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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 643 Documents
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Aspek Klinik dan Karakteristik Tipe Histopatologik Timoma Maria Mayella Vianney; Lisnawati Rachmadi
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.455

Abstract

BackgroundThymoma is the most common neoplasm found in thymus gland and is classified into 5 main histopathological types, A, AB, B1, B2,and B3. Thymomas are most commonly found in the anterior mediastinum and accompanied with myasthenia gravis. The aim of thisstudy was to find out clinical feature and histopathological characteristics of thymomas in Department of Anatomical Pathology, Facultyof Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital (FKUI/RSCM) in 2014-2018.MethodsThis is a descriptive study, using a cross-sectional design. Clinical and histopathological data obtain from the medical records andarchives of the Department of Anatomical Pathology of FKUI/RSCM. Clinical data consists of age, sex, tumor location, clinicalsymptom, concomitant disease, metastasis, and treatment. Histopathological assessment consists of histopathology type using WorldHealth Organization criteria and staging using Masaoka-Koga staging system.ResultsThere were 31 thymoma cases matched the inclusion criteria. Nineteen (61.3%) of 31 cases were women. The mean age of thesubjects was 46.7 years old. A total of 12 cases (37.5%) had muscle weakness due to myasthenia gravis as chief complaint and 21cases (67.7%) of tumor mass in the anterior mediastinum. There 9 cases of type AB and 2 cases of type B2.ConclusionThymoma is more common in women with an average age of 46.7 years. The most common paraneoplastic syndrome is myastheniagravis and mostly found in the anterior mediastinum. The most common histopathologic type is type AB, while type B2 is the least.
Uji Diagnostik Ekspresi CK19 dan HBME-1 pada Lesi Jinak dan Ganas Tiroid Indah Yati; Henny Sulastri; Aspitriani
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.456

Abstract

BackgroundThyroid carcinoma is the most common malignancy of the endocrine system. Some cases histopathologically have overlappingmorphological features among papillary thyroid carcinoma follicular variants and follicular adenomas; beetween nodular hyperplasiaand protruding papillary protrusion; nuclear feature and thyroid papillary carcinoma. The combination of CK19 and HBME-1imunohistochemical staining have been proven as specific and sensitive markers to distinguish benign and malignant lesions thyroid.The purpose of this study was to determine the differences in CK19 and HBME-1 expression in benign and malignant Thyroid lesions.MethodsThis study used a diagnostic test of 50 cases (16 cases of nodular hyperplasia, 8 cases of follicular adenoma, 21 papillary thyroidcarcinomas and 5 cases of thyroid follicular carcinoma) clinicopathological data were noted. Immunohistochemical staining wasperformed using CK19 and HBME-1antibodies and the their expression assessed. Data were analysed by SPSS version 22.0.ResultsBased on the four histopathological diagnoses, the majority patient, were females between 20-50 years.Fifty percent of macroscopicsample size was more than 5 cm. The expression of CK19 and HBME-1 has a sensitivity value of 76.9% and 92.3% and a specificityvalue of 79.2% and 79.2%, consecutively. While positive predictive value 80% and 82.8% and negative predictive value 76% and90.5%, accuracy of 78% and 86%, respectively.ConclusionHBME-1 expression could be used to distinguishing benign from malignan lesions of thyroid with high diagnostic sensitivity thanCK19 expression.
Hubungan Ekspresi Interleukin-17 dan Indeks Proliferasi Ki67 pada Karsinoma Payudara Ika Kartika,; Theodorus; Citra Dewi; Nyiayu Fauziah Kurniawati
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.460

Abstract

BackgroundTumor cells have the ability to change the phenotype of inflammatory cells in the tumor environment into protumoral factors. One ofthe mediators produced such as interleukin 17 (IL-17) also plays a role in increasing tumor proliferation and invasion. Similar to IL-17,Ki67 has generally been used as a marker to assess the extent of breast carcinoma proliferation. This is the first study to determinethe relationship of IL-17 expression with Ki67 proliferation index of breast carcinoma patients.MethodsThis is a case series study using 38 paraffin block samples of breast carcinoma patients. The clinicopathological characteristicsdocumented are age, histopathological subtype and grade, TILs (tumor infiltrating lymphocytes) and molecular subtypes. Interleukin17 and Ki67 expressions were assessed using immunohistochemistry examination and data were analysed using the Pearson andSpearman test to assess correlations between the two variables.ResultsGeneral characteristics of the sample in this study were breast cancer patients aged >40 years (73.7%), histopathological subtypesof non-specific invasive carcinoma (84.2%), high tumor rates (78.9%), non-dominant TILs (94.7%) and molecular subtype luminal B(55.3%). There is no relationship between IL-17 expression and Ki67 proliferation index (p 0.72 and OR of 1.417), even though lowerexpression of IL-17 showed a higher Ki67 proliferation index.ConclusionExpression of IL-17 cannot describe the Ki67 proliferation index in breast carcinoma. Studies using another analytical techniques andlarge sample size are suggested to obtain more accurate results.
Analisis Ekspresi Interleukin-17 pada Karakteristik Klinikopatologi Karsinoma Payudara Nyiayu Fauziah Kurniawati; Ika Kartika; Citra Dewi; Theodorus
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.461

Abstract

BackgroundInteraction between cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. Many type ofcytokine produced by inflammatory cells in tumor stroma could stimulate tumor proliferation and invasiveness, such as interleukin-17.The aim of this study is to determine the correlation between IL-17 expression and clinicopathological characteristics of breast cancer.MethodsSerial cases study was performed by enrolling 40 paraffin block of breast cancer patients. Clinicopathological characteirstics werenoted, including age, histopathological subtype and grade, TILs, lymphovascular invasion and molecular subtype. TILs were scoredby denomination area of stromal tissue occupied by mononuclear cells over total stromal area. Expression of IL-17 was examined byusing immunohistochemistry with anti-IL-17 antibody and counted from stromal mononuclear cells cytoplasm staining from five areas.The average value was used as a cut-off point in determining level of expression. Data were analysed by using SPSS v.22.ResultsMajority of the patients were more than 40 years old (75%), histopathological grade III (77.5%), without lymphovascular invasion(62.5%), luminal B molecular subtype (57.5%), and non-dominant TILs (95%). IL-17 expression was not significantly correlated withclinicopathological characteristics with p value=0.079, 0.600, 0.739, 0.883 and 1.000 respectively for age, histological grade,lymphovascular invasion, molecular subtype and TILs.ConclusionInterleukin-17 expression and clinicopathological on characteristics of breast carcinoma between histopathological grade, TILs, andlymphovascular invasion showed no significant differences. There was a tendency that the higher IL-17 expression, the higherhistopathological grade, the lower TILs and positive lymphovascular invasion
Hubungan Ekspresi CD133 dan EGFR Terhadap Derajat Keganasan pada Karsinoma Ovarium Agung Dwi Suprayitno; Dyah Fauziah; Gondo Mastutik
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.462

Abstract

BackgroundOvarian carcinoma account for 90% of all malignant ovarian tumors. Epidermal Growth Factor Receptor (EGFR), also known asErbB1/HER1, has an important role in tumor cell proliferation. CD133 is a marker for hematopoietic stem cell and it is involved in tumorcell proliferation, self renewal and cell differentiation. The objective to analyze the expression of CD 133 and EGFR in high grade andlow grade ovarian carcinoma, and to determine the correlation between the expression of CD133 and EGFR expression in ovariancarcinoma.MethodsThe study was conducted with observational and cross sectional method on paraffin blocks of patients diagnosed as ovariancarcinoma from 1 January until 31 December 2017 in Dr. Soetomo Hospital. Ovarian carcinoma was divided into 2 grade, low gradeand high grade. Immunohistochemistry for EGFR and CD133 was performed. Immuno-reactive Score (IRS) was applied to evaluatethe expression of EGFR and CD133. The difference expression of CD133 and EGFR in low grade and high grade ovarian carcinomawas analyzed with Mann-Whitney test. Correlation between CD133 with EGFR was analyzed with Spearman test.ResultsThere were significant difference in expression of CD133 (p=0.0001) and EGFR (p=0.0005) in high grade and low grade OvarianCarcinoma. There was significant positive correlation between CD133 and EGFR expression in Ovarian Carcinoma (p=0.035; r=0.37)ConclusionExpression of CD133 and EGFR were higher in high grade ovarian carcinoma. The higher expression of CD133 will increaseexpression of EGFR in ovarian carcinoma. Both markers may be used as prognostic factor.
Hubungan Antara Karakter Klinikopatologik dengan Grup Prognostik WHO pada Pasien Gastrointestinal Stromal Tumor di RSUP Dr. Mohammad Hoesin, Palembang Nur Azizah; Suly Auline Rusminan; Subandrate
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.463

Abstract

BackgroundGastrointestinal stromal tumors are the most common mesenchymal tumors in the gastrointestinal tract. Based on tumor size andmitotic index, WHO classified GIST into three prognostic groups which were benign, uncertain malignant potential, and malignant.Some studies revealed that there was variation in association between age, gender, tumor location, histopathologic type and prognosisof GIST patients. This study aimed to identify and analyze the association between clinicopathologic characteristics and WHOprognostic group in GIST patients at RSUP Dr. Mohammad Hoesin Palembang.MethodsThis study used 30 medical records of GIST patients during 01 January 2014 to 27 December 2018 in the Department of AnatomicPathology RSUP Dr. Mohammad Hoesin. Clinicopathologic characteristics and WHO prognostic group data were collected. Theassociation between clinicopathologic characteristics (age, gender, tumor location, histopathologic type) and WHO prognostic groupwere analyzed by chi-square test.ResultsFrom 30 subjects, 40% of the patients aged 52-58 years.There was no gender predilection. A total of 33.3% of the GISTs were locatedin the small intestine. Majority of histopathologic type was spindle cell type (93.3%). Bivariate analysis showed there were no significantassociation between clinicopathologic characteristics: age (p=0.811), gender (p=0.682), tumor location (p=1.000), histopathologic type(p=0.469) and WHO prognostic group.ConclusionThere was no significant association between clinicopathologic characteristics and WHO prognostic group in GIST patients at RSUPDr. Mohammad Hoesin Palembang. We suggest doing a cohort study about association between clinicopathologic characteristics andsurvival rate in GIST patients.
Kepadatan CD8 di Lingkungan Mikrotumor pada Subtipe Diffuse Large B Cell Lymphoma Indah Yunalda; Krisna Murt; Aida Farida; Ika Kartika; Erial Bahar
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.466

Abstract

BackgroundDiffuse Large B Cell Lymphomas (DLBCL) is divided into two subtypes, GCB and non-GCB, which are determined based on Hans'salgorithm. The GCB subtype has a better prognosis than non-GCB. Some studies indicate that the tumor progression wasinfluenced by tumor microenvironment, including CD8+ TILs located both surrounding tumor cells and peripheral. This study aims todetermine the density of CD8+ TILs in the tumor microenvironment of DLBCL subtypes.MethodsA Cross sectional study of 40 samples of DLBCL registered to Department of Anatomical Pathology Faculty of Medicine UniversitasSriwijaya/Dr. Mohammad Hoesin Palembang Hospital from 1st October 2017 to 31st December 2018. All samples were stained usinganti-CD8 antibody, afterward, lymphocytes express CD8 were assessed both in surrounding tumor cells and peripheral. The densityof CD8 in each DLBCL subtype was analyzed statistically using Mann Whitney U Test.ResultsIn this study, non-GCB subtype was found higher in comparison to GCB subtype (72.5%) and the samples was dominated by youngages (75%). Significantly, peripheral CD8 density was higher than that of surrounding tumor cells, both in the GCB (p=0.003) andnon-GCB subtypes (p=0.000).ConclusionIn both subtypes, CD8 density is higher in peripheral than surrounding tumor cells and a high density in surrounding tumor cells willbe followed by an increase in peripheral CD8 density.
Analisis Ekspresi P53 pada Karsinoma Urotelial Kandung Kemih Derajat Rendah dan Derajat Tinggi serta Hubungannya dengan Stadium Tumor Silitonga, Imelda Setiana; Tanurahardja, Budiana; Kusmardi
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.467

Abstract

BackgroundUrothelial carcinoma is the most common bladder malignancy in men. Risk factors include smoking, chemicals exposure, radiation,schistosoma hematobium infection. P53 mutation is the most common mutation in urothelial bladder carcinoma that cause p53 proteinaccumulation which are detected through immunohistochemical examination. The aim of this study is to analyze the differencesbetween p53 expression in low and high grade urothelial and the carcinomas association of p53 expression with tumor stage.MethodsThis was a cross sectional study with 47 cases (22 cases of low grade and 25 cases of high grade) urothelial carcinoma in AnatomicalPathology Department Faculty Medicine of Universitas Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) in 2009-2017. Allcases stained with p53 antibody with immunohistochemical methods with positive cut off ≥20%.ResultsP53 positive expression are found in 33 samples, 20 cases of high grade and 13 cases in low grade; 22 cases of Nonmuscle invasivebladder cancer and 11 cases of Muscle invasive bladder cancer.ConclusionThe expression of p53 in low grade and high grade urotelial carcinoma of the bladder and its association with tumor stage showed nosignificant difference.
Analisis Ekspresi Fibroblast Activation Protein (FAP) terhadap Faktor Klinkopatologi dan Respon Kemoterapi pada Tumor Ganas Epitelial Ovarium Yunike Rinelda; Wresnindyatsih; Aida Farida Farida
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.468

Abstract

BackgroundEpithelial ovarian carcinoma is the most common cause of death among gynecological malignancies in the women. The interactionamong cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. One of important component oftumor microenvironment that could stimulate tumor proliferation and invasiveness, is fibroblast. Activated fibroblasts also known ascarcinoma associated fibroblasts (CAFs). The purpose of research is to analyzed FAP expressions to clinicopathologic characteristic(histopathology subtype and clinical stadium of FIGO) and chemotherapeutic responses.MethodsThis study is a retrospective observational analytic study with cross-sectional designs was undertaken during January 1, 2016 to June30, 2018. The sample was 55 paraffin block sample epithelial ovarian carcinomas consists of 11 samples for each histopathologysubtype collected used purposive sampling technique. All samples were immunostained with FAP antibody. FAP expressions wasevaluated based on Min Shi et al studies. It analyzed stained area/ proportion (P) and intensity (I). Statistical analysis using chi-squarewas performed using SPSS version 17.ResultsPatients of 40-49 years old (24; 43.6%), clinical stadium is III (30; 54.5%), Complete response (CR) of chemotherapeutic response(38; 69.1%). The statistic analyses between histopathology subtypes (p=0.038), clinical stadium of FIGO (p=0.000) and chemotherapyresponse (p=0.000) showed significant differences.ConclusionFAP expressions could showed correlation between clinicopathologic characteristic (histopathology subtype and clinical stadium ofFIGO) and chemotherapeutic response.
Hubungan antara Ekspresi P16 dengan Respon Histologik Kemoterapi Neoadjuvan pada Osteosarkoma Konvensional Vathonati, Dian Sari Oethia; Siregar, Nurjati Chairani; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.469

Abstract

BackgroundOsteosarcoma is the most common primary malignant bone tumor in children and young adult. Its pathogenesis has been linked toalterations in several genes. The high percentage is found involving Retinoblatoma (RB) pathway. p16 plays as a tumor suppressorin RB pathway to controll proliferation of the tumor cell. The degree of neoadjuvan chemotherapy histological necrosis response isrelated to prognosis of patients with osteosarcoma. Chemotherapy and p16 both synergic in inhibit the cell tumor proliferation andsupport apoptotic. Loss of p16 function is related to progressiveness of the tumor. The aim of this study was to investigate therelationship of p16 expression in pretreatment osteosarcoma to pathologic necrotic histological response after neoadjuvanchomotherapy.MethodsThis is a cross sectional study p16 stainning was done and count the positive expression tumor cell in percentage. Positive wasdefined as strong and medium nuclear stainning in 30% or greater. The samples is catagorized into positive and negative expressionthen it is correlated into tumor necrotic area based on grade of Huvos.ResultsSamples consist of 33 cases. Positive stainning was found in 10 cases (30.3%), 6 of 10 cases had good chemotherapy response.Negative stainning was found in 23 cases and 21 of 23 cases had poor chemotherapy response. A significant association was notedbetween p16 expression and histological necrotic response to neoadjuvan chemotherapy (p=0.004).ConclusionThe result showed that p16 expression associate significantly with histological necrotic response to neoadjuvan chemotherapy inconventional osteosarcoma (p=0.004).

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