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Jurnal Respirasi (JR)

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Published by Universitas Airlangga

ISSN : 24070831 EISSN : 26218372 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.

Arjuna Subject : -

Articles 321 Documents

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Perbaikan Kualitas Hidup pada Pasien Solitary Fibrous Tumor Mediastinum: Perspektif Kemoterapi Paliatif: [Improvement of Quality of Life in Mediastinal Solitary Fibrous Tumor: Paliative Chemoteraphy Perspective] Aryo Dirgantara Putra; Winarinani Koesoemoprodjo
Jurnal Respirasi Vol. 5 No. 2 (2019): Mei 2019
Publisher : Faculty of Medicine Universitas Airlangga

Background: Mediastinal solitary fibrous tumor (SFT) is a rare spindle cell neoplasm. Approximately 1 to 8% of these intrathoracic tumors have been reported to occur in the mediastinum. The chief complaints of mediastinal SFT are cough, shortness of breath or chest pain, or may occur as asymptomatic incidental mass. The treatment of choice for SFT is extensive surgical resection. However, when the tumor cannot be removed surgically or when metastases occur, chemotherapy and or radiotherapy can be proposed as palliative treatments. Case: A 19-year-old man with chief complaint of left chest pain and referred to his left back. The complaint is accompanied by cough without sputum and hoarseness. In thoracic CT scan with contrast, we found giant cystic mass suspect malignancy around 17x12x18 cm in left hemithorax, a minimal pericardial effusion, and left pleural effusion. There were positive tumor cell cytoplasm results in vimentin, negative tumor cell cytoplasm in CK, positive tumor cell membrane in CD99, cytoplasm of focal positive tumor cells in EMA, and negative tumor cells in CD34 which supported a solitary fibrous tumor in the immunohistochemical staining analysis. Doxorubicin-Ifosfamide regimen was the choice of chemotherapy palliative treatment in the case report. In the CT scan evaluation of thorax with contrast, we found stable disease (RECIST criteria) with improve quality of life (QOL) according to EQ-5D-3L, 11111 indicated no problems in 5 dimensions, such as mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Conclusion: Mediastinal SFT is a rare spindle cell neoplasm, and the diagnosis requires pathological and immunohistochemical staining analysis. Doxorubicin-Ifosfamide regimen can be proposed as a palliative chemotherapy regimen, which has been shown to improve QOL patients in Mediastinal SFT. EQ-5D is a simple tool that can be used to measure QOL such as mobility, self-care, usual activities, pain or discomfort, and anxiety or depression.

Back Matter Vol 3 No 2, 2017 Back Matter
Jurnal Respirasi Vol. 3 No. 2 (2017): Mei 2017
Publisher : Faculty of Medicine Universitas Airlangga

Hubungan Kadar Interleukin-10 dan Tuberkulosis Multi-Drug Resistant: [Interleukin-6 Serum Level in Multidrug-Resistant Tuberculosis] Nurjanah Lihawa; Resti Yudhawati
Jurnal Respirasi Vol. 1 No. 2 (2015): Mei 2015
Publisher : Faculty of Medicine Universitas Airlangga

Background: Prevalence of multi-drug resistant tuberculosis (MDR-TB) is increased by the time. In Indonesia, there were an estimated 1.9% of new cases and 12% of previously treated cases. Protection against Mycobacterium tuberculosis is dependent on Th1 cell CD4+ that produced pro-inflammatory cytokines such as IFN-γ and TNF-α. T cell regulators (Tregs) produced IL-10 as anti- inflammatory cytokine is against the function of those pro-inflammatory cytokines. It is believed that immune suppression is responsible for MDR-TB. The previous study showed impaired Th1 responses and enhanced regulatory T-cell levels in circulatory blood of MDR- TB patients. The study of IL-10 represented anti-inflammation cytokine as immune suppression never been conducted in Indonesia. Objective: To analyze relationship between level of interleukin-10 and Multi-drug resistant tuberculosis. Methods: The study was conducted at the outpatient department of MDR-TB and DOTS of Dr. Soetomo hospital in Surabaya. Total sample was 38 of TB patients that consist of 19 MDR-TB patients (secondary resistant) and 19 non-MDR TB patients as control. Results: In this study we found that the median level of IL-10 as 5.7±3.3 pg/mL in the group of MDR-TB patients with minimum level was 1.3 pg/mL and maximum level was 14.0 pg/mL while median level of IL-10 in non-MDR TB patients was 7.0±3.4 pg/mL with 3.2 pg/mL and 16.5 pg/mL, respectively. To analyze correlation between time to first of having TB until became MDR-TB and level of IL-10 by using Pearson’s correlation, we showed that no statistical correlation (p>0.05). According to statistical classification, we found that no statistical correlation between level of IL-10 and the history of treatment in MDR-TB patients (p>0.05). Data showed that all the history of treatment classification dominated by MDR-TB patients with the low level of IL-10. We also found that no statistical difference with the level of IL-10 in MDR- TB and non-MDR TB patients (p>0.05) although in descriptive state we found the level of IL-10 was higher in non-MDR TB patients. And also there was no relationship between level of IL-10 and MDR-TB (p>0.05). It could be explained that the host factor was not involved and in the other side we still not known the factor of agents, yet. The low level of IL-10 that was observed in this study could be interfering by the strain of M.tb which not assessed in this study. Conclusion: In this study we found that level of IL-10 is not increase in MDR-TB patients and there was no relationship between level of IL-10 and MDR-TB (p>0.05).

Probiotic-Based Therapy for Active Tuberculosis Infection: The Role of Gut-Lung Axis and Granulocyte Macrophage-Colony Stimulating Factor Made Indira Dianti Sanjiwani; Nyoman Budhi Wirananda Setiawan; Agus Indra Yudhistira Diva Putra; Agus Eka Darwinata
Jurnal Respirasi Vol. 7 No. 2 (2021): May 2021
Publisher : Faculty of Medicine Universitas Airlangga

Tuberculosis is a global health problem with a total of 1.4 million cases in 2015. Over the last decade, several studies have demonstrated the potential role of gut-lung axis in the treatment of tuberculosis. The exact mechanism of the gut-lung axis on tuberculosis is still unknown, however modulation of the gut-lung axis can be performed via probiotic administration. The administered probiotics are capable of inducing an immunomodulating effect which helps in the process of tuberculosis infection. One of the molecules that can be activated with probiotics and plays a role in tuberculosis infection is granulocyte macrophage-colony stimulating factor (GM-CSF). GM-CSF can control intracellular production of M. tuberculosis, inflammation in granulomas, and lung tissue reparation. This article aimed to explore the role of the gut-lung axis, GM-CSF, and the potential of probiotic-based therapy on active tuberculosis infection. It was found that probiotics mediate the immune response via the activation of several inflammatory cytokines and interleukins related to lung infection, but not directly with the tuberculosis pathogen. Thus, probiotic-based therapy has the potential to increase immunity during active tuberculosis infection. Further studies to explore the other mechanisms of the gut-lung axis against tuberculosis through probiotic administration need to be performed.

Faal Paru Statis: [Static Lung Function] Arief Bakhtiar; Wirya Sastra Amran
Jurnal Respirasi Vol. 2 No. 3 (2016): September 2016
Publisher : Faculty of Medicine Universitas Airlangga

Respiration or breathing is the body’s attempt to meet the needs of O2 in the metabolic process and emit CO2 as a result of intermediary metabolism by lung and respiratory organs together so that the resulting cardiovascular oxygen rich blood. Respiration has three phases: ventilation, diffusion, perfusion. The situation is said to somebody normal lung function if the work process of ventilation, diffusion, perfusion, and the relationship between ventilation to perfusion of the person is in a relaxed state resulted in the partial pressure of arterial blood gas (PaO2 and PaCO2) were normal. Examination of lung function has an important role in assessing a lung function. However, the thing to know that these checks are supporting and quite helpful in making a specific diagnosis. With spirometry examination can be known or determined all the static volume except residual volume and respiratory capacity than the capacity of residual volume that contains components such as total lung capacity and functional residual capacity. Functional residual capacity measured by special methods such as by using the inert gas helium (helium dilution test), N2 washout and bodyplethysmograph. Some static pulmonary function parameters can interpret any kind of disturbance in the lungs. In restrictive disorders in general decreased static lung volumes. While the obstruction interference parameters are quite significant, namely an increase in residual volume (RV), functional residual capacity (FRC) and the ratio of residual volume and total lung capacity (RV/TLC).

Lung Pseudomesothelioma in Patient with Asbestos Exposure: A Case Report Devy Trianne Putri; Isnin Anang Marhana; Dhihintia Jiwangga Suta Winarno
Jurnal Respirasi Vol. 6 No. 2 (2020): May 2020
Publisher : Faculty of Medicine Universitas Airlangga

Background: Pseudomesotheliomatous carcinoma is a rare case of lung cancer with marked pleural extension resembling malignant pleural mesothelioma on diagnostic imaging. One of tool to diagnose lung pseudomesothelioma is by performing thorocoscopy pleural biopsy. Diagnostic thoracoscopy also has a higher sensitivity than pleural fluid cytology and needle biopsy.Case: We report a rare case of pseudomesotheliomatous carcinoma of the lung in a 50-year-old man with asbestos exposure. The patient had complained of dyspnea and chest roentgenogram showed left pleural effusion. Computed tomography (CT) of the chest revealed diffuse irregular left pleural thickening and without a clear initial primary lesion found in both of lung parenchyma, which mimicked pleural mesothelioma. Pleural tissue sampling was performed to obtain definitive diagnosis by video-assisted thoracoscopic surgery. At the operation, the tumor was found to have spread along the pleural surface and primary lesion was not detected in the right lung parenchyma. Immunohistochemically, the tumor was positive for Thyroid Transcription Factor- 1 (TTF-1), but negative for calretinin, P63, and Neuron Specific Enolase (NSE). Final diagnosis was adenocarcinoma of the lung and patient had good clinical response to Gefitinib.Conclusion: Based on the results of clinical studies (images and clinical observations), although pseudomesotheliomatous in patient with asbestos exposure is difficult to distinguish from pleural mesothelioma, we have a case of pseudomesotheliomatous lung diagnosed by a thoracoscopic pleura biopsy. For such cases, thoracoscopic pleural biopsy should be performed at an early stage.

Front Matter Vol 2 No 1, 2016 Front Matter
Jurnal Respirasi Vol. 2 No. 1 (2016): Januari 2016
Publisher : Faculty of Medicine Universitas Airlangga

Problema Diagnostik dan Respons Kemoterapi pada Seorang Penderita Classical Limfoma Hodgkin Tipe Mixed Cellularity dengan Temporary Spontaneus Regression: [Difficult Case of Classical Hodgkin Lymphoma Mixed Cellularity Type with Temporary Spontaneous Regression] Daniel Maranatha; Bintang Bestari
Jurnal Respirasi Vol. 3 No. 1 (2017): Januari 2017
Publisher : Faculty of Medicine Universitas Airlangga

Background: Mixed cellularity classical hodgkin lymphoma (MCCHL) is the secound subtype of classical hodgkin lymphoma (cHL) which often happens. MCCHL is aggressive but has a relatively high recovery rate. The diagnosis of cHL is sometimes difficult. Spontaneous regression can occur in cHL but is very rare, temporary or permanent. CHL including diseases with a fairly high cure rate, about 80% of patients recover with first-line chemotherapy. Case: Male age 26 years, 9 months cough, shortness of breath, chest pain 8 months, 6 months fever disappear with enlargement of right supraclavicular lymph nodes appearing at 11 days before admission. Chest X-ray shows the presence of mediastinal mass supported by contrast thoracic CT scan. FNAB has been done three times with no meaningful results. In one of the chest radiographs and CT scan of the thoracic with contrast evaluation showed a reduction in tumor size. Open thoracotomy biopsy is performed with Hodgkin’s lymphoma results. On immunohistochemical examination obtained MCCHL. Chemotherapy with ABVD regimen was administered for three cycles with partial remission and was continued with 6 cycles with stable disease outcomes. Conclusion: Spontaneous temporary regression in cases with mediastinal tumor suspicion may occur in cHL and may cause difficulties in diagnosing. Open biopsy is required as a gold standard and has to be supported by immunohistochemical test. First-line chemotherapy response in cHL is good.

Ventilasi dan Perfusi, serta Hubungan antara Ventilasi dan Perfusi: [Ventilation, Perfusion, and Its Correlation in Pulmonary Diagnostic] Afrita Amalia Laitupa; Muhammad Amin
Jurnal Respirasi Vol. 2 No. 1 (2016): Januari 2016
Publisher : Faculty of Medicine Universitas Airlangga

Lung is a place for gas exchange where ventilation and perfusion occurs. Ventilation is the first step where sequential process of inhalation and exhalation take place. Meanwhile perfusion as the other step facilitates the gas exchange and tissue supply need. Blood flows through the lungs are equals as the amount of cardiac output where the factors that control cardiac output are mainly peripheral factors, also control pulmonary blood flow. In general condition, pulmonary blood vessels act as a passive tube, which can be increased with the increasing pressure and narrowed the pressure drop. Oxygen absorption level from lungs into bloodstream is a critical determinant for functional capacity, and an important factor wheter in normal conditions (including exercise) or even in illness state. Lung diffusion capacity is influenced by several geometric and functional factors. Gravitation influence systematic gradient in ventilation and perfusion distribution. Ventilation and blood flow variations at horizontal level also occur due to intrinsic anatomic variations and vascular geometry, as well as the differences in airway and vascular smooth muscle response which modifies the distribution. The change of integrity intrapleural chamber, hydrostatic pressure and osmotic imbalance, malfunction of surfactants, other intrinsic weakness of the branching system in the form of a progressive airway, and all the things that could potentially damage the structure of the lung can cause ventilation and diffusion dysfunction.

Hemoptisis pada Pasien Aspergilloma Paru Kiri: [Hemoptysis in Aspergiloma Patient: A Case Report] Gilang Muhammad Setyo Nugroho; Laksmi Wulandari
Jurnal Respirasi Vol. 4 No. 2 (2018): Mei 2018
Publisher : Faculty of Medicine Universitas Airlangga

Background: Aspergilloma is a fungus ball (misetoma) that occurs because there is a cavity in the parenchyma due to previous lung disease. This fungus ball can move inside the cavity but does not invate the cavity wall. The presence of fungus ball causes recurrent hemoptysis. Case: We present a 45-year-old female patient with left lung Aspergilloma. Diagnosis of Aspergilloma was based on histopathology from FNAB CT guiding of left pulmonary which showed Aspergillus. Patient was treated with left superior lobe lobectomy at the hospital. The examination result of anatomical patology obtained from lung tissue was aspergillosis, from GeneXpert examination lung tissue showed positive MTB with rifampisin sensitive. Post-operative condition of the patient was stable, surgical wound improved, took off drain patient. There were clinical improvements after the surgery. Discussion: Diagnosis of Aspergilloma was based on clinical, radiology, and microbiology. Aspergilloma with severe symptoms (hemoptysis massive with life-threatening or other complications that require more than 1 time hospitalisation) and good physical condition should undergo surgical therapy in the form of lobectomy in accordance with the extent of lung abnormalities. Patient got first category anti tuberculosis drugs for 6 months and fluconazole for 2 months. Conclusion: It is necessary to consider the suspicion of Aspergillus infection, in patient with history of previous tuberculosis accompanied by a history of recurrent hemoptysis. Patient with reccurent hemoptysis and good physical condition should undergo surgical therapy.

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Jl. Mayjen Prof. Dr. Moestopo 6-8 Surabaya 60286 Indonesia

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Kota surabaya,

Jawa timur

INDONESIA