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All Journal Folia Medica Indonesiana Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Respirasi (JR) Indian Journal of Forensic Medicine & Toxicology
Azwin Mengindra Putera
Department Of Pediatrics, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Profile of Determinant Factors on Drug Allergy Severity in Indonesian Children at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Bagas Triambodo; Azwin Mengindra Putera; Bambang Hermanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14671

Abstract

Background: Drug allergy in children is a rare case that needs special attention. Identifying the factorsthat affect the severity of drug allergy is important for the improvement of drug allergy management inIndonesian children. Objective: to analyze the factors that influence drug allergy severity in Indonesianchildren. Methods: This study used a retrospective design and consecutive sampling in 2014-2018. The datacollected included sex, types of allergy-causing drugs, previous allergy history, parental allergy history, andclinical manifestations. The data were analyzed by using a logistic regression test where the statistical testresults were significant if p <0.05. Results: The average age of the participants was 93.00 ± 50.54 monthswith a median value of 84 (12 - 204) months. Drug allergy severity in children is influenced by severalthings, such as the type of drug (? = 5.76; 95% CI 1.29 - 25.70; p = 0.022), sex (? = 1.27; 95% CI 0.30 - 5.36;p = 0.743), previous allergy history (? = 2.44; 95% CI 0.10 - 58.67; p = 0.583), and a drug allergy history onparents (? = 0.65; 95% CI 0.06 - 6.75; p = 0.719). Conclusion: There is a significant relationship betweendrug allergy severity and the type of drug whereas sex, previous allergy history, and a history of allergy onparents do not find a significant connection.
Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children Dinda Anes Tunjungsari; Anang Endaryanto; Ahmad Suryawan; Ariyanto Harsono; Zahrah Hikmah; Azwin Mengindra Putera
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14707

Abstract

Background: Allergic rhinitis (AR) is the most common chronic disease in children. Allergic symptomsaffect daily activities and increase risk of psychosocial emotion and attention deficit hyperactivity disorder(ADHD). Immunotherapy has been proven in improving AR symptomsObjective: To identify prevalence of the risk of psychosocial emotion disorder and ADHD and its relationwith immunotherapy duration in AR children.Methods: A cross-sectional study was held in AR children aged 4-18 years at Allergy Immunology OutpatientClinic, Dr. Soetomo Hospital, during March 2017. Immunotherapy duration categorized into 0-6 months, 6months-1 year, 1-2 years, 2-3 years. Psychosocial emotion disorder risk assessed using Pediatric SymptomsChecklist 17 (PSC-17), scored into four different subscales: Internalizing, Externalizing, Attention, andTotal Score. ADHD risk was assessed using Abbreviated Conner’s Rating Scale (ACRS). Statistical analysisusing One-Way ANOVA and Eta test, with a value of p< 0.05 considered as significant.Results: Total of 37 children included. Based on immunotherapy duration 0-6 months, 6 months-1 year, 1-2years, and 2-3 years, prevalence risk of ADHD are 20.6%, 15.4%, 12.5%, and 12.5%, and prevalence ofpsychosocial emotion disorder risk are only in immunotherapy duration 6 months-1 year 12.5%. There wereno correlation between immunotherapy duration with risk of psychosocial emotion disorder (p = 0.945) andsignificantly correlated to ADHD (p = 0.049, r = 0.326).Conclusion: Prevalence risk of ADHD decrease as the immunotherapy duration increase and immunotherapyduration weakly correlated with risk of ADHD.
Correlation of Age, Sex, and Symptoms to Number of Problematic Joints in Children with Idiopathic Juvenile Arthritis Made Retna Paramita Savitri; Azwin Mengindra Putera; Noor Idha Handajani
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14791

Abstract

Background: Juvenile Idiopathic Arthritis (JIA) is a rare case in Asia, including Indonesia. Objective:Analyze the correlation between age, sex, and symptoms on the number of joint problems in children withJIA symptoms. Methods: This study used a retrospective design from January 2016 to December 2019.The data collecting in this study was included age, sex, symptoms, and the number of joint problems. Theanalysis used was multiple linear regression with p <0.05. Results: The correlation between sex (? = 0.015;95% CI -0.002 – 0.002; p = 0.916), age (? = 0.015; 95% CI -0.197 – 0.291; p = 0.916) to the number ofjoint problems was not significant. While, the correlation between symptoms and the number of joints withproblems was significant, which included swelling (? = 1.012; 95% CI 0.243 – 1.782; p = 0.011), fever(? = 1.000; 95% CI 0.082 – 1.918; p = 0.034), and pain. (? = 0.931; 95% CI 0.082 – 1.918; p = 0.007).Conclusion: There is a significant relationship between symptoms and the number of problem joints whileage and sex are not significant
Food allergies in children: a comparison of parental reports and skin prick test results Camilia Metadea Aji Savitri; Azwin Mengindra Putera Lubis; Gatot Soegiarto
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.752 KB) | DOI: 10.14238/pi58.2.2018.59-65

Abstract

Background Food allergy is common in children and its prevalence is generally on the rise. Imprecise parental reports about reactions to particular foods can lead to unnecessary restrictions. Since children have specific growth requirements, such nutritional restrictions may have disturbing effects on children's growth and development. Objective To compare parental reports on food reactions to skin prick test results in their children. Method Retrospective, cross sectional study using patient's medical record data during one-year study period. Data were analyzed manually and statistically, to assess the degree of agreement (Kappa's coefficient) and significance (P). Results We collected data from 154 subjects aged 0-18 years. For every allergen assessed, parents reported more food reactions than positive skin prick test results. Allergy incidence were caused, in order, by cow's milk and chicken (25.3%), eggs (22.1%), chocolate (20.1%), fruits (14.3%), seafood (13%), and saltwater fish (1.9%). Kappa coefficient are all poor (<0.2) and P value are all >0.05 except for chicken (P=0.02). Conclusion Most parents tend to overestimate which food cause reactions in their children, as reactions reported were not necessarily allergenic. Therefore, every patient experiencing allergy reactions should undergo skin prick testing to confirm the possibility of allergy.
Second-Hand Smoke and Early Allergic Manifestation in Children Sitisalma Amirah Dzakiyyah; Anang Endaryanto; Linda Dewanti; Azwin Mengindra Putera; Anisa Ayu Maharani
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.634 KB) | DOI: 10.20473/jr.v8-I.3.2022.126-132

Abstract

Introduction: The interaction between genetic and environmental factors plays an important role in shaping the early development of allergies, including exposure to cigarette smoke. This study aimed to determine the relationship between second-hand smoke exposure and early allergic manifestations in children. Methods: This was an observational analytic study with a cross-sectional design. Pediatric patients who suffered from allergies in the allergy outpatient clinic at the Department of Pediatrics, Dr. Soetomo General Hospital, Surabaya were included in this study. Data were obtained through medical records. Results: This study involved 190 patients and showed that 50% of the patients have families who smoke at home, the most common early manifestations were at 11-20 months old (32.10%), and the most common early manifestations were respiratory manifestations (98.42%). There was a significant relationship between the presence of a family member who smoked at home with the age of early manifestation, respiratory manifestation, and skin manifestation in allergic pediatric patients (all p < 0.05). There was no significant relationship between the presence of family members who smoked at home with gastrointestinal manifestations in allergic pediatric patients (p = 0.301). Conclusion: There was a significant relationship between the presence of family members who smoke at home with age, respiratory tract, and skin manifestations in allergic pediatric patients.
Hubungan Fungsi Tiroid Dengan Pertumbuhan Pada Anak Sindrom Down Di Poli Endokrin Anak Rsud Dr. Soetomo Surabaya Hafidhatul Aisy; Nur Rochmah; Hermawan Susanto; Azwin Mengindra Putera Lubis
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.917 KB) | DOI: 10.36418/syntax-literate.v7i11.9973

Abstract

Anak-anak dengan Sindrom Down (SD) memiliki peningkatan risiko mengalami disfungsi tiroid. Hormon tiroid berperan penting dalam proses pertumbuhan sehingga gangguan fungsi tiroid dapat mempengaruhi pertumbuhannya. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi tiroid dengan pertumbuhan pada anak SD. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional menggunakan sumber data rekam medis pasien. Variabel bebas dalam penelitian ini adalah fungsi tiroid dan variabel terikatnya adalah pertumbuhan. Tinggi/ panjang badan merupakan parameter pertumbuhan yang dinilai menggunakan kurva standar untuk anak-anak dengan SD. Hasil dari penelitian ini adalah subjek penelitian terdiri dari 27 pasien SD (17 laki-laki, 20 perempuan) yang berusia 1 sampai 47 bulan dengan rerata usia 10.00±10.87 bulan. Distribusi fungsi tiroid terdiri dari 15 hipotiroid sentral (55.6%), 8 hipotiroid subklinis (29.6%), 3 hipotiroid primer (11.1%), dan 1 eutiroid (3.7%). Mayoritas subjek memiliki tinggi badan normal (22/27, rerata z-score -0,03±2,37). Nilai signifikansi korelasi antara fungsi tiroid (kadar TSH dan FT4) dan pertumbuhan (perubahan z-score) berturut-turut p=0,287 dan p=0,143 yang berarti p>0,05 sehingga tidak ada korelasi yang signifikan. Sehingga dapaty diterik kesimpulan bahwa tidak terdapat hubungan antara fungsi tiroid dengan pertumbuhan anak dengan SD. Namun disarankan untuk melakukan skrining fungsi tiroid, mendiagnosis, memonitor, dan memberikan terapi dini pada anak SD untuk mencegah perburukan kondisi perkembangan, pertumbuhan, dan metabolisme.
Hubungan Fungsi Tiroid Dengan Pertumbuhan Pada Anak Sindrom Down Di Poli Endokrin Anak Rsud Dr. Soetomo Surabaya Hafidhatul Aisy; Nur Rochmah; Hermawan Susanto; Azwin Mengindra Putera Lubis
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.522 KB) | DOI: 10.36418/syntax-literate.v7i11.10034

Abstract

Anak-anak dengan Sindrom Down (SD) memiliki peningkatan risiko mengalami disfungsi tiroid. Hormon tiroid berperan penting dalam proses pertumbuhan sehingga gangguan fungsi tiroid dapat mempengaruhi pertumbuhannya. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi tiroid dengan pertumbuhan pada anak SD. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional menggunakan sumber data rekam medis pasien. Variabel bebas dalam penelitian ini adalah fungsi tiroid dan variabel terikatnya adalah pertumbuhan. Tinggi/ panjang badan merupakan parameter pertumbuhan yang dinilai menggunakan kurva standar untuk anak-anak dengan SD. Hasil dari penelitian ini adalah subjek penelitian terdiri dari 27 pasien SD (17 laki-laki, 20 perempuan) yang berusia 1 sampai 47 bulan dengan rerata usia 10.00±10.87 bulan. Distribusi fungsi tiroid terdiri dari 15 hipotiroid sentral (55.6%), 8 hipotiroid subklinis (29.6%), 3 hipotiroid primer (11.1%), dan 1 eutiroid (3.7%). Mayoritas subjek memiliki tinggi badan normal (22/27, rerata z-score -0,03±2,37). Nilai signifikansi korelasi antara fungsi tiroid (kadar TSH dan FT4) dan pertumbuhan (perubahan z-score) berturut-turut p=0,287 dan p=0,143 yang berarti p>0,05 sehingga tidak ada korelasi yang signifikan. Sehingga dapaty diterik kesimpulan bahwa tidak terdapat hubungan antara fungsi tiroid dengan pertumbuhan anak dengan SD. Namun disarankan untuk melakukan skrining fungsi tiroid, mendiagnosis, memonitor, dan memberikan terapi dini pada anak SD untuk mencegah perburukan kondisi perkembangan, pertumbuhan, dan metabolisme.
Holistic Management of Pediatric Patients with Asthma through the Family Medicine Approach: A Case Series Azwin Mengindra Putera; Dinda Sella Octaviana; Fanny Gunawan; Manika Putri Kunigara; Junjungan Nimasratu Rahmatsani; Lavenia Kurniawati; Ferrel Bramasta; Istianah Istianah; Jihan Nabila Pranjasdhina; Gerald Sebastian Davis; Ashfa Diniyya Assabella; Akbar Rizky Ramadhan; Veronika Intan Krismaningrum; Wigaviola Socha Purnamaasri Harmadha
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.229-236

Abstract

Introduction: Asthma is a global problem, with around 100-150 million people estimated to suffer from this disease. Based on data from the Centers for Disease Control and Prevention (CDC), around 8.4% of people in the United States suffer from asthma. Asthma requires holistic treatment, one of which is family medicine. However, there is a lack of data or research discussing this matter. Hence, this case report aims to provide an overview of family medicine in asthma, especially in children. Case: This study is a case series report involving four pediatric patients with asthma. Data collection was performed by conducting home visits and hetero-anamnesis. Many things affect asthma treatment apart from pharmacology, including family medicine. In this case series, the role of the family proved significant in the patient's healing and daily functioning. Conclusion: Family medicine is a type of holistic management critical in various diseases, especially asthma. Support from the patient's family and environment has an essential role in the success of asthma therapy in children.
Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia Natalia Erica Jahja; Zahrah Hikmah; Azwin Mengindra Putera; Anang Endaryanto
Folia Medica Indonesiana Vol. 60 No. 1 (2024): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i1.53175

Abstract

Highlights:1. A questionnaire, comprising various risk factors associated with food allergies, is anticipated to provide reliable indications for determining the necessity of restrictive diets for patients within primary healthcare settings.2. Over time, the findings of this study can facilitate the development of a streamlined and cost-effective diagnostic tool, which will be particularly beneficial in remote regions due to its practical and efficient means of identifying food allergies. AbstractIn Gresik, Indonesia, limited resources have led to challenges in accurately diagnosing food allergies. This study aimed to identify risk factors for food allergies among children in Gresik using a questionnaire-based approach. The study's ultimate goal was to develop a simple diagnostic tool in primary healthcare settings. Conducted at Petrokimia Gresik Hospital, this cross-sectional study enrolled children aged ≥6 months experiencing respiratory symptoms or atopic dermatitis for ≥1 week. The subjects (n = 247) underwent a two- to four-week restrictive diet for diagnostic purposes. The questionnaire demonstrated validity and reliability. Bivariate statistical analyses were performed to examine the correlations between risk factors and the incidence of food allergies (p < 0.05). A receiver operating characteristic (ROC) curve analysis was used to establish the cut-off values for the number of food allergies and atopic family members. The majority of the 247 children enrolled in this study were 6 to 12 years old. Respiratory symptoms (56.3%) were more common than atopic dermatitis (38.1%). The significant risk factors for food allergies included atopic dermatitis (p = 0.001; R = 0.203), previous history of suspected food allergies (p < 0.001; R = 0.747), and atopy in the family (p = 0.013; R = 0.157). The ROC curve analysis established the cut-off values for the number of atopic family members at 1.5 (p = 0.005; 95% CI 0.53-0.67) and the number of food allergies at 0.5 (p = 0.000; 95% CI 0.85-0.94). In conclusion, children are considered at risk of food allergies if they display persistent respiratory symptoms or atopic dermatitis, considering the history of suspected food allergies even to only one specific type of food.
Successful management of a 7-year-old-female with juvenile dermatomyositis at a tertiary hospital in low-income country Wulandari, Desy; Lubis, Azwin Mengindra Putera; Hikmah, Zahrah; Endaryanto, Anang
Paediatrica Indonesiana Vol 64 No 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.551-8

Abstract

Juvenile dermatomyositis (JDM) is a rare chronic autoimmune disease belonging to idiopathic inflammatory myopathies. Pathological skin lesions and proximal weakness primarily characterize this entity, but clinical symptoms can be heterogeneous. Children are more likely to have long-term complications such as lipodystrophy, calcinosis, and vasculopathy. Calcinosis is one of the characteristic sequelae of JDM, despite recent advances in the treatment of JDM, about one-third of patients still develop dystrophic calcinosis. In low-income countries, the availability of medicines is very limited. In our case, a 7-year-old female diagnosed with JDM presented with calcinosis. Aggressive and adequate treatment with steroids, methotrexate, hydroxychloroquine, and aluminium hydroxide can treat the complications. It is challenging to establish an early diagnosis, treatment, prevention of long-term complications, and improved prognosis of JDM, which then will improve the patient’s quality of life, especially in low income countries with limited drug availability.
Co-Authors Ahmad Suryawan Akbar Rizky Ramadhan Anang Endaryanto Anisa Ayu Maharani Ariyanto Harsono Ashfa Diniyya Assabella Bagas Triambodo Bambang Hermanto Camilia Metadea Aji Savitri desy wulandari Dinda Anes Tunjungsari Dinda Sella Octaviana Fanny Gunawan Ferrel Bramasta Gatot Soegiarto Gerald Sebastian Davis Hafidhatul Aisy Hermawan Susanto, Hermawan Istianah Istianah Jihan Nabila Pranjasdhina Junjungan Nimasratu Rahmatsani Lavenia Kurniawati Linda Dewanti Made Retna Paramita Savitri Manika Putri Kunigara Natalia Erica Jahja Noor Idha Handajani Nur Rochmah Sitisalma Amirah Dzakiyyah Veronika Intan Krismaningrum Wigaviola Socha Purnamaasri Harmadha Zahrah Hikmah, Zahrah