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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 9 Documents
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Search results for , issue "Vol 14, No 1 (2007)" : 9 Documents clear
PERBANDINGAN CYSTATIN C DENGAN PARAMETER UJI FUNGSI GINJAL LAINNYA Pusparini .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.919

Abstract

The Gold standard for the evaluation of the glomerular filtration rate (GFR) is inulin clearance, but in widespread use is prevented by several technical difficulties. The most commonly used marker for GFR is serum creatinine alone or in conjunction with 24 hoururine collection for determination of creatinine clearance, but these marker have several limitation include following: influence of age,sex, muscle mass on endogenous creatinine production, dietary intake and the difficulties of 24 hour urine collection. Fifty six patientwith chronic renal failure and 53 control had analyze for serum creatinin, creatinine clearance and serum cystatin C. The chronic renalfailure patient aged range from (64 + 14.54) year and the control group aged range from (62.5+ 17.5) year. The proposed of this studywas to compare cystatin C with another parameter for renal function test. The result showed that in control group serum creatinineand creatinine clearance had influence with age, sex and body mass index, but serum cystatin C was not. The normal value of cystatinC was (0.85 + 0.13) mg/dL In chronic renal failure group there were significant correlation between level of cystatin C with creatininclearance (p = 0.000, r = 0.69). The level of cystatin C increase higher than serum creatinine in patient with low clearance creatinine.In control group we were determined low creatinine clearance in patient with normal serum creatinine and cystatin C.
KADAR N TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE PADA PENDERITA PENYAKIT JANTUNG HIPERTENSI Febria Asterina; B Nasution; N Akbar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.924

Abstract

Patients with hypertension are at high risk for development of Left Ventricle Hypertrophy (LVH) and Left Ventricular Systolic Dysfunction (LVSD). These conditions should be identified earlier to prevent cardiac morbidity and mortality. To measured serumlevel of NT-proBNP in hypertensive and mild symptomatic Hypertensive Heart Disease (HHD) patients (NYHA class I-II), to performechocardiography evaluation to all of the patients and associated with serum level of NT-proBNP. A cross sectional study was done at H.Adam Malik Hospital Medan, participants were recruited from consecutive samples of 15 hypertensive and 16 mild symptomatic HHDpatients whose visited cardiovascular and internal medicine out patient clinics. Of these patients, blood samples were taken and a twodimension echo-Doppler study was performed. The patients divided into three groups based on echocardiography studies respectively:Group 1: 9 hypertensive patients with normal echocardiography finding; group 2: 13 patients with LVH and ejection fraction (EF) ≥60%; and group 3: 9 patients with LVH and EF < 60%. Mean NT-proBNP serum level (in pg/mL) for groups 1-3 respectively, were:56.4 ± 34.5, 245.4 ± 339.2 and 852.0 ± 1218.9. Mean NT-proBNP serum level differed among all three groups (p = 0.050), butthe significant difference found between group 1 and group 3 (p < 0.05) only. There were significant correlation between NT-proBNPserum level and the three stages of echocardiography finding (r = 0.488 and p = 0.005). The result suggests that NT-proBNP serumlevel correlated with deterioration of heart function and structure according echocardiography studies. The Significant rise in NT-proBNPserum level happened only when Left Ventricular Systolic Dysfunction (LVSD) develops in hypertension.
HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2 Rikarni .; lillah .; yoesri .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.918

Abstract

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macroand microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there isendothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration andmicroalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectionalmethod and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinineratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with totalsample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, andfibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantlystatistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma andalbuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patientswith normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio
PERALIHAN (KONVERSI) SPUTUM BTA ANTARA PEMBERIAN DOSIS BAKU (STANDAR) DAN TINGGI RIFAMPICIN PADA PENGOBATAN (TERAPI) ANTI TUBERKULOSIS KELOMPOK (KATEGORI) I Yani Triyani; Ida Parwati; I. Sjahid; J. E. Gunawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.917

Abstract

Acid fast bacilli (AFB) sputum microscopy is used as a diagnostic tool of pulmonary tuberculosis (TB) in TB eradication program with directly observed treatment short course (DOTS) strategy. The AFB sputum microscopy should be performed before treatment,two months after intensive phase and four months after advance phase treatment. This study is a part of a research to compare thestandard (450 mg) and high (600 mg) rifampicin dose in patients with pulmonary tuberculosis in Indonesia. The aim of this studywas to detect the sputum conversion time of AFB in pulmonary TB patients who obtained category I antituberculous treatment with standard dose compared to one who received high dose of rifampicin at the beginning and at the end of the intensive phase. This AFB sputum microscopy have been performed from September 2003 until August 2005 from 85 pulmonary TB patients every two weeksusing Ziehl Neelsen and read by means of International Union Against Tuberculosis and Lung Diseases (IUATLD) scale, in PoliklinikParu Balai Pengobatan Penyakit Paru-paru and Department of Internal Medicine RS. Dr. Hasan Sadikin. Patients with pulmonary TBwho obtained category I antituberculous treatment of the intensive phase were divided randomly double blind into two groups, usingstatistical analysis by Page test for order alternative and Mann Whitney test. After randomization, there were 52 patients who receivedstandard dose and 33 patients who had high dose of rifampicin. Sputum conversions of AFB on week 2, 4, 6, and 8 were 36.1%, 63.9%,75%, and 91.7% for standard dose group. Sputum conversions of AFB on week 2, 4, 6, and 8 were 46.2%, 80.8%, 80.8%, and 84.6%for high dose group. Sputum conversion of AFB for high dose group were faster than standard dose group (p=0.030). Dropout (DO)patients were 5.9% (5/85) and no sputum conversion of AFB on week 8 was 8.3% and 15.4% for standard dose group and high dosegroup of rifampicin, respectively. Sputum conversions of AFB for high dose group were found significant more quickly than standarddose group of rifampicin statistically.
ERITROPOITIN FISIOLOGI, ASPEK KLINIK, DAN LABORATORIK P B Notopoero
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.922

Abstract

Erythropoietin is a glycoprotein hormone produced by kidney and functioning as regulator for eryhtropoietic processes. The regulation of erythropoietic processes are stimulation of proliferation, maturation erythroid progenitor cells and prevention of apoptotic process.The balance between dinamic erythropoietic processes and loss of erythrocytes is regulated by homeostatic mechanism. The decrementof EPO production will cause anemia such as anemia in end state renal disease. The development of rHuEPO support the invention ofsensitive and specific immunoassay methods to measure the level of EPO. There are various commercial kit using various immunoassaymethods used to achieve this purpose. The use of rHuEPO gives dramatic impact for the improvement of end state renal disease patients’squality of life. The research for the effect of EPO in the neuron, vascular, and retinous tissue develop the use of EPO for the neurology,cardiology and opthalmology area. This should be followed with the understanding of the patophysiology of EPO effect in the variousorgans. In 1990. the rHuEPO is used to replace the blood transfusion as the blood doping. The various direct and indirect methods candetect the missuse of rHuEPO as doping in the world sport events.
NILAI DIAGNOSTIK UJI TROPONIN I KUANTITATIF METODE IMMUNOKROMATOGRAFI Siti Fatonah; Anik Widijanti; Tinny Endang Hernowati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.920

Abstract

Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage but there is no standardization of WHO for cardiac troponin I, resulting in a variability for diagnostic value. It is necessary to determine diagnostic value for a new kitof troponin I. To evaluate a new quantitative immunochromatography assay for troponin I at a various cut off level. A cross sectionalstudy was conducted in 64 patients with acute myocardial infarction (AMI) and 55 non-AMI as control from February to September2007. The level of cardiac troponin I (cTnI) was measured and determined it diagnostic value at a various cut off level. The sensitivity,specificity, PPV and NPV of this assay were 91%, 91%, 92% and 89% at cut off level of 1,0 ng/ml (according to the kit), respectively.The cut off of cTnI were divided into five levels: 0.8, 1.0, 1.2, 1.5, and 2.0 with the area under curve were 0.923, 0.908, 0.912, and0.897, respectively. The sensitivity were 94%, 91%, 86%, 81% and 72%, respectively, the specificity were 91%, 91%, 96%, 98% and98%, respectively. This rapid diagnostic test is sensitive and specific to diagnose an acute coronary syndromes.
KEPUASAN PELANGGAN INTERNAL Rosni Faika; O Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.925

