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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Search results for , issue "Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)" : 68 Documents clear

Potensi antibakteri tetes telinga ekstrak daun Anredera Cordifolia terhadap Pseudomonas aeruginosa penyebab Otitis Media Supuratif Kronis (OMSK) Ni Putu Oktaviani Rinika Pranitasari; Eka Putra Setiawan; I Wayan Lolik Lesmana
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Chronic Suppurative Otitis Media (CSOM) is a chronic inflammation of the middle ear and mastoid mucosa characterized by perforation of the tympanic membrane and persistent discharge from the middle ear. The high resistance rate to CSOM pathogen brings hope for the development of natural-based drugs. The Binahong plant (Anredera cordifolia) has been known for a long time and is widely used as a traditional herb by Indonesian people. Flavonoid, saponins and alkaloids compounds from Binahong leaf extracts in several studies reveal its antibacterial activity. This study aims to determine the antibacterial activity of Binahong leaf extract ear drops against Pseudomonas aeruginosa, CSOM pathogen in-vitro. Methods: This is an experimental study with a post-test only control group design by testing antibacterial activity of binahong leaf extract at 1%, 3% and 5% concentrations into Pseudomonas aeruginosa American Type Culture Collection (ATCC) 9027. Chloramphenicol 1% was used as a positive control and ethanol 96% as a negative control. Data were analyzed using SPSS version 20 for Windows. Results: The minimum Inhibitory Zone Diameter (IZD) in the treatment groups A1, A2, A3 and A4 was the same, namely 0.00 mm and the maximum IZD in the treatment groups A1, A2, A3, A4 was also the same, which was 0.00 mm, so that the average IZD of the treatment groups A1, A2, A3, A4 was 0.00 mm. Meanwhile, in the A4 treatment group, the minimum IZD was 11.00 mm and the maximum IZD was 12.00 mm, so the average IZD was 11.20 mm. Conclusion: Antibacterial activity of the Binahong (Anredera cordifolia) leaf extract ear drops at 1%, 3% and 5% concentrations showed weak inhibitory response to Pseudomonas aeruginosa bacteria. Latar Belakang: Otitis media supuratif kronis (OMSK) adalah inflamasi kronis mukosa telinga tengah dan mastoid ditandai perforasi membran timpani dan keluarnya cairan dari telinga tengah yang menetap. Tingginya angka resistensi terhadap bakteri penyebab OMSK membawa harapan bagi pengembangan obat yang berbahan dasar alam. Tanaman Binahong (Anredera cordifolia) telah dikenal sejak dahulu dan banyak digunakan sebagai tanaman obat oleh masyarakat di Indonesia. Senyawa flavonoid, saponin dan alkaloid yang terkandung pada daun Binohong diketahui memiliki aktifitas antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri tetes telinga ekstrak daun Binahong terhadap Pseudomonas aeruginosa penyebab OMSK secara in-vitro. Metode: Penelitian ini merupakan penelitian eksperimental dengan rancangan post-test only control group design yaitu menguji aktivitas antibakteri berupa diameter daerah hambat (DDH) sediaan tetes telinga ekstrak daun Binahong konsentrasi 1%, 3% dan 5% terhadap Pseudomonas aeruginosa ATCC-9027. Sebagai kontrol positif digunakan Chloramphenicol 1% dan sebagai kontrol negatif digunakan ethanol 96% Data dianalisis menggunakan SPSS versi 20 untuk Windows. Hasil: Diameter daerah hambat (DDH) minimal pada kelompok perlakuan A1, A2, A3 dan A4 adalah sama, yaitu 0,00 mm dan DDH maksimal pada kelompok perlakuan A1, A2, A3, A4 juga sama, yaitu sebesar 0,00 mm, sehingga rerata diameter daerah hambat kelompok perlakuan A1, A2, A3, A4 adalah 0,00 mm. Sedangkan pada kelompok perlakuan A4, DDH minimal adalah 11,00 mm dan DDH maksimal sebesar 12,00 mm, sehingga rerata DDH adalah 11,20 mm. Kesimpulan: Aktivitas antibakteri sediaan tetes telinga ekstrak daun Binahong (Anredera cordifolia) pada konsentrasi 1%, 3% dan 5% menunjukkan respon hambat lemah terhadap pertumbuhan bakteri Pseudomonas aeruginosa.

Uji toksisitas akut dan subkronik ekstrak daun binahong (Anredera cordifolia) pada mencit Balb/C betina I Wayan Lolik Lesmana; Eka Putra Setiawan; Ni Putu Oktaviani Rinika Pranitasari
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: The antibacterial potential of Binahong leaf extract has been known but has not been studied further, especially against disease-causing bacteria in the Ear, Nose and Throat (ENT) field. The antibacterial activity is made possible by the presence of flavonoid compounds, saponins and alkaloids. This study aims to test the acute toxicity in determining the LD50 value and the subchronic toxicity test in the phytopathological examination of liver and kidney function in female Balb/C mice. Methods: Experimental research was conducted on acute and subchronic toxicity of binahong leaf extract in mice. An acute toxicity test was carried out by giving a single dose of Binahong leaf extract, starting at a dose of 5 mg/kgBW and increasing until 2 mice died or 1 mouse showed symptoms of toxicity. After 28 days of offering Binahong leaf extract, blood serum was taken to check kidney and liver function, while the kidneys and then histopathological examinations were carried out. Data were analyzed with SPSS version 20 for Windows. Results: There was a significant difference in SGPT levels in the group that received binahong extract treatment at a dose of 250 mg/kgBW (24.08±3.08/L), 500 mg/kgBW (26.84±1.47/L), and 1000 mg/kgBW (30.38±0.68/L) compared to the control group (18.18±0.46/L) (p<0.05). Significant differences were also found in BUN and SC levels measurement compared to the control group (p<0.05). However, significant differences in SGOT levels were only found in the binahong extract group at a dose of 500 mg/kgBW (44.88±2.88/L) and 1000 mg/kgBW (58.18±2.56/L) compared to the control (37 ,48±0.44 /L) (p<0.05). Conclusion: There were significant differences in the levels of SGPT, SGOT, BUN, and SC after the administration of various doses of binahong leaf extract in female Balb/C mice. Latar Belakang: Potensi antibakteri ekstrak daun Binahong telah diketahui namun belum diteliti lebih jauh terutama terhadap bakteri penyebab penyakit di bidang Telinga Hidung dan Tenggorok (THT). Aktivitas antibakteri tersebut dimungkinkan oleh adanya kandungan senyawa flavonoid, saponin dan alkaloid. Penelitian ini bertujuan untuk menguji toksisitas akut dalam menentukan nilai LD50 dan uji toksisitas subkronik berupa pemeriksaan fungsi hepar dan ginjal secara biokimia dan histopatologi pada mencit Balb/C betina. Metode: Penelitian eksperimental dilakukan terhadap toksisitas akut dan subkronik ekstrak daun Binahong pada mencit. Uji toksisitas akut dilakukan dengan memberikan ekstrak daun Binahong dosis tunggal mulai dari dosis 5 mg/kgBB dan ditingkatkan sampai didapatkan ≥ 2 ekor mencit yang mati atau ≥ 1 ekor mencit menunjukkan gejala toksisitas. Setelah 28 hari pemberian ekstrak daun Binahong, dilakukan pengambilan serum darah untuk diperiksa fungsi ginjal dan hepar, sedangkan organ ginjal dan hepar selanjutnya akan dilakukan pemeriksaan histopatologi. Data dianalisis dengan SPSS versi 20 untuk Windows. Hasil: Terdapat perbedaan yang bermakna kadar SGPT pada kelompok yang mendapatkan perlakuan ekstrak binahong dengan dosis 250 mg/kgBB (24,08±3,08 µ/L), 500 mg/kgBB (26,84±1,47 µ/L), dan 1000 mg/kgBB (30,38±0,68 µ/L) dibandingkan dengan kelompok kontrol (18,18±0,46 µ/L) (p<0,05). Perbedaan yang bermakna juga ditemukan pada pengukuran kadar BUN dan SC dibandingkan dengan kelompok kontrol (p<0,05). Akan tetapi perbedaan bermakna kadar SGOT hanya ditemukan pada kelompok ekstrak binahong dengan dosis 500 mg/kgBB (44,88±2,88 µ/L) dan 1000 mg/kgBB (58,18 ± 2,56 µ/L) dibandingkan dengan kontrol (37,48±0,44 µ/L) (p<0,05). Simpulan: Terdapat perbedaan yang bermakna pada kadar SGPT, SGOT, BUN, dan SC pasca pemberian berbagai dosis ekstrak daun binahong pada mencit Balb/C betina.

