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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) JIKUM: Jurnal Ilmu Komputer
Rikarni Rikarni
Department Of Clinical Pathology And Laboratory Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Limfopenia dan Rasio Neutrofil-Limfosit pada Infeksi Severe Acute Respiratory Syndrome Coronavirus 2 Hevrina Yufani; Rikarni Rikarni; Zelly Dia Rofinda
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1734

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause cytokine storm characterized by the excessive release of pro-inflammatory cytokines, leading to lymphopenia and neutrophilia. Lymphopenia and high Neutrophil-Lymphocyte Ratio (NLR) on admission were associated with the severity of the disease. Objectives: To found out lymphopenia and high NLR in SARS-CoV-2 infection. Methods: This was a cross-sectional descriptive study on all patients infected with SARS-CoV-2 who met the inclusion and exclusion criteria at Dr. M. Djamil Hospital Padang from March until August 2020. Lymphocyte count and neutrophil count on admission were examined by flowcytometry method and NLR was calculated. Lymphopenia is a lymphocyte count of <1.5x103/mm3 and high NLR is ≥ 3.13.  Results: The study samples were 123 patients, with 58.5% women. The mean age was 47.80 (15.59) years. Lymphopenia was present in 39% of patients with mean lymphocyte count was 1.84 (0.83) x103/mm3. High NLR was present in 48% of patients with a mean NLR was 5.06 (4.87). Conclusion: Lymphopenia was present in 39% of patients infected with SARS-CoV-2 and high NLR was present in 48% of patients infected with SARS-CoV-2.Keywords:  lymphopenia, neutrophil-lymphocyte ratio, SARS-CoV-2
Uji Kesesuaian Hasil Pemeriksaan Sedimen Urine Metode Shih-Yung pada Volume Urine 10 mL dan 5 mL Putri Niawaty; Rikarni Rikarni; Dwi Yulia
Jurnal Kesehatan Andalas Vol 10, No 2 (2021): Online July 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1721

Abstract

Microscopic examination of urine sediment using shih-yung system requires 10ml urine volume. Pediatric patients and kidney disease patients with oliguria difficult to get 10mL urine samples, so it needs to be studied to determine the accuracy of results with smaller sample volumes. Objectives: To analyze agreement of urine sediment examination using Shih-yung system in 10 mL and 5 mL urine volume. Methods: This study was a cross-sectional analysis of 37 urine specimens that met inclusion and exclusion criteria at the central laboratory of Dr. M. Djamil Hospital from July to September 2020. Examination of erythrocyte sediment, leukocyte sediment, and non-hyaline cast using Shih-yung system was done in 10 mL and 5 mL urine volume. Data were analyzed using kappa reliability/agreement test and significant if p<0.05. Results: Agreement test of erythrocyte sediment examination using Shih-yung system in 10ml and 5mL urine volume were moderate significantly (κ=0.600; p<0.05), agreement of leukocyte sediment examination were moderate significantly (κ=0.571; p<0.05), and agreement of nonhialin cast examination were substantial significantly (κ=0.767; p<0.05). Conclusion: Agreement test of erythrocyte and leukocyte sediment examination in 10ml and 5mL urine volume is moderate, so 5ml urine volume was not recommended. Manual examination with microscope and difference in urine sample volume causing difference sediment concentration and amount of sediment per microscope field of view.Keywords: Shih-yung,  urine sediment,  urine volume
Pancreatic Cancer: Pathogenesis, Diagnosis, and Laboratory Tests Rikarni Rikarni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1891

Abstract

Pancreatic cancer is the eleventh cause of cancer death in Indonesia in 2020. However, pancreatic cancer is the second leading cause of cancer death in the United States after lung cancer. Although it is substantially less common than the other malignancies, pancreatic carcinoma is near the top of the list of killers because it is a highly aggressive cancer. Pancreatic cancer has multistep carcinogenesis, starting from the Pancreatic Intraductal Neoplasia (PanINs IA, IB, II, and III) and is ended with an invasive neoplastic lesion. The different incidence of pancreatic cancer between countries also shows the important role of environmental factors for the disease. A better understanding of the risk factors, genetics, molecular pathogenesis, symptoms associated with this disease, and the laboratory aspect is essential to inform both health professionals and the general population as the potential preventive and/or early detection measures.
HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2 Rikarni .; lillah .; yoesri .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.918

