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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 15 Documents
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Search results for , issue "Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)" : 15 Documents clear
EFFECTIVENNES OF SKIN EXTRACT OF POMEGRANATE (PUNICA GRANATUM L) AND OLIVE OIL AS LIP MOISTURIZING (LIP BALM) Sumitra, Jhoti
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1006

Abstract

Lip balm preparatios can contain active ingredients that aim to protect the lips from extreme weather and hot sun. The active ingredient added to lip balm preparations can use natural ingredients from nature or pure chemical compounds. Natural ingredients have the advantage of having minimal side effects for long-term use. So that natural ingredients are currently the prima donna in the formulation of cosmetic preparations, including lip balm preparations. The properties of pomegranate skin protect and repair lips in lip balm preparations. pomegranate peel (Punica granatum L.) as a natural colorant and utilizes olive oil (Olive oil) as an emollient or moisturizer formulated in lip balm preparations. The results showed that all homogeneous lip balm preparations had a pH of 5.6-6.1 and were stable for 12 weeks of storage. Lip balm preparations with 10% concentration of pomegranate peel extract can provide the best lip moisturizing effect to restore lip skin once a week after application for 4 weeks. All preparations of pomegranate peel extract lip balm do not irritate the skin.
ANTI-BACTERIAL ACTIVITY TEST OF SURGERY RHIZOME (CURCUMA DOMESTICA VAL) AGAINST BACTERIA STREPTOCOCCUS MUTANS Pratiwi, Asti; Ritonga, Zulfan Hardiansyah
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1008

Abstract

Abstract Turmeric (Curcuma domestica Val) contains various compounds such as alkaloids, flavonoids, curcumin, essential oils, saponins, tannins and terpenoids. The curcuminoids in turmeric rhizome are a group of phenolic compounds. Curcumin damages the cytoplasmic membrane and denatures cell proteins which causes the leakage of nutrients from the cells thereby inhibiting the growth of bacteria. The purpose of this study was to test the antibacterial activity of turmeric (Curcuma domestica Val) rhizome against Streptococcus mutans bacteria. In this study, its activity against Streptococcus mutans was seen through laboratory examination using the paper disc method. From the results of the four turmeric rhizome extracts, the average inhibition zone obtained a concentration of 10% produced an average of 14.48 mm. Concentration of 20% produces an average of 16.35 mm. concentration of 30% produces an average of 17.26 mm. Concentration of 40% produces an average of 19.47 mm. In this case, turmeric rhizome extract has strong activity against Streptococcus mutans bacteria. Turmeric rhizome contains secondary metabolites of flavonoids, alkaloids, and tannins. Which works as an antibacterial are flavonoids. Because flavonoids can inhibit nucleic acid synthesis, inhibit cell membrane function and inhibit energy metabolism.
TEST OF ANTIBACTERIAL ACTIVITY FROM THE COMBINATION OF ETHANOL EXTRACT OF WARU (HIBUSCUSTILIACEUS L.) LEAVES AND LEAF RED PUCUK (SYZYGIUM OLEANA) AGAINST SALMONELLA THYPI ON 2021 Purba, Novandi; Putri, Nabila
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1009

Abstract

The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB.
EVALUATION OF TITER RESULTS ON WIDAL EXAMINATION BASED ON THE DURATION OF FEVER IN HOSPITAL GRANDMED LUBUK PAKAM Rahayu, Asvia; Krisdianilo, Visensius; Hutabarat, Sintya; Siregar, S'aadah; Rizky, Vincentia Ade
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1010

