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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Malnutrition and Pneumonia among Under-five Children in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia Myggi Rizdwike Nanda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.742

Background: Pneumonia is one of the top causes of morbidity in children younger than 5 years old. In Indonesia, pneumonia was the second leading cause of death in children under five years in 2017. The most important risk factors for pneumonia in children are malnutrition, household air pollution, non-exclusive breastfeeding, low birth weight (2500 g), overcrowding (≥ 7 or more person in the same household), and lack of measles immunization. This study aimed to determine the relationship between nutritional status and pneumonia in under-five children in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia. Methods: Analytical observational studies with a cross-sectional approach. A total of 191 subjects took part in the study. Observations of the nutritional status and degree of pneumonia were carried out in this study. Univariate and bivariate data analysis was carried out with the help of SPSS version 25 software. Results: The majority of study subjects with pneumonia had normal nutritional status. Meanwhile, study subjects with severe pneumonia conditions had malnutrition nutritional status. The results showed that nutritional status was associated with pneumonia, with a p-value of < 0.05. Conclusion: There is a relationship between nutritional status and the severity level of pneumonia in children under five years old in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia.

Use of Personal Protective Equipment and Length of Work as Risk Factors for Occupational Contact Dermatitis on the Hands of Woodworkers Anggelina Aiyoslla Nabilla Putu Pratomo; Ratih Pramuningtyas; Flora Ramona Sigit Prakoeswa; Yusuf Alam Romadhon
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.746

Background: Occupational contact dermatitis (OCD) is an inflammatory response caused by contact with allergens or irritants in the work environment, and this disease is most often found as an occupational disease. Personal protective equipment (PPE) is a safety tool that must be used by workers to protect the body from possible potential hazards in the workplace. Construction workers, woodworkers, batik workers, and farmers can take preventive measures to avoid the occurrence of OCD. This study aimed to determine the relationship between the length of work and the use of PPE on the incidence of OCD on the hands of woodworkers in Serenan, Klaten. Methods: Cross-sectional analytic observational study. A total of 30 research subjects participated in this study. The research subjects were woodworkers in Serenan, Klaten, Indonesia. Univariate and bivariate data analysis was carried out with the help of the SPSS program. Results: The majority of research subjects with OCD have worked for more than 3 years and do not use PPE. Studies show that there is a relationship between the length of work and the use of PPE with the incidence of OCD. Conclusion: There is a significant relationship between the length of work and the use of PPE on the incidence of OCD on the hands of woodworkers in Serenan, Klaten, Indonesia.

The Prevalence of Bimaxillary Protrusion in Ethnic Malay, Medan, Indonesia Zulfan Muttaqin; Lina Hadi; Widia Hirdayanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.748

Background: Malocclusion is a deviation from the normal position of the teeth when the jaw is closed. The bimaxillary protrusion is the most prominent or most common of Angle's class I malocclusions. This study aimed to determine and present the prevalence of bimaxillary protrusion disorder in ethnic Malay adolescents in Medan, Indonesia. Methods: Descriptive observational study. A total of 35 research subjects were included in this study. An exploration of bimaxillary protrusion disorders was also carried out, and an exploration of demographic data was also carried out. Univariate analysis was carried out to determine the frequency distribution of each test variable with the help of SPSS version 25 software. Results: The majority of study subjects had bimaxillary protrusion angle class I malocclusion, namely 22 people (62.9%), while only 13 respondents (37.1%) had no bimaxillary protrusion malocclusion. The results of this study indicate that the prevalence of bimaxillary protrusion abnormalities in the Malay ethnicity is quite high, namely 62.9%. Conclusion: The prevalence of bimaxillary protrusion disorders in ethnic Malay is 62.9%.

Profile of Skin Prick Test in Urticaria Patients: 5 Years Retrospective Study at Dermatology and Venereology Polyclinic, Dr. Moewardi General Hospital, Surakarta, Indonesia Winda Wijayanti; Annisa Fildza Hashfi; Muhammad Eko Irawanto; Triasari Oktavriana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.749

