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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 17 Documents
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Search results for , issue "Vol 20, No 3 (2014)" : 17 Documents clear
KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT Ani Kartini; Mansyur Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.470

Abstract

Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 μg/mL and 4.29 μg/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 μg/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.
PROKALSITONIN, CRP DAN PRESEPSIN SERUM DI SIRS Hendrianingtyas Hendrianingtyas; Banundari RH; Indranila KS; Imam Budiwiyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.475

Abstract

Infection in ICU patients can lead to a septic condition with clinical signs similar to Systemic Inflammatory Response Syndrome (SIRS). The high risk of death and high cost of sepsis is the reason to find an early marker in diagnosing sepsis. Blood culture can givea result in 1-3 days, so C reactive protein, procalcitonin and presepsin which are fast and accurate are needed to find a septic condition in SIRS patients. The aim of this study is to determine the diagnostic value of CRP, PCT and presepsin of sepsis with blood culture as the gold standard., The samples were collected from 32 clinically SIRS patients in the Dr. Kariadi Hosiptal, Semarang. The PCT level was measured using ELFA method, CRP level by PET IA method, while presepsin level by CLEA method. The determined area was under curve (AUC) and the cut off level was determined by 2×2 table to find out the sensitivity, spesificity, positive predictive value, negative predictive value and likelihood ratio of CRP, PCT and presepsin as well. The AUC of PCT, CRP and presepsin was 0.78 (cut off 4.314 ng/mL); 0.673 (cut off 10.245 mg/L) and 0.814 (cut off 1134.5 pg/mL). The presepsin level had a higher sensitivity (90%) than PCT (80%) and CRP (70%). PCT specificity was 72.73%, presepsin and CRP specificity each was 68.18%. Based on this study, AUC and sensitivity of presepsin level were found higher than the PCT and CRP level.
ST2 DI INFARK MIOKARD AKUT Hery Priyanto; Jusak Nugraha; SP Edijanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.478

Abstract

Acute Myocardial Infarction (AMI) is a major problem threatening Indonesian inhabitants as well as in many countries. Each year AMI patients are increasing. ST2 is a novel cardiac marker for the diagnosis and prognosis of acute myocardial infarction. The purpose of this study was to know and find the diagnostic value of ST2 serum in patients with AMI. This cross sectional study was conducted on 46 patients who had chest pain as the main complaint in the Emergency Department, Dr. Soetomo Hospital, Surabaya between April 20 to July 20, 2013. The sera were examined for ST2, cTn-T, the diagnostic value was determined using the acute myocardial infarction clinical criteria according to the Universal Definition of Myocardial Infarction (2007) as the gold standard. The results of ST2 serum levels measurement showed a sensitivity of 83% and specificity of 70% at a cut-off value of ST2 16.64 ng/mL and AUC 0.878, p=0.000. The concordance examination between using cTn-T levels and ST2 was 48.1%. A significanct correlation was obtained with a correlation coefficient r=0.489, p=0.001 between the levels of cTn-T and ST2. Based on this study, the ST2 serum levels can be used for screeningto aid the diagnosis of acute myocardial infarction. However, there is a weak correlation and concordance between cTn-T with ST2. Thus, the researchers need a further study to determine the diagnostic value of ST2 for the detection of acute myocardial infarction.
JAMUR DI PERALATAN neonATAL InTenSIve CARe unIT Ariani Said; Irda Handayani; Nurhayana Sennang
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.468

Abstract

Fungus is the one of the micro organisms that causes nosocomial infections. Fungal infections are becoming more frequent occurred from the irrational use of broad spectrum antibiotics, steroids, cytostatica drugs, and chronic disease, and malignancy, babies with low birth weight and patients with decreased immunity. Neonatal Intensive Care Unit (NICU) is a room with specialized treatment, care and equipment to treat infants with high risk. The purpose of this study was to know by identification of the fungus species on the instrument at the NICU of dr. Wahidin Sudirohusodo hospital, Makassar at June 2011. The study design was a cross sectional one. The samples are the incubators and the Continuous Positive Airway Pressure (CPAP) at the NICU of dr. Wahidin Sudirohusodo hospital. The sampling was done by rubbing swab on the incubator and CPAP. The identification of the fungus were carried out with lacto phenol cotton blue staining performed at the Central Public Health Laboratory, Makassar. The Streptomyces sp and Penicillium sp were identified at four incubators, Candida sp was identified at one incubator and so was the Aspergillus sp identified; The fungus that identified at the CPAP was only Penicillium sp. Based on this study it can be concluded that Penicillium sp, Streptomyces sp, Aspergillus sp, as well as Candida sp were found at all incubators and only Penicillium sp was found at CPAP.
MANAJEMEN PENGETAHUAN UNTUK KESELAMATAN PASIEN Hartono Hartono; Rika Subarniati; Widodo J. Pudjirahardjo; FM. Judajana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.474

Abstract

Many mistakes are often made in the laboratory such as: confusing results of specimen examination, wrong process of laboratory services and many problems appearing during services can result in patient’s error. The knowledge management can be a systematically way to capture and communicate knowledge to the laboratory technicians in order to minimize errors made in the laboratory. The purpose of this study is to prove that by implementation of patient’s safety using management strategy of knowledge about patient’s safety can increase the performance of laboratory personnel. The study is carried out pre-experimentally by using a pre-post design in a group without a control group comprising 55 respondents. Prior to giving implementation about knowledge of patient’s safety, the study subjects were tested by a pre-test about: the personnel’s potentials (mindset, attitude, awareness and knowledge), quality of work and performance of the personnel. Knowledge management was implemented in several stages, starting from dispersion of knowledge by making: modules, stages of setting up a team, distribution of knowledge by training and executing patient’s safety and acquainting knowledge by routine team meetings, recording, reporting and evaluation of patient’s safety. The increase of potentials, work process quality and personnel performance was post-tested to show a change and implementation effect of knowledge management about patient’s safety. The result showed a significant change in the personnel potentials post implication of knowledge management (p<0.001). A significant change was also shown in increase work quality (p<0.001). The influence of potential increase of work process quality showed a significant correlation (p=0.172, β=01.87). The increase of personnel potentials also influenced the improvement of their performance (p=0.002, β: 0.406). However, the increase of personnel work process quality significantly influenced the improvement of personnel performance (p<0.001, (β=0.581) Based on this study it can be concluded that knowledge management about patient’s safety can influence the increase of potentials and quality of personnel work process. The increase of quality on the personnel work process can significantly influence the improvement of personnel performance as well.
CARCInoeMBRYonIC AnTIGen (CEA) DI KANKER KOLOREKTAL Nur Rahmi Raehaan; Asvin Nurulita; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.465

Abstract

Colorectal cancer is a common gastrointestinal malignancy of the colon and rectum. According to the American Society of Clinical Oncology (ASCO) in 2006, preoperative CEA level is useful in dtermining the tumour stage, plan of action and monitoring therapeutic response during the active treatment. Several factors which influence CEA level in patients with colorectal cancer is the staging and the degree of tumour, liver function, and as well as its location. This retrospective study is aimed to know the preoperative CEA levels in 51 patients with colorectal cancer and to compare the levels of CEA based on tumour stage, degree of tumour based on histopathology and tumour location.. This study was carried out at the Dr.Wahidin Sudirohusodo Hospital (RSWS), Makassar during January 2009−December of 2011. The researchers found a significant difference between the levels of CEA with the tumour stage (p=0.000) and its relation with the degree of the tumour (p=0.002), however, based on the tumour location (p=0.585) there was no significant difference between the levels of CEA. In conclusion, it was found that the higher the tumour stage, the higher the levels of the produced CEA. A well differentiated tumour of colorectal cancer produced a higher level of CEA compared to the moderate or poor-differentiated tumours.
HoSPITAL ACQuIReD PneuMonIA onSeT DAN BAKTEREMIA Bellya Affan Roes; Dewi Kartika; Basti Andriyoko
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.466

Abstract

Hospital acquired pneumonia (HAP) is significantly impact the patient morbidity and mortality that cause etiologic identification becomes a microbiological emergency in HAP. The etiologic identification based on the onset of pneumonia is important to determine the specific pathogens, that impact patient prognosis and prevent bacteremia. The aim of the study is to know the bacterial profile and antibiotic susceptibility pattern of early onset HAP by determination, late onset HAP and HAP with bacteriaemia in the intensive care setting. The design of this study was retrospective descriptive. The data was collected from the Clinical Microbiology Laboratory, Department of Clinical Pathology and the medical record from Dr. Hasan Sadikin hospital Bandung, from April 2013–March 2013. From the 61 episodes of HAP, 18 were early onset HAP and 43 were late onset HAP, including five (5) related to (8.2%) HAP with bacteriaemia. Klebsiella pneumoniae is the most common etiology of the early onset HAP (22.2%), with the highest susceptibility (75%) to amikacin, meropenem, and tigecyclin. Acinetobacter baumannii is the most common etiology of the late onset HAP (27.9%), with the highest susceptibility (75%) to amikacin and cotrymoxazole. The most common etiology of HAP with bacteriaemia is Klebsiella pneumoniae confirmed ESBL (40%) with the highest susceptibility to amikacin and meropenem (100%). Based on this study, it can be concluded that the most common bacterial profile of the early onset HAP is K. pneumoniae, while for the late onset HAP is A. baumannii, and HAP with bacteriaemia is K. pneumoniae confirmed ESBL. All of them have the highest susceptibility to amikacin.

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