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JCPS (Journal of Current Pharmaceutical Sciences)
Published by Universitas Muhammadiyah Banjarmasin
ISSN : 25982087     EISSN : 25982095     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Current Pharmaceutical Sciences is a scholarly journal and expects to Publish articles related to the science of pharmaceutical science became the main focus of the problem at this time. This journal may publish research results as well as the results of theoretical studies and reviews. JCPS has had an ISSN print version 2598-2087 and has an online version 2598-2095 since Vo. 1 No.1 year 2017.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol. 9 No. 1: March 2025" : 6 Documents clear
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Jambu Biji (Psidium Guajava L.) Terhadap Shigella dysenteriae ATCC 13313 Irma Tia Trinanda; Dani Prasetyo; Desti Kameliani
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1151

Abstract

Bloody diarrhea, also known as bacterial dysentery, is caused by Shigella dysenteriae bacteria. One potential treatment fot dysentery involves the use of guava leaves (Psidium guajava L.). The aim of this study was to determine the secondary metabolite compounds contained in the ethanol extract of guava leaves and to evaluate its antibacterial activity against Shigella dysenteriae ATCC 13313. The secondary metabolite compounds were identified through phytochemical screening by observing color changes after mixing the ethanol extract of guava leaves with specific reagents. The antibacterial activity was tested using the paper disc diffusion method with extract concentrations of 10%, 25%, and 40%. Antibacterial activity was indicated by the formation of a clear inhibitor zone around the paper discs. The results showed that guava leaf extract contains secondary metabolites such as flavonoids, saponins, tannins and alkaloids, which contribute to bacterial growth inhibition. The antibacterial activity of the extract showed that the 40% extract concentration exhibited the largest inhibition zone (15,33 mm), which is categorized as strong antibacterial activity.
Analisis Perbandingan Kadar Senyawa Tanin pada Buah Kakao (Theobroma cacao L.) Muda dan Matang dengan Menggunakan Metode Spektrofotometri UV-Vis Anita Agustina Styawan; Rita Nurjanah
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1232

Abstract

Cocoa pods (Theobroma cacao L.) contain various bioactive compounds that have significant benefits for human health. One of the main components found in cocoa pods is tannin which has antioxidant, antibacterial, and antimicrobial properties. This study aims to determine and compare the tannin content of young and mature cocoa pods using the UV-Vis spectrophotometric method. This research was conducted using an observational approach. Samples of young and mature cocoa pods were collected from cocoa plantations in Nglanggeran, Patuk, Gunung Kidul. Tannins were extracted using maceration method with 70% ethanol solvent. Quantitative analysis was performed using UV-Vis spectrophotometry at a wavelength of 750.0 nm, resulting in an absorbance value of 0.877. The standard curve for gallic acid was made with the equation y = 0.0094x + 0.0299 and the coefficient of determination (R²) of 0.998. The results showed that the average tannin content of young cocoa pods was 7.696 mg/kg, while that of ripe cocoa pods was 3.810 mg/kg. Statistical analysis using Independent T-Test showed a p-value of 0.000 (p < 0.05), indicating a significant difference in tannin content between young and mature cocoa pods. This study confirms that tannin concentration decreases as cocoa pods mature, indicating the potential of young cocoa pods as a richer source of bioactive compounds.
Aktivitas Ekstrak Kunyit Hitam (Curcuma caesia) Terhadap Penyembuh Luka Sayat Pada Model Hewan Diabetes yang Diinduksi Aloksan Bellatry Maharani; Inaratul Rizkhy Hanifah; Tri Wijayanti
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1247

Abstract

Black turmeric (Curcuma caesia) influences the wound healing process in male white Wistar rats suffering from diabetes with a focus on the anti-inflammatory content it contains. This study aimed to determine the activity of varying concentrations of black turmeric extract (Curcuma caesia) in healing diabetic wounds in a male white rat model involving 6 treatment groups, namely the no treatment group, the positive control group (bioplacenton gel), the negative control group (Na-CMC), groups varying the dose of black turmeric extract, namely 10%, 15%, 20%. The incision is applied and then smeared with the test preparation for up to 14 days in the morning and evening. Wound healing is measured by monitoring healing time and reduction in wound size. Data were analyzed statistically using the One Way ANOVA method. The study results showed that black turmeric extract could heal diabetic wounds in male white rats with an increase in the concentration of black turmeric, namely black turmeric extract containing 20%.
Pengaruh Kombinasi Polimer HPMC dan PVP terhadap Sifat Fisik Sediaan Patch Ekstrak Pelepah Pisang Ambon (Musa paradisiaca var.sapientum L.) Yetti Hariningsih; Indri Dwi Rahasasti; Syamsul Ma’arif; Haqoiroh; Kiki Puspitasary
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1258