The potential role of vitamin D supplementation in the treatment of Dry Eye Disease (DED): a systematic review Tiara Alexander; Eunike Cahyaningsih
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Dry Eye Disease (DED) is a prevalent condition that involves instability, increased osmolarity, and inflammation of the tear film and ocular surface. Vitamin D is known for its anti-inflammatory properties. Association between vitamin D deficiency and increased incidence of DED has been suggested. However, no study currently exists that systematically reviews the potential role of vitamin D as a treatment for DED. Methods: The literature search was performed on December 2021 through PubMed, Scopus, ProQuest, EBSCOhost, ScienceDirect, dan Cochrane Library using the relevant keywords. The risk of bias was assessed using the Cochrane Risk of Bias tool, ROBINS-I tools, and the Newcastle-Ottawa Scale. Results: A total of 700 articles were found, 6 of which were considered relevant based on PRISMA protocol. The included articles consist of 2 case controls, a randomized interventional study, and 3 observational studies. Vitamin D supplementation improved tear stability, symptoms of dry eye disease, and serum vitamin D level affected the efficacy of topical therapy for DED. Conclusion: Despite this beneficial finding, serum vitamin D level does not significantly correlate with DED symptoms which the multifactorial nature of the disease might cause.

Kasus kromoblastomikosis yang awalnya diduga furunkel pada seorang perempuan Roslina Horo; Ni Luh Putu Ratih Vibriyanti Karna; Ni Putu Ayu Riska Yunita Sari
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Chromoblastomycosis is a chronic profound fungal infection caused by dematiaceous from the surrounding environment. Trauma was the site of fungal implantation. The prevalence is mainly in agriculture workers. The clinical picture varies. Diagnosis is made when muriform cells are found. Early diagnosis is very important because it affects the prognosis. Case Description: A woman, 24 years old, Balinese, went to The Skin and Genital Polyclinic of Sanglah General Hospital with the main complaint of boils in the area below the left knee six months ago. It starts from red papules and then becomes a painless lump. The lump breaks and contains yellowish pus. Patients have a history of gardening. Physical examination within normal limits. Dermatological status on left cruris, there are solitary erythema nodules, firm borders, round shape, a diameter of 2.5 cm, smooth and shiny surface, and fluctuations containing yellowish pus. From sabouraud dextrose agar culture (SDA) obtained the growth of Cladophialophora carrionii. The diagnosis was chromoblastomycosis. Patients were given a pulse dose of itraconazole 400 mg every 24 hours intraorally. There was a clinical improvement. Conclusion: There have been reported cases of chromoblastomycosis that were initially suspected to be furuncle in a 24-year-old woman. Diagnosis is made based on anamnesis, physical examination, and laboratory examination. Patients were given a pulse dose of itraconazole. There was a clinical improvement. The prognosis is dubius ad bonam. Extended observations still need to monitor the clinical and mycological healing, medication side effects and complications of the disease. Latar belakang: Kromoblastomikosis adalah infeksi jamur profunda kronik yang disebabkan oleh dematiaceous yang berasal dari lingkungan sekitar. Penyakit ini biasanya diawali oleh trauma sebagai situs implantasi jamur. Prevalensi penyakit ini terutama pada individu yang bekerja di bidang agrikultural. Gambaran klinis kromoblastomikosis bervariasi. Penegakan diagnosis bila ditemukan sel muriform pada jaringan. Diagnosis dini pada lesi awal sangat penting karena mempengaruhi prognosis penyakit. Deskripsi kasus: Seorang perempuan, 24 tahun, suku Bali, berobat ke Poliklinik Kulit dan Kelamin RSUP Sanglah Denpasar dengan keluhan utama bisul pada area bawah lutut kiri sejak 6 bulan yang lalu. Awalnya berupa bintil kemerahan lalu menjadi benjolan yang tidak nyeri. Benjolan pecah dan mengeluarkan nanah. Pasien memiliki hobi berkebun. Pemeriksaan fisik dalam batas normal. Status dermatologi pada regio kruris sinistra terdapat nodul eritema soliter, batas tegas, bentuk bulat, diameter 2,5 cm, permukaan halus dan mengkilap, tampak fluktuasi berupa pus kekuningan. Pemeriksaan kultur sabouraud dextrose agar (SDA) didapatkan pertumbuhan Cladophialophora carrionii. Diagnosis kerja adalah kromoblastomikosis. Pasien diterapi dengan itrakonazol 400 mg setiap 24 jam intraoral dosis denyut dan terdapat perbaikan klinis pada lesi. Simpulan: Telah dilaporkan kasus kromoblastomikosis yang awalnya diduga furunkel pada seorang perempuan usia 24 tahun. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pasien diberikan terapi itrakonazol dosis denyut dan tampak perbaikan klinis yang signifikan pada lesi. Prognosis pada pasien dubius ad bonam. Pengamatan lanjutan masih perlu dilakukan untuk mengamati kesembuhan secara klinis maupun mikologi, efek samping terapi, dan komplikasi penyakit.

