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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 8 Documents
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Search results for , issue "vol. 28 no. 3, september 2019" : 8 Documents clear
Korelasi Ekspresi MMP-9 dengan Derajat Histologik dan Faktor Karakteristik Derajat Histologik pada Karsinoma Payudara Invasif Yolanda Isabela Simon; A.A.A.N Susraini; Moestikaningsih
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

BackgroundHistological grade and MMP-9 expression are prognostic factors in invasive breast carcinoma, nevertheless thecorrelation between both prognostic factors is still debatable. The aim of this study was to determine therelationship between expression of MMP-9 and histological grade and to evaluate which characteristic factor ofthe histological grade is dominant to MMP-9 expression in invasive breast carcinoma.MethodsThis study was carried out using a cross sectional analytical method. The samples were paraffin blocks frominvasive carcinoma of no special type grade I, II, and III at Pathology Anatomy Department UdayanaUniversity/RSUP Sanglah Denpasar from 1st January 2013 to 31st July 2016. Histopathologically re-diagnosiswas conducted to get the eligible samples and obtained 47 samples, consisted of 7 samples grade I, 18samples grade II, and 22 samples grade III. Immunohistochemistry of the MMP-9 was done and the result wascorrelated to histological grade and characteristic factor of histological grade.ResultsThe study results showed high expression of MMP-9 2.1% (n=1) in grade I, 19.2% (n=9) in grade II, and 36.2%(n=17) in grade III. Chi-square test analysis showed there was a significant correlation between tumor gradeand MMP-9 expression (p=0,010). The logistic regression test showed the mitotic counting was statisticallysignificant dominant factor (p=0.012) determining MMP-9 expression, whereas tubular formation and nuclearpleomorfia were not statistically significant (p>0.05).ConclusionHigh expression of MMP-9 was correlated with high histological grade, which also indicated worse prognosis.MMP-9 testing is an important examination to determine the level of tumour aggresive-ness and plan theeffective therapies
Hubungan Ekspresi Reseptor Progesteron dan Ki-67 Labeling Index dengan Derajat Histopatologik Meningioma Dwi Sri Rejeki; Salmiah Agus; Yuliarni Syafrita
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundMeningioma is tumor originating from meningothelial cells (arachnoid) attached to duramater. These is thesecond most tumor in central nervous system. All degrees meningioma have risk for recurrence, unfortunatelythe biologic behavior of meningioma can’t be seen from histopathology alone. Therefore, many studies haveshown progesterone receptor influence the degree of meningioma and Ki-67 LI also has important role indetermining risk of recurrence in the degree meningioma. Therefore, the examination of progesterone receptorand Ki-67 LI in meningioma is required to see character of meningioma tumor cells and hence to determinetreatment and prognosis.MethodsThe study was a cross-sectional study, which conducted patients with diagnosis of meningioma from 5Pathological Anatomy Laboratories in West Sumatra. Total of 64 cases meningioma were obtained duringJanuary 2012 to December 2015 and 35 samples were taken and met the inclusion criteria.Immunohistochemical examination was using specific antibodies to progesterone receptor and Ki-67. Datacollected were analyzed using the Kruskal-Wallis test and p value <0.05 was considered as statisticallysignificant.ResultsFrom 35 samples, 29 samples (82.9%) classified meningioma grade I, 4 samples (11.4%) meningioma grade IIand 2 samples (5.7%) meningioma grade III. Meningioma was most prevalent the age range 41-50 years,female gender and histopathological grade I.ConclusionNo differences expression progesterone receptor on the degree histopathological meningioma. No differencesexpression Ki-67 LI on the degree histopathological meningioma. There is inverse relationship betweenexpression progesterone receptor and Ki-67 LI on the degree histopathological meningioma
Hubungan Jumlah Sel Mast dengan Tampilan Ekspresi Vascular Endothelial Growth Factor (VEGF) pada Cutaneous Squamous Cell Carcinoma Edi Kerina Sembiring,; Delyuzar; Soekimin
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundThe most common non-melanocytic skin cancers are basalioma and squamous cell carcinoma. Squamouscell carcinoma is a malignancy of squamous epithelium. Mast cells stimulate neovascularization andangiogenesis in multiple tumors. One of the main factors of angiogenesis in squamous cell carcinoma isthe Vascular Endothelial Growth Factor (VEGF). The aim of this study is to investigate the associationbetween number of mast cells with the expression of VEGF of cutaneous squamous cell carcinoma.MethodsThis is an analytical descriptive study with cross sectional approach. The sample of this study are paraffinblocks of skin tissue which diagnose histopathologically as squamous cell carcinoma. Then the sampleswill be stained with immunohistochemistry CD117 (Novocastra®) to count the number of mast cells andVEGF (Dako®) to see angiogenesis. Their expression will be analyzed with Fisher’s Exact Test statisticalanalysis to investigate the association between number of mast cells with expression of VEGF ofcutaneous squamous cell carcinoma.ResultsThe number of mast cells ≥15 cells were 7 cases (23.3%). Expressed VEGF positive expression in 30cases (100%). Suitability test Fischer's Exact Test has value not significant (p> 0.05).ConclusionThere is no conformance relationship between the number of mast cells with VEGF expression of p-value.
Hubungan Ekspresi Ki-67 dan E-Cadherin dengan Kedalaman Invasi Melanoma Malignum Berdasarkan Clark Level Santy Saberko; Salmiah Agus; Satya Wydya Yenny
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundMalignant melanoma (MM) is a neoplasia derived from melanocytes. This is the most aggressive cancer ofskin. Even small tumors may have a tendency to metastasize and thus lead to a relatively unfavorableprognosis. Malignant melanoma depth of invasion based on Clark level is one of the important prognosticfactors to determine survival rate of MM patient. Determination of invasion based on this Clark level issubjective, more objective checks such as Ki-67 and E-Cadherin are required. This examination isexpected to see the risk of metastasis in MM. Cell proliferation is the main key for tumor progression and itcan be measured with Ki-67 expression. E-cadherin is one of transmembrane protein that plays importantrole in metastasis. The purpose of this study is to determine correlation between Ki-67 and E-Cadherinexpression with depth of invasion of malignant melanoma based on Clark level.MethodsThis is cross sectional study in Padang and Jakarta, with 42 cases of malignant melanoma which havebeen diagnosed in Pathology Anatomic Laboratory in West Sumatera. Samples were obtained fromparaffin block of or tissue from surgery and have been reviewed depth of invasion based on the Clark level.These samples were divided into I-V Clark level group. Ki-67 expression of cells nuclei and expression ofE-Cadherin of cells membrane were analyzed using immunohistochemistry assay. One Way Annovabivariate statistical analysis were used and value p<0.05 were considered significant.ResultsPositive Ki-67 expression were found in 42 cases, 6 samples with II Clark level, 8 samples with III Clarklevel, 19 samples with IV Clark level, 9 samples with V Clark level. Malignant melanomas were mostlyfound in male 60-79 age group and depth of invasion in IV Clark level. Positive E-Cadherin expression in IIClark level. There was significant correlation between Ki-67 and E-Cadherin
Ekspresi Bcl-2 pada Karsinoma Urotelial Kandung Kemih dan Hubungannya dengan Berbagai Faktor Prognosis Hendy Setyo Yudhanto; Budiana Tanurahardja; Puspita Eka Wuyung
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundUrothelial carcinoma comprises of 90% of all cases in bladder. There are two groups which are non invasivedepend on whether the tumor has reached muscularis mucosa. 5-Years survival rate depend on grading andstaging. Low malignant grade and non invasive may reach 90% survival rate, with recurrence rate 40-60%. Highmalignant grade and invasive tumor has only10-17% survival rate. Mitosis and lymphovascular invasion arerelated with recurrency. However, there are some controvesi regarding Bcl-2 expression in bladder urothelialcarcinoma. This study was aimed to evaluate different expression of Bcl-2 with 4 related factors contributed tosurvival, which are degree of malignancy, stage, mitosis, and lymphovascular invasion.MethodsA retrospective cross sectional study on urothelial carcinoma of the bladder was conducted in the Departmentof Anatomical Pathology, Faculty of Medicine, University of Indonesia/RSCM. The cases were collected fromthe year of 2010 to 2014. In this study 21 cases of low grade and 21 cases of high high grade were found. Bcl-2immunohistochemistry staining performed in all cases and percentages are calculated to make 0-3 scoring.ResultsMost case is fifth decade as many as 27 cases. Obtained 4 cases found limfovaskuler invasion. This studyobtains the relationship between mitosis with grade of tumor (p: 0.000). the result suggests that there are nodifferences between the expression of Bcl-2 with the degree of malignancy stage, mitosis and lymphovascularinvasion.
Hubungan Ekspresi Matriks Metaloproteinase-9 dengan Jenis Histopatologi Karsinoma Serviks dan Invasi Limfovaskular Meta Oktora; Salmiah Agus; Pelsi Sulaini
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundMatrix Metalloproteinase 9 (MMP-9) is a proteolytic enzyme assumed to have an important role in cervicalcarcinogenesis. Limfovascular invasion (LVI) and higher expression of MMP-9 will make cervical tissuedegradation faster, invasion process and metastasist easier. Adenocarcinoma is suspected of having poorprognostic than squamous cell carcinoma (SCC). The aim of this study was to examine the relationshipbetween expression of MMP-9 with histopathological cervical carcinoma and LVI.MethodsA cross sectional analytic study was performed on 36 sample that divided into 18 KSS and 18 adenokarsinoma.Samples were tooken from block paraffin from surgery or biopsy in Anatomic Pathology laboratories are locatedin West Sumatra. Sample are reviewed and found the LVI. Immunohistochemical was staining with primaryantibody MMP-9 then its expression were assessed in stroma and cytoplasmic cell tumour.ResultsMMP-9 expression was found positive in 80.6% (41.1% for SCC and 58.6% for cervical adenocarcinoma. Themean of expression of SCC was 17.4 and cervical adenocarsinoma was 19.56. Expression of MMP-9 waspositive in LVI sample.ConclusionThere is not significant relationship between the expression of MMP-9 with type of histopatologic cervicalcarcinoma (p=0.088) and LVI (p=0.566). Expression of MMP-9 in cervical adenocarcinoma was higher thanSCC, but it was not significant (p=0.563).
Akurasi Pemeriksaan Polymerase Chain Reaction Menggunakan Primer IS6110 dan MPB64 untuk Mendeteksi Mycobacterium tuberculosis pada Spesimen Formalin-Fixed Paraffin-Embedded Timotius Benedict Djitro; Faramitha Nur Izzaty; Nur Rahadiani
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundOne of the chalangges faced in controlling tuberculosis (TB) is the availability of a fast and precise diagnostictool. The current gold standard for diagnosis of TB is acid-fast bacterial culture. However, FFPE (formalin-fixedparaffin-embedded) tissues are not ammenable for culture and the time required makes this method impracticalfor many centers. PCR is an alternative rapid diagnostic tool, and can be used with FFPE tissues. PCR hasshown high sensitivity and specificity for detecting M.tuberculosis, however there has been reports of lesssensitivity and specificity when using FFPE specimens. This report aims to determine the accuracy of PCRdetection of M.tuberculosis using primer IS6110 and MPB64 on FFPE specimens.MethodsLiterature searches were carried out on the Pubmed, Scopus, Proquest, Springer Link and Cochranedatabases. Two journals were relevant to the clinical scenario, then a critical review is carreid out using theDiagnostic Study Appraisal Worksheet from the Center for Evidence-based Medicine, University of Oxford,2010.ResultsCurrently, the accuracy of PCR primer IS6110 and MPB is not satisfactory. Sensitivity ranges from 45.5-88.9%and specificity is between 88.1% - 100. This broad sensitivity range is probably caused by tissue volume andembedding process that can cause damages to the integrity of M.tuberculosis DNA.ConclusionPCR examinations using IS6110 and MPB64 primers can be used as confirmation tests in FFPE specimensdue to its high specificity value. Broad sensitivity values can produce significant false negatives if no otherexamination is used in conjunction with PCR in FFPE specimens.
Hubungan Ekspresi Imunohistokimia Cyclooxygenase-2 (COX-2) dengan Derajat Histopatologi Meningioma Indri Mahrani; Delyuzar; Joko S. Lukito
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundMeningioma is the most common intracranial primary neoplasm in adults, which arise from arachnoid cap(meningothelial) cells. Histological appearance of a meningioma is an important predictor of tumor behavior.Cyclooxygenase-2 (COX-2) enzyme is overexpressed in different types of tumors and is known to beassociated with malignant behavior of tumors. The aim of this study was to evaluate cyclooxygenase-2 (COX-2)immunoreactivity in meningioma and to find association with histopathologic grading of meningioma.MethodsThis is an analytical descriptive study with cross sectional approach. The histopathologic grading of 22 samplesof meningioma were determined and stained with COX-2 immunohistochemistry. The color intensity: 1 (mild), 2(moderate), 3 (strong). Percentage of positive cells: 0 (0%), 1 (<10%), 2 (10-50%), 3 (>50%). The evaluationwas the sum of color intensity and percentage of positive cells: positive (>4), negative (<4).ResultsTwnty two cases of meningioma: mean age=41 years, 90.9% females, meningothelial=22.7%, grade I=77.3%).COX-2 expression: negative: 17 cases (77,3%) all was first degree of malignancy. COX-2 positive: 5 cases(22,7%): 4 cases of second degree and 1 case of third degree of malignancy. The expression of COX-2 inmeningioma cells was associated with WHO histopathologic grading (p=0.001).ConclusionThis study showed a relationship between COX-2 immunohistochemical expression and histopathologic gradingof meningioma, where COX-2 was more expressed in grades II and III.

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