Abstract

Customer satisfaction survey is one of efforts of continuously quality improvement of care and also can be used to maintain customers that already utilize available services. Efforts of corrective action should be done based on result of this survey. The objective of this surveyis to assess desired-service and reality of the service undergone by internal customer and to improve quality of service of laboratorymedicine in Clinical Laboratory of Dr. Sardjito Hospital, Yogyakarta. This is cross sectional customer satisfaction survey. Subject of thissurvey are 23 doctors work in Dr Sardjito Hospital. Data collected by questionnaire that contain 18 items about desired-service andreality of service undergone by internal customer from service given by Clinical Laboratory of Dr. Sardjito Hospital. Respondents assessdesired-service and reality of service using Likert scale. The obtained data are analyzed by Cartesius diagram. Result of the survey showsthat average concordant between desired-service and reality of service is 85.5%. Main priority corrective action to improve quality ofservice are: 1) readiness of registry staff; 2) easiness of registration procedure; 3) skill of laboratory staff in explaining and recordingtest parameter; 4) service of cito service; 5) 24 hours laboratory service and 6) timely laboratory test.
PENGARUH RESTRIKSI KALORI TERHADAP KADAR HIDROGEN PEROKSIDA DAN KADAR GLUKOSA DARAH PADA TIKUS TUA E. Harianja; Anik Widijanti; Putu Moda Arsana; K. Handono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.921

Abstract

Aging is a syndrome of progressive, universal and irreversible alterations. Endocrinology alterations in aging consist of insulin resistance, hyperinsulinemia, increase of hydrogen peroxide and glucose blood level. At the beginning of aging process the Pancreaticcellsproducemoreinsulininorderiskeepbloodglucosewithinnormallevel.Butthepersistentofhyperglycemiaconditioncausedthepancreatic-cellsunabletoproduceadequateinsulinduetointernalfactorsorexternalfactors.Asthisconditionprogress,wouldbedisturbedfastingandpost-prandialbloodglucose(hyperglicemia).Besidesinsulinresistance,freeradicalsalsoincreasedasaconsequenceoffailurecompensationofcellsinthebody.TheaimofthisstudyistodeterminethatintermittentanddailycalorierestrictioninoldmaleWistarratscanreduceserumhydrogenperoxide,andbloodglucoselevel.Themethodofthisstudywasanexperimentalstudywithpost-testcontrolgroupdesign.TwentyfourmaleWistarratsabout12monthsold,weredividedintofourequalgroupsandeachgroupcontainsixrats:(i)adlibitumfed(control),(ii)2-1intermittentwith2daysfedand1dayfast,(iii)1-1intermittentwith1dayfedand1dayfast,and(iv)40%continuouscalorierestrictioneveryday.Independentvariableinthisstudywascalorieintakeandbodyweight.Dependentvariableswerehydrogenperoxideleveland.Bloodglucoselevel.Thedifferenceofeachgroupwasanalyzedwithone way ANOVA and the least significant difference was analyzed by the use post hoc tests, using p < 0.05. The result of this study for hydrogen peroxide and blood glucose level in control group with experimental groups were p 0.000 and p 0.001. There was positivecorrelation between hydrogen peroxide level and blood glucose level r 0.791. We conclude that calorie restriction decrease hydrogenperoxide level and as well as regulating of blood glucose level. The best one of this method is 40% calorie restriction.
PENYEBARAN GUMPALAN DALAM PEMBULUH DARAH (DISSEMINATED INTRAVASCULAR COAGULATION) AKIBAT RACUN GIGITAN ULAR Prihatini .; Trisnaningsih .; muchdor .; U N Rachman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.923

Abstract

Cases of snake bites were seldom happened in town. From the 2500–3000 world-wide distributed species of snakes, 500 are venomous. The snake produce some toxic substance which is dangerous in men , and could cause morbidity or mortality. It’s caused byophitoxaemia, which influence the permeability of capilers with consequence bleeding. There patients must be examined physically, localas well systemic. The laboratoric examinations were based on clinical symptoms, by determination of the snake venom causal and thesequalae in the human body, including coagulopathy, anemia as well as renal failure, etc. The snake venom may cause necrotic tissue offoot and anemia by trombocytopenia.The condition of this victim patient was severre due to his diabetic syndrome. This article presenteda study of snake bite incident on an old man with DIC laboratoric results, following anemia and renal failure which caused his death.

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