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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Prevalensi Depresi pada Mahasiswa Semester 7 di Fakultas Kedokteran Universitas Udayana tahun 2014 Gythrie Karthikason; Lely Setyawati
Intisari Sains Medis Vol. 8 No. 2 (2017): (Available online: 1 August 2017)
Publisher : DiscoverSys Inc.

Latar Belakang: Depresi adalah kata yang umum digunakan, sering digunakan oleh orang-orang untuk menggambarkan perasaan tertentu, merasa rendah atau tidak bahagia. Depresi sering digunakan untuk menggambarkan perasaan tertentu, perasaan pada hari tertentu, atau perasaan tentang situasi atau keadaan tertentu. Dalam kebanyakan kasus, perasaan ini muncul dengan sendirinya setelah waktu yang singkat, atau mengikuti perubahan Â lingkungan. Studi di kalangan mahasiswa kedokteran di US didapati 23% nmengalami depresi dan 57% dibawah stress psikologis. Kegagalan untuk mendeteksi gangguan ini menyebabkan peningkatan morbiditas psikologis dengan efek yang tidak diinginkan di sepanjang perjalanan Â karier dan kehidupan mereka. Metode: merupakan studi deskriptif. Sebanyak 50 sampel dipilih dari mahasiswa semester 7 Fakultas Kedokteran Universitas Udayana. Hasil: Terdapat masalah depresi di kalangan mahasiswa kedokteran. 62% menderita depresi ringan dan 38% menderita depresi sedang. Simpulan: Sebagian besar mahasiswa kedokteran Universitas Udayana yang menderita depresi. Diharapkan pihak universitas bekerja sama dengan lembaga-lembaga kesehatan Â untuk memberikan informasi yang lengkap dan berguna pada manajemen stres.

Ekstrak daun meniran (Phyllanthus niruri. L) memperbaiki kerusakan sel-Î² pankreas dan menurunkan kadar gula darah tikus wistar hiperglikemia diinduksi aloksan Sri Wahjuni
Intisari Sains Medis Vol. 8 No. 2 (2017): (Available online: 1 August 2017)
Publisher : DiscoverSys Inc.

Increased production of reactive oxygen species (ROS) is probably one of cause the present of hyperglycemia. This study aims to investigate the effectiveness of Phyllanthusniruri L leaves extract to repair pancreatic b-cells and decrease of blood glucose levels on hyperglycemia wistar rat aloxan induced.This is a true experimental employing pre and posttest control group design. Experimental was started by generating hyperglycemia of the 32 rats using aloxan. Then, the rats were divided into two groups, i.e. control group (C) and treatment group (T). Treatment group was fed with 5,0 mg/Kg bw/d phyllanthus niruri L extract. Â Repaired of pancreatic b-cells for these two groups were compared descriptively using immunohysto-chemistry. In addition blood glucose levels between these two groups were compared statistically using t-test.The results indicate that there was a different between pancreatic b-cells in these two groups. In addition there were also a significant different between blood glucose levels in these two groups, i.e. for control group were 217.46Â±23.38 mg/dL (pretest) and 206.17Â±22.16 mg/dL (posttest) compared to 217.49Â±23.33 mg/dL (pretest) and Â 117.93Â±21.23 mg/dL (posttest) for treatment group. It can be concluded that Phyllanthusniruri L leaves extract in a dose of 5.0 mg/kg bw/d effective to repair pancreatic b-cells disability and also for decreasing blood glucose levels on hyperglycemic wistar rats. This is probably due to the antioxidant and anti inflammation activity of this leaf.Â

Gambaran tingkat pengetahuan dan perilaku tentang pemeriksaan payudara sendiri (SADARI) pada remaja putri di wilayah kerja UPT Puskesmas Blahbatuh II Gianyar Bali Indonesia Karen Singam; I B Wirakusuma
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Worldwide, breast cancer is amongst the leading cause of morbidity and mortality in women. Â Early detection and diagnosis is key in acquiring a better prognosis and can be achieved through self breast examination (SADARI). This was a cross sectional descriptive study. A senior high school was chosen at random to select samples from and that is SMA PGRI Blahbatuh and 50 samples were chosen at random. The instrument used to conduct this study was a questioner that was adapted from a few different questioners of the same nature. From the collected data, there were 0% teenage girls at the work territory of UPT Kesmas Blahbatuh II that has good knowledge about breast cancer and self breast examination. The majority has lesser (88%) knowledge and (98%) practice about self breast examination (SADARI). Also, there is a possibility for 100% of teenage girls that have inadequate SADARI knowledge to have inadequate SADARI practice. Teenage girls at the age â‰¤16 years old have 89.7% of inadequate SADARI knowledge and 96.6% have the possibility to have inadequate SADARI practice. Because of the low and inadequate knowledge and practice in regards to SADARI, it is hoped that the Puskemas provide enlightment and awareness towards breast cancer and self breast examination (SADARI) for teenage girls and women in the working district of the health centre.Â

Gambaran perilaku masyarakat dalam pemberantasan sarang nyamuk demam berdarah dengue (PSN DBD) dan kemampuan mengamati jentik di wilayah kerja Puskesmas Banjarangkan II Rubagan Chelvam; I Gede Ngurah Indraguna Pinatih
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus infection which transmitted through Aedes aegypti mosquito bite and still a public health problem in tropical or subtropical areas worldwide.Â One of the efforts which are considered appropriate in the prevention and eradication of DHF through cut the chain of transmission and controlling the vectors by eradication of mosquito nest caused Dengue Hemorrhagic Fever (PSN DBD). This study used cross sectional design in Puskesmas Banjarangkan II to describe the peopleâ€™s behavior in eradicating mosquito nest caused DHF. Minimum sample size is 35 people which cover 6 villages and 26 hamlets (banjar)/environments in it. The results showed respondents who have poor PSN DBD behavior aound 57.1% and good around 42.9%. Based on the ability to monitor larvaes, respondents who have poor capabilities to observing it around 62.9% whereas who having good capabilitiesapproximately 31.1%. Accordingly, it can be concluded most of the people who included within the scope of Puskesmas banjarangkan II have poor PSN DBD capabilities as well as observing larvae so that it is necessary to do some attempts to overcome it.Â

Faktor resiko terjadi infestasi kutu pada anak-anak di panti asuhan Haritharan Ganesan; Putu Ayu Asri Damayanti
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Infestation with lice is most common among preschool- and elementary school-age children and their household members and caretakers hence becoming an increasing problem in orphanage because of the poor hygiene and knowledge of children on lice. This study explores about the risk factor of knowledge, social risk and personal risk among the students who are living in the orphanage. Study design chosen for this research is descriptive study with 98 student from two orphanages home as respondents. Questionnaires were given to answer to all the 98 respondents. The questionnaire were subdivided into three section to determine the respondentâ€™s knowledge, social and personal risk. Later on the risk factors were evaluated according to the score and categorized into categories to determine the risk level. Among all the 98 respondents it is known most of the students have adequate knowledge about lice and infestation of lice shows that the students knows about lice, and average risk in social history which shows there is a chance of infestation from this risk factor because of the close living conditions, it was also show that the students have good personal history which shows that the responders have good personal behavior and hygiene, the risk factors was also researched using the difference between the orphanages and the age of the responder for a better understand of the risk factor. Thus, it is concluded that lice infestation risk in the orphanage is low considered as the students have adequate knowledge, social and personal risk. The results of this research could be applied as an analytical studies for further research in lice infestation.

Skor kualitas hidup dermatologi berkorelasi positif dengan Melasma Area And Severity Index IGAA Praharsini; Nyoman Suryawati; Hasri Dewi
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Melasma adalah gangguan hiperpigmentasi yang terjadi pada kulit di daerah paparan sinar matahari. Kondisi ini seringkali memberikan dampak yang besar akibat lesi wajah yang sangat jelas dan dapat mempengaruhiÂ kualitas hidup pasienÂ seperti: menurunnya fungsi sosial, produktivitas serta hilangnya rasa percaya diri. Penelitian cross sectional bertujuan membuktikan adanya pengaruh melasma terhadap kualitas hidup dengan menggunakan nilaiÂ Melasma Area and Severity Index (MASI)Â Â yang dihubungkan dengan skor kualitas hidup dermatologi. Empat puluh enam orang sampelÂ pasien melasmaÂ Â yang memenuhi kriteria eksklusi dan inklusi diikutsertakan dalam penelitian, yang diperoleh dari pasien rawat jalanÂ poli kulit dan kelamin RSUP SanglahÂ periodeÂ Agustusâ€“Desember 2016. Sampel diambil secaraÂ Â consecutive sampling. Selanjutnya dilakukan penilaian derajat keparahan melasma dengan skor MASI dan pengisian kuisioner kualitas hidup dermatologi . Data terkumpulÂ dianalisis dengan SPSS 20 dengan uji korelasiÂ Spearman-rho. Subyek penelitian terdiri dari 42 perempuan dan 4 laki-laki, dengan rata-rata umur 43.9Â± 6.2. Melasma yang berdistribusi sentrofasial dan tipe melasma campuran mendominasi karakteristik subyek penelitian. Pada penelitian ini didapatkan adanya korelasi positifÂ kuat antara skor kualitas hidup dermatologi dengan nilai MASI (r = 0.856; p < 0.05). Melasma memberi efek yang besar pada kualitas hidup pasien melasma.

Mekanisme repigmentasi dan peran melanocyte stem cell folikel rambut pada vitiligo IGAA Praharsini; Nyoman Suryawati
Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018)
Publisher : DiscoverSys Inc.

Vitiligo merupakan kelainan pigmen yang karakteristik dengan adanya destruksi progresifmelanosit matur di epidermis akibat respon autoimun. Terapi vitiligo bertujuan memulihkanpigmentasi yaitu mengganti melanosit yang rusak dengan melanosit yang baru yang berasal darimelanocyte Stem Cell unit folikel rambut. Melanosit folikel rambut ini berperan penting dalamrepigmentasi lesi vitiligo. Pola repigmentasi pada vitiligo meliputi repigmentasi perifolikuler,repigmentasi difus, repigmentasi marginal, kombinasi, dan medium spottled. Mekanisme repigmentasimelalui melanosit berasal dari tepi lesi vitiligo, bulge, selubung akar luar rambut dan dermal sertaepidermal precursors melanocyte yang persisten terletak di tengah lesi vitiligo, yang bermigrasisecara sentrifugal sehingga menyebabkan pigmentasi difus. Proliferasi dan diferensiasi melanosit inijuga tergantung pada growth factor, gen, faktor transkripsi dan jalur signaling pada prosesmelanogenesis. Seiring dengan perkembangan biologi molekuler, penelitian-penelitian saat iniberfokus pada Melanocyte Stem Cell folikel rambut dan terus dikembangkan sebagai terapi vitiligodi masa depan.

Korelasi antara kadar testosteron total dengan trans epidermal water loss (TEWL) pada pria late onset hypogonadism Daniel Widiyanto; Reny Iâ€™tishom
Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018)
Publisher : DiscoverSys Inc.

Background: Late Onset Hypogonadism (LOH) is a clinical and biochemical condition in the elderly with testosterone levels below the reference value of young and healthy men, accompanied by symptoms of testosterone deficiency. Increased age or aging process is one of the factors causing sebaceous gland function decreased both regarding quantity and regarding quality associated with the function of lipid barrier. Decreased sebum gland function can be seen from several parameters, one of which is the increase of Trans Epidermal Water Loss (TEWL). Methods: This study was an observational analytic study with cross-sectional design to determine the relationship between total testosterone and TEWL in LOH men. This research was conducted in Outpatient Unit Andrology of dr. Soetomo from May 2017 to July 2017. 16 samples of elderly male patients (â‰¥60 years) were selected using the consecutive sampling technique who met the inclusion and exclusion criteria. Performed total testosterone test and TEWL level examination by using Tewameter to the research sample. Interpretation of results adjusted to Research and Development Department, Courage & Khazaka Electronics GmbH, Koln, Germany. Results: The Total testosterone levels of the patient were ranged from 146.11 - 575.10 ng/dL with a mean of 351.67 ng/dL and standard deviation of 116.34. The TEWL level of the patients was ranged from 17.2 - 50.8 g/jam/m2 with a mean of 31 g/jam/m2 and standard deviation of 9.20. The correlation coefficient value between total testosterone and TEWL was -0.853 with a significance of 0.0001 (p <0.05). Conclusion: There was a significant relationship between total testosterone and TEWL. The association of total testosterone with TEWL is unidirectional. The lower the testosterone level, the higher the TEWL value.

Profil pasien baru HIV di poliklinik VCT BRSU Tabanan Bali pada tahun 2009 sampai 2017 R Prawira Bayu; I Gusti Ngurah Made Budiana Indrawan; Ni Nengah Sukarni; Made Edwin Sridana
Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018)
Publisher : DiscoverSys Inc.

Background: HIV infection is a disease that currently becomes a global problem. Bali is one of the provinces in Indonesia with very high HIV infection new case. Badan Rumah Sakit Umum (BRSU) Tabanan is one of the leading hospitals in Tabanan. Based on data in Voluntary Counseling and Testing (VCT) clinic in BRSU Tabanan, new diagnosed HIV patients are increasing from year to year, so research about new diagnosed HIV patient profile is needed. This research is a descriptive research. Methods: The research design used in this study is cross-sectional study. Population and sample in this study were all newly diagnosed patients with HIV infection in BRSU Tabanan VCT clinic from 2009 to 2017 with a total of 872 people were obtained by total sampling. Secondary data were then processed statistically using statistical software. Results: From this research obtained that new case is the most in the year 2016 (18,5%). With the most patient in age 30 â€“ 39 years old age group (34,9%), male (60.1%), still in employment (22.4%), still living (93.9%), and predicted risk factor heterosexual (93,7%). When the sample is diagnosed HIV most of the patient in stadium 3 (53,6%), with the most clinical sign is weight loss more than 10% in one month (50,2%), and opportunistic infection Candidiasis (55.6%). Conclusions: In an attempt to reduce spreading of HIV, education about transmitted sexual disease and reproduction health are important, especially in high-risk groups.Â

Hubungan pola jajan kariogenik dengan karies pada siswa sekolah dasar di wilayah kerja Puskesmas III Denpasar Selatan, Bali 2016 Ni Made Sirat; Asip Arifin Senjaya; I Nyoman Wirata
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Karies gigi merupakan salah satu penyakit gigi dan mulut yang paling sering dijumpai di masyarakat. Karies gigi erat hubungannya dengan konsumsi makanan yang kariogenik. Pola jajan terdiri dari jenis dan frekuensi konsumsi makanan. Anak-anak memiliki kegemaran untuk mengkonsumsi jenis makanan jajanan manis secara berlebihan, khususnya anak-anak usia sekolah dasar (6-12 tahun). Tujuan penelitian yaitu untuk menganalisis hubungan pola jajan kariogenikÂ dengan karies pada siswa sekolah dasar di wilayah kerja Puskesmas III Denpasar Selatan Tahun 2016. Desain penelitian observasional dengan pendekatan cross sectional. Sampel diambil dengan teknik simple random sampling yang berjumlah 550 responden. Analisis data menggunakan uji Chi Square. Hasil penelitian diperoleh 363 orang kariogenik (66%) dan tidak kariogenik 187 orang (34%), Rerata pola jajan kariogenik sebesar 1,93 Â± 3,02 jajan setiap hari, 369 orang karies (67,1%) dan 181 orang tidak karies (32,9%) serta Rerata karies gigi sebesar 3,20 Â± 3,45 karies. Kesimpulan yaitu terdapat hubungan antara konsumsi makanan kariogenik dengan karies gigi dengan p = 0,000. Diharapkan pihak sekolah mengetahui dampak dari konsumsi makanan kariogenik dan mengurangi penjualan makanan yang bersifat kariogenik di area sekolah

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