Description of hydrocephalus knowledge in pregnant woman at Puskesmas 1 Denpasar Utara Made Indra Erlangga Prathiwindya; I Wayan Niryana; Tjokorda Gde Bagus Mahadewa; Sri Maliawan
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Hydrocephalus is a pathological brain disorder resulting from increased cerebrospinal fluid without or with elevated intracranial pressure resulting in widening of the space where cerebrospinal fluid flows. Maternal environment such as experiencing infection during pregnancy, consuming alcohol and drugs, lifestyle such as obesity, diabetes, or hypertension, and lack of examinations in preparing for prenatal care and low socioeconomic status affect the risk factors for congenital hydrocephalus. The purpose of this study is to to determine awareness and knowledge level among pregnant women towards hydrocephalus. Methods: This descriptive research was conducted with a cross-sectional method using consecutive sampling as a sampling technique. 106 Pregnant Women at Puskesmas I Denpasar Utara was involved in completing the survey regarding Hydrocephalus during this research. For the collecting data using a questionnaire filled directly by each respondent containing 9 questions and then analyzed using the software Statistical Package for the Social Sciences (SPSS). Results: This study was participated by 106 respondents and figured that approximately 84,9% among the total number of respondents have a good knowledge of hydrocephalus while the rest, 15,1% are still at a low level with common characteristics of the respondents, including the age of 24 years old (age group 19-25), multipara (59.4%), with a college education background (45.3%), and working as a housewife (59.4%). Conclusion: This study conveys good knowledge about hydrocephalus in pregnant women, especially those who have a good level of education.

Penetrating ocular injury due to fish hook accident: A case report Nyoman Tarita Dewi; Putu Rima Adilitha Widyasari; Fazella Kirara Sakti; Ida Ayu Putri Kartiningsih
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Introduction: Open globe trauma is caused by sharp objects (lacerations) or blunt objects (ruptures). Lacerations can be divided into three parts: penetrating wound, intraocular foreign body (IOFB), and perforating wounds. One of the ocular laceration trauma that needs to be aware of is the penetration of fishing hooks. There are two important aspects of injuries due to fishing hooks: intraocular foreign bodies and infections.Case description: The patient of a 4-year-old girl with a chief complaint left eye was exposed to a fishing hook approximately 3 hours before coming to the hospital. Ophthalmological examination was obtained visual acuity on the right eye fixes and follow the object. Examination of the anterior segment of the right eye was found corneal edema, penetrating injury due to fish hook direction at nine o'clock. The fish hook was stick on the entire thickness of the cornea. Then we also found iris trauma and opacity in the lens. The patient was diagnosed with traumatic cataracts with ocular iridolysis dextra. Initial therapy is tobroson eye drop 1 drop every 3 hours, cefadroxil syrup three times a day, and methylprednisolone 3x1/2 tablets. The patient was advised to undergo surgery.Conclusion: Initial management should be quick and careful to aggravate the trauma. Adequate eye protection and supervision are necessary to prevent fishing hook trauma, especially children.

