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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 19 Documents

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Search results for , issue "Vol 16 No 1 (2018): JIFI" : 19 Documents clear

Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat Neng Fisheri Kurniati; Elin Yulinah Sukandar; Rian Pardilah; Nova Suliska; Dhyan Kusuma Ayuningtyas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sonchus arvensis L. leaves have been used traditionally to treat various disease conditions. This study is designed to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar albino rats were divided into three main groups: negative control (saline only), positive control (isoproterenol only), and S. arvensis extract treated groups. S. arvensis extract was administered in three doses; 50, 100, and 200 mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was given intraperitoneally to positive control and extract treated groups. The parameters studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could significantly (P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infarcted rats compared to positive control. The increase of the dose of S. arvensis extract was not followed by an increase of its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg b.w. has potential to be developed as cardioprotective drug.

α-GLUCOSIDASE INHIBITORY ACTIVITY AND FORMULATION OF SOLID LIPID NANOPARTICLE CONTAINING ETHANOL 70% STANDARDIZED EXTRACT OF KUMIS KUCING LEAVES (Orthosiphon stamineus Benth.) Risma Marisi Tambunan; Winda Dwi Juliyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Kumis kucing leaves (Orthosiphon stamineus Benth.) are one type of plants that is able to inhibit the activity of α-glucosidase enzyme. This study aims to formulate Solid Lipid Nanoparticle from ethanol 70% standardized extract of kumis kucing leaves and which give α-glucosidase enzyme inhibitory activity. The result of SLN characteristic for particle size of formula I, II and III shows the result of 51,60 nm; 12.81 nm; 11.87 nm and zeta potential of formula I, II and III show the results -27.67; -10,7; -15.0, respectively. The results of the α-glucosidase enzyme inhibitory activity of the standardized extract, SLN formula I, II and III respectively showed IC50 of 132.9 ppm; 130.3 ppm; 131.4 ppm; 132.2 ppm and Acarbose as comparison showed IC50 of 50.0 ppm. Data processing using t-test statistically at α = 0,05 showed that extract and SLN of formula I had significant difference, thus the best SLN formula was formula I with concentration of tween 80 and propylenglycol of 6% and 10%.

Specificity of Mercury Detecting Reagents for Skin Lightening Creams Liliek Nurhidayati; Titiek Martati; I Wayan Redja; Nofanti Sandra
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Inorganic mercury compound have been used for long time in cosmetics preparations for its skin lightening effect. The used of mercury in cosmetics has been prohibited as stipulated in the decision of the BPOM RI (Head of the Food and Drug Supervisory Agency) No.HK.00.01.432.6147. Based on health department research from various countries, there are a number of skin lightening products containing mercury between 660-57.000 μg/kg. People needs a quick and easy way to detect mercury in a lightening cream, so that people can test the safety of cream that used. One alternative that can be used to detect mercury in skin lightening cosmetics is using detecting reagents. The aim of this study was preparation of specific and sensitive mercury detecting reagents. The detecting reagents consisted mixtures of diphenylcarbazone and acetic acid in 96% of ethanol. The specificity test is performed by adding diphenylcarbazone solution into a lightening cream containing whitening agents such as mercury, hydroquinone, bangkuang extract and mixture of these substances. Assay was also performed on simulated cream that contained mercury, zinc oxide, bismuthsubnitrate, and mixture of mercury, zinc oxide and bismuthsubnitrate. The mercury detecting reagents gives a distinctive result that shown by the formation of purple mercury complex in less than 3 minutes.

PENGEMBANGAN DAN VALIDASI KUESIONER UNTUK MENGIDENTIFIKASI FAKTOR PENYEBAB PERILAKU PENGGUNAAN ANTIBIOTIK TANPA RESEP DOKTER Eko Setiawan; Dewi Paskalia Andi Djawaria; Adji Prayitno
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Factors attributing to the behavior of non-prescription used of antibiotics in Indonesia setting have not been identified yet. The availability of effective and efficient instrument or method to identify the attributing factors might be the cause of non-optimal identifying process. The objective of present study was to develop instrument, i.e questionnaire, to identify factors contributing to the behavior of non-prescription used of antibiotics. The questionnaire was developed based on factors identified on published scientific literatures. Face and content validity were conducted by having the experts’ judgement, while the construct validity was conducted by using the Spearman Correlation Test. Reliability was tested by using Cronbach’s alpha test. There were 14 rating and 8 multiple answer questions in the questionnaire that could be classified unto 5 domains. After conducting the validity and reliability test, the final questionnaire had a R value 0.276-0.628 and Cronbach’s alpha 0.833. This valid and reliable questionnaire could be used to portray the attributing factors of non-prescription used of antibiotics in larger area, therefore, the most appropriate intervention could be planeed based on the identified factors.

Off-Label Prescribing in Pediatric Inpatients With Pneumonia in a Children's Hospitaal Hesty Utami Ramadaniati; Heni Safarini; Aishah A Regine
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Off-label is a term used in which a drug prescribed outside the official information of the marketing authorization. Off-label prescribing may occur as the result of several factors including lack of clinical trials data involving pediatrics and suitable formulations for medicines commonly prescribed to this fragile population. Objective: This study aimed to estimate the nature and prevalence of off-label prescribing in pediatric inpatients with pneumonia. Material and Methods: a retrospective study was conducted in a study hospital using medical records from pediatric inpatients with pneumonia during the period of January-December 2015. Patient and prescribing data were collected, and drugs were classified as on-label or off-label based on the Indonesia National Drug Information (IONI) and British National Formulary for Children (BNFC). Thereafter, off-label drugs were categorized with a hierarchical system of age, indication, route of administration and dosage. Results: There were 1141 drugs with 77 different types of drug were administered to 207 patient during the study period. The data uncovered that 405 (35,5%) of the drug prescriptions were used off-label based on IONI, and 319 (28%) of the drug were used off-label based on BNFC. Based on IONI and BNFC, most off-label drugs were from anti infection drugs. Conclusion: The prevalence of off-label use in pediatric inpatients with pneumonia is not high. The off-label prescribing may not be necessarily be considered irrational, yet this fact reveals that the use of drugs does not comply with the drug label. Clinical trials for pediatric drugs are essential to provide complete product information for pediatric use.

Profile Of Antiretroviral Side Effects On Hiv In Rspi Prof. Dr. Sulianti Saroso Jakarta Yelfi Anwar; Sucahyo Adi Nugroho; Sri Dwi Wulandari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Symptoms of Acquired Immuno Deficiency Syindrome (AIDS) is a militia or disease caused by me infection of Human Immunodeficiency immune deficiency due to Antiretroviral. Due to Virus (HIV). The therapy used is a drug that the use of Antretroviral is the appearance of unwanted reactions or side effects will appear. The objectives of the study were to analyze the side effects of antiretroviral therapy in HIV / AIDS patients in RSPI Sulianti Saroso, North Jakarta, January-June 2016 period. The sample was 95 patients. The research was done by retrospective method, data analysis desknptif data presented in tabular form and presented with pie chart. The result of the research is the combination of TDF + 3TC + Efavirenz Tenofovir-Lamivudin-Efavirenz) as much as 73,68% (0 person). There were 94.73% (90 people had mild adverse reactions and 5.27% (5 people) severe side effects.

Uji Klinik Khasiat Sediaan Rebusan Ramuan Jamu Hipertensi Dibanding Seduhan Jamu Hipertensi Agus Triyono; Peristiwan Ridha; Danang Ardianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

To search for scientific evidence the efficacy of herbal medicine, has conducted clinical trial the efficacy of hypertension herbs compared with hydrochlorotiazide. Efficacy of clinical trials were conducted with the design open-label, randomized clinical trials and parallel design. It was involving 80 subjects who have met the inclusion and exclusion criteria. Subjects randomized study that is divided into two groups, a herbs group and hydrochlorotiazide group. Subjects performed once a week to check the complaint history, the development of clinical symptoms, the possibility of side effects and diagnostic physical examination. Assessment score of quality of life by questionnaires Short Form 36 (SF-36) every four weeks. Results showed that administration of herbal medicine for 56 days hypertension, lower blood pressure (systolic and diastolikic) is equivalent to hydrochlorotiazide (HCT). Lowering blood pressure to normal (normotensive) 62.7% of the subjects. Eliminating the clinical symptoms of hypertension (dizziness / headache, stiff neck / whiny and myalgia) herbs group subjects at almost the same time with the hidrochlorthiazide group. Raising the quality of life scores (SF-36) subjects herbs group equivalent to the increase in quality of life scores (SF-36) hydrochlorotiazide group.

Faktor yang Mempengaruhi Ketersediaan Obat Program Rujuk Balik (PRB) di Fasilitas Pelayanan Obat PRB Wilayah Eks Karesidenan Kediri (Studi pada Ketersediaan Obat Hipertensi) Sri Dias Tuti; Umi Athiyah; Wahyu Utami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

PRB drugs service was given to chronically patients who still need long term treatment therefore there was need to guarantee the availability of medicines for their therapeutic needs. The objectives of this research were to know about PRB drug management, to know drug management support, policy, the availability of PRB drugs, and to analize the effects of drug management, drug management support, and policy on drug availability in PRB drug facility in Ex Karesidenan Kediri. Study on the availability of drugs hypertension due to prevalence of hypertension disease tends to increase from 7.6% in 2007 to 9.5% in 2013. This research used cross sectional approach by giving questionnaires to 18 respondents of PRB drug managers who had fulfilled the inclusion criteria. Those respondents were measured on the capability in PRB drug managements and assessment of PRB drug management support and policy. The questionnaires were valid and reliable. The management, management support, and policy score were tested for effect on PRB drug availability for Hypertension by using multiple linear regression. From this research, it was known that PRB Drug Management, PRB Drug Management Supporting Assessment, and PRB Policy by PRB drug managers in drug service facilities in Ex Karesidenan Kediri were mostly categorized as good enough. The availability of PRB drugs at PRB drugs facility with stock calculations indicated the ability to provide PRB medication to serve PRB prescription of hypertension was 28.71%. While the facilitieas that were able to serve an average of 72.67, thus providing substitution drugs beyond the average of PRB stock of 43.95%. The efforts were done for examples, borrowed similar drugs from regular supplies, medicines administered when they were available, or established the similar drugs at prices closed to e-catalogue. The results of the analysis showed that simultaneously PRB Drug Management factors, PRB Drug Management Supports, and PRB Policy have significant effects on PRB Drug Availability (p<0.10). PRB drug management had the greatest effects on the availability (p<0.10), especially in the case of Drug Selection (p<0.10). Selection of drugs was the first step to be done from a cycle of drug management, where the early step was the step that most determine the next steps. The pharmaceutical management framework affected the availability of PRB drugs, particularly the Drug Management factor, especially in the drug selection step. Drug selection was an early step of the drug management cycle that determined the next step.

FORMULASI CREAMBATH DENGAN VARIASI KONSENTRASI SARI BONGGOL PISANG AMBON (Musa acuminata Colla) Teti Indrawati; Nabhilla Sofia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Ambon banana (Musa acuminata Colla) humps contain anthraquinone compounds that effectives This research aims to take advantage of the hump to be confectionary cream bath as hair growth. Water extracts of Ambon banana humps were blended and filtered, and then, this water extracts of Ambon banana was made into cream bath using concentration of 8%, 10%, and 12%. The method that is used to make cream bath is dissolution and mixing methods at a temperature of 75oC–80oC and the water extract was add at 40oC. These cream bath products weres evaluated by organoleptic, homogeneity, emulsion type, pH, spreading ability, viscosity and flow character. All formula cream bath preparations had white to ivory white, odourless bananas, emulsion type o/w, homogenized, pH 6.05 to 6.38, spreading ability 4862.05 mm2-3672.67 mm2, has a viscosity of 12000 cps-145000 cps, and showed the flow properties pseudo-plastic thixotropic.

Profil Swamedikasi Analgesik di Masyarakat Surabaya, Jawa Timur Stevan Victoria Halim; Antonius Adji Prayitno S; Yosi Irawati Wibowo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Self-medication is one of the patient's efforts to treat the symptoms or health problems with drug without using a prescription. The most often class of drugs used as self-medication is analgesic (36,2-59,0%). Aim of this study is to describe analgesic self-medication profile among East Surabaya communities, especially Mulyorejo subdistrict. This study is an observational descriptive study that involving 225 patients from 9 pharmacies. The data were collected by using validated questionnaire contains sociodemographic profiles, the frequency of using analgesic, and analgesic profiles purchased by the patients. The data analyze was perfomed by comparing the average of analgesic self-medication frequency based on the patients sociodemographic profiles. The results showed that the average frequency of analgesic used as self-medication is 10.71 (95% CI 8.81-12.60) times a month. The average frequency of analgesic used as self-medication may differ based on sociodemographic profiles. Male patients, elderly, low education level, unemployed, low income (< 2 million), living alone/ divorce, having history of smoking or drinking alcohol showed a higher average frequency of self-medication than the other groups. The results of the study related to analgesic profile showed the majority of patients (80.00%) bought 1 type of analgesic. The most common analgesic group (67.03%) purchased by the patient is Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Headache (42.22%) is a symptom that often encourages patients to use analgesic as self-medication. Based on the results of the study, education about the use of analgesic as self-medication can be more focused on groups of patients with a particular sociodemographic background and NSAIDs drug groups. It aims to avoid the less responsible use of analgesic as self-medication.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Syafira Dwi Cahyani

Contact Email adminjifi@univpancasila.ac.id

Phone +6287780957284

Journal Mail Official syafira.ffup@univpancasila.ac.id

Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA