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Jurnal Farmasi Higea

higea
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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 9 Documents

Search results for , issue "Vol 1, No 1 (2009)" : 9 Documents clear

Pengaruh Cara Pengeringan dengan Microwave terhadap Perolehan Kadar Senyawa Fenolat dan Aktivitas Antioksidan dari Daun Dewa (Gynura pseudochina (Lour.), Merr.) Zet Rizal; Deswati Deswati; Harrizul Rivai
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The research about the effect of microwave drying methods on content of phenolic compounds and antioxidant activity of Gynura pseudochina,(Lour.) Merr. have been done. The determination of phenolic compounds was carried out according to Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method, calculated as gallic acid equivalent (GAE). The research showed that the highest phenolic compounds and the strongest antioxidant activity obtained by microwave drying method compared by air drying method. The phenolic compounds each gram sample by using microwave drying is 1.673 mg phenolic compounds and antioxidant activities were calculated as the IC50 at concentration 2.876 mg/mL.

Uji Aktivitas Antimikroba Ekstrak Metanol Daun Tabat Barito ( Ficus deltoidea Jack) Krisyanella Krisyanella; Meri Ardianti; Dachriyanus Dachriyanus
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

An antimicrobial activity studies from methanol extract of the leaves Tabat Barito (Ficus deltoidea Jack) to some bacterias and fungis with diffusion method and determination of Minimum Inhibitory Consentration (MIC) by using dilution method have been done. From antimicrobial activity test by using diffusion method show that methanol extract of the leaves Tabat Barito (Ficus deltoidea Jack) can inhibit the growth of bacterias and fungis. The MIC for staphylococcus aureus is 1%, for staphylococcus epidermis is 0.7%, for staphylococcus aeruginosa is 0.8%, and for eschericha coli is 0.7%.

Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat Rieke Azhar; Muslim Suardi; Salman Umar
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

Effects of polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersion systems have been studied. Solid dispersions were prepared by solvent method using several ratios of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9, 3:7, 5:5, 7:3, 9:1. Physical mixtures of ketoprofen-polyvinylpyrrolidone K-30 were used as a comparison. The solid dispersion systems and physical mixtures were evaluated for physicochemical properties and dissolution characteristics. Dissolution tests were measure with modified basket method using pH 7.2 phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15, 20, 30, 45, and 60 minutes. Results generally showed that solid dispersion system of ketoprofenpolyvinylpyrrolidone K-30 have a different physicochemical properties compared to physical mixtures and pure ketoprofen and exhibited better dissolution rate and dissolution efficiency of ketoprofen. Dissolution efficiency and dissolution rate constant of the solid dispersion system were 59.41%, and 1.66 mg/s, respectively.

Pengaruh Perebusan Terhadap Kadar Senyawa Fenolat Total dan Daya Antioksidan Dari Daun Kol (Brassica oleracea L. Var. capitata L.) Mardius Syarif; Mutiara Vani; Mahyuddin Mahyuddin
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

A determination of total phenolic compounds and antioxidant activity from cabbage leaves (Brassica olerace L var capitata L,) using spectrophotometry has been done. The determinan of total phenolic compounds was carried out according to Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Result of total phenolic compounds determinant showed that a fresh sample, sample boiled for 10 minutes, sample boiled for 20 minutes, sample boiled for 30 minutes were 363.395 μg/g, 44.198 μg/g, 39.510 μg/g, 33.156 μg/g while antioxidant activity at fresh sample were 60.55% in 0,1 g/mL fresh extract and for 10 minutes, sample boiled for 20 minutes, sample boiled for 30 minutes were 75.16%; 45.65%; 44.40%. Based on result of this research, concluded that treatment of boiling can reduce total phenolic compounds and antioxidant activity from cabbage leaves (Brassica olerace L. var capitata L,).

Efek Ekstrak Etanol Daun Cacao Theobroma Cacao L. terhadap Aktifitas Sistem Saraf Pusat Zet Rizal; Harto H.; Helmi Arifin
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The research about stimulant activity of the central nervous system from the ethanol extract of cacao leaves ( Theobroma cacao L.) to mice ( Mus musculus ) has been done. The observation of stimulant activity from the other doses gives to experiment of animal with oral. It does with rota – road tools, the motoric of activity test, automatichole board tools and the times of inductive sleep and the long time sleep by mice with 50 mg/Kg BB i.p doses. The finalty reseach knows that ethanol extract of cacao leaves with 250 and 500 mg/Kg BB doses characteristic stimulant. It looks that mount the power of venture, activity motoric, feel knows, the time of inductive sleep and the short time with experiment of animal if it compare with control group.

Pembuatan Emulsi Virgin Coconut Oil (VCO) Dengan Pulvis Gummi Arabici (PGA) Dan Uji Aktivitasnya Terhadap SGOT Dan SGPT pada Mencit Putih Nori Wirahmi; Sonia Yuwana; Salman Umar
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The research of the making of Virgin Coconut Oil emulsion with the Acasia and its activity test as a SGOT dan SGPT against white female mouse had been done. The liver damage was inducted using paracetamol doses 0.026 g/20g BB. The emulsion was made with dry gom method and evaluated in stability and VCO emulsion viscocity using a Viscometer Stomer. The parameter observed was the decreasing of SGOT and SGPT activities during giving 1, 3, 7 medicine. The result indicated that the emulsion VCO was stable using Acasia as emulsifying agent to 50°C during 6 hours and can be used as the decreasing SGOT and SGPT activities at observating on day 2, 4 and 8.

Uji Disolusi Beberapa Tablet Parasetamol yang Ada di Perdagangan Maria Dona Octavia; Resita Sandra; Auzal Halim
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The dissolution test four generic tablets and one branded name of parasetamol tablets has been undertaken. Method applied was in the paddle method as required by Pharmacopea of Indonesian ed. IV. Paracetamol concentration measured spectrophotometrically at maximum wave length of 243 nm in dissolution medium pH 5.8 phosphate buffer solution. The result dissolution test to comply with tolerance is not less than 80% of the labeled amount of paracetamol is dissolved in tweenty minutes. The dissolution about drown from the plot between percentage of paracetamol dissolved versus time.The percentage of paracetamol dissolved at T30 analyzed by using ANOVA test. Result showed in the dissolution rates between generic 1,2,3,4 and branded name were significant different take. Then continued to DUNNET test , only generic 2 tablets was not significantly difference whereas the other generic tablets were significant differences.

Pengaruh Cara Pengeringan terhadap Perolehan Kadar Senyawa Fenolat dan Aktivitas Antioksidan dari Daun Jambu Biji (Psidium guajava Linn.) Harrizul Rivai; Hasnah Hasnah; Mardius Syarif
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

A determination of phenolic compounds and antioxidant activity from Psidium guajava leaf by UV–Visible spectrophotometry has been done. The determination of phenolic compounds was carried out according to Folin-Ciocalteau method and antioxidant activity was evaluated by DPPH method, calculated as gallic acid equivalent (GAE). The determination of phenolic compound showed that the fresh sample , air drying, oven drying 40C and oven drying 60C contained 11.207; 4.129; 4.525 and 8.357 mg GAE/g Sample, IC50 of these sample were 0.218; 0.515; 0.50 and 0.315 mg/g, respectively.

Pengaruh Pemberian Kombinasi Kromium (III) Klorida dengan Vitamin C terhadap Kadar Kolesterol Darah Mencit Putih Nori Wirahmi; Novi Elliyana; Surya Dharma
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

Research about giving influence of combination of chloride (III) chromium with vitamin C to rate kolesterol white mouse blood has been done. Attempt animal is divided by five groups of that is group of control, group given vitamin C 0.52 mg/20 g body weight (BW), group given vitamin C 0.52 mg/20g BW and chromium (III) chloride with dose 5.2; 6.5; and 7.8 g /20g BW. Measurement of cholesterol rate done at day to day 8, 15, and 22 with enzimatis method applies spectrophotometer. Result of research show that giving of combination of chromium (III) chloride at dose 5.2; 6.5; and 7.8 g/20g BW give vitamin C 0.52 mg/20 g BW and give time depth can give influence to rate kolesterol white mouse blood.

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