Staphylococcal scalded skin syndrome pada bayi: laporan kasus Alberto Afrian; Florencia Christina Sindhu; Peter Prayogo Hsieh; Felicia Emiliana Hosea; Anak Agung Made Sucipta; Tjokorda Dalem Pemayun
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Under-five populations are at higher risk of Staphylococcal Scalded Skin Syndrome (SSSS). The incidence of SSSS in developing countries is still a concern because the staphylococcal infection rate is high. This report aims to describe the clinical profiles of SSSS in infants below 1-year-old. Case: 7 month-old baby boy came with a chief complaint of skin blister for 7 days. It had been preceded by erythema on the right axilla, which turned into blisters on both axilla, perioral, trunk region, and both extremities the following day. The complaint was accompanied by fever. Five days before, he had experienced the common cold. On examinations, he was alert, weighed 9.1 kg, with a heart rate of 134 beats/minute, respiratory rate 40 times/minute, SpO2 98%, and axillary temperature 37.8oC. There were crusts and blisters on the face and trunk with positive Nikolsky’s sign. Genital and lower extremities looked erythematous. Laboratory results showed leukocytes 19,240/uL, neutrophil 50.7%, lymphocytes 35.2%, hemoglobin 9.9 g/dL, hematocrit 30.2%, and platelet 679,000 /uL. He was diagnosed with SSSS and was suggested for hospitalization. He received maintenance fluid therapy with D5%:¼NS 100 ml/kg/day, Cefotaxime injection 3 x 35 mg/kg, Paracetamol syrup 3 x 10 mg/kg, Fusidic Acid 2% cream twice a day, Gentamicin eye ointment 0.3% twice a day, and non-adherent dressing twice a day. He was discharged in good condition after 5 days of hospitalization. Conclusion: The knowledge about the clinical profiles of SSSS is important in order to give rapid management and reduce mortality. Latar Belakang: Populasi di bawah usia 5 tahun rentan mengalami Staphylococcal scalded skin syndrome (SSSS). Di negara-negara berkembang, insidens SSSS masih tinggi karena infeksi staphylococcus masih banyak terjadi. Laporan kasus ini ditulis untuk memberi gambaran mengenai SSSS pada bayi berusia di bawah 1 tahun. Kasus: Bayi laki-laki berusia 7 bulan dibawa dengan keluhan utama kulit melepuh sejak 7 hari sebelumnya. Keluhan didahului kemerahan di ketiak kanan dan keesokan harinya, kulit di ketiak kanan, kiri, dan daerah sekitar bibir, dada, perut, kemaluan, serta kedua tungkai melepuh. Dua hari kemudian, kulit di seluruh tubuh mengelupas. Keluhan disertai dengan demam. Lima hari sebelumnya, pasien mengalami pilek. Pada pemeriksaan, pasien sadar dengan berat badan 9,1 kg, denyut nadi 134 kali/menit, laju pernafasan 40 kali/menit, SpO2 98%, dan suhu aksila 37,8oC. Kulit tampak melepuh disertai krusta pada wajah, dada, abdomen,dan punggung. Tanda Nikolsky positif. Daerah ekstremitas bawah dan genital tampak kemerahan. Pemeriksaan darah menunjukkan leukosit 19.240/uL, neutrofil 50,7%, limfosit 35,2%, hemoglobin 9,9 g/dL, hematokrit 30,2%, dan trombosit 679.000 /uL. Dokter mendiagnosis pasien mengalami SSSS dan menyarankan rawat inap. Pasien menerima terapi cairan rumatan dengan D5%:¼NS 100 ml/kg/hari, Cefotaxime injeksi 3 x 35 mg/kg, Parasetamol sirup 3 x 10 mg/kg, krim Asam Fusidat 2% 2 kali/hari, salep mata Gentamisin 0,3% 2 kali/hari, dan perawatan luka 2 kali/hari. Setelah dirawat selama 5 hari, pasien sembuh dan diizinkan pulang. Simpulan: Pengetahuan mengenai gambaran klinis SSSS penting untuk memberi tatalaksana yang cepat dan tepat sehingga mortalitas dapat ditekan.

Persistent secondary spontaneous pneumothorax as a complication of tuberculosis infection: a case report Ni Made Lintya Andani; Putu Diah Savitri
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Introduction: A pneumothorax is a collection of air outside the lung contained within the pleural cavity. Primary spontaneous pneumothorax (PSP) and secondary spontaneous pneumothorax (SSP) are two types of spontaneous pneumothorax that differ due to the underlying illness. If the patient has a history of pulmonary disease, including tuberculosis infection, SSP may be present. Chest X-rays, chest ultrasonography, and CT scans are imaging tests that can be used to diagnose pneumothorax. We report a case of a 20-year-old man with persistent secondary spontaneous pneumothorax as a complication of tuberculosis infection.Case description: A 20-year-old man complained of shortness of breath two weeks before being admitted to the hospital. He had a story of a TB infection. A chest X-ray and a CT scan were used to assess the patient. The pneumothorax is seen with the sign of reactive old tuberculosis. The surgeon inserted a chest tube drainage to empty the pneumothorax. However, following the assessment, the pneumothorax grew even larger than before.Conclusion: Clinical evaluation should probably be the key determinant of the care strategy and assist with the initial diagnosis. Imaging modalities can help confirm a pneumothorax diagnosis and provide information about the extent of the pneumothorax.

Karakteristik anak dengan infeksi dengue di RSUP Sanglah, Denpasar, Bali Niluh Putu Wida Pangestika; I Wayan Gustawan; I Made Gede Dwi Lingga Utama
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Dengue infection is a global health problem. The incidence of this disease in children has tended to increase in the last three decades. The World Health Organization (WHO) noted that Indonesia has the highest dengue infection cases in Southeast Asia. Objective: To find the characteristics of children with dengue infection in Sanglah General Hospital, Denpasar, Bali Methods: This research is a retrospective cross-sectional study of pediatric patients aged 1-18 years with dengue infection treated at Sanglah Hospital, Denpasar City, from August 2017 until July 2021 using frame sampling. The collected data was analyzed statistically using SPSS for Windows version 23.0. Results: In this study, 137 children with dengue infection were treated at Sanglah Hospital. The median age of the subjects was 9 years (range 1-18 years), with the highest number in the 5-to-9-year age group (33.5%). 61.3% male and 38.7% female. The average length of stay of the subjects was 4 days. 79.6% of the subjects live in urban areas. The degree of infection in the study subjects was dengue fever 35.8%, dengue hemorrhagic fever grade I 19%, dengue hemorrhagic fever grade II 14,6%, dengue hemorrhagic fever grade III 19%, and dengue hemorrhagic fever grade IV 11.7%. Based on the outcome of the research subjects, 98.5% of the subjects had good outcomes. Conclusion: Children with dengue infection are mostly found in school-age children with male sex, living in urban areas, with an average length of stay of 4 days and a good outcome. Latar belakang: Infeksi dengue masih merupakan masalah kesehatan dunia. Angka kejadian penyakit ini pada anak cenderung meningkat dalam tiga dekade terakhir. World Health Organization (WHO) mencatat negara Indonesia sebagai negara dengan kasus infeksi dengue tertinggi di Asia Tenggara. Penelitian ini bertujuan mengetahui karakteristik anak dengan infeksi dengue di RSUP Sanglah, Denpasar, Bali Metode: Penelitian ini dilakukan menggunakan rancangan penelitian retrospektif dengan desain potong lintang yang dilakukan di RSUP Sanglah, Denpasar, Bali pada bulan Juli 2021. Penelitian ini menggunakan data register pasien anak usía 1-18 tahun dengan infeksi dengue yang dirawat di RSUP Sanglah, di Kota Denpasar pada Agustus 2017 sampai Juli 2021. Pengambilan sampel dilakukan dengan cara frame sampling. Data yang terkumpul kemudian dianalisis secara statistik menggunakan SPSS for Windows versi 23.0. Hasil: Pada penelitian ini, terdapat 137 anak dengan infeksi dengue yang berobat di RSUP Sanglah yang dijadikan sampel penelitian. Median usia subjek didapatkan 9 tahun (rentang 1-18 tahun), dengan jumlah terbanyak pada kelompok usia 5-9 tahun (33,5%). Jenis kelamin laki-laki 61,3% dan perempuan 38,7%. Rerata lama rawat subjek adalah 4 hari. 79,6% subjek tinggal di daerah urban. Derajat infeksi pada subjek penelitian adalah demam dengue 35,8%, demam berdarah dengue derajat I 19%, demam berdarah dengue derajat II 14,6%, demam berdarah dengue derajat III 19%, dan demam berdarah dengue derajat IV 11,7%. Berdasarkan luaran subjek penelitian didapatkan 98,5% subjek dengan luaran baik. Simpulan: Anak dengan infeksi dengue banyak didapatkan pada anak usia sekolah, dengan jenis kelamin laki-laki, tinggal didaerah urban, dengan rerata lama rawat inap 4 hari dan luaran yang baik.

Penanganan inversio uteri: sebuah tinjauan pustaka Endang Sri Widiyanti; I Gede Mega Putra
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Acute uterine inversion is a rare but life-threatening emergency in the field of obstetrics. The main signs and symptoms of acute uterine inversion are bleeding and shock. The accuracy and speed of diagnosis and case management will reduce morbidity and mortality due to uterine inversion. This literature review is expected to increase our knowledge as practitioners in dealing with uterine inversion cases. In principle, there are two goals for the treatment of acute uterine inversion, namely repositioning the uterus and treating the shock that occurs. The success of uterine inversion repositioning is highly dependent on the speed of early detection. The longer the uterus is inverted, the more difficult it will be to reposition it. There are several non-surgical techniques for repositioning the uterus, including: Johnson maneuver, Henderson and Alles maneuver, use of tocolytics, and repositioning with hydrostatic pressure. Surgical procedures can be performed abdominally, namely the Huntington's Procedure, with abdominal repositioning laparotomy and the Haultain's Procedure, with abdominal cervical repositioning-repositioning laparotomy. Kejadian inversio uteri akut merupakan kegawatdaruratan di bidang Obstetri yang jarang terjadi namun mengancam nyawa. Tanda dan gejala utama inversio uteri akut adalah perdarahan dan syok. Ketepatan dan kecepatan diagnosa dan penanganan kasus akan mengurangi morbiditas dan mortalitas akibat inversio uteri. Tinjauan pustaka ini diharapkan dapat menambah pengetahuan kita sebagai praktisi dalam menangani kasus inversio uteri. Pada prinsipnya ada dua tujuan penanganan inversio uteri akut, yaitu reposisi uterus dan penanganan syok yang terjadi. Keberhasilan reposisi inversio uteri sangat tergantung pada kecepatan deteksi dini. Semakin lama uterus terinversi akan semakin sulit melakukan reposisi. Terdapat beberapa teknik non-bedah untuk reposisi inversio uteri, antara lain: manuver Johnson, manuver Henderson dan Alles, penggunaan tokolitik, dan reposisi dengan tekanan hidrostatik. Prosedur pembedahan dapat dilakukan melalui abdominal, yaitu Prosedur Huntington, dengan laparotomi-reposisi melalui abdominal dan Prosedur Haultain, dengan laparotomi- insisi cincin servikalis-reposisi melalui abdominal.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

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Editorial Address -

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

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Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA