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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 652 Documents
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The Relationships between p16INK4a Immunohistochemistry Expression with Histopathological Subtypes in Cervical Adenocarcinoma. Sarah Adila; Ibnu Alferraly; Jessy Chrestella; Joko S. Lukito; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol. 35 No. 2 (2026): Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.690

Abstract

Background Cervical adenocarcinoma is one of the epithelial malignancies that frequently occurs in the cervix after squamous cell carcinoma. The association between human papillomavirus (HPV) and cervical carcinoma is well known, with HPV being identifiable in almost all cervical squamous carcinomas. Research on HPV in cervical adenocarcinoma is less extensive but generally suggests a significant association. p16INK4a, a tumor suppressor gene, serves as a marker for oncogenic HPV infection and can aid in diagnosing cervical adenocarcinoma. Methods This research cross-sectional study with 34 cases cervical of adenocarcinoma that have been diagnosed at Haji Adam Malik central Hospital, Medan, Prof. Dr. Chairuddin Panusunan Lubis Hospital, North Sumatra University, and Putri Bidadari Hospital Langkat. Histopathological subtypes were assessed using Hematoxylin and Eosin staining, followed by immunohistochemical staining for p16INK4a. The Somers' d test evaluated the relationship between p16INK4a expression and adenocarcinoma subtypes. Results The study found that among HPV-associated adenocarcinomas, 20 cases (58.8%) had strong positive p16INK4a expression, while 4 cases (11.8%) were negative. For HPV-independent adenocarcinomas, 5 cases (14.7%) had strong positive expression, 2 cases (5.9%) had weak positive expression, and 3 cases (8.8%) were negative. Statistical analysis using the Somers' d test resulted in a p-value of 0.097, indicating no significant correlation (p-value > 0.05). Conclusion No significant association was found between p16INK4a expression with histopathological subtype in cervical adenocarcinoma.
Korelasi antara Ekspresi Imunohistokimia Human Epidermal Growth Factor Receptor-2 (HER2) dan Indeks Aktivitas Mitotik (IAM) pada Pasien Karsinoma Payudara Invasif: Tinjauan Terhadap Agresivitas Tumor Dyonesia Ary Harjanti; Kidyarto Suryawinata; Lilis; Bayu Perkasa Rosari; Angelina Halim; Jasmine Rosalyn
Majalah Patologi Indonesia Vol. 35 No. 3 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Breast cancer is a leading cause of cancer-related deaths among women globally, Indonesia is no exception Biological markers such as HER2 and MAI both play a critical role in predicting prognosis of invasive breast carcinoma (IBC). These two are associated with tumor proliferation and correlate with recurrence and survival rates. The correlation between these two prognostic factors has not been extensively studied. This study aims to investigate the correlation between HER2 immunoexpression score and mitotic activity index. Method: Medical records of 60 patients diagnosed with invasive breast carcinoma histopathologically were reviewed. Patient characteristics and clinicopathological features were analyzed. The correlation between HER2 and MAI was analyzed using Kendall's Tau-B correlation, and multivariate analysis was performed. Results: There were 48 patients with no-special type (IBC-NST) and 12 patients with other types, with a mean age of 49.53 years. More than 50% of patients were HER2-negative, and only a few (16.67%) had a high MAI. The correlation between HER2 and MAI was not statistically significant. Interestingly, patients with HER2 score of 1 were seven times more likely to have a higher MAI compared to HER2 score of 3. Discussion and Conclusion: This study found no statistically significant correlation between HER2 score and MAI in IBC patients, which suggests that HER2 status may not be directly related to mitotic activity. However, further trials with larger sample sizes are needed to confirm this result.

Page 66 of 66 | Total Record : 652

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