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Jurnal Respirasi (JR)

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Published by Universitas Airlangga

ISSN : 24070831 EISSN : 26218372 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.

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Articles 11 Documents

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Search results for , issue "Vol. 8 No. 3 (2022): September 2022" : 11 Documents clear

Second-Hand Smoke and Early Allergic Manifestation in Children Sitisalma Amirah Dzakiyyah; Anang Endaryanto; Linda Dewanti; Azwin Mengindra Putera; Anisa Ayu Maharani
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: The interaction between genetic and environmental factors plays an important role in shaping the early development of allergies, including exposure to cigarette smoke. This study aimed to determine the relationship between second-hand smoke exposure and early allergic manifestations in children. Methods: This was an observational analytic study with a cross-sectional design. Pediatric patients who suffered from allergies in the allergy outpatient clinic at the Department of Pediatrics, Dr. Soetomo General Hospital, Surabaya were included in this study. Data were obtained through medical records. Results: This study involved 190 patients and showed that 50% of the patients have families who smoke at home, the most common early manifestations were at 11-20 months old (32.10%), and the most common early manifestations were respiratory manifestations (98.42%). There was a significant relationship between the presence of a family member who smoked at home with the age of early manifestation, respiratory manifestation, and skin manifestation in allergic pediatric patients (all p < 0.05). There was no significant relationship between the presence of family members who smoked at home with gastrointestinal manifestations in allergic pediatric patients (p = 0.301). Conclusion: There was a significant relationship between the presence of family members who smoke at home with age, respiratory tract, and skin manifestations in allergic pediatric patients.

Effect of Walking Exercise with Breathing Control on the Degree of Shortness of Breath, Anxiety, and Depression in COPD: A Systematic Review Orita Satria; Dewi Elizadiani Suza; Mula Tarigan
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Chronic obstructive pulmonary disease (COPD) is a high disease burden and negatively impacts the bio-psycho-social well-being of patients, such as anxiety, depression, and shortness of breath. Anxiety and depression can increase morbidity and worsen the condition and health status of the patient. This systematic review aimed to analyze the effect of walking exercises with breathing control on the degree of shortness of breath, anxiety, and depression in COPD patients. Methods: The data sources were taken from EBSCO, PubMed, and ProQuest using related keywords. Articles were selected using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) diagram method. Results: Ten articles in this systematic review obtained three intervention categories: 1) intervention combined walking exercises with breathing control can be performed 30 minutes per session 2-3 times a week; 2) walking exercise intervention is performed thrice a week for 30-45 minutes per session; 3) breathing control exercise intervention is performed 10-30 minutes with a duration of 2 times a day in the morning and night or can be performed three times a week. Those three intervention categories significantly reduced the degree of shortness of breath, anxiety, and depression in COPD patients. Conclusion: Findings from this systematic review suggest that walking exercise intervention in COPD patients can help reduce the degree of shortness of breath, anxiety, and depression.

Phantom Tumors in COVID-19: A Case Report Felita Ferdiana; Wayan Wahyu Semara Putra; Velensia Lawrence; Jennifer Mochtar
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: A phantom tumor, or vanishing lung pseudotumor, is an atypical type of pleural effusion in which fluid is accumulated in the pleural cavity. It is a transient and well-demarcated pleural fluid accumulation in the interlobar pulmonary fissures. In this study, we reported a rare case of a pleural effusion appearing as a phantom tumor in COVID-19 without congestive heart failure. Case: A 29-year-old man was presented with complaints of dry cough, sore throat, fever, and fatigue. He denied shortness of breath and loss of taste and smell. He had no smoking habit and did not have any past medical history. Physical examinations were within normal limits, except for a slight fever. The laboratory examination showed positive SARS-CoV-2 RT-PCR and an increased liver function test. His chest X-ray revealed findings suggestive of a phantom tumor accompanied by bilateral pneumonia. The patient received COVID-19 treatments. A follow-up chest X-ray revealed the complete resolution of the lesion. Conclusion: A phantom tumor is a rare case. It is caused by heart disease and other causes, one of which is COVID-19. The treatment for this condition is based on the underlying disease.

Respiratory Travel Medicine Ni Wayan Candrawati
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

International tourist arrivals continue to increase over time due to global economic growth, increasing middle class in developing countries, technological advances, innovative business concepts, cost-effective travel, and facilitation of visas. The increase in tourist visits has resulted in health problems due to the trips. Respiratory tract infections are the main reason tourists seek medical care. Respiratory infections occur in 20% of all tourists, almost the same as the incidence of diarrhea. The majority of international inbound tourism involved air travel. Though physiological changes happen in everyone while air travel, people with lung disease are at high risk for significant complications and necessitate a specific risk assessment strategy. A pre-flight evaluation is conducted if there is any uncertainty regarding the patient's fitness for flight and the effect of eligibility to fly. This literature review summarized the important aspect of travel medicine from the respiratory medicine point of view.

Bedaquiline Correlation to QT Interval Prolongation in DR-TB Patients Vandu Primadana; Indra Yovi; Dyah Siswanti Estiningsih
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: The regimen of drug-resistant tuberculosis (DR-TB) is Bedaquiline. One of the adverse events is QT interval prolongation, which can increase the risk of Torsade de Pointes (TdP) and lead to death. DR-TB patient screening before starting the treatment and monitoring QT interval during the treatment should be performed. This study aimed to determine Bedaquiline correlation to QT interval prolongation in DR-TB patients. Methods: This was a retrospective study using an observational design by viewing medical records of DR-TB patients who underwent treatment from January 2019 to March 2022. Results: This study involved 46 DR-TB patients with an average age of 41.4 years old, and 58.7% were males with a regimen of Bedaquiline. The comparison of Baseline QT intervals before and after one month of therapy showed QT interval prolongation (457.1 ± 18.2 ms and 443.8 ± 10.2 ms; p < 0.001). The comparison of QT intervals before the therapy and six months after the therapy showed prolongation QT intervals (443.8 ± 10.2 ms and 458.4 ± 23.7 ms; p < 0.001). QT intervals after one month of therapy compared to six months after the therapy showed insignificant slight prolongation (457.1 ± 18.2 ms and 458.4 ± 23.7 ms; p = 0.587). Conclusion: QT interval prolongation occurred in DR-TB patients who received treatment using Bedaquiline regimen. It was seen significantly between baseline QT interval and after receiving the therapy for one month and six months.

Prognostic Value of the Systemic Immune-Inflammation Index in EGFR Mutation-Positive Lung Adenocarcinoma Patients Treated with Tyrosine Kinase Inhibitors Marsheilla Riska; Haryati Haryati; Eko Suhartono; Tenri Ashari Wanahari
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Inflammatory parameters calculated from complete blood counts such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) are related to poor prognosis in lung cancer patients. This study aimed to explore a correlation between NLR, PLR, and SII to survival rates in advanced lung adenocarcinoma with tyrosine kinase inhibitors (TKIs) as the main treatment choice. Methods: This was a retrospective observational study of patients with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma treated by TKIs at Ulin General Hospital Banjarmasin from January 2017 to December 2019. The optimal cut-off values for NLR, PLR, and SII were obtained using the receiver operating characteristic curve (ROC). Kaplan–Meier analyses were used to assess the prognostic value of inflammation parameters in overall survival (OS) and progression-free survival (PFS). Results: This study involved 50 samples, 62% male, with an average age of 55.98 years old, 94% in stage IVA, EGFE mutation in exon 19 (58%) and exon 21 (42%). About 58% of patients have a smoking history. The optimal cut-off value for NLR, PLR, and SII was 6.095, 356.935, and 1767.0, respectively. However, only the SII was significantly associated with survival; SII ≥ 1767.0 correlated with shorter OS (18 months vs. 28 months, p = 0.014) and PFS (7 months vs. 12 months, p = 0.004). Conclusion: Pre-treatment SII can be a prognostic factor for survival in EGFR mutation-positive lung adenocarcinoma patients receiving TKIs.

Challenging Treatment of Drug-Resistant Tuberculosis during Pregnancy: A Case Report Ni Luh Putu Eka Arisanti; Ni Putu Ayu Widiasari; Ni Wayan Candrawati; Ida Ayu Jasminarti Dwi Kusumawardani; Ida Bagus Ngurah Rai; Made Ary Sarasmita
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Globally, drug-resistant tuberculosis (TB) still has a high number of cases. Pregnant women are one of the high-risk populations for TB infection, especially multidrug resistance (MDR)/Rifampicin resistance (RR) TB. Physiological differences in pregnant women and the safety of the fetus make drug resistance TB treatment challenging. Case: A 20-year-old woman was 22 weeks pregnant while undergoing the third month of the late phase for short-regimen. Thus, Kanamycin was one of her early phase treatment combinations during the first trimester of pregnancy. After we consulted with other departments, especially the obstetric department, we decided not to change her regimen. Her chief complaint before treatment was cough with white sputum and fluctuated shortness of breath for two months. The patient only experienced minor side effects in the early treatment phase. The patient was cured of MDR TB on 8 October 2020 at 34 weeks of gestation. Her baby was born on 10 November 2020 at 37 weeks without congenital abnormality. Observation for her baby continued by the pediatric department. The last follow-up of her baby in the middle of 2022 found no abnormality in the child’s growth and development. Conclusion: Drug-resistant TB therapy in pregnant women requires the collaboration of a multidisciplinary team to consider the benefits and risks of the therapy based on gestational age and disease severity.

Lung Abscess as a Delayed Complication in a COVID-19 Pneumonia Patient: A Case Report Indah Rahmawati; Regia Anadhia Pinastika; Raditya Bagas Wicaksono
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: In March 2020, the World Health Organization (WHO) proclaimed coronavirus disease 2019 (COVID-19) a global pandemic. Indonesia is one of the nations that is still dealing with the COVID-19 outbreak. COVID-19 has several complications, including lung abscesses in extremely rare cases. We presented the first reported COVID-19 patient in Indonesia with a delayed lung abscess. Case: A 30-year-old man presented to the hospital with breathlessness and tested positive for COVID-19. Chest X-ray revealed typical COVID-19 pneumonia. He was discharged after 16 days of hospitalization and was educated on using oxygen at home lest the breathlessness recurred. We planned to evaluate the patient’s chest X-ray after 2 weeks of discharge. The follow-up chest X-ray revealed an air-fluid level in the upper lobe of the right lung, indicating a lung abscess. The patient was treated with antibiotics for 2–3 weeks. Clinical follow-up 4 weeks after the treatment revealed no symptoms, and chest X-ray showed significant improvement. Conclusion: Lung abscess is one of the rare complications of COVID-19. A pulmonary infection creates an air-fluid level by forming a cavity in the lung parenchyma. Notably, this complication manifested 2 weeks after the patient was discharged. COVID-19 can have several unexpected complications, including lung abscesses. It is crucial to monitor patients after discharge for such complications, especially if they are symptomatic.

Role of Nintedanib in COVID-19-Related Lung Fibrosis Alif Fathurrachman; Linda Andriani; Rouly Pasaribu; Sudarto Sudarto; Ahmad Rasyid; Zen Ahmad; Tommy Setiawan
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

In December 2020, Indonesia was introduced to the long Coronavirus disease 2019 (COVID-19) phenomenon. The Centers for Disease Control and Prevention (CDC) introduced the term "post-COVID condition" as a health problem that persists after four weeks from the first exposure to COVID-19. The National Institute for Healthcare and Care Excellence (NICE) classifies COVID-19 infections into three categories based on disease duration: (1) acute infection for up to 4 weeks; (2) ongoing infection within 4-12 weeks; and (3) post-COVID-19 syndrome for more than 12 weeks and not associated with an alternative diagnosis. One of these phenomena is lung fibrosis. About 80% of COVID-19 survivors had mild to severe chest X-rays in 6 months of follow-up with decreasing lung function. COVID-19-related lung fibrosis is still not widely researched. COVID-19 survivors who develop lung fibrosis usually recover independently, but some develop persistent lung fibrosis. The use of antifibrotic agents, such as nintedanib, has long been approved for idiopathic pulmonary fibrosis (IPF). However, its use in the cases of lung fibrosis due to COVID-19 has not been widely studied. Nintedanib is a tyrosine kinase inhibitor. It inhibits receptor activity of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF). Those actions will eventually inhibit the proliferation, migration, and transformation of fibroblasts into myofibroblasts in lung fibrogenesis. Therefore, an antifibrotic agent is potentially needed to inhibit COVID-19-related lung fibrosis to improve quality of life and prevent further lung damage.

Front Matter Vol 8 No 3, 2022 Front Matter
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

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Jl. Mayjen Prof. Dr. Moestopo 6-8 Surabaya 60286 Indonesia

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Journal Mail Official respirasi@journal.unair.ac.id

Editorial Address Jl. Mayjen Prof. Dr. Moestopo 6-8 Surabaya 60286 Indonesia

Location Kota surabaya, Jawa timur INDONESIA

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Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
respirasi@journal.unair.ac.id

Editorial Address
Jl. Mayjen Prof. Dr. Moestopo 6-8 Surabaya 60286 Indonesia

Location
Kota surabaya,

Jawa timur

INDONESIA