mentioned. Conclusion: The supra auricular approach could be recommended as a good technique for preauricular fistula, in particular for the infected and/or the recurrent cases. Latar belakang: Fistel preaurikula adalah suatu kelainan malformasi kongenital, dimana tuberkulum arkus brakialis pertama tidak menyatu dengan tuberkulum lainnya, sehingga terbentuk sebuah traktus (saluran). Fistel preaurikula ditandai oleh adanya nodul atau cekungan yang tampak di dekat telinga luar. Bila terjadi infeksi biasanya menyebabkan daerah di depan daun telinga bengkak dan nyeri, serta bernanah. Ekstirpasi fistel sebaiknya dilakukan setelah infeksi akut mereda. Tujuan: Mengevaluasi teknik bedah dengan tingkat komplikasi dan kekambuhan terendah. Laporan kasus: Dilaporkan 4 kasus fistel preaurikula yang ditatalaksana oleh bedah THT-KL plastik-rekonstruksi, dari sejumlah 26 kasus yang datang berobat di RSUPN Cipto Mangunkusumo, antara Januari 2015 dan April 2017. Metode: Penelitian literatur melalui Pubmed, Wiley, Proquest, dan Google Schoolar dengan kata kunci “Preauricular fistula AND surgery treatment”. Seleksi literatur lebih lanjut melalui pertanyaan klinis. Hasil: Didapati 1 jurnal yang menyajikan hasil operasi dari teknik bedah eksisi sinus preaurikular secara systematic review. Dilaporkan 4 kasus yang ditatalaksana dengan bedah plastik-rekonstruksi berdasarkan systematic review tersebut di atas. Kesimpulan: Pendekatan supra aurikula dapat direkomendasikan sebagai teknik bedah yang baik untuk penatalaksanaan fistel preaurikular, khususnya yang terinfeksi dan/atau berulang.
Anthropometric study of nasal index of Bali Aga population Agus Rudi Asthuta; I Putu Yupindra Pradiptha
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.273

Abstract

Background: Anthropometry is the measurement of human and more inclined to focus on the dimensions of the human body. Nasal indexes can be used to help determine personal identity, especially race, ethnic and gender differences. Purpose: The general objective of this study was to find out the results of nasal index anthropometric studies on Bali Aga populations in Tenganan. Methods: In this study, 20 samples (4 male and 16 female) within age group of 17-30 years old of Bali Aga population in Tenganan Village were measured strictly on Frankfort’s plane with the help of a sliding caliper. Results: The results of nasal anthropometry measurements obtained an average width of the nose of 38.790 mm, the average nose length of 45.490 mm and nasal index measurements obtained an average of 85.6416. Conclusion: Nasal index can be used to help determine personal identity, especially race, ethnic and gender differences. The result of nasal index in Bali Aga population in Tenganan Village is the Platyrrhine nose (wide nose). Latar belakang: Antropometri adalah pengukuran manusia dan lebih cenderung terfokus pada dimensi tubuh manusia. Nasal indeks dapat digunakan untuk membantu menentukan identitas personal, terutama perbedaan ras, etnis, dan jenis kelamin. Tujuan: Tujuan umum penelitian ini adalah untuk mengetahui hasil studi antropometri nasal index pada populasi Bali Aga di Tenganan. Metode: Studi ini melibatkan, 20 sampel (4 laki-laki dan 16 perempuan) dari penduduk Bali Aga Desa Tenganan yang diukur pada Frankfort’s plane dengan bantuan jangka sorong. Hasil: Pada hasil pengukuran antropometri hidung didapatkan rata-rata lebar hidung sebesar 38.790, rata-rata panjang hidung sebesar 45.490 serta pengukuran nasal index didapatkan rata-rata 85.6416. Kesimpulan: Nasal indeks dapat digunakan untuk membantu menentukan identitas personal, terutama perbedaan ras, etnis, dan jenis kelamin. Hasil nasal index pada populasi bali aga di Desa Tenganan adalah jenis hidung Platyrrhine (hidung lebar).
Prevalensi biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis Ade Asyari; Aci Mayang Sari; Embun Dini; Novialdi Novialdi; Fachzi Fitri; Erly Indrama; Hafni Bachtiar
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.274

Abstract

Latar belakang: Tonsilitis kronis merupakan salah satu bentuk infeksi yang paling banyak terdapat pada anak-anak maupun dewasa. Kegagalan terapi antibiotika dalam mengeradikasi bakteri penyebab tonsilitis kronis ini masih menjadi perdebatan dan dihubungkan dengan keberadaan biofilm pada tonsil. Biofilm memiliki peran dalam infeksi kronis dan rekurensi dari tonsilitis kronis. Tujuan: Mengetahui gambaran biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis. Metode: Penelitian ini merupakan penelitian deskriptif yang dilakukan terhadap 96 responden. Setiap sampel dilakukan pemeriksaan swab tonsil dan kultur bakteri aerob kemudian dilanjutkan pemeriksaan biofilm dengan metode tube menggunakan crystal violet (0,1%) dan dibandingkan dengan kontrol. Data dianalisis secara statistik menggunakan komputer serta disajikan dalam bentuk tabel. Hasil: Terdapat 64,7% dari total bakteri pada usapan tonsil mengandung biofilm. Kesimpulan: Lebih dari separuh sampel terdapat biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis. Background: Chronic tonsillitis is one of the most common infections in children and adults. Failure of antibiotic therapy in eradicating the bacteria that cause chronic tonsillitis is still being debated and is associated with the presence of biofilm on the tonsils. Biofilms play a role in chronic infections and recurrence of chronic tonsillitis. Purpose: To determine aerobic bacterial biofilm on tonsil swabs with tube method in patients with chronic tonsillitis. Methods: This was a descriptive study conducted on 96 respondents. Each sample underwent tonsillar swab and aerobic bacterial culture, followed by examination of the biofilm with tube method using crystal violet (0.1%) and compared with controls. Data were analyzed statistically using computer program, and presented in a tabular form. Results: There were 64.7% of total bacteria in tonsil swabs containing biofilm. Conclusion: More than half of the whole samples contained aerobic bacterial biofilms on tonsil swabs with tube method in patients with chronic tonsillitis.
Hasil BERA & TEOAE dengan kadar HbA1c pada pasien Diabetes Melitus tipe-2 Novi Primadewi; Hadi Sudrajad; Eka Prasetya
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.279

Abstract

Latar belakang: Neuropati adalah salah satu komplikasi yang paling sering dari Diabetes Melitus(DM) tipe 2. Disamping neuropati perifer dan otonom, pasien dengan DM tipe 2 juga dapat menderitagangguan pendengaran tipe sensorineural hearing loss (SNHL) pada frekuensi tinggi. Pada studi inihubungan HbA1c dengan hasil pemeriksaan brainstem evoked response audiometry (BERA) dan transient evoked otoacoustic emissions (TEOAE) digunakan untuk mendeteksi neuropati akustik dan sentral pada pasien DM tipe 2. Tujuan: Untuk mengetahui hubungan kadar HbA1c pada DM tipe 2 dengan masa laten gelombang BERA dan respon TEOAE. Metode: Desain penelitian cross sectional study, dilakukan dari Maret 2018 hingga jumlah sample terpenuhi. Penelitian dimulai dengan mengidentifikasi pasien DM tipe 2 dengan profil kadar HbA1c, kemudian dilanjutkan dengan pemeriksaan TEOAE dan BERA. Hasil: Dari hasil pemeriksaan BERA terdapat hubungan signifikan antara HbA1c dengan masa laten gelombang BERA di intensitas 70 dB dan 80 dB kecuali latensi antar-puncak I-V, tetapi tidak berhubungan signifikan pada intensitas 90 dB. Didapatkan pada pemeriksaan TEOAE di telinga kanan kadar HbA1c berhubungan dengan hasil pemeriksaan TEOAE kategori refer rata-rata 8,67+1,14%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,73+0,95%. Hasil uji t test didapatkan nilai p=0,021 (p<0,05). TEOAE di telinga kiri kategori refer rata-rata 8,82+1,09%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,66+0,88%. Hasil uji t test didapatkan nilai p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan secara statistik antara kadar HbA1c dengan hasil pemeriksaan gelombang BERA dan TEOAE. Background: Neuropathy is complication of type 2 diabetes mellitus (DM). Besides peripheraland autonomic neuropathy, patients with type 2 DM may also have sensorineural hearing loss at highfrequency. In this study the association of HbA1c level with the results of BERA and TEOAE tests was used to detect acoustic and central neuropathy in type 2 DM patients. Objective: To find out the relationship of HbA1c level in type 2 DM with BERA and TEOAE. Method: Research design cross sectional study, conducted from March 2018 until the number of samples fulfilled. The study began by identifying patients with type 2 DM with the HbA1c profile, followed by TEOAE and BERA examinations. Result: There was a significant relationship between HbA1c and the latent period of waves at the intensity of 70 dB and 80 dB except on the interpeak I-V latency, but not significantly related to the 90 dB intensity. Results of TEOAE test in the right ear: the average levels of HbA1c with refer category results on TEOAE test was 8.67+1.14 %, whereas patients with pass category results on TEOAE was 7.73+0.95 %. The result of t test value was p=0.021 (p<0.05). TEOAE on the left ear: average refer category 8.82+1.09%, whereas patients with TEOAE examination results in the mean pass category 7.66+0.88%. The result of t test value was p=0.003 (p<0.05). Conclusion: There was a statistical significant relationship between HbA1clevel and BERA and TEOAE.
Prosedur penatalaksanaan celah bibir inkomplit bilateral dan rinoplasti primer dengan modifikasi mulliken Al Hafiz; Debby Apri Grecwin
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.280

Abstract

Latar belakang: Celah bibir dengan atau tanpa celah lelangit merupakan abnormalitas perkembangan kraniofasial yang paling sering terjadi. Kelainan ini bisa unilateral atau bilateral, dan mungkin disertai dengan anomali kongenital lain. Celah bibir bilateral berpotensi mengubah struktur dan bentuk wajah serta menyebabkan gangguan dalam perkembangan makan, bicara, gigi geligi, dan kosmetik. Celah bibir selalu disertai dengan deformitas hidung, termasuk pada kasus celah bibir inkomplit. Mulliken adalah pionir yang melakukan perbaikan celah bibir bilateral dan rinoplasti primer dalam satu tahap operasi. Tujuan: Mengetahui keberhasilan operasi celah bibir inkomplit bilateral dan rinoplasti primer dengan teknik modifikasi Mulliken. Laporan kasus: Dilaporkan satu kasus celah bibir inkomplit bilateral pada anak laki-laki usia 7 bulan yang ditatalaksana dengan teknik modifikasi Mulliken. Metode: Telaah literatur berbasis bukti mengenai perbaikan celah bibir inkomplit bilateral dan rinoplasti primer dengan teknik modifikasi Mulliken melalui database Cochrane library, Pubmed Medline, dan hand searching. Hasil: Pertumbuhan nasal tip projection, nasal width, columellar length, upper lip height, cutaneous lip height, dan vermilion-mucosal height mendekati nilai normal. Kesimpulan: Prosedur celah bibir inkomplit bilateral disertai rinoplasti primer dengan teknik modifikasi Mulliken memberikan hasil yang baik. Introduction: Cleft lip with or without cleft palate is the most common disorder of craniofacial development. This disorder could be occurred unilaterally or bilaterally, and sometimes were also accompanied by other type of congenital disorders. Bilateral cleft lip potentially could change the face structure and shape, causing interference in eating, speech, dental development, and aesthetics. Cleft lip always occurred with nasal deformity, even in incomplete cleft lip. Mulliken is a pioneer in performing a repair in bilateral cleft lip and primary rhinoplasty altogether at the same time. Purpose: To find out the result of surgery procedure in bilateral incomplete cleft lip and primary rhinoplasty using Mulliken modification technique. Case report: A bilateral incomplete cleft lip case in a 7 months old boy and managed by Mulliken modification technique. Method: Evidence based literature study of bilateral incomplete cleft lip and primary rhinoplasty with Mulliken modification technique through Cochrane library, Pubmed Medline, and hand searching. Result: The growth of nasal tip projection, nasal width, collumellar length, upper lip height, cutaneus lip height, and vermilion mucous height were close to normal size. Conclusion: Procedure of bilateral incomplete cleft lip and primary rhinoplasty repair using Mulliken modification technique delivered a good outcome.
Correlation of malondialdehyde and hearing threshold level at frequency 4000 Hz post gunshot exposure Nyilo Purnami; Fauzi Helmi; Sri Herawati
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.283

Abstract

Background: The incidence of acoustic trauma after gunshot exposure in students of the SekolahPolisi Negara (SPN) is quite high. Malondialdehyde (MDA) is a compound that can portray oxidativestress due to free radicals. The correlation between the levels of MDA and the hearing threshold frequencypost gunshot exposure could be used as the base for administering antioxidants to prevent acoustictrauma. Objective: To find out the correlation between the levels of MDA and the hearing thresholdfrequency post gunshot exposure, in East Java SPN students. Method: An observational analytic studywith a retrospective cross sectional approach using secondary data of medical records of the East JavaSPN students batch 2017/2018. The samples were selected by simple random sampling. Result: Out of50 students, the mean of age was 19.62 years. All samples were male with mean 559.17 and standarddeviation (SD) 959.86. The calculation of the 4000 Hz frequency threshold value obtained an averagevalue of 31.52 and SD of 13.4. Hearing loss complaint was found in 1 student (2%). No complaints oftinnitus and vertigo were found. Statistical tests with Pearson correlation between serum MDA levels and4000 Hz frequency threshold values showed a correlation coefficient (r) of 0.74 and p = 0.00 (p<0.05).Conclusion: There was a significant correlation between MDA levels and the hearing threshold at 4000Hz frequency after gunshot exposure in East Java SPN students.Keywords: acoustic trauma, malondialdehyde, hearing threshold level at frequency 4000 HzABSTRAKLatar belakang: Insiden trauma akustik pasca pajanan letusan senjata api pada siswa Sekolah PolisiNegara (SPN) cukup tinggi. Malondialdehid (MDA) merupakan senyawa yang dapat menggambarkanstres oksidatif akibat radikal bebas. Adanya hubungan antara kadar MDA dengan nilai ambang dengarfrekuensi 4000 Hertz (Hz) dapat menjadi dasar pemberian antioksidan untuk pencegahan traumaakustik. Tujuan: Membuktikan hubungan antara kadar MDA dengan nilai ambang dengar frekuensi4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Metode: Penelitian ini adalahobservasional analitik dengan pendekatan retrospektif cross sectional menggunakan data sekunderberupa rekam medik siswa SPN Jawa Timur angkatan 2017/2018. Sampel dipilih secara simple random sampling. Hasil: Dari 50 siswa, usia rerata adalah 19,62 tahun. Seluruh sampel penelitian adalah laki-laki, rerata=559,17 dan standar deviasi (SD)=959,86. Penghitungan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil nilai rerata=31,52 dan SD=13,4 Keluhan penurunan pendengaran hanya dijumpai pada 1 siswa (2%). Uji statistik dengan korelasi Pearson antara kadar MDA dalam serum dengan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil koefisien korelasi (r) sebesar 0,74 dan p = 0,00 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur.Kata kunci: trauma akustik, malondialdehid, nilai ambang dengar frekuensi 4000 Hz
Pemeriksaan Otoacoustic Emission (OAE) untuk menilai keberhasilan terapi metilprednisolon Brastho Bramantyo; Jenny Bashiruddin; Widayat Alviandi; Risdawati Risdawati
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.285

Abstract

Latar belakang: Penatalaksanaan tuli mendadak menggunakan steroid sebagai terapi utama merupakan hasil konsensus terapi tuli mendadak tahun 2010 di Madrid-Spanyol dan Cochrane systematic review tahun 2009, yang saat ini diterapkan di Divisi Neurotologi Departemen Telinga Hidung Tenggorok-Kepala Leher Rumah Sakit Cipto Mangunkusumo. Evaluasi hasil pengobatan dilakukan dengan pemeriksaan audiometri dan Distortion Product Otoacoustic Emission (DPOAE). Pasien yang mengalami kesembuhan akan memperlihatkan peningkatan ambang dengar dan nilai Signal to Noise Ratio (SNR) emisi otoakustik. Tujuan: Mengevaluasi hasil terapi metilprednisolon dosis terbaru pada tuli mendadak dengan pemeriksaan DPOAE dan audiometri nada murni. Metode: Penelitian ini menggunakan desain pre dan post eksperimental. Diberikan terapi metilprednisolon 1 mg/kgBB dengan tapering off 20 mg setiap 5 hari. Dilakukan pemeriksaan DPOAE dan audiometri sebelum dan setelah terapi. Hasil: Total sampel yang diolah adalah 22 subjek. Penelitian ini mendapatkan perubahan yang bermakna nilai audiometri nada murni sebelum dan sesudah terapi pada semua frekuensi. Nilai SNR pada OAE sebelum dan setelah terapi rata-rata mengalami perubahan nilai pass, dengan perubahan nilai SNR pass terbanyak adalah pada frekuensi 8000 Hz (6 subjek). Tingkat perubahan ambang dengar sesudah terapi yang mengalami perbaikan paling banyak pada frekuensi 2000 Hz, 3000 Hz, 6000 Hz dengan masing-masing 16 subjek. Perbaikan emisi terjadi lebih awal dibandingkan perbaikan ambang dengar. Kesimpulan: Pada penelitian ini terdapat perubahan bermakna nilai audiometri, dan nilai DPOAE. Didapatkan hubungan bermakna perubahan SNR pada OAE dengan tingkat perubahan ambang dengar frekuensi 8000 Hz dan 10.000 Hz, setelah pengobatan metilprednisolon sesuai protokol penelitian ini. Background: Methylprednisolone as a drug of choice in sudden deafness was consented in Madrid, Spain 2010 and in Cochrane systematic review in 2009, and already applied in Neurotology Division, ENT Department Cipto Mangunkusumo Hospital. Sudden deafness treatment evaluation conducted by audiometry and Distortion Product Otoacoustic Emission (DPOAE) examinations. Hearing recovery could be assessed from the improvement of hearing threshold and Signal to Noise Ratio (SNR) of otoacoustic emission (OAE). Objective: To evaluate the current dose of methylprednisolone therapy for sudden deafness, by DPOAE and pure tone audiometry. Methods: This was a pre-post experimental study using methylprednisolone 1 mg/kg body weight tapered off 20 mg in every 5 days. DPOAE and audiometry examination were conducted pre and post therapy. Result: Total sample were 22 subjects. Significant improvement was seen in overall frequencies of audiometry examination. Pass result in SNR of OAE showed remarkable improvement in 8000 Hz (6 subjects). The level of pure tone threshold mainly increased in frequencies of 2000 Hz, 3000 Hz, and 6000 Hz, each 16 subjects. Improvement of the emision level occurred earlier than the hearing threshold. Conclusion: This study revealed significant improvement of audiometry threshold and OAE level. Significant correlation was found between SNR of OAE improvement with increased pure tone level in 8000 Hz and 10.000 Hz after methylprednisolone therapy according to the protocol of this study.

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