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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Characteristics of non-Hodgkin lymphoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Fadhlia Fadhlia; Benny Kurnia; Lily Setiani; Yerni Karnita; Juniar Juniar; Iip Berliananda
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.352

Abstract

Background: Non-Hodgkin’s lymphoma (NHL) is a primary malignancy in the lymphatic system and extranodal lymphoid tissue originating from B lymphocyte cells, T lymphocytes or natural killer (NK) cells. The incidence of NHL continues to increase with various characteristics. Objective: To find out the characteristics of NHL sufferers undergoing treatment in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin Regional General Hospital (RSUDZA), Banda Aceh from January 2015 to December 2018. Method: This was an observational descriptive study conducted at Banda Aceh RSUDZA using retrospective secondary data collection from medical records that met the inclusion criteria, in total sampling method. Result: Found 32 research subjects, dominantly male (20), the highest age range was 56-65 years (10). The main complaints were neck lumps (10) and oropharynx lumps (11). The most common NHL was from B lymphocyte cells (6). The chemotherapy regimens used are cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The most frequent side effects are anemia, hypoalbuminemia, and leukopenia. Conclusion: The results showed that NHL was most common in men with an increased incidence in the fifth decade. Neck lumps are the most common complaint. The chemotherapy regimen used is CHOP and R-CHOP.Keywords : Non-Hodgkin’s Lymphoma, chemotherapy ABSTRAK Latar belakang: Limfoma Non-Hodgkin (LNH) adalah keganasan primer pada sistem limfatik dan jaringan limfoid ekstranodal yang berasal dari sel limfosit B, limfosit T atau sel natural killer (NK). Kejadian LNH terus meningkat dengan berbagai karakteristik. Tujuan: Melihat karakteristik penderita LNH yang menjalani pengobatan di Departemen THT-KL RSUD dr. Zainoel Abidin (RSUDZA), Banda Aceh pada periode Januari 2015 sampai Desember 2018. Metode: Penelitian deskriptif observasional dengan pengambilan data sekunder secara retrospektif dari rekam medis yang memenuhi kriteria inklusi, dengan metode total sampling. Hasil: Didapatkan total subjek penelitian 32 orang, dominan pada lakilaki (20), rentang usia tertinggi antara 56-65 tahun (10). Keluhan utama terbanyak adalah benjolan di leher (10) dan benjolan orofaring (11). LNH yang berasal dari sel limfosit B paling banyak dijumpai (6). Regimen kemoterapi yang digunakan adalah cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) dan rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Efek samping paling sering adalah anemia, hipoalbuminemia dan leukopenia. Kesimpulan: Hasil penelitian menunjukkan LNH paling sering pada laki-laki dengan angka kejadian meningkat pada dekade kelima. Keluhan yang paling sering adalah benjolan di leher. Regimen kemoterapi yang digunakan adalah CHOP dan R-CHOP.
The correlation between IL-10 expression and histopathological type in nasopharynx carcinoma patients Hamita Hamita; Muhtarum Yusuf; Manshur Shidiq Wiyadi
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.353

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a malignancy originated from nasopharyngeal epithelial cells. NPC therapy response could be predicted from histopathological type, but some patients with the same histopathological type, showed a different therapy response. Interleukin (IL)-10 expression is expected to be able to predict a better response of therapy in NPC patients. Purpose: To find out the correlation between IL-10 expression and histopathological type in NPC patients. Method: An analytic observational study with cross sectional approach towards 33 samples taken from the Oncology Polyclinic of Outpatient Unit of Otorhinolaryngology Head and Neck Surgery Department, Dr. Soetomo General Hospital. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The IL-10 expression was studied with immunohistochemistry using rabbit polyclonal antibody Anti IL-10. Assessment of the staining used Allred scale. The Fisher exact test was utilized to determine the correlation of IL-10 expression and histopathological type of NPC, with p value = 0.05. Result: The result of IL-10 expression in NPC patients with histopathological WHO type I NPC obtained 1 sample (8.3%) with strong positive expression and 2 samples (9.5%) with weak positive expression. In patients with histopathological WHO type II NPC obtained 2 samples (16.7%) with strong positive expression and 12 samples (57.1%) with weak positive expression. In patients with histopathological WHO type III NPC obtained 9 samples (75%) with strong expression and 7 samples (33.3%) with weak positive expression. Conclusion: There was moderate positive correlation between IL-10 expression and histopathological type in NPC patients.Keywords: nasopharyngeal carcinoma, IL-10 expression, histopathological type ABSTRAK Latar belakang: Karsinoma nasofaring (KNF) adalah suatu keganasan yang berasal dari epitel nasofaring. Respon terapi KNF selama ini dapat dinilai berdasarkan tipe histopatologi, namun pada kenyataannya penderita KNF dengan tipe histopatologi sama dapat menunjukkan respon terapi berbeda. Pemeriksaan ekspresi interleukin (IL)-10 diharapkan dapat memberikan prediksi lebih baik mengenai respon terapi pada penderita KNF. Tujuan: Mengetahui hubungan antara ekspresi IL-10 dengan tipe histopatologi pada penderita KNF. Metode: Penelitian observasional analitik dengan pendekatan cross sectional pada 33 sampel yang diperoleh dari Poliklinik Onkologi Unit Rawat Jalan, Departemen THTBedah Kepala Leher, RSUD Dr Soetomo. Ekspresi IL-10 diperiksa dari blok parafin dengan teknik pemulasan imunohistokimia menggunakan rabbit polyclonal antibody Anti IL-10. Ekspresi IL-10 dinilai dengan menggunakan skala Allred. Uji Fisher exact digunakan untuk menentukan korelasi antara ekspresi IL-10 dan tipe histopatologi KNF, dengan p = 0,05. Hasil: Ekspresi IL-10 pada KNF WHO tipe I didapatkan ekspresi positif kuat 1 penderita (8,3%) dan ekspresi positif lemah 2 penderita (9,5%). Hasil ekspresi IL-10 pada KNF WHO tipe II didapatkan ekspresi positif kuat 2 penderita (16,7%) dan ekspresi positif lemah 12 penderita (57,1%). Hasil ekspresi IL-10 pada KNF WHO tipe III 9 penderita (75%) dengan ekspresi positif kuat dan 7 penderita (33,3%) dengan ekspresi positif lemah. Kesimpulan: Didapatkan korelasi positif sedang antara ekspresi IL-10 dan tipe histopatologi pada penderita KNF
Management of Presbyphonia Fauziah Fardizza; Mirta Hediyati Reksodiputro
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.354

Abstract

Background: The proportion of individuals over 65 years of age in developed countries is increasing rapidly, due in large part to current and projected increases in life expectancy.Within the aging population, the incidence of vocal disorders is estimated to be between 12%-35%. Literature Review: Presbyphonia, or age-related dysphonia, is a diagnosis of exclusion. Patients’ other comorbidities must be evaluated completely. The complexity of presbyphonia involves the changes in the diverse tissues of the true vocal folds, musculature, and cartilage. Patients would get benefit from treatment of voice therapy or surgical laryngeal augmentation procedures. Purpose: The aim of this literature review is to describe presbyphonia and several kinds of its management. The primary treatment goal is to enhance glottal closure either by voice therapy or surgical interventions (phonosurgery) such as injection augmentation (IA) and bilateral thyroplasty surgery (BTS). Holistic physical evaluation had to be done to reach complete medical therapy. Conclusion: The best therapy for presbyphonia are voice therapy, or surgery followed by voice therapy and voice hygiene.Keywords: vocal disorder, presbyphonia, voice therapy, phonosurgery, management ABSTRAKLatar belakang: Prevalensi individu yang berusia diatas 65 tahun di negara maju semakin meningkat dengan cepat seiring dengan meningkatnya usia harapan hidup. Dalam populasi lanjut usia, angka kejadian gangguan fonasi diperkirakan antara 12%-35%. Tinjauan Pustaka: Presbifonia, atau disfonia terkait usia lanjut, membutuhkan evaluasi faktor komorbid secara lengkap. Kerumitan dari presbifonia adalah karena melibatkan perubahan jaringan, otot, dan tulang rawan di sekitar pita suara. Tatalaksana yang dilakukan adalah perawatan terapi suara dan prosedur bedah augmentasi pita suara. Tujuan: Untuk menggambarkan presbifonia serta berbagai jenis tatalaksananya. Keberhasilan utama penatalaksanaan presbifonia adalah meningkatnya penutupan glotis, baik dengan terapi suara atau intervensi bedah (phonosurgery) seperti injeksi augmentasi dan bedah tiroplasti bilateral. Dibutuhkan evaluasi fisik secara holistik untuk mencapai hasil terapi medis yang baik. Kesimpulan: Penatalaksanaan terbaik untuk presbifonia adalah terapi suara, atau pembedahan diikuti dengan terapi suara dan higiene suara. 
Comprehensive management of malignant otitis externa with tuberculosis and cranial nerve paresis in geriatrics Ratna Dwi Restuti
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.355

Abstract

Background: Malignant otitis externa is an inflammatory condition of the external ear which has the propensity to spread to the skull base. It can be a difficult entity to treat as clinical presentation varies and response to treatment differs between patients. Purpose: Evaluating the management of malignant otitis externa with complications in geriatric patients who had multiple comorbidities. Case: A 71 years old female with a diagnosis of left malignant otitis externa with complications of multiple cranial nerve palsies (N.VII, IX, X) and comorbidity in the form of diabetes mellitus and chronic kidney disease. The patient underwent subtotal temporal bone resection and petrosectomy. Clinical Question: “Could surgical management of malignant otitis externa with cranial nerve palsies complication in geriatric patients with multiple comorbidities achieve better result than conservative treatment?” Review Method: Literature search using keywords ’malignant otitis externa’ OR ’temporal bone osteomyelitis’ AND ’geriatric’ OR ’elderly’ AND ’multiple cranial nerve palsy’ AND ’diabetes mellitus’ AND ’tuberculosis’ AND ’surgery’ OR ’surgical’ was conducted through Cochrane, Pubmed, and Google Scholar. Result: The search obtained 11 articles published in the last 10 years. Selection based on inclusion and exclusion criteria, 2 studies were found relevant with the topic. Conclusion: Management of malignant otitis externa with complications in geriatric patients with multiple comorbidities requires a multidisciplinary approach to determine the need for surgery intervention.Keywords: malignant otitis externa, cranial nerve palsy, subtotal temporal bone resection, geriatric, diabetes mellitus ABSTRAK Latar belakang: Otitis eksterna maligna adalah suatu kondisi peradangan pada telinga luar yang memiliki kecenderungan untuk meluas hingga ke dasar tengkorak. Penyakit ini menjadi sulit ditangani karena manifestasi klinis yang bervariasi dan respons terhadap pengobatan yang berbeda antara pasien. Tujuan: Mengevaluasi tatalaksana otitis eksterna maligna dengan komplikasi pada pasien geriatri yang memiliki komorbiditas multipel. Kasus: Pasien perempuan 71 tahun dengan diagnosis otitis eksterna maligna telinga kiri dengan komplikasi paresis saraf kranial multipel (n.VII, IX, X) dan penyakit penyerta berupa diabetes melitus dan gagal ginjal kronik. Pasien menjalani operasi reseksi tulang temporal subtotal dan petrosektomi. Pertanyaan klinis: “Apakah tatalaksana pembedahan memberikan hasil yang lebih baik dibandingkan terapi konservatif pada pasien geriatri dengan otitis eksterna maligna disertai paresis saraf kranialis dengan komorbiditas multipel.” Telaah Literatur: Dilakukan menggunakan kata kunci ’malignant otitis externa’ ATAU ’temporal bone osteomyelitis’ DAN ’geriatric’ ATAU ’elderly’ DAN ’multiple cranial nerve palsy’ DAN ’diabetes melitus’ DAN ’tuberculosis’ DAN ’surgery’ ATAU ’surgical’ pada beberapa sumber data seperti Cochrane, Pubmed, dan Google Scholar. Hasil: Didapatkan 11 artikel publikasi 10 tahun terakhir. Berdasarkan kriteria inklusi dan eksklusi diperoleh 2 artikel yang relevan dengan topik. Kesimpulan: Tatalaksana otitis eksterna maligna dengan komplikasi pada pasien geriatri dengan komorbiditas multipel, membutuhkan pendekatan multidisiplin terutama untuk menentukan perlunya dilakukan tindakan pembedahan.
Interlay technique type 1 tympanoplasty, an alternative for closing large central tympanic membrane perforation Anton Budhi Darmawan
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.356

Abstract

Background: Type 1 tympanoplasty or myringoplasty is the most frequently performed procedure in the field of otology. Type 1 tympanoplasty is a surgical procedure to repair and only involves the restoration of the perforated tympanic membrane. There are three most accepted methods often used universally, namely underlay, overlay, and interlay. The interlay method is a relatively new method developed in 1992 for closing tympanic membrane perforation. This method has a high success rate of 96%. Objective: To report the success of type 1 tympanoplasty with an interlay method to close large central tympanic membrane perforations at Margono Soekarjo District Hospital. Case Report: Reporting 3 cases of chronic tubotympanic suppurative otitis media with large central tympanic membrane perforation which were repaired by type 1 tympanoplasty using interlay method. Clinical Question: Does interlay method type 1 tympanoplasty performed on large central tympanic membrane perforation provide better result compared with other methods of type 1 tympanoplasty? Review Method: Studying the evidence-based literatures on type 1 tympanoplasty interlay methods through Cochrane, Pubmed, and Google Scholar databases. Based on the inclusion and exclusion criteria, three journals were relevant with the reported cases. Result: All three journals stated that interlay method type 1 tympanoplasty had high success rate in terms of closing the tympanic membrane perforation and diminishing air-bone gap. Conclusion: Type 1 Tympanoplasty interlay method could be used as an alternative for the closure of a large central tympanic membrane perforation.Keywords: Chronic Tubotympanic Suppurative Otitis Media, large central tympanic membrane perforation, interlay tympanoplasty ABSTRAK Latar belakang: Timpanoplasti tipe 1 atau miringoplasti merupakan prosedur di bidang otologi yang paling sering dilakukan. Timpanoplasti tipe 1 merupakan metode pembedahan yang bertujuan untuk memperbaiki, dan terbatas hanya di membran timpani. Terdapat tiga metode yang paling diterima dan sering digunakan secara universal, yaitu underlay, overlay, dan interlay. Metode interlay merupakan metode penambalan perforasi membran timpani yang relatif baru, dikembangkan pada tahun 1992. Metode ini mempunyai keberhasilan yang tinggi yaitu mencapai 96%. Tujuan: Melaporkan keberhasilan timpanoplasti tipe 1 dengan metode interlay untuk penutupan perforasi membran timpani sentral besar di RSUD Margono Soekarjo. Laporan kasus: Dilaporkan 3 kasus otitis media supuratif kronik tipe tubotimpani dengan perforasi sentral besar, yang dilakukan timpanoplasti tipe 1 dengan metode interlay. Pertanyaan klinis: Apakah metode interlay timpanoplasti tipe 1 yang dilakukan pada perforasi membran timpani yang besar, dapat memberikan hasil yang lebih baik daripada metode lain timpanoplasti tipe 1? Telaah literatur: Telaah berbasis bukti mengenai timpanoplasti tipe 1 metode interlay melalui database Cochrane, Pubmed, dan Google Scholar. Berdasarkan kriteria inklusi dan ekslusi didapatkan tiga jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Ketiga jurnal tersebut menyatakan bahwa timpanoplasti tipe 1 metode interlay mempunyai angka keberhasilan yang tinggi dalam hal penutupan perforasi membran timpani maupun mengurangi air-bone gap. Kesimpulan: Timpanoplasti tipe 1 metode interlay dapat digunakan sebagai alternatif untuk penutupan perforasi membran timpani sentral yang besar
Effectiveness of immediate primary correction and medial canthopexy in bilateral naso-orbito-ethmoid fracture Al Hafiz; Dolly Irfandy; Bonny Murizky
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.357

Abstract

Background: The naso-orbito-ethmoid (NOE) region is a functionally and aesthetically important area of the face. Traffic accidents are the most often cause of NOE fracture and contribute about 35 to 60% of cases. Clinical symptoms are associated with location and the impact. The best way to make an assessment is by clinical examination combined with 3D CT scan. The management usually required reconstruction of the injured anatomical structures of the face with Open Reduction and Internal Fixation (ORIF) method. Purpose: To report the result of immediate reconstruction surgery in a NOE fracture case. Case Report: A case of bilateral NOE fracture in a 24 years old woman, treated with ORIF. Clinical Question: Does immedate primary correction and medial canthopexy provides good result on face reconstruction of NOE fracture? Review Method: Literature searching through Cochrane database, Pubmed, Clinicalkey and Google Scholar, using keywords of correction procedure in NOE fracture, Open Reduction and Internal Fixation and medial canthopexy. Result: The search obtained 35 literatures published in the last 10 years, and found 21 articles relevant with the topics. Conclusion: NOE fracture is a fracture which often occurs as a result of traffic accidents. The diagnosis is established by anamnesis of patient’s complaints and symptoms, physical examination, and 3D CT scan. Immediate reconstruction in NOE fracture cases gives a better result compared to delayed surgical management, as implemented in this case.Keywords: Naso-orbito-ethmoid (NOE) fracture, Open Reduction and Internal Fixation (ORIF), immediate reconstruction ABSTRAK Latar belakang: Naso-orbito-etmoid (NOE) adalah daerah yang penting pada wajah secara fungsional dan estetika. Kecelakaan lalu lintas merupakan penyebab terbanyak, dan menyumbang 35- 60% angka kejadian dari fraktur NOE. Gejala klinis berhubungan dengan lokasi dan tingkat keparahan cedera. Cara terbaik mendiagnosis adalah dengan pemeriksaan klinis dan CT scan 3D. Penatalaksanaan dilakukan dengan rekonstruksi struktur anatomi wajah yang terluka, menggunakan metode reduksi terbuka dan fiksasi internal (Open Reduction and Internal Fixation/ORIF). Tujuan: Melaporkan keberhasilan rekonstruksi segera pada fraktur NOE. Laporan kasus: Dilaporkan satu kasus fraktur NOE bilateral pada seorang perempuan usia 24 tahun, yang dilakukan reduksi terbuka dan fiksasi internal. Pertanyaan klinis: Apakah rekonstruksi segera dan kantopeksi medial pada fraktur NOE memberikan hasil yang baik? Metode telaah literatur: Penelusuran berbasis bukti melalui database Cohrane, Pubmed, Clinicalkey dan Google Scholar menggunakan kata kunci rekonstruksi pada fraktur NOE, Open Reduction and Internal Fixation, dan kantopeksi medial. Hasil: Diperoleh 35 literatur yang terbit dalam 10 tahun terakhir, dan didapati 21 artikel yang relevan dengan topik. Kesimpulan: Fraktur NOE merupakan fraktur yang sering terjadi akibat kecelakaan lalu lintas. Diagnosis ditegakkan berdasarkan anamnesis mengenai keluhan dan gejala yang dirasakan pasien, pemeriksaan fisik serta pemeriksaan CT scan 3D. Penatalaksanaan pembedahan pada kasus fraktur NOE sesegera mungkin, memberikan hasil yang lebih baik dibandingkan dengan tindakan pembedahan tertunda, seperti yang tergambar pada kasus yang dilaporkan ini.
Profile of Head and Neck Cancer Patients at Hasan Sadikin Hospital in 2013-2018 Nur Nathania; Yussy Afriani Dewi; Agung Dinasti Permana
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.361

Abstract

ABSTRACTBackground: Head and neck cancer (HNC) is the 6th highest cancer worldwide. Risk factors include history of smoking, exposure of carcinogen, diet, oral hygiene, HPV and EBV infections, genetic, and alcohol consumption. Purpose: To identify the profile of HNC patients in the Department of Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) Hasan Sadikin General Hospital Bandung from 2013 to 2018. Method: A retrospective descriptive study was conducted in 2013-2018 in the Department of ORL-HNS Hasan Sadikin General Hospital, using total sampling method. Medical record of the patients were used as secondary data. Result: There were 2952 HNC patients consisted of 1689 males and 1263 females. Most of the subjects were graduated from elementary school (45.56%), with mean age 47.45 years old. The majority types of HNC were nasopharyngeal (31.20%), sinonasal (19.65%) and laryngeal (14.16%) carcinoma. The main histopathological types were undifferentiated carcinoma (47.15%) and squamous cell carcinoma (34.08%). The major risk factors were smoking and salted fish consumptions. Discussion: Unlike previous studies, our study found out that most HNC cases occurred in patients under the age of 30 years old. In this research, smoking was the highest risk factor of research subjects, followed by salted fish intake, mosquito burnt coils, and alcohol consumption. Nasopharyngeal carcinoma and stadium IV were the highest incidence of HNC, mostly found in male patients. Histopathologically, the dominant type was the undifferentiated carcinoma. Conclusion: Nasopharyngeal carcinoma was the main cancer type. The main histopathological type was undifferentiated carcinoma. The main risk factors were smoking and salted fish consumptions. ABSTRAKLatar belakang: Karsinoma kepala leher (KKL) merupakan keganasan terbanyak ke enam di dunia. Faktor risiko KKL antara lain riwayat merokok, paparan karsinogen, diet, kebersihan mulut, infeksi Human Papilloma Virus, Virus Epstein Barr, genetika, konsumsi alkohol. Tujuan: Untuk mengetahui profil penderita KKL di Departemen T.H.T-K.L Rumah Sakit Hasan Sadikin Bandung, tahun 2013- 2018. Metode: Penelitian deskriptif retrospektif dengan total sampling, pada periode 2013-2018 di Dept/KSM THT-KL RSUP Dr Hasan Sadikin. Rekam medis subjek penelitian digunakan sebagai data sekunder. Hasil: Terdapat 2.952 penderita KKL terdiri dari 1.689 laki-laki dan 1.263 perempuan. Mayoritas berpendidikan SD (45,56%), dengan rerata usia 47,45 tahun. Jenis KKL terbanyak karsinoma nasofaring (31,20%), sinonasal (19,65%), dan laring (14,16%). Karakteristik histopatologi terbanyak karsinoma tak berdiferensiasi (47,15%) dan karsinoma sel skuamosa (34,08%). Faktor risiko terbanyak merokok serta konsumsi ikan asin. Diskusi: Berbeda dengan penelitian sebelumnya, penelitian kami mendapatkan kasus KKL terbanyak didapati pada pasien di bawah usia 30 tahun. Didapatkan juga faktor risiko tertinggi adalah merokok, diikuti oleh mengonsumsi ikan asin, obat nyamuk bakar, dan minum alkohol. Angka kejadian KKL terbanyak adalah karsinoma nasofaring stadium IV, yang kebanyakan didapati pada pasien laki-laki. Secara histopatologi, tipe yang dominan adalah jenis karsinoma tak berdiferensiasi. Kesimpulan: Karsinoma nasofaring merupakan jenis KKL terbanyak. Jenis histopatologi terbanyak karsinoma tak berdiferensiasi. Faktor risiko KKL yang paling banyak ditemui yaitu merokok dan konsumsi ikan asin.
Mometasone furoate effect on interleukin-6 of adenoid surface and serum in adenoid hypertrophy patients Zainul Mujahid; Rus Suheryanto; Iriana Maharani
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.362

Abstract

Background: Adenoid hypertrophy is one of the most common problems in children resulting in obstruction of the posterior nasal cavity. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a role in acute and chronic infections, hematopoesis, T cells and B cells formation. Purpose: To determine the effect of intranasal mometasone furoate administration on IL-6 level of adenoid surface and serum and the adenoid size in patients with adenoid hypertrophy. Method: A one group pre- and post-test design involving 17 patients aged 5 to 12 years. The subjects underwent nasoendoscopic examination to determine the adenoid size, also measurement of IL-6 level of adenoid surface and serum before and after 6 weeks treatment with intranasal mometasone furoate. Results: There were a significant decrease of the adenoid surface IL-6 level, serum IL-6 level, and adenoid size with p value <0.05. There was a significant positive correlation between the levels of adenoid surface IL-6 and serum IL-6 (r=0.517; p=0.033). A significant positive correlation was obtained between the decrease of adenoid surface and serum IL-6 levels with the decrease of adenoid size (p<0.05). Conclusion: The use of intranasal mometasone furoate could decrease the IL-6 levels of adenoid surface and serum, and the adenoid size in patients with adenoid hypertrophy.ABSTRAK Latar belakang: Hipertrofi adenoid merupakan salah satu masalah tersering pada anak-anak yang mengakibatkan obstruksi pada rongga hidung posterior. Interleukin-6 merupakan sitokin pleiotropik yang berperan pada infeksi akut maupun kronis, hematopoesis, pembentukan sel T dan sel B. Tujuan: Mengetahui pengaruh pemberian mometason furoat intranasal terhadap kadar IL-6 permukaan adenoid dan serum, serta ukuran adenoid pada penderita hipertrofi adenoid. Metode: Suatu one group pre- and post-test design melibatkan 17 subjek berusia 5 sampai 12 tahun. Subjek menjalani pemeriksaan nasoendoskopi, pengukuran kadar IL-6 serum, dan IL-6 permukaan adenoid sebelum dan setelah pemakaian mometason furoat intranasal selama 6 minggu. Hasil: Didapatkan penurunan kadar IL-6 permukaan adenoid, IL-6 serum, dan penurunan ukuran adenoid yang bermakna dengan nilai p<0,05. Didapatkan korelasi positif yang signifikan antara kadar IL-6 permukaan adenoid dengan IL-6 serum (r=0,517; p=0,033). Didapatkan korelasi positif yang signifikan antara penurunan kadar IL-6 permukaan adenoid dan IL-6 serum dengan pengecilan ukuran adenoid (p<0,05). Kesimpulan: Penggunaan mometason furoat intranasal dapat menurunkan kadar IL-6 permukaan adenoid dan IL-6 serum, serta ukuran adenoid pada penderita hipertrofi adenoid. Kata kunci: hipertrofi adenoid, interleukin-6, mometason furoat intranasal
Oropharyngeal dysphagia in extrapyramidal syndrome ferdinand simanjuntak; Rery Budiarti; Muyassaroh -
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.366

Abstract

Background: Dysphagia could be caused by mechanical or motoric problems. Dysphagia is associated with neurological disorders in extrapyramidal syndrome (EPS), including tardive dyskinesia caused by long-term chronic use of antipsychotic drugs. Dysphagia in EPS about 9.4% occurs in young adults. Dysphagia in EPS could be a single symptom or as an concomitant symptom. Purpose: To discuss a case of oropharyngeal dysphagia in EPS due to the effects of antipsychotic drugs on a patient who was treated under multidisciplinary management. Case report: A 32-year-old male patient came to Emergency Unit of Dr.Kariadi Hospital with chief complaint of a sudden onset of difficulty in swallowing liquid and solid food. He had a history of longterm use of Chlorpromazine. The diagnosis of oropharyngeal dysphagia was established with Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Clinical question: What is the proper management for dysphagia in EPS? Method: Literature search through database Pubmed and Google Scholar found 88 journals. Results: There were 4 journals relevant with the case. Those journals reviewed the diagnosis and disclosed the management of EPS with dysphagia was discontinuation of the analogous antipsychotic drugs and swallowing practice physiotherapy. Conclusion: Dysphagia in this case was an EPS due to chlorpromazine use, and made a good respond after drug replacement.ABSTRAK Latar belakang: Disfagia dapat disebabkan oleh gangguan mekanik maupun motorik. Disfagia dapat berhubungan dengan kelainan neurologis pada sindrom ekstrapiramidal (SEP), antara lain tardive diskinesia yang disebabkan pemakaian obat antipsikotik jangka panjang. Disfagia pada SEP sekitar 9,4 % terjadi pada usia dewasa muda. Disfagia pada SEP dapat merupakan gejala tunggal atau sebagai gejala penyerta. Tujuan: Membahas kasus disfagia orofaringeal pada SEP akibat efek obat antipsikotik pada pasien yang diterapi secara multidisipliner. Laporan kasus: Seorang laki-laki usia 32 tahun datang ke IGD RSUP Dr. Kariadi dengan keluhan utama mendadak tidak dapat menelan sama sekali, baik cairan maupun makanan padat. Didapatkan tanda gejala SEP dengan riwayat pemakaian chlorpromazine jangka panjang. Diagnosis disfagia orofaringeal ditegakkan dengan pemeriksaan Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Pertanyaan klinis: Bagaimana penatalaksanaan yang tepat untuk kasus disfagia pada sindrom ekstrapiramidal? Metode: Penelusuran kepustakaan melalui database Pubmed dan Google Scholar diperoleh 88 jurnal. Hasil: Didapatkan 4 jurnal yang relevan dengan kasus. Empat jurnal tersebut menyatakan tatalaksana disfagia dengan SEP ialah dilakukan penghentian obat antipsikotik tipikal dan latihan menelan. Kesimpulan: Disfagia pada SEP akibat penggunaan chorpromazine memberikan respon baik setelah dilakukan penggantian obat.Kata kunci: disfagia orofaringeal, sindrome ekstrapiramidal, chlorpromazine 
Hearing Loss in Treacher-Collins Syndrome Fezzan Athama Fuadi; Wijana -
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.375

Abstract

Background: Treacher Collins Syndrome (TCS) is a craniofacial disorder that has a dominant autosomal disorder in facial development, found 1 in every 50.000 births. The most often manifestations could be mandibulofacial disorder, microtia, atresia of the ear canal, and hearing loss. This syndrome is also accompanied by bone malformations of the ossicular chain in the middle ear, which can lead to conductive hearing loss up to 50% of cases, besides sensory neural hearing loss. Purpose: To report one case of Treacher Collins syndrome who came to the Audiology-Vestibular Clinic, Dr. Hasan Sadikin General Hospital Bandung. Case report: The patient came with symptoms of micrognathia and microtia with bilateral hearing loss. The right ear is smaller than the left ear, and compliant with 3rd grade microtia. He had undergone reconstruction ear surgery of the right ear, and had an improvement in audiological examination after the second stage of reconstruction. There was TCOF 1 (Treacle Ribosome Biogenesis Factor 1) gene mutation involved in this case. Clinical question: What is the best management for TCS with micrognathia, microtia and severe bilateral hearing impairments? Review method: Literature search was performed with keywords Treacher Collins Syndrome AND microtia AND hearing loss. Result: The search obtained 263 literatures published in the last 10 years, and found 12 articles relevant with the topics. Conclusion: TCS is a rare inherited disorder, but the diagnosis could be easily established. Early intervention with hearing rehabilitation, audio-verbal rehabilitation, and reconstruction ear surgery should be carried out for a better quality of life.ABSTRAK Latar belakang: Sindroma Treacher Collins adalah kelainan kongenital auotosom dominan pada kepala dan wajah, yang ditemukan pada 1 dari 500,000 bayi lahir. Manifestasi yang paling sering didapati adalah kelainan mandibulofasial, mikrotia, atresia liang telinga, dan gangguan pendengaran. Pada sindroma ini terjadi malformasi rangkaian tulang-tulang pendengaran di telinga tengah, yang mengakibatkan tuli konduktif pada 50% kasus, dan dapat juga disertai tuli sensorineural. Tujuan: Melaporkan satu kasus sindroma Treacher Collins yang datang ke poliklinik Audiology-Vestibular, Rumah Sakit Umum Dr. Hasan Sadikin, Bandung. Laporan Kasus: Keluhan utama pasien adalah mikrognatia dan mikrotia disertai gangguan pendengaran kedua telinga. Bentuk telinga kanan lebih kecil daripada telinga kiri, yang sesuai dengan mikrotia derajat 3. Pasien menjalani bedah rekonstruksi telinga kanan, dan memperoleh perbaikan hasil pemeriksaan audiogram pasca tahap kedua bedah rekonstruksi. Pada kasus ini didapati ada mutasi genetik TCOF 1 (Treacle Ribosome Biogenesis Factor 1). Pertanyaan klinis: Bagaimana penatalaksanaan terbaik untuk kasus STC dengan mikrognatia, mikrotia dan gangguan pendengaran berat kedua telinga. Telaah literatur: Penelusuran literatur melalui Google Scholar dilakukan dengan kata kunci Treacher Collins Syndrome DAN microtia DAN hearing loss. Hasil: Didapatkan 263 literatur mengenai STC yang terbit dalam 10 tahun terakhir, dan 12 literatur yang sesuai dengan topik. Kesimpulan: Sindroma Treacher Collins adalah kelainan bawaan langka yang merupakan penyakit keturunan, namun diagnosisnya tidak sulit ditegakkan. Perlu dilakukan intervensi dini berupa rehabilitasi pendengaran, rehabilitasi wicara, dan bedah rekonstruksi telinga untuk memberikan kualitas hidup yang baik bagi penderita.Kata kunci: sindroma Treacher Collins, mikrognatia, mikrotia, gangguan pendengaran

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