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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 12 Documents
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Search results for , issue "Vol 8 No 1 (2025)" : 12 Documents clear
Gambaran Schizencephaly dengan Polymicrogyria pada Berbagai Magnetic Resonance Imaging (MRI) Sekuens Tanaji, Tandy; Hendara, Farah; Marliana, Caecilia; Astien, Astien; Nareswari, Gupita; Napitupulu, Partogi; Rahmansyah, Mulia; Wahab, Revalita
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.73-78

Abstract

Schizencephaly is a rare congenital cerebral malformation within the category of neurological migration defects. Hemiparesis, developmental delays, and seizures are clinical signs that are influenced by both the size and the location of the lesion. This condition is characterized by a cleft that traverses the brain's parenchyma lined by grey-mater (transmantle cleft). In less severe cases, the cleft does not extend into the lateral ventricle. Identification of the cleft's path, accurate assessment of the cortex, and recognition of polymicrogyria are crucial for the radiological evaluation of schizencephaly. We report a case of 18-year-old male diagnosed with closed-lip schizencephaly, which supported by MRI findings. The transmantle cleft and polymicrogyria are most effectively visualized in T2-weighted and FLAIR images. The utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences as well as susceptibility-weighted imaging (SWI) sequence in the context of schizencephaly currently remains uncertain, however it may be useful for ruling out other abnormalities such infarct, hemorrhagic, tumors or other vascular abnormalities. In this context, we emphasize the significance of MRI examination for diagnosing this condition and for recognizing the related abnormalities.
Human Metapneumovirus (hMPV): Tantangan Baru dalam Kesehatan Global Khairani, Rita
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.1-5

Abstract

Human metapneumovirus (hMPV) is a respiratory virus belonging to the Pneumoviridae family, first identified in 2001. hMPV is closely related to respiratory syncytial virus (RSV), causing upper and lower respiratory tract infections that primarily affect vulnerable populations, such as children, the elderly, and individuals with weakened immune systems. It often circulates seasonally during winter and early spring. The incidence of hMPV is highest in young children. It is responsible for 5-10% of acute respiratory infections in hospitalized children and causes a crude mortality rate of 9%, similar to influenza A. Symptoms of hMPV infection vary from mild upper respiratory tract infections to bronchiolitis, bronchitis, and pneumonia. Nasal congestion and runny nose, cough, sore throat, and fever are common symptoms of this infection. Wheezing is common in children and requires the use of bronchodilators. Most hMPV patients recover within 7-10 days without complications. Some groups are at high risk for severe complications such as pneumonia and multi-organ failure requiring intensive care. Currently, laboratory diagnosis of hMPV infection is done by detecting viral nucleic acid in respiratory tract specimens. Serological tests using Immunofluorescence or ELISA (Enzyme-Linked Immunosorbent Assay) can be used to detect hMPV-specific antibodies, which are helpful in retrospective diagnosis and epidemiological studies. Rapid antigen tests, although practical, can vary in sensitivity and specificity. There is currently no specific treatment, and vaccination is still in the development stage, although significant progress has been made. Prevention remains the most important aspect in reducing the impact of hMPV, focusing on infection control to limit the spread of the virus, especially in vulnerable populations.

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