Abstract

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macroand microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there isendothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration andmicroalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectionalmethod and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinineratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with totalsample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, andfibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantlystatistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma andalbuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patientswith normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio
Agreement of Urine Sediment Using Shih-Yung Method in Aspirated and Decanted Supernatant Removal Technique Jesi Anggraini; Rikarni Rikarni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1819

Abstract

The technique of supernatant removal in urine sediment examination using the Shih-Yung method can be done by aspirating and decanting. The aspirated technique is the recommended technique. The Central Laboratory Installation of Dr. M. Djamil Hospital, Padang used decanted supernatant removal technique. The variety of preanalytical procedures affect the results of urine sediment examination. This study aimed to analyze the agreement of erythrocyte, leukocyte, and non-hyaline cast sediment examination results using the Shih-Yung method in aspirated and decanted supernatant removal technique. This study was an analytical observational study with a cross-sectional design of 37 urine specimens that met the inclusion and exclusion criteria at the Central Laboratory Installation of Dr. M. Djamil Hospital, Padang from July to September 2020. Examination of erythrocyte, leukocyte, and non-hyaline cast sediment using Shih-Yung method with aspirated and decanted supernatant removal technique. Numeric data were analyzed using the Mann-Whitney U test and Cohen's Kappa test for the degree of agreement, p-value < 0.05 was considered significant. The agreement test results for erythrocyte, leukocyte, and non-hyaline cast sediment in aspirated and decanted supernatant removal technique were (Kappa=0.88, p < 0.05), (Kappa=0.83, p < 0.05), and (Kappa=0.86, p < 0.05), respectively. The degree of agreement test results for erythrocyte, leukocyte, and non-hyaline cast sediment using the Shih-Yung method in aspirated and decanted supernatant removal technique were almost perfect and statistically significant. The technique for supernatant removal in urine sediment examination using the Shih-Yung method can be done by decanting.
DIFFERENCE IN GLICATED HEMOGLOBIN LEVEL BETWEEN BORONATE AFFINITY METHOD AND ION EXCHANGE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD IN TYPE 2 DIABETES MELLITUS Tuti Asryani; Ellyza Nasrul; Rikarni Rikarni; Tutty Prihandani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1466

Abstract

Background: Glycated Hb (HbA1c) test is needed to control glycemic in high prevalence type 2 diabetes mellitus (DM) patients. Hemoglobin fraction separated and chemical reaction are two main concepts in HbA1c test. Ion exchange-high performance liquid chromatography (HPLC) and boronate affinity use first concept. Ion exchange-HPLC is reference method in most of clinical laboratorium. Point of care testing (POCT) with boronate affinity method that has been standardized by international institution is available. The aim of this study was to compare boronate affinity POCT method and ion exchange-HPLC method.Method: This cross sectional study was conducted to 22 type 2 DM patients those fullfill inclusion and exclusion criteria in January 2017 to February 2018. Level of HbA1c was assayed with boronate affinity POCT and ion exchange-HPLC method. T-test was used to analyse data and no significance difference if p>0.005Results: Subjects of this study are women (59.1%) more than men (40.9%) with age mean 59.23 years old (8.1). Uncontroled type 2 DM (77.3%) more than controled type 2 DM (22.7%).Mean of HbA1 level was 8.0% (1.7) in boronate affinity POCT and 8.3% (1.8) in ion exchange-HPLC. T-test showed no significance difference between those two HbA1C assay methods (p>0.005).Conclusion: There was no difference HbA1c level between boronate affinity POCT method and ion exchange-HPLC method.
Analisis Jumlah Trombosit Pada Pasien Terinfeksi Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Ratih Hasma; Rikarni Rikarni; Dwi Yulia
Majalah Kedokteran Andalas Vol 44, No 5 (2021): Online Oktober 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i5.p316-324.2021

Abstract

Tujuan: Penelitian bertujuan untuk mengetahui jumlah trombosit pada pasien terinfeksi SARS-CoV-2. Metode: Penelitian deskriptif cross sectional terhadap 123 pasien terinfeksi SARS-CoV-2 yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan mulai bulan Juli-September 2020 di Laboratorium Sentral RSUP Dr M Djamil Padang. Pemeriksaan jumlah trombosit dilakukan dengan alat hematologi otomatis metode Hydrodynamic Focusing DC Detection. Pemeriksaan trombosit dilakukan saat awal rawatan. Data jumlah trombosit disajikan dalam bentuk tabel distribusi frekuensi. Hasil: Sampel penelitian perempuan (58,5%) lebih banyak daripada laki-laki (41,5%), rerata umur 47,8(15,6) tahun. Rentang umur pasien yaitu 21-82 tahun. Kelompok umur 30-39 dan 50-59 terbanyak yang terinfeksi SARS-CoV-2. Rerata jumlah trombosit 295.154(108.783) /mm3. Trombositopenia ditemukan pada 6 pasien (4,9%), trombositosis pada 17 pasien (13,8%) dan jumlah trombosit normal pada 100 pasien (81,3%). Jumlah kematian dengan trombositopenia sebanyak 1 pasien (16,7%). Jumlah kematian dengan trombosit normal sebanyak 13 pasien (13%). Jumlah kematian dengan trombositosis sebanyak 4 pasien (23,5%). Simpulan: Jumlah trombosit pasien terinfeksi SARS-CoV-2 memperlihatkan trombositopenia 4,9%  dan trombositosis 13,8%.Kata kunci: COVID-19 ; SARS-CoV-2 ; trombosit.
Artritis Septik Najirman Najirman; Rikarni Rikarni; Rika Florensia
Majalah Kedokteran Andalas Vol 45, No 1 (2022): Online Januari 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i1.p63-68.2022

Abstract

Artritis septik (dikenal juga dengan artritis piogenik atau artritis supurativa) merupakan kondisi emergensi akibat infeksi oleh bakteri pada sendi sehingga mengakibatkan terbentuknya pus pada rongga sendi bersangkutan. Beberapa faktor risiko dapat meningkatkan insiden terjadinya artritis septik. Diagnosis dan tatalaksana dini penting dilakukan dalam kondisi ini untuk mencegah kerusakan sendi. Kami melaporkan sebuah kasus artritis septik pada laki-laki dewasa dengan DM tipe II, dislipidemia, dan tromboemboli vena. Seorang laki-laki 37 tahun dibawa ke Rumah Sakit Umum Pusat Dr. M. Djamil dengan keluhan lutut kanan nyeri, bengkak, kemerahan, dan kaku dengan riwayat DM tipe II tidak terkontrol. Pada pemeriksaan fisik, ditemukan tanda inflamasi pada lutut kanan disertai keterbatasan ROM. Punksi  dan analisis cairan sendi dilakukan untuk memastikan diagnosis yang diderita pasien tersebut. Dilakukan penatalaksanaan dengan memberikan, steroid, gabapentin, ditambahkan ketorolak serta antibiotik spektrum luas. Penyakit sekunder yang menyertainya juga ditatalaksana sebagaimana mestinya. 
Analysis of Reticulocyte Hemoglobin Equivalent Levels in Patients with Chronic Kidney Disease Stage IV and V Agri Febria Sari; Rikarni Rikarni; Deswita Sari
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2718

Abstract

Reticulocyte hemoglobin equivalent (RET-He) represents hemoglobin content in reticulocyte. Reticulocyte hemoglobin equivalent test can be used to asses iron status of chronic kidney disease (CKD). Iron deficiency happens in 40% CKD and could lead to anemia manifestation. Level of RET-He gives real-time assesment of iron availability for hemoglobin production and the level will getting lower when iron storage for erythropoiesis decreasing. Reticulocyte hemoglobin equivalent is more stabil than feritin and transferin saturation in assessing iron status. Aim of this study is to determine RET-He level in patients with CKD stage IV and V. This study is  a cross sectional descripstive study. Subjects were 96 CKD stage IV and V patients that met inclusion and exclusion criterias. Subjects conducted blood tests at Central Laboratory Installation Dr. M. Djamil Hospital Padang from July to September 2020. Examination of RET-He level was analyzed by Sysmex XN-1000 flowcytometry fluorescense method. Data was presented in frequency distribution table. The RET-He level below cutoff (<29,2 pg) indicates the need for iron suplementation therapy for CKD stage IV and V patients. Samples with RET-He level below cutoff were 48 (50%) and 48 (50%) were above cutoff.
Hubungan Kadar Cancer Antigen 15-3 Serum dengan Metastasis Kanker Payudara Fakhriyyatur Rahmi M; Rikarni Rikarni; Nora Harminarti
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1364.467 KB) | DOI: 10.25077/jikesi.v1i3.110

Abstract

Background: CA 15-3 serum is one of the tumor marker that has been recommended by American Soviety of Clinical Oncology to show the response of the therapy, prognosis and metastasis of the breast cancer. CA 15-3 serum is a mucin that will be expressed by breast cancer cell. The over expression of CA 15-3 serum can be occurred if the cell progressivity is increase. Several studies have shown that CA 15-3 serum is increasing in metastasis breast cancer. Objective: This study aimed to determine the relationship between the CA 15-3 serum with metastasis breast cancer. Methods: This study used a cross sectional design in breast cancer patient at Dr. M Djamil Hospital. Sampling using consequtive sampling technique with a total sample of 46 people. Data was analyzed by using Mann-Whitney test. Results: Distant metastasis of Breast cancer was more common in age group of 40-60 years (65,21%) and 86,96% had shown a lymphatic metastasis. The mean of CA 15-3 serum was higher in the group with distant metastasis 385,0439 U/mL compared to group without distant metastasis. Distant metastasis was more common in single state metastasis (69,6%) with the mean 472,24 U/mL. Common targeting organ of the distant metastasis was lung (69,9%). The highest mean of CA 15-3 serum was in pleura 557,2 U/mL. Conclusion: There was a statistically significant relationship between the mean of CA 15-3 serum with metastasis breast cancer (p=0.000).
Co-Authors Adi K Aman, Adi K Agri Febria Sari Agri Febria Sari Alfarizhi, Habieb Almurdi Almurdi Amalina Ananda, Gita Putri Asterina Asterina Beti E. E Dewi, Beti E. E Burhan, Ida Rahmah Chairunnisa Kusumawardhani Dedy Kurnia Defrianti, Serli Deswita Sari Desywar Desywar Dia Rofinda, Zelly Dia Dian Pertiwi Doan Atrya Dwi Yulia Dwi Yulia Efrida Efrida Elfira Yusri Ellyza Nasrul Elmatris Sy Elsa Fitriani Elvira Yusri Endrinaldi Fakhriyyatur Rahmi M Fitriani, Elsa Harika Putra Harry Isbagyo, Harry Hevrina Yufani Intan, Shinta Ayu Jesi Anggraini lillah . Malinda Meinapuri Nabila, Wulan Najirman Najirman Najirman, Najirman Niawaty, Putri Nora Harminarti Nuzirwan Acang Putri Ariani Putri Niawaty Rahajuningsih Dharma Rahmadian, Rizki Ratih Hasma Rianto Setiabudy Rika Florensia Rina Gustia Rinal Effendi Rudy Afriant Saptino Miro Selfi Renita Rusjdi Suryo Nugroho Suhardi Tambunan L Tambunan, Tambunan L Tuti Asryani Tutty Prihandani Wella Novile Izora Winanda, Mirza yoesri . Yufani, Hevrina Yulia, Dwi Yusri, Elfira Yustini Alioes Zelly Dia Rofinda