Abstract

Kultur merupakan salah satu metode yang digunakan untuk diagnosis demam tifoid, namun di beberapa daerah seringkali tidak ada fasilitas untuk kultur, maka cara lain untuk membantu menegakkan diagnosis yang praktis dan tersedia di rumah sakit adalah dengan tes Widal. Tujuan penelitian ini adalah untuk mengetahui evaluasi hasil titer pada pemeriksaan Widal berdasarkan lama demam di RS GrandMed Lubuk Pakam. Penelitian ini dilakukan di Laboratorium Patologi Klinik RS GrandMed Lubuk Pakam. Jenis penelitian ini adalah deskriptif yang dilaksanakan mulai bulan Mei 2021 sampai dengan Juni 2021. Jumlah sampel yang diperoleh sebanyak 25 orang. Dari 25 sampel tersebut, hasil uji Widal dengan titer antibodi terhadap antigen O 1:80 adalah 2 orang, 1:160 orang, 1:320 orang, 2 orang. Titer antibodi terhadap antigen H 1:80 sebanyak 2 orang, 1:160 sebanyak 4 orang, 1:320 sebanyak 2 orang, dan titer antibodi terhadap antigen AH 1:80 sebanyak 6 orang, 1:160 sebanyak 5 orang dan 1:320 sebanyak 1 orang. Kesimpulan dari penelitian ini adalah 1:160 merupakan titer paling banyak ditemukan dengan titer antibodi tertinggi terhadap antigen H yaitu 1:320 lebih sering ditemukan pada durasi demam dengan kisaran 6-9 hari sedangkan titer antibodi tertinggi terhadap antigen AH adalah 1:320 ditemukan selama penelitian. demam dengan kisaran 6-9 hari.
ANTIBACTERIAL ACTIVITY OF KERSEN LEAF EXTRACT (MUNTINGIA CALABURA L) AGAINST STAPHYLOCOCCUS AUREUS Kartika, Dewi; Marbun, Romauli Anna Teresia; Dewi, Ayu Puspita
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1012

Abstract

Kersen (Muntingia calabura) is a shady plant that is usually used as a shade. Cherry leaves contain several secondary metabolites such as flavonoid, tannin and terpenoid. Flavonoid can inhibit bacterial growth by denaturing proteins and damaging cell membranes and dissolving fats contained in cell walls. According to the World Health Organization as many as 25 million deaths worldwide in 2011, one third were caused by infectious diseases. One of the most common infectious diseases caused by the bacterium Staphyloccus aureus. The purpose of this study was to see whether the 96% ethanol extract of cherry leaves had antibacterial activity against Staphylococcus aureus. The concentration of the extract used was 15%, 30%, 45% and 60%. From the test results, it can be concluded that the largest inhibition zone diameter is at a concentration of 60% with an inhibition zone diameter of 6.78 mm and the smallest at a concentration of 30%, which is 0.42 mm. Concentration of 45% has (weak) activity inhibiting bacterial growth with an inhibition zone of 2.13 mm, while at a concentration of 15% it has no activity in the inhibition zone of bacterial growth.
FORMULATION OF RED SPINNING LEAVES (AMARANTHUS) TRICOLOR L. AS NATURAL DYES IN PREPARATIONS EYESHADOW COMPACT POWDER Cahya, Cucu Arum Dwi; Silalahi, Mega
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1015

Abstract

Berbagai jenis kosmetik yang sering kali diminati bagi para wanita yaitu eye shadow. Pada sebagian produk eye shadow masih terdapat penyalahgunaan pewarna tekstil yang berbahaya jika digunakan bagi tubuh. Daun bayam merah (Amaranthus tricolor L.) mempunyai pigmen betasianin yang dapat dijadikan pewarna alami pada sediaan eye shadow compact powder. Penelitian ini bertujuan untuk membuat sediaan eye shadow compact powder dengan menggunakan ekstrak daun bayam merah sebagai pewarna alami serta memenuhi persyaratan mutu fisik dan tidak mengiritasi kulit.Daun bayam merah segar dilakukan ekstraksi dengan metode maserasi dengan menggunakan pelarut etanol 70% dan ditambahkan asam sitrat, kemudian pelarut diuapkan dengan bantuan alat rotary evaporator pada suhu 50°C, kemudian dipekatkan dengan waterbath (penangas air) pada suhu 78°C sampai didapatkan ekstrak kental. Kemudian diformulasikan ke dalam bentuk sediaan eye shadow compact powder dengan menggunakan kaolin, zink stearat, nipagin, isopropyl miristat, lanolin, oleum rosae, dan talkum. Dengan variasi konsentrasi ekstrak daun bayam merah F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%). Kemudian campuran serbuk dicetak dengan alat press. Selanjutnya dilakukan pemeriksaan persyaratan mutu fisik sediaan eye shadow compact powder yaitu uji dispersi warna (homogenitas), uji poles, uji kerapuhan, dan uji stabilitas terhadap bentuk,warna dan aroma pada penyimpanan suhu kamar selam 30 hari, serta uji iritasi terhadap sediaan F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%). Berdasarkan hasil yang diperoleh semua sediaan F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%) homogen terdispersi merata, tidak rapuh, stabil dalam penyimpanan suhu kamar selama 30 hari, dan tidak mengiritasi kulit. Namun pada pemeriksaan uji oles pada sediaan F3 (18%) memiliki daya oles yang kurang baik dikarenakan perlu 5 kali pengolesan agar warna terlihat jelas menempel pada kulit sedangkan pada sediaan F0 (Blanko), F1 (8%) dan F2 (12%) cukup dengan 3 kali pengolesan warna sudah terlihat dan menempel.
ANTI-BACTERIAL ACTIVITY TESTING OF ETHANOL EXTRACT 96% PAINAGE SKIN (ANANAS COMOSUS (L.) MERR) AGAINST ESCHERICHIA COLI BACTERIA) . S, Aminah; Abdilantri, Dewi
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1016

Abstract

Pineapple peel (Ananas comosus (L.) Merr) is waste form the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Escherichia coli. Escherichia coli is a bacterium that generally lives in the large intestine of humans can become a pathogen when it reaches tissues outside the digestive tract which can cause diarrheal disease. The pineapple peel extract is made by using the ectraction method in the form of meceration. The method used in the inhibitory test using the two replication sampels in each treatment groups. The samples consisted of 6 treatment groups is pineapple peel extract concentration 25mg/ml, 50mg/ml, 75mg/ml, and 100mg/ml, as well as positive and negative control. The results obtained from pineapple screening contain alkaloi, flavonoid, tanin, and saponin compounds. The data analysis showsthat pineanepple peel extract concentrations of 25mg/ml, 50mg/ml, 75mg/ml, and 100mg/ml had inhibitory sones with the medium-strong category while ciproloxacin as the control has a strong inhibition zone. The conclusion that while the extract concentration increases, the diameter of the inhibition zone increases.
FORMULATION OF SOLID BATH SOAP PREPARATIONS OF PURPLE SWEET POTATO ETHANOL EXTRACT (IPOMEA BATATAS L) AS A SKIN MOISTURIZER Wulandari, Suci; Niasari Silaen, Ayu Renta; Wahyuni, Siti
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1018

Abstract

Soap is a surfatctant used to clean or wash something that is available in solid and liquid form. Soap can be useful as a cleaning tool, this is because soap molecules contain polar (bonded with water) and non-polar (bonded with oil) groups so that they can clean grease or dirt that is not lifted by water. Soap is made by applying a saphonification reaction using olive oil, NaOH, and purple sweet potato extract as the basic ingredients. The addition of NaOH concentration an affect the weight of the soap produced. Purple sweet potato is a sweet potato that has natural dyes a anthocyanins that function as antioxidant. The purpose of this study was to obtain a solid bath soap formulation with purple sweet potato extract. Furthermore, purple sweet potato extract was formulated based on formula with concentration difference of 3,5%, 4,5%, 5,5%. Furthermore, preparations have been made with organoleptic tests, pH tests, and foam stability tests. It can be concluded that purple sweet potato extract can be used as a solid soap preparation and there is a concentration effect on the organoleptic test soap quality, pH, foam stability and moisture content. The preparation of solid bath soap from purple sweet potato ethanol extract has the ability to moisturize the skin, and the highest concentration obtained at a concentration of 5,5% with 57,83% moisture can moisturize the skin and at concentration of 4,5% with 48,3% humidity as well. Can moisturize the skin but with a moderate level of humidity, and at a concentration of 3,3% with 43,00% humidity with a lower humidity level.
ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF MANILA SAWO LEAVES (MANILKARA ZAPOTA) AGAINST BACTERIA STREPTOCOCCUS MUTANS) Turnip, Nur Ulina M. Br.; Sirait, Nia Yoseva; ., Sunariati
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1022

Abstract

Daun sawo manila merupakan salah satu tanaman yang dapat digunakan sebagai obat tradisional. Daun sawo manila mengandung senyawa metabolit sekunder flavonoid, fenolik, tanin, saponin, yang bersifat sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri pada ekstrak daun sawo manila (Manilkara zapota) terhadap bakteri Streptoccocus mutans. Penelitian ini merupakan penelitian eksperimental laboratorium. Sampel yang digunakan diperoleh dari daun sawo diekstraksi dengan metode maserasi menggunakan pelarut etanol. Metode yang digunakan dalam uji daya hambat antibakteri menggunakan difusi cakram dengan 6 kelompok perlakuan yang terdiri dari konsentrasi 50%, 60%, 70%, 80%, serta Amoxicillin sebagai kontrol positif dan DMSO sebagai kontrol negatif diulang sebanyak 4 kali pengulangan. Parameter yang diamati adalah diameter zona hambat pertumbuhan bakteri Streptococcus mutans. Analisis data menggunakan One way-ANOVA. Hasil penelitian menunjukkan ekstrak etanol daun sawo manila memiliki kemampuan daya hambat antibakteri pada konsentrasi 50% (15,85 mm), 60% (16,45 mm), 70% (17,05 mm), 80% (17,45 mm). Kesimpulan dari penelitian ini membuktikan bahwa ekstrak etanol daun sawo manila memiliki aktivitas daya hambat antibakteri terhadap bakteri Streptococcus mutans.
TESTING THE EFFECTIVENESS OF FORMULATION OF ANTIFUNCIAL PREPARATION OF GARLIC (ALLIUM SATIVUM L.) ETHANOL EXTRACT MOUNTWASH ON THE GROWTH OF CANDIDA ALBICANS Pranata, Chandra; Sundara, Putri; ., Evi
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1024

Abstract

Telah dilakukan penelitian tentang uji efektivitas formulasi sediaan antifungi obat kumur ekstrak etanol bawang putih (Allium sativum L.) Terhadap pertumbuhan jamur Candida albicans. Ekstrak etanol bawang putih mengandung beberapa senyawa metabolit sekunder, dimana yang berperan sebagai antijamur adalah alkaloid, flavonoid, saponin, dan tanin. Obat kumur ekstrak etanol bawang putih dibuat menjadi lima formula yaitu F0 (basis), F1 (ekstrak etanol bawang putih 15%), F2 (ekstrak etanol bawang putih 25%), F3 (ekstrak etanol bawang putih 50%), dan F4 (ekstrak etanol bawang putih 100%). Evaluasi obat kumur meliputi pemeriksaan Organoleptis, dan Homogenitas. Uji aktivitas antijamur sediaan obat kumur dilakukan dengan metode difusi agar dan dianalisis menggunakan ANOVA satu arah. Hasil evaluasi menunjukkan bahwa sifat fisik sediaan obat kumur memberikan hasil yang baik dan memenuhi syarat sediaan obat kumur. Hasil uji aktivitas antijamur sediaan obat kumur memberikan diameter rata-rata daya hambat sebesar F1 (12,3 mm), F2 (17,3 mm), F3 (18,5 mm) dan F4 (21,6 mm).

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