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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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The Relationship between Metabolic Control Status and Microalbuminuria in Pediatric Diabetes Mellitus Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Fatmah Sindi; Aumas Pabuti; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.757

Background: Diabetes mellitus (DM) is a complex metabolic disorder that can cause many complications. HbA1c measurement can help monitor long-term serum glucose regulation. Microalbuminuria in DM patients is a risk factor for these complications, so evaluation of risk factors for prevention is necessary. This study aimed to determine the relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study is an analytic observational study with a cross-sectional approach. A total of 34 children with DM aged 1-18 years participated in this study. Sampling was carried out using the consecutive sampling method at the pediatric polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from November 2021-April 2022. Metabolic control status was assessed by measuring HbA1C levels and microalbuminuria by measuring the urine albumin-creatinine ratio. Data analysis used the Chi-square test, with a p-value <0.05. Results: The average respondent was 13.2 ± 3.3 years old with a duration of suffering from DM 2.5 ± 2 years. Most of the respondents were male (52.9%), suffered from type 1 DM (94.1%), had uncontrolled metabolic control status (82.3%), had a normal creatine albumin ratio (82.4%), never had diabetic ketoacidosis (79.4%), had no family history of DM (85.3%) and had normal blood pressure (94.1%). It is known that the average urea and creatinine are within normal limits. The average HbA1c value is 11.9 ± 3.39%. The median urine creatine albumin ratio was 7.98 (0-255.74) ug/mg. Microalbuminuria in uncontrolled metabolic control status was found in as much as 17.6%, whereas in controlled metabolic control status, no microalbuminuria was found. Statistically, there is no significant relationship (p>0.05). Conclusion: There is no relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

Diagnosis and Treatment of Typical Cold-Induced Urticaria: A Case Reports Nurul Nisa Ulfa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.758

Background: Urticaria is a common disease in society. 15-25% of individuals must have experienced urticaria at least once in their life. Cold urticaria is included in the type of chronic inducible urticaria and is a type of urticaria that accounts for 3% of cases of all types of chronic urticaria that occur. The age group that most suffers from urticaria is the age 12-25 years. This study was aimed at presenting the diagnosis and treatment of cold urticaria. Case presentation: A 29-year-old woman came with complaints of itching and redness on the hands, feet, and neck, starting with a small round reddish rash that widened and the center was paler than the edges, then disappeared within 1-2 hours, there is no a history of infectious or autoimmune diseases but has a family history of the same complaint. Examination of the ice cube test obtained positive results after 7 minutes of contact with ice cubes. Patients were given therapy in the form of cetirizine 10 mg per day for 2 weeks, which was then increased by a dose of 20 mg with a combination of cetirizine 10 mg in the morning and loratadine 10 mg at night. Conclusion: Exploration of precipitating factors through detailed anamnesis and supporting examinations with a cold stimulation test can establish a diagnosis of typical cold-induced urticaria.

The Effect of Intravenous Essential Amino Acid Supplementation on Recovery of Kidney Function in Acute Kidney Injury Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Maya Sari; Novadian; Yulianto Kusnadi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.759

Background: Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function that causes homeostatic failure in regulating fluid, electrolyte, and acid-base balance within hours to days. Nutritional supplementation is effective in replacing lost protein and as an energy reserve. This study aimed to determine the effect of intravenous essential amino acid supplementation on the recovery of kidney function in acute kidney injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study is an open clinical trial of experimental research. A total of 34 research subjects participated in this study, where the subjects were grouped into treatment (IV amino acid supplementation) and placebo groups. Data analysis was carried out using STATA in univariate and bivariate. Results: Administration of amino acid supplements can reduce creatinine by 1.36. Meanwhile, the placebo was unable to reduce creatinine levels and even caused an increase in creatinine by 0.26. Conclusion: Intravenous administration of essential amino acid supplements has an effect on the recovery of kidney function in acute kidney injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Effectiveness of Garlic Extract (Allium sativum) against Decreased Serum Levels Tumor Necrosis Factor-α (TNF-α) in Chronic Hemodialysis Patients at Dr. Mohammad Hoesin General Hospital Eeng Yoneska; Zulkhair Ali; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.760

Background: Chronic kidney disease (CKD) is a pathophysiological process with various etiologies resulting in a progressive decline in kidney function and generally ends in kidney failure. During hemodialysis, inflammation and activation of TNF-α and other proinflammatory cytokines occur. This inflammatory condition causes a decrease in the effectiveness of HD in reducing the mortality of patients with CKD. Garlic has the potential as an anti-inflammatory agent due to its high antioxidant content in garlic. This study aimed to determine the effectiveness of garlic extract (Allium sativum) on decreasing serum levels of tumor necrosis factor-α (TNF-α) in chronic hemodialysis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study is an experimental study with a randomized, controlled, double-blind trial crossover design. A total of 40 research subjects participated in this study which was grouped into treatment (garlic extract) and placebo groups. TNF-α levels were measured using the ELISA method. Data analysis was carried out using SPSS univariate and bivariate. Results: The results of the study showed that the administration of garlic extract was able to reduce TNF-α levels by 12.5 pg/mL, p<0.05. In contrast, in the placebo group, there was an increase in TNF-α levels of 8.3 pg/mL, p<0.05. Conclusion: Garlic extract (Allium sativum) is effective in reducing tumor necrosis factor-α (TNF-α) serum levels in chronic hemodialysis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Neutrophil Lymphocyte Ratio and Hepatitis C Virus RNA in Hepatitis C Coinfected HIV Patients Receiving Direct-Acting Antiviral Therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Suyata; Prabjot Singh; Harun Hudari; Taufik Indrajaya; Nurmalia Purnama Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.761

Background: Hepatitis C is an inflammatory disease of the liver caused by infection with the hepatitis C virus (HCV). Inflammatory markers are significant in assessing the course of an infectious or inflammatory disease. One of them is the neutrophil-lymphocyte ratio (NLR) and the amount of HCV RNA viral load, which combines neutrophils as an active inflammatory component and lymphocytes as a regulatory and protective component in a single parameter. Research on the relationship between NLR and HCV RNA in HIV patients coinfected with HCV is still limited. This study aimed to determine the relationship between NLR and HCV RNA in HIV-HCV coinfected patients who received DAA therapy and went to the outpatient polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: Analytic observational study. A total of 38 research subjects participated in this study. Observation of NLR was carried out using hematology analyzer, and observation of HCV RNA levels was carried out using the PCR technique. Data analysis was carried out using SPSS univariate and bivariate. Results: There was a difference between pre-post therapy NLR and pre-post therapy HCV RNA viral load, p<0.05. NLR is in line with HCV RNA viral load as a prognostic tool for successful DAA therapy in HIV patients coinfected with hepatitis C. Conclusion: There is a relationship between HIV and HCV RNA in hepatitis C coinfected HIV patients receiving direct-acting antiviral therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Overview of Microorganism Patterns Causing Pathological Fluor Albus at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Raden Ayu Kusuma Andini; Ferry Yusrizal; Azhari Rozali; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.763

Background: Fluor albus, also known as leucorrhoea, vaginal discharge, or leukorrhea, is the name given to fluids that are secreted from the genitals that are not blood. Pathological fluor albus can be caused by an infection in the lower genitalia or in areas that are more proximal. This study aimed to determine the pattern of microorganisms that cause pathological fluor albus at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study was a descriptive observational study and used primary data from a direct examination of research subjects at the obstetrics and gynecology polyclinic of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 63 research subjects participated in this study. Analysis of microorganism patterns was carried out univariately using SPSS software. Results: The majority of microorganisms that cause pathological fluor albus are Gardnerella vaginalis. Meanwhile, in non-pathological conditions of fluor albus, the majority of causative microorganisms are E. coli. Conclusion: Gardnerella vaginalis is the most common causative microorganism of pathological fluor albus disorders at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Update Management of Chemotherapy-Induced Neutropenia: A Narrative Literature Review Mita Adriani; Mediarty Syahrir; Yenny Dian Andayani; Norman Djamaluddin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.764

One of the most frequent and significant complicated side effects of myelosuppressive drugs is neutropenia. Neutropenia is not only associated with high morbidity but also mortality. Generally, the onset of neutropenia occurs within 3-7 days after the administration of anticancer agents. Approximately 5-30% of patients will develop febrile neutropenia. The highest incidence occurs during the first cycle of chemotherapy. This literature review aimed to describe chemotherapy-induced neutropenia and its prevention and management. Administration of granulocyte colony-stimulating factor as prophylaxis can prevent neutropenia-induced anticancer drugs. The use of granulocyte colony-stimulating factor (G-CSF) as therapeutic is contradictive, and some guidelines recommend not to use the G-CSF for therapeutic purposes. Up to 70% of mortality among these populations was associated with gram-negative sepsis, therefor empirical antibiotics, and antifungals are the keys to the management of neutropenia. In conclusion, prevention and appropriate management of neutropenia are extremely important in the treatment of patients with cancer.

En Coup De Sabre in 16-Year-Old Girls: A Case Report Gardenia Akhyar; Fauzana Nazifah; Ennesta Asri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.770

Background: En coup de sabre (ECDS) is one of the clinical variations of morphea. ECDS refers to a variant of linear morphea that usually involves the forehead and frontal scalp that may be associated with alopecia. This study aimed to describe a case of en coup de sabre with its diagnosis and management. Case presentation: A girl, aged 16 years, came to the dermatology polyclinic with the main complaint of a sunken brown spot on the left forehead and corner of the left eye, which has been expanding since 2 months ago. This complaint does not feel itchy or painful, but because it is getting more widespread, patients feel embarrassed and often cover it up. On dermatological examination, depressed hyperpigmented macules, plaque size, firm boundaries, and location on the left medial superior lid and left medial glabella were found. On dermoscopy examination, a reticular pigment network obliterating the follicular opening was found. The results of the histopathological examination showed the impression of a linear morphea type with en coup de sabre. This patient was diagnosed with linear morphea type with en coup de sabre Conclusion: En coup de sabre is a rare autoimmune disorder and is a subtype of morphea. Early detection and appropriate intervention will reduce disease progression.

Allergy on HIV Infections: A Narrative Literature Review Muhammad Iqbal Andreas; Dwitya Elvira; Raveinal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.771

HIV infection causes not only immune insufficiency but also immune dysregulation. Following HIV infection, cytokine profiles change, with a production of IL-4 rising along with IL-5 and a decrease in INF-g. This literature review aimed to describe allergy on HIV infection. At the initial phase after infection, cytokines produced by Th1 and Th2 are balanced, but later as the infection progresses, cytokines produced by Th2 will rise, while cytokines produced by Th1 will fall. Elevation of IL-4 will make B cells produce more IgE. Patients with even lower CD4 still have this allergic phenomenon caused by IgE. Allergic manifestations of HIV include rhinitis, asthma, adverse cutaneous drug reactions (ACDR), immune reconstitution inflammatory syndrome, hyperallergic state (IRIS), and atopic dermatitis. In conclusion, it is important to consider allergic manifestations even in AIDS patients, especially incidents of ACDR and IRIS, which can be life-threatening.

The Role of Immunophenotyping in the Diagnosis of Acute Leukemia: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Drajad Priyono; Raveinal; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.772

Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one of the modalities of leukemia therapy that is selective for certain cells that can be given based on the results of immunophenotyping.

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

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Contact Name
Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA