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Biomolecular and Health Science Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 26208636     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.
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Articles 140 Documents
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A Patient With Graves’ Disease And Thyroid-Associated Orbitopathy Undergoing Radioactive Iodine in Dr. Soetomo General Academic Hospital, Surabaya Rizki Adrian Hakim; Stepanus Massora; Delfitri Lutfi; Hermina Novida
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26914

Abstract

Graves’ Disease (GD) is the most common etiology of thyrotoxicosis, followed by toxic multinodular goiter and toxic adenoma. GD can be managed with anti-thyroid drugs (ATDs), surgery, or radioactive iodine (RAI). Thyroid-associated orbitopathy (TAO) or Graves’ Ophthalmopathy (GO) affects 25%-50% patients with GD, and its presence usually dissuade clinicians to use RAI in treating hyperthyroidism. The presence of GO is a relative contraindication use of RAI in patients with GD, as RAI can worsen existing GO. Corticosteroid prophylaxis can be given to such patients to reduce likelihood of worsening of GO. However, patient with moderate to severe active GO is currently advised against undergoing RAI. Established guidelines recommend the use of corticosteroid prophylaxis in these patients. We reported a patients with GD and orbitopathy who was treated with RAI and was given steroid prophylaxis to prevent worsening of GO.
Front Matter Vol 3 No.2 2020 Front Matter
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.26440

Abstract

A Case Series Of Arthritis In Hansen’s Disease Hendra Gunawan; Deasy Natalia Adriana; Awalia Awalia; Joewono Soeroso
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22287

Abstract

Hansen’s disease or leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Musculoskeletal complaints might be the initial presentation of patients with Hansen’s disease. Symptoms are common with clinical spectrum ranging from mild to debilitating arthritis.  Regarding its wide clinical spectrum, a history taking especially in an endemic area like Indonesia on the possibility of Hansen’s disease cannot be ruled out in patients with arthritis. We reported 3 cases of arthritis in Hansen’s disease. First case was a 62-year-old Javanese female who had a deformity and chronic poly symmetry arthritis. Second case was a 45-year-old Javanese male with chronic bilateral knee pain as initial presentation of Hansen’s disease and the last case was 61-year-old Javanese male who had acute bilateral knee pain with erythematous maculae associated with Erythema Nodosum Leprosum. All cases responded to corticosteroid 1 mg/BW/day.
The Characteristics of Children with UTI Due to ESBL-producing Bacteria at Dr. Soetomo General Hospital, Surabaya Ida Fitriawati; Manik Retno Wahyunitisari; Risky Vitria Prasetyo; Dwiyanti Puspitasari; Tuksin Jearanaiwitayakul
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.25392

Abstract

Introduction: Urinary tract infection (UTI) by extended-spectrum beta-lactamase-producing bacteria often results in a delay in obtaining appropriate antibiotics. The information on patients’ clinical characteristics is necessary for early recognition and the selection of empiric antibiotic therapy. This study aims to investigate the clinical characteristics and the length of therapy of patients with urinary tract infections by those resistant bacteria.Method: This study utilizes a cross-sectional design. Medical records of hospitalized children aged 1-18 months with UTI due to ESBL-producing bacteria at Dr. Soetomo general hospital between January 1, 2017 - July 20, 2020, were reviewed retrospectively. Variables of interest were the demographic data, underlying diseases, causative organism, clinical presentation, maximal body temperature, and length of antibiotic therapy.Results: Among 37 patients enrolled, 25 patients were female. The incidence of urinary tract infection in children was dominated by age 1-12 months old (37.8%). Urological abnormalities were presented in 62.2% of patients. ESBL-producing Escherichia coli was the most common isolated uropathogen (62.2%). High fever was found in 10/28 patients (35.7%). In 17 patients (45.9%), the total duration of antibiotic therapy was 8-14 days.Conclusion: In children with UTI, especially in the infant group, who had urological abnormality or present with a high fever, and who do not respond to empiric therapy should be suspected of developing UTI due to ESBL-producing bacteria.
A Systematic Review On The Outcomes Of Fibular Strut Graft For Femoral Neck Fractures In Adults Bintang Soetjahjo; Udi Heru Nefihancoro; Rieva Ermawan; Gilang Teguh Pratama
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26912

Abstract

Introduction: Femoral neck fractures are a type of intracapsular hip fracture which also be found in younger patients who suffered from high-energy trauma such as vehicle accidents. Non-union and avascular necrosis are the most frequent complications following femoral neck fractures. In this study, we reviewed the outcomes of fibular grafting techniques for femoral neck fractures in adults.Methods: Online libraries PubMed, Cochrane Library and Scopus were searched for relevant papers. We searched for scientific publications published between 2009 and 2020. Inclusion and exclusion criteria were used, and prespecified characteristic were extracted from each study.Results: We found 172 papers relevant to the topic. At last, we included 6 papers in this systematic review with a total of 198 patients. Fibular strut graft for femoral neck fractures have shown excellent outcomes, uniting 177 (89,39%) of 198 fractures reviewed. Overall, 15 patients (7,57%) experiencing non-union and 12 patients (6,06%) having avascular necrosis.Conclusion: The outcomes of the intervention turned out to be excellent, assessed by both functional outcome criteria and radiographic bony union. It is important to established a consensus on surgical intervention for femoral neck fractures, specifically including fibular strut grafting.
Organ Damage due to Elevation of Blood Pressure on NaCl-induced Hotimah Masdan Salim; Ilham Putra Alam; Widya Dio Kharisma
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22089

Abstract

Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.
The Effectiveness of Extract Basil Leaves on Motility and Morphology of Spermatozoa Mice Exposed with Cigarette Smoke Bagas Setiawan Ihsan Zaini; Izki Masyaqqoni Pujiana; Evi Octavia Djamaludin; Hotimah Masdan Salim
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22169

Abstract

Introduction: The incidence of infertility is still a problem in the world, including Indonesia (21.3%), and throughout Asia. Fertility in men is strongly influenced by several factors, one of them is smoking. Smoking can increase ROS, reduce antioxidants in semen, cause DNA damage, and morphological abnormalities of spermatozoa. Basil contains flavonoids which are rich in antioxidants, boron, and zinc to stimulate androgen hormones.Methods: This research used eight weeks old Mus musculus, exposed with smoke of 20 cigarettes/day and was administered of extract basil leaves (Ocimum sanctum L.) in dose dependency (100 mg/kg, 200mg/kg, and 300mg/kg) for 4 weeks. We examined the motility and morphology of spermatozoa by microscope. This research consisted of 5 groups. In CS-, CSBL-2 and CSBL-3, it showed that the spermatozoa motility was more progressive than CS+ and CSBL-1.Results: The morphology of spermatozoa in CS+ and CS- found different results with a significance value of 0.10 (p < 0.05) but the results of CSBL- 1, CSBL-2, and CSBL-3 were not significantly different from CS- and CS+ (p > 0.05).Conclusion: There was an effect of giving basil leaves to increase motility and improvement of the morphology of spermatozoa that had been exposed to cigarette smoke especially in dose 300 mg/kgBB, but it was not significant.
Maximizing Millennial Students Role in Combating COVID-19 Hoaxes and Myths Astri Dewayani; Euvanggelia Dwilda Ferdinandus; Rizki Putra Prastio; Indah Fahmiyah; Amila Sofiah; Rodik Wahyu Indrawan; Mochammad Nurul; Gagas Gayuh Aji; Nanda Rachmad Putra Gofur; Siti Khaerunnisa; Dewi Sriani; Yankel Sena
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26910

Abstract

Introduction: Since the outbreak of Corona Disease-19 (COVID-19) spreads all over the world, various ways of health attempts have been conducted. However, overflowed information intertwines with mis/disinformation could raise public anxiety and stigma-related diseases. We aimed to assess the help of the young generation of millennials and Gen-Z whom are active college students in debunking hoaxes and myths of COVID-19 into their community.Method: The selected students were given a short course on COVID-19 basic information, prevention, and circulated myths. Later, they become ambassadors and actively educated via offline and online platforms. The impact of outspread information on audiences was investigated through a qualitative survey.Result: The knowledge of students were measured by pre- and post-test within the short course. Prior knowledge showed the least understanding part was prevention and myth of COVID-19. There was a significant improvement of knowledge in post-test after receiving seminar (p=0.0002). There were 97 respondents who filled the online survey that predominantly in young adulthood age. Respondent's insight was enhanced and they likely intend to spread the actual information to their surroundings.Conclusion: Appointing student as the spokesperson for health education can raise their social responsibility. Clarifying misinformation and health behaviour could be more influential within the same sharing community. In addition, the use of various online platforms could efficiently reach massive target, especially young ages.
Back Matter Vol 3 No.2 2020 Back Matter
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.26441

Abstract

The Comparison of Giardia lamblia Infection and Nutritional Status of Elementary School Students in Mandangin Island, Sampang and Mojo Village, Surabaya, Indonesia Zaidan Arifiansyah Bachtiar; Amalia Putri Uswatun Hasanah; Muhammad Yasin; Rahmadany Isyaputri; Budiono Budiono; Sukmawati Basuki
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22406

Abstract

Introduction: Giardia lamblia infection can cause impaired absorption of nutrientsand affects to the nutritional status that has not yet fully investigated in Indonesia.This study aimed to investigate the comparison of prevalence of Giardia lambliainfection and nutritional status of elementary students in Mandangin island and Mojovillage where were different condition.Methods: An analytical observational study with cross sectional design wasconducted in Mandangin island in July 2017 and Mojo village in June 2018 byinformed consent. Stools of elementary students were collected for Giardia lambliaidentification under a light microscope using direct smear method. Nutritional statusof students were determined by body mass index (BMI), and categorized as severeunderweight, underweight, healthyweight, overweight, and obese.Results: Forty-five stools samples were collected from elementary students inMandangin island and 55 stools samples in Mojo village. Prevalence of Giardialamblia infection without symptoms was higher in elementary students in Mandanginisland than Mojo village (28,9%, 13/45 and 1,8%, 1/55, respectively). Giardiasisprevalence in Mandangin island was significantly difference with Mojo village(p&lt;0.0001, chi square-test). Nutritional status of students in both study sites showeddominant healthy-weight that were 73.3% (34/55) in Mandangin island and 61.8%(33/45) in Mojo village. Giardiasis was commonly observed in students with healthy-weight and it was higher in Mandangin island (8/33, 24.2%) than Mojo village (1/34,2.9%).Conclusion: Asymptomatic giardiasis was highly found in elementary students inMandangin island and commonly observed in students with healthy-weight from both 3 regions. It suggested that asymptomatic giardiasis might not affect to the nutrition status of students.

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