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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol 17, No 3 (2011)" : 11 Documents clear
INFEKSI VIRUS RABIES DI ANAK-ANAK A.A.N. Subawa; DGD. Dharma Santhi; A.A Raka Sudewi; IWP. Sutirta Yasa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (566.285 KB) | DOI: 10.24293/ijcpml.v17i3.1093

Abstract

Rabies has been known in ancient Egypt and China since the fifth century. The disease is caused by the Rhabdovirus of the genusLyssavirus spread from animals or bats to humans by saliva. A five-year-old kid was admitted to Sanglah General Hospital on February19. 2010 with fever complaints, before admitted to the hospital, since the morning he always stuck out his tongue, bit his lips, drinkinga little of water and hard to swallow. From the anamnesis, it is known that the patient has a history of bitten by a dog on February 4.2010 at the lower eyelid and had received wound treatment and VAR, after a while having the treatment the patient eventually died onFebruary 21. 2010. According to the post-mortem sample of the LCS it is showed a positive PCR result of rabies virus infection.
IMUNOKIMIAWI PGE2 USUS ILEUM YANG KEKURANGAN ENERGI PROTEIN R. Heru Prasetyo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1057

Abstract

Diarrhoeal disease mortality which suffered by children less than five years due to protein energy deficiency is increased significantly.The pathological mechanisms are not known in detail yet. The objective of this research was able to explain the intestine motility inprotein energy deficiency of mice Balb/c. Hormonal mechanism that regulates the intestine motility is roled by prostaglandine E2 hormone(PGE2). The observed variable was the immunity component of PGE2. The measurement was performed using immunohistochemistrymethod with monoclonal antibody against PGE2 to the ileum mice tissue. The result of this study showed that protein energy deficiencymice had much reduced PGE2 (reduction from 1492 to 145, p = 0.000 ). In conclusion, the marked decrease of ileum PGE2 will decreaseintestine motility and it may be one cause of the high diarrhoeal mortality due to protein energy deficiency.
PEMETAAN EPITOP DAN APLIKASI KLINISNYA Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1168

Abstract

Epitope mapping is one of the important findings in immunoIogy. The idea of systematic epitope mapping was first described byGeysen et al (Geysen et al., 1987a,b). This technic is further developed together with other important findings such as monoclonalantibody production, DNA recombinant, peptide synthesis and phage display of peptide or protein. The usage of this technic is to know theexact binding site of antigen with antibody or T cell receptor, and can be used as the basic information to design a vaccine or diagnostictools. The term epitope can be further classified as functional epitope, structural epitope, binding epitope, protective epitope, heavyinfection epitope, neutralization epitope etc. In this article will be reviewed topics about epitope: B and T cell epitope mapping technicsusing synthetic pin and its application.
MENINGITIS TUBERCULOSIS Silvia Rachmayati; Ida Parwati; A Rizal; D Oktavia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1166

Abstract

Tuberculosis meningitis is one of the clinical manifestations of extra-pulmonary TB, which is localized in the central nervous system(CNS). The mortality of these patients is usually caused by the delays in diagnosis and treatment; hence up to this day tuberculosismeningitis remains a health problem. The diagnosis of tuberculosis meningitis based on the discovery of M.tuberculosis established inthe cerebrospinal fluid (CSF) and is the gold standard by culture, although the examination results will be obtained after 6–8 weeks.Nevertheless the patient in this case needs an immediate and accurate treatment. Recently there is a rapid and accurate test to confirmthe diagnosis of tuberculosis meningitis, that is the detection of an immunoglobulin (Ig) M and G in the serum. The aim of this study isto know the validity and the correlation of IgG and IgM test to the gold standard by investigated them. The research is an observationalstudy conducted cross sectional in the Clinical Pathology Department of Hasan Sadikin Hospital, from October 2008 up to January 2009.Eighty samples were obtained, which included the criteria for patients with suspected tuberculosis meningitis. The result of this studyshows: sensitivity 94.1%, specificity 100%, positive predictive value 100%, negative predictive value 95.8%, positive infinite likelihoodratio (LHR), negative LHR 0.06 and kappa 0.95. According to this study it can be concluded, that the IgM/IgG TB is a test that has anexcellent validity and correlation for the future.
GAMMA-GLUTAMYLTRANSFERASE DAN APOLIPOPROTEIN B DENGAN SINDROMA METABOLIK Tahono .; M.I. Diah Pramudianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1056

Abstract

The number of Metabolic Syndrome (MS) patient has been rapidly increased. Diabetes Mellitus (DM) is a risk factor of coronaryheart disease that increased four fold in the general population. Gamma-glutamyltransferase (GGT) is located on the external surfaceof most cells and mediates the uptake of glutathione, which is an important component of intracellular antioxidants defenses. The aimsof this study was to analyze the correlation between GGT, Apolipoprotein B and metabolic syndrome parameters, a high sensitivityC-Reactive Protein (hs-CRP) as a marker of inflammation, and glutathione peroxidase (GPx) as an antioxidant marker in type 2 DMpatients. This study used a cross sectional design. The subject of this study was type 2 DM patients who came to the EndocrinologySubdivision of Internal Medicine Department and Laboratory of Clinical Pathology at Dr. Moewardi Hospital Surakarta. To analyze thisresult, the researchers used Spearman (r) correlation test with significance degree p < 0.05 and confidence interval 95%.The gammaglutamyltransferase serum showed a weak positive correlation with waist circumference (r = 0.18; p = 0.045) and Apo B with fastingblood glucose (r = 0.32; p = 0.001); a mild positive correlation between Apo B and triglyceride (r = 0.45; p = 0.001); a weak negativecorrelation between HDL cholesterol and GGT (r = –0.22; p = 0.020) and Apo B (r = –0.20; p = 0.027); a weak positive correlationbetween hs-CRP and GGT (r = 0.38; p = 0.001), and Apo B (r = 0.18; p = 0.042); and a weak negative correlation between Apo Band GPx (r = –0.22; p = 0.019). Gamma-glutamyltransferase examination is superior to notice any inflammatory process than apoB(r = 0.38 vs. R = 0.18), whereas apoB is superior as a predictor of inflammation than GGT (r = –0.51 vs. R = –0,20). Gammaglutamyltransferase serum as an early marker of oxidative stress and Apo B was related to inflammation at the metabolic syndromeand diabetes. Measurement of GGT serum is reliable, easy, and not expensive, it might have important implications both clinically andepidemiologically
CREATINE KINASE MYOCARDIAL BAND, MYELOPEROXIDASE, MATRIX METALLOPROTEINASE-9 DAN TROPONIN T PADA IMA IA Hutagalung; I Patellongi; R Pakasi; M Arif; AA Mappahya; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1055

Abstract

In many patients presenting with chest pain symptoms at the emergency room, cardiac markers are measured not only to detect acutemyocardial infarction (AMI) but to exclude them too. Presently, the only biochemical markers used for diagnosis of MI are creatine kinasemyocardial band (CKMB) and troponin T (cTnT) as the markers of myocardial necrosis. Other biochemical markers have been sought tofind marker which can reflect the important, upstream processes in the pathophysiology of MI that therefore might give an earlier signalof ongoing MI. These markers are myeloperoxidase (MPO) and matrix metalloproteinase-9 (MMP-9) as markers of plaque destabilization.The aim of this study was to analyze the CKMB, MPO, MMP-9 activityies and troponin T level in MI. A cross sectional study had beendone at the Cardiovascular Centre Unit and Internal Ward of Dr. Wahidin Sudirohusodo Hospital during April up to August 2010 period.The laboratory tests were done at the Clinical Pathology Laboratory of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Researchand Esoteric Unit of Prodia Clinical Laboratory, Jakarta. Ffifty-three patients with AMI had been examined. The results showed that themeans of CKMB, cTnT, MPO and MMP-9 were 52.4 U/L, 2.0 ng/mL, 217.9 ng/mL and 920.3 ng/mL, respectively. MMP-9 had positivelyvalue (69.8%) higher than cTnT (60.4%), MPO (58.5%) and CKMB (45.3%). Troponin T and MMP-9 were higher in patients with highCKMB. The higher level of CKMB will be the higher MPO, MMP-9 and cTnT. There were strong correlation between MPO and MMP-9, alsobetween CKMB and Troponin T. Troponin T and CKMB were lower in inferior wall infarction compared with anterolateral/anteroseptal wallinfarction. The most sensitive biochemical marker in patients with AMI is the MMP-9. The MMP-9 usage is suggested to assist the diagnosisof AMI. It is suggested a further study to establish the specificity of MMP-9 in all patients suffering with chest pain.
D-DIMER PENDERITA SINDROM KORONER AKUT DAN STENOSIS Birhasani .; Lisyani B S; Ria T
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1092

Abstract

Acute coronary syndrome (ACS) is the multisystem of coronary artery disease. The clinical manifestation of ACS is acute myocardialinfarction (AMI). About 90% coronary attack is caused by thrombus occlusion in coronary artery. The suspect of thrombosis can bediagnosed definitely by Angiography, but it is invasive. D-dimer used to measure thrombosis abnormality and fibrinolisys. The result oftheir correlation between D-dimer with ACS is still controversived. The aim of this research is to analyse, the different between plasmaD-dimer level ACS with stenosis ≥ 50% and stenosis < 50%. This study used a cross sectional design. The study consist of seventeenspecimen ACS with stenosis ≥ 50% and 17 specimen with stenosis < 50%. Plasma D-dimer level was measured with quantitativeagglutination latex method. An independent t-test statistical analysis is used in this study. The average Plasma D-dimer of ACS withstenosis ≥ 50% is 960.2 ± 404.99 µg/L thus ACS with stenosis < 50% is 300.3 ± 128.75 µg/L (p = 0.00). The plasma D-dimer levelof ACS with stenosis ≥ 50% is more significant than ACS with stenosis < 50%.
LEUKOSIT INFEKSI BAKTERI SISTEMIK Meita Hendrianingtyas; MI. Tjahjati DM
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1094

Abstract

Patients in intensive care unit (ICU) have a high risk for systemic bacterial infection. Serum procalcitonin (PCT) known as a markerto predict bacterial infection, systemic inflammation responsse (SIRS) or sepsis. Another simple and easy indicator is by using leucocytecount-differential count, absolute neutrophyl count (ANC), and immatur/total (I/T) neutrophyl ratio. The aim of this study was toknow the comparation of the leucocyte count-differential count, ANC, and I/T ratio with procalcitonin serum value in patients suspectto systemic bacterial infection at ICU. A cross sectional study on 20 patients suspected with systemic bacterial infection in ICU. The datawas classified in 3 groups based on PCT serum value: group A (< 0.5 ng/mL), group B (0.5–2 ng/mL) and group C (> 2 ng/mL). Thedata was analysed by one way ANOVA test if normally distributed, and by Kruskall-Wallis test if not normally distributed. Significancywas confirmed at p < 0.05. A post hoc and Mann-Whitney test performed on a significant result. The frequency of group A was 3 (15%),group B = 5 (25%), and group C = 12 (60%). There is no significant difference on leucocyte count in 3 groups (p = 0.953), neutrophylI/T ratio (p = 0.259), ANC (p = 0.91), eosinophyl count (p = 0.287), segment neutrophyl (p = 0.094), and monosit (p = 0.152).There was a difference on lymphocyte count (p = 0.01) between group C with group A and group B and there was a difference on staffneutrophyl count (p = 0.029) and total neutrophyl count (p = 0.003) between group A with group B and C (p = 0.029). In this studywere found differences on lymphocyte, staff neutrophyl and total neutropyl count to the PCT value
UMBI UBI JALAR UNGU BALI (Ipomoea batatas) DI TRANSAMINASE SERUM, MALONDIALDEHIDE HEPAR DAN ALKOHOL KRONIS I Wayan Putu Sutirta-Yasa; I Made Jawi; Ida Bagus Ngurah; Anak Agung Ngurah Subawa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1170

Abstract

Oxidative stress as a consequence of chronic alcoholic intake causes lesions of liver tissue. The objective of this study was to identifythe antioxidant effect of ethanol extract derived from Balinese purple sweet potato on the liver tissue in mice after chronic consumptionof alcohol. Subjects of this study were 32 adults male Swiss mice (12–14 weeks) divided into 4 groups with control group post-testonly design. Post-treatment of blood and liver samples were collected from each group of 8 mice. The MDA liver was quantified withthiobarbituric acid reactive substances (TBARS) method. Samples were collected from control group of 8 mice without sweet potatoextract and alcohol, 8 mice with 1 mg extract of Balinese purple sweet potato, 8 mice with 0.8 gram alcohol, and 8 mice with combineof alcohol and extract of Balinese purple sweet potato, each treatment was carried out every day for 4 weeks. The results showed asignificant increase of serum SGOT, SGPT and liver MDA level, after chronic consumption of alcohol (p = 0.00). The decrease of serumSGOT, SGPT and liver level MDA was significant in the group with extract of Balinese purple sweet potato (p = 0.00). The researchersconcluded that the extract of Balinese purple sweet potato had an antioxidant effect in mice which consumed alcohol chronically. Basedon this study it is concluded that extract of Balinese purple sweet potato has a protective effect on the liver cell in mice which consumedalcohol chronically.
UJI HEMATOLOGI PASIEN TERDUGA DEMAM BERDARAH DENGUE INDIKASI RAWAT INAP Juranah .; Darwati Muhadi; Mansyur Arif; Burhanuddin Bahar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1169

Abstract

Indonesia is an endemic area of Dengue Hemorrhagic Fever (DHF). The clinical symptoms of this disease varies; it can beasymptomatic or atypical fever. Therefore, the early detection of Dengue virus is important to reduce the incidence of new victims fromhis infection. The aim of this study was to find out the haematological features of DHF suspected patients indicated for hospitalization. Aross-sectional study was done on DHF suspected patients indicated for hospitalization. The data were obtained from the Medical Recordat Wahidin Sudirohusodo Hospital from January-July 2009. The data were presented in the form of table. The results showed that themean leukocyte counts was 5.138 103/µL ranging from 2.10–16.70 103/µL, the mean erythrocyte count was 5.136 106/µL rangingrom 3.2–6.40 106/µL, the mean platelet count was 111.27 103/µL ranging from 11.40–260 103/µL. The DHF patients at admissionwho had leucositopenia, thrombocytopenia, and monocytosis were 54.30%, 71.40%, and 51.40%, respectively. Based on the result itan be concluded, that the most common haematological abnormality in DHF suspected patients whom indicated for hospitalizationwere thrombo cytopenia, leucocytopenia and monocytosis.

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