Abstract

The banana plant is one of the traditional plants often used for wound healing. In this study, the sheath of Ambon banana (Musa paradisiaca var. sapientum L.) was used as the active ingredient. The extract of Ambon banana sheath contains secondary metabolite compounds such as flavonoids, saponins, and tannins, which play a role in the wound healing process. The formulation was made in the form of a patch to enhance the effectiveness of active ingredient delivery. This study aims to determine the best patch formulation and analyze the effect of varying concentrations of HPMC and PVP on its physical properties. The patch was prepared using the solvent casting method with three polymer combinations, F1: 2% HPMC and 1% PVP, F2: 1.5% HPMC and 1.5% PVP, F3: 1% HPMC and 2% PVP. The evaluation data were analyzed experimentally and statistically using a one-way ANOVA test. The results showed that the most optimal formula was F1, as it met all the patch testing requirements with the following evaluation data (average ± standard deviation), Weight uniformity 1.1±0.083 (CV<5%), patch thickness: 0.04±0.012 mm (<1 mm),  Folding endurance: 324±6.51 (>300 folds), pH: 5.6±0.025 (range 4.6–8), Moisture absorption: 5.1%±0.182 (<10%). Based on the physical stability test, the results showed that the pH test and weight uniformity had a significance value of ρ > 0.05, indicating no significant differences in each test cycle. Meanwhile, the folding endurance stability test (>300 folds) had a significance value of ρ < 0.05, indicating a significant difference in each test cycle
Analisis Natrium Siklamat Pada Minuman Sirup Varian Rasa Di Wilayah Kecamatan Kertak Hanyar M. Awaluddin Padjrin; Najwi Hasani; Daipadli
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1257

Abstract

The addition of sodium cyclamate is commonly found in flavored syrup beverages in Indonesia and often exceeds BPOM’s limits. Excessive consumption over time may pose health risks. This study aims to detect sodium cyclamate, determine its concentration in flavored syrup beverages sold in Kertak Hanyar, and validate the analytical method used. Qualitative precipitation tests and quantitative UV-Vis spectrophotometry were employed. Four samples were analyzed, showing that three tested positive in the qualitative test, while all contained sodium cyclamate in the quantitative analysis, with concentrations ranging from 71.35 to 152.43 mg/kg. The discrepancy is likely due to the higher detection limit of the precipitation test, making it less sensitive to low concentrations. Method validation showed good performance, with an r-value of 0.9954, LOD and LOQ of 1.5405 mg/L and 5.1351 mg/L, RSD from 0 to 0.4773%, and recovery between 84.76% and 92.86%. The method met validation criteria, including linearity, detection capability, precision, and accuracy. In conclusion, sodium cyclamate levels in all samples were within BPOM’s safety limit of 250 mg/kg, ensuring their safety for consumption, while the analytical method was validated for determining sodium cyclamate using UV-Vis spectrophotometry.
Pengaruh Cycling Test Terhadap Mutu Fisik Sabun mandi Cair ekstrak Meniran Hijau (Phyllanthus Ninuri L) Nor Latifah; Raudatul Patimah; Kurnia
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1263

Abstract

The skin can be cleansed and treated using soap. The most common bacteria found on the skin is Staphylococcus aureus, which can cause various skin problems. A natural ingredient known for its antibacterial properties is green Phyllanthus niruri leaves. To facilitate its application, it is necessary to develop it into a stable liquid soap formulation in terms of physical quality. The aim of this study was to determine the physical stability of a liquid soap formulation containing ethanol extract of green Phyllanthus niruri leaves, both before and after undergoing a cycling test on the best formulation.This research began with the processing of simplicia and extraction, followed by the formulation of liquid soap using green Phyllanthus niruri leaf extract with variations in KOH concentrations (14%, 16%, and 18%). The liquid soap formulations were then evaluated until the best formula was selected and subjected to a cycling test. Among the three formulas tested, the best formulation based on physical characteristics was F2, which used 16% KOH concentration. This formula was subsequently subjected to a cycling test for six cycles. The cycling test included organoleptic examination, homogeneity, pH, viscosity, foam height, and foam stability. The conclusion of this research on cycling tests shows that the physical quality of the preparation in the best formula, namely F2 (16%), showed significant changes in physical quality which was stable for 6 cycles.

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