Background: Urticaria is a skin disorder due to the release of mast cell mediators, which is characterized by raised skin (urtica) accompanied by itching. Skin prick test (SPT) is a rapid, sensitive test for detecting IgE-mediated allergic disease. This study aimed to determine the profile of SPT in urticaria patients. Methods: A descriptive observational study involving 67 research subjects retrospectively using medical record data for the period January 2017-June 2022. Univariate data analysis was carried out in this study with the help of SPSS version 25 software. Results: A total of 67 urticarial patients with positive results on the SPT investigation found that there were more women (71.64%) than men (28.36%), with the most age group being 16-25 years old with 16 patients, followed by 13 patients aged 56-65 years, 12 patients aged 46-55 years, 10 patients aged 36-45 years, 9 years of 26-35 years, 5 patients aged ≥ 65 years and the last age group, namely ≤ 15 years of age in 2 patients. Distribution of urticaria with the most locations in the generalized region, with as many as 20 patients (29.85%), followed by the extremity region with as many as 18 patients (26.87%), the facial region with as many as 17 patients (25.37%) and the least location in the trunk region as many as 12 patients (17.91%). Allergen tests that caused the most were house dust in 21 patients (11.86%), crabs in 18 patients (10.17%), and egg yolk in 11 patients (6.21%). Conclusion: Skin prick test profile at the dermatology and venereology polyclinic, Dr. Moewardi General Hospital, Surakarta, Indonesia, for the period January 2017-June 2022, where the results obtained were that there were more women than men, the largest age group was 16-25 years, the most common distribution of urticaria locations was found in the generalized region and the most common allergens caused by house dust.

A Rare Case of Giant Congenital Melanocytic Nevi: A Case Report Marina Saribulan; Ennesta Asri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.750

Background: Giant congenital melanocytic nevi are often characterised as melanocytic lesions present at birth. It is thought that it affects 1 in 20,000 births. The lesion is significant because it may be associated with serious consequences, such as malignant melanoma, and may also result in neurological deficits, such as neurocutaneous melanocytosis. This study aimed to present the case of giant congenital melanocytic nevus as a rare case. Case presentation: This study reported a 14-year-old female reported with large blackish rough spots on the trunk that were neither itchy or painful since birth. The patient had no previous history of convulsions, headaches, or vomiting. Plaque hyperpigmentation, macula hyperpigmentation, and hypertrichosis were found on the trunk. Dermoscopy show reveals brown-black homogeneity. Histopathology examination reveals brown-pigmented nevus cells distributed diffusely, with some nevus cells surrounding adnexa skin. Conclusion: Regular examination is essential to monitor the possibility of neurocutaneous melanosis and malignant melanoma development.

The Effectiveness of Antiplatelet Therapy in COVID-19 Patients: A Narrative Literature Review Muhammad Ridhwan Fatharanifurqan; Rudy Afriant; Raveinal; Fauzar; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.751

Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 patients is still unclear, so further research is needed.

The Role of Virtual Reality in Cancer Pain Management: A Systematic Literature Review Ignatia Novianti Tantri; Aida Rosita Tantri; Sidharta Kusuma Manggala; Riyadh Firdaus; Tasya Claudia Pardede
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.752

Background: Virtual reality (VR) is a 3D environment-based simulation using computer technology that creates a realistic multi-sensorial experience. VR allows users to simulate real-world scenarios in a safe, attractive virtual space. Immersive VR has been proposed as a non-pharmacologic approach to cancer pain management. This systematic review aimed to explore the role of virtual reality in cancer pain management. Methods: The current review was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This study used PICO consisting of population: adult patients with cancer pain, intervention: virtual reality, comparison: placebo, outcome: reducing cancer pain. Results: Four studies of moderate to the high quality that met the inclusion and exclusion criteria were reviewed in this study. Two studies show VR can reduce stress and anxiety and increase relaxation. Two RCTs demonstrated the effectiveness of VR in reducing cancer pain. Conclusion: Virtual reality technology can help to reduce cancer pain. In addition to pain severity, other parameters such as fatigue, depression, anxiety, and stress also were decreased. VR also could increase the level of relaxation. Virtual reality's role in reducing pain can have good implications for cancer pain management and increasing patient comfort.

Antibacterial Effectiveness of Jatropha Leaf Extract (Jatropha curcas L.) against Aggregatibacter actinomycetemcomitans: In Vitro Study Shieny Lokanata; Molek; Muthia Ayu Siregar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.754

Background: Periodontal disease is one of the most common dental and oral health problems. Periodontal disease is characterized by inflammation as well as damage to the periodontal tissues, including the alveolar bone, cementum, gingiva, and the periodontal ligament. Aggregatibacter actinomycetemcomitans is the dominant bacterium in cases of periodontitis. Jatropha curcas plant is one of the ingredients that has been widely used for traditional medicine in the community, especially for the leaves. This plant is rich in active compounds such as alkaloids, tannins, phenols, flavonoids, and saponins, which are effective against gram-positive and gram-negative bacteria. This study aimed to determine the effectiveness of Jatropha extract (Jatropha curcas L.) as an antibacterial against Aggregatibacter actinomycetemcomitans in vitro. Methods: In vitro experimental studies. A total of 28 petri dishes contained bacterial colonies Aggregatibacter actinomycetemcomitans were used and divided into 7 test groups, treatment, and control groups. Obtained data were analyzed using SPSS program. Results: Jatropha extract treatment group with a concentration of 35% to 65% had optimal antibacterial abilities as the dose increased. This study also showed that at a concentration of 25%, Jatropha curcas extract did not have the antibacterial ability. Conclusion: Jatropha curcas extract has an antibacterial effect as the concentration of the extract increases againts Aggregatibacter actinomycetemcomitans.

Immunotherapy in Lung Cancer: A Narrative Literature Review Hendris Utama Citra Wahyudin; Afriani Afriani; Fenty Anggrainy; Sabrina Ermayanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.755

Lung cancer is the most common cause of death from cancer in both men and women worldwide. Cancers with low immunogenicity often do not present antigens, so immune responses can be avoided. Uncontrolled growth of tumor cells occurs due to various factors such as activation of immunosuppressive mechanisms, induction of various immunosuppressive cells, and expression of immune checkpoint molecules. The development of lung cancer management has progressed since the discovery of molecular-based target therapy and immunotherapy. The high expression of tumor mutational burden in lung cancer indicates high immunogenicity in lung cancer. Various immunological mechanisms involving programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been developed for the treatment of lung cancer by utilizing immune system modulation. Nivolumab is the first approved immunotherapy for lung cancer, followed by pembrolizumab, atezolizumab, and durvalumab. The use of immunotherapy involving immune checkpoint inhibitors is an important breakthrough in the management of cancer, including lung cancer. This literature review aimed to describe immunotherapy in lung cancer that focuses on immune checkpoint inhibitors anti-PD-1 and anti-PD-L1.

Comparison of Accuracy Scores between CLOC and RSCLO Scoring Systems in Predicting the Risk of Preoperative Laparoscopic Cholecystectomy Conversion at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia Nurhayat Usman; Bambang Am Am Sulthana; Reza Syahrial Adiguna
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.756

Background: Cholecystectomy is a surgical therapy for cholelithiasis which can be performed by open cholecystectomy or laparoscopic cholecystectomy. Not all laparoscopic cholecystectomy procedures work properly. Sometimes it requires conversion from laparoscopic cholecystectomy to open cholecystectomy. A risk factor scoring system has been developed and validated using a large prospective cholecystectomy database and can accurately predict the likelihood of conversion with the conversion from laparoscopic to open cholecystectomy (CLOC) score and risk score for conversion from laparoscopic to open cholecystectomy (RSCLO). This study aimed to compare the accuracy value between CLOC and RSCLO in predicting the risk of preoperative laparoscopic cholecystectomy conversion at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Methods: This study was an observational study with a cross-sectional approach. A total of 183 research subjects participated in this study. Observation of CLOC and RSCLO scores was carried out in this study. Univariate and bivariate data analysis was carried out using SPSS. The analysis of the value of sensitivity, specificity, positive predictive value, and negative predictive value were carried out using Medcalc software. Results: A CLOC score > 5.5 has a greater conversion risk than a CLOC score ≤ 5.5. Meanwhile, an RSCLO score >-2 has a greater conversion risk than an RSCLO score ≤ -2. Sensitivity value CLOC for the prediction of preoperative conversion from laparoscopic cholecystectomy to open cholecystectomy obtained 75% and a specificity of 74.85%, with value negative predictive value, which is higher than a positive predictive value and 74.86% accuracy. The sensitivity value RSCLO for the prediction of preoperative conversion from laparoscopic cholecystectomy to open cholecystectomy was obtained at 75% and a specificity of 77.78%. With value negative predictive value, which is higher than the positive predictive value and 74.86% accuracy. Conclusion: The CLOC and RSCLO scores were equally accurate in predicting preoperative conversion from laparoscopic cholecystectomy to open cholecystectomy.

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

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Contact Name
Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA