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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 22 Documents
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Search results for , issue "Vol. 31 No. 2 (2025)" : 22 Documents clear
Transient Hepatitis B Antigenemia After Vaccination in Pediatric Patient Solin, Ro Shinta Christina; Bahasoan, Yusuf
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2112

Abstract

The hepatitis B surface antigen (HBsAg) test is a perioperative examination used for hepatitis B screening to prevent and control bloodborne infections. The interpretation of HBsAg results in post-vaccination cases requiring vigilance. A 2-month-old pediatric patient was referred to the hospital for colostomy surgery. The patient undergoes routine screening for surgery, including screening for hepatitis B. The laboratory test obtained reactive HBsAg results using the Chemiluminescent Microparticle Immunoassay (CMIA) method. The HBsAg confirmatory testing was done, and reactive results were obtained. Patients are vaccinated against hepatitis B at 0 and 2 months. On the seventeenth day after the initial assessment, a second examination was conducted, and the results were negative for HBsAg, anti-HBs, total anti-HBc, and anti-HBe. Hepatitis B surface antigenemia may occur after vaccination in pediatric patients. Increasing patient and hospital staff awareness of this phenomenon aids in the reduction of unnecessary medication or therapy.
Cryptococcus Neoformans Infection in Non-HIV Cryptococcal Meningoencephalitis Mutiara, Frederica; Novianingtyas, Dwi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2118

Abstract

Cryptococcus meningoencephalitis is an inflammation of the meningeal membrane due to Cryptococcus fungal infection. This fungus attacks the Central Nervous System (CNS) with a low immune system, especially in patients infected with advanced Human Immunodeficiency Virus (HIV), opportunistic diseases related to Acquired Immunodeficiency Syndrome (AIDS), and non-HIV patients with long-term corticosteroid treatment, organ transplants, lymphoreticular malignancies. This article reports the case of a 49-year-old female patient with complaints of decreased consciousness accompanied by severe headaches experienced during the previous 14 days. There was impaired nerve function also. The patient was found to have reduced Glasgow Coma Scale (GCS), neurologic deficit, and rigidity. Laboratory examinations found leukocytosis, with a positive brain fluid analysis examination of budding fungal cells in Indian ink staining and growing Cryptococcus neoformans species in SDA culture and non-reactive HIV blood test results. Cryptococcus meningoencephalitis can occur in patients with non-HIV infection. The use of NSAIDs can impair the immune system. A definitive diagnosis is established by finding the fungus.
Association between Platelet-Lymphocyte Ratio and Troponin-I in NSTE-ACS Patient Riyanti, Rini; Sutejo, Ika Rahmawati; Arif, Dina Rizky Amalia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2166

Abstract

Non-ST segment elevation acute coronary syndrome (NSTE-ACS) accounts for 2/3 of cases of acute coronary syndrome in the hospitals in United States. Acute coronary syndrome causes myocardial ischemia, which results in the release of cellular elements like cardiac troponin into interstitial and intravascular spaces. Troponin-I is a marker of heart muscle damage with high sensitivity and specificity. Researchers were interested in analyzing the relationship between Troponin-I and the inflammatory biomarkers Platelet-Lymphocyte Ratio (PLR). Complete blood count is a routine test, which provides information about red and white cells as well as platelets and lymphocytes. This study aimed to determine the correlation between PLR and Troponin-I in a patient presenting NSTE-ACS using cross-sectional design and medical records data of patients presenting NSTE-ACS at Slamet Martodirdjo Hospital, Pamekasan from January to December 2022. The correlation between variables was analyzed using Spearman correlation tests. The Spearman test results showed a p-value of 0.132, indicating a very weak positive correlation between PLR and Troponin-I in NSTE-ACS patients at Slamet Martodirdjo Hospital (r= 0.150, very weak correlation). Receiver Operating Characteristic (ROC) curve analysis of PLR to determine infarct (NSTEMI) in NSTE-ACS patients showed a cut-off of 139.5 for PLR with a sensitivity of 57.9% and a specificity of 59.3%.
Down Syndrome Combined with Robertsonian Translocation (13;14) Carrier Lestari, Esa Loyallita; Utari, Agustini; Winarni, Tri Indah; Hendrianingtyas, Meita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2205

Abstract

Down Syndrome (DS) is a genetic disorder in the form of adding chromosome 21 due to abnormal cell division. This condition causes a distinctive physical appearance and intellectual impairment. The prevalence of DS is between 10-11 out of 10,000 live births worldwide. A 2-week-old baby presented with complaints of jaundice with the clinical picture of DS. There was a mild increase in fT4 levels, and TSH levels were still within the reference value range. Karyotype examination showed Robertsonian translocation of chromosomes 13 and 14 and several abnormalities, namely trisomy 21.
Analysis of Magnesium as A Prognostic Marker for Chronic Kidney Disease at Dr. Wahidin Sudirohusodo Hospital Bahri, Suryanti; Kartini, Ani; Widaningsih, Yuyun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2273

Abstract

Magnesium (Mg) is an essential mineral that plays a role in many organ functions, including the kidneys. Magnesium has roles in regulating mitochondrial function, inflammatory processes, immune defenses, heart excitability, and blood pressure. Chronic Kidney Disease (CKD) can disrupt Mg balance and can have an impact on the progression and prognosis of CKD. This study aimed to analyze Mg levels as a prognostic marker for CKD. This was a descriptive retrospective study with a cross-sectional approach. The total sample consisted of 136 subjects with CKD patients, comprising stage I (n=3), stage II (n=2), stage III (n=11), stage IV (n=26), and stage V (n=94) based on the KDIGO classification. According to KDIGO, they were categorized as low risk (n=5), moderate risk (n=11), and high risk (n=120). Magnesium levels were assessed using the colorimetric method. Statistical analysis was performed using SPSS version 25, including the Kolmogorov-Smirnov test, a Kruskal-Wallis test, the least significant difference, and Spearman's correlation test. The cut-off point was determined using the ROC curve. Results were considered statistically significant if p< 0.05. This study demonstrated a significant positive correlation between eGFR values and Mg levels falling into the moderate category (0.2250<R<0.500). Characteristics of research subjects showed that the lowest Mg levels (1.81) were found in high risk prognosis (p<0.001) and stage 5 CKD (1.72) (p<0.001). The optimal cut-off point for Mg levels in CKD patients was 2.40 mg/dL, with a sensitivity of 76% and specificity of 69%. Magnesium levels can be used as a prognostic marker for CKD.  
Bacterial Identification and Antibiotic Sensitivity Tests of COVID-19 Patients at ICU Wahidin Sudirohusodo Hospital Ampulembang, Diana Tangdan; Handayani, Irda; Abdul Kadir, Nursin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2275

Abstract

The use of antibiotics in COVID-19 pneumonia patients admitted to the ICU with various risk factors can increase the possibility of antibiotic resistance. Irrational antibiotic use during the pandemic is one of the causes of antibiotic resistance. This study aimed to describe bacterial identification and antibiotic resistance in pneumonia patients admitted to the COVID-19 and non-COVID-19 ICU Dr. Wahidin Sudirohusodo Hospital. This study was a descriptive observational study with a cross-sectional method. Data were collected from medical records from Dr. Wahidin Sudirohusodo Hospital for the period January 2020-December 2022. The population that met the inclusion criteria were pneumonia patients admitted to the COVID ICU and non-COVID ICU and had pneumonia thoracic photographs, positive culture results, and antibiotic sensitivity tests. A total of 532 patients diagnosed with COVID-19 and 53 non-COVID-19 were treated in the ICU. Samples that met the inclusion criteria were 77 subjects with COVID-19 with 87 culture specimens and 36 non-COVID-19 patients with 47 culture specimens. The most common types of bacteria were Gram-negative bacteria in the COVID-19 (70.1%) and non-COVID-19 (78.7%) groups, Acinetobacter baumannii were primarily found in non-COVID-19 (29.8%) and COVID-19 patients (14.9%). The most common sensitivity test result was MDR in the COVID-19 (65.5%) and non-COVID-19 (72.3%) groups. The most common antibiotic resistance in both groups were Cephalosporins, Carbapenems, and Fluoroquinolones against Acinetobacter baumannii. Antibiotics that remained sensitive to Acinetobacter baumannii were Amikacin and Gentamicin. Bacterial identification results of COVID-19 and non-COVID-19 patients showed dominance of Gram-negative bacteria. The antibiotic sensitivity test showed MDR as the most common result.
The Galectin-3 Comparison in NSTEMI and STEMI Patients at Dr. Wahidin Sudirohusodo Hospital Halimah, Halimah; Lopa, Amaliyah Tahir; Rauf, Darmawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2276

Abstract

A common cardiovascular ailment called Coronary Artery Disease (CAD) is characterized by plaque buildup in the coronary arteries, leading to impaired blood circulation to the myocardium. Plaque deposits have the potential to occlude the lumen of the coronary arteries partially, and in certain cases, they can lead to complete occlusion. To differentiate between the two conditions, it is imperative to conduct an electrocardiogram (ECG) and assess cardiac biomarkers. Galectin-3, a protein with a molecular weight ranging from 29 to 35 kilodaltons, is among the biomarkers that have been extensively investigated. The expression of messenger RNA for Galectin-3 can be observed within a time frame of 30 minutes following the occurrence of acute myocardial infarction. It reaches its highest level at 24 hours and remains detectable for a duration of up to 14 days. This study aimed to compare the analysis of the Galectin-3 levels in patients diagnosed with STEMI versus NSTEMI. The present study used a cross-sectional research design. A cohort of 70 samples was categorized into two distinct categories, including STEMI and NSTEMI. Exclusion criteria were applied to eliminate patients with jaundice, infections, sepsis, liver cirrhosis, and malignancy. The Enzyme-Linked Immunosorbent Assay (ELISA) method was utilized to assess the serum levels of Galectin-3. The statistical tests employed in the study included the Kolmogorov-Smirnov test, the Mann-Whitney test, and the Kruskal-Wallis test. It is considered statistically significant at p-value <0.05. The patients' average age was 58.8±9.8 years, while the Galectin-3 value ranged from 2.13 to 65.54 ng/mL, with an average value of 20.41±15.66 ng/mL. Patients with Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) had a Galectin-3 level of 20.26 ng/mL, which was lower than the concentration of 20.55 ng/mL observed in patients with ST-Segment Elevation Myocardial Infarction (STEMI). However, statistical analysis revealed that this difference was not statistically significant (p>0.05). There was a significant statistical difference (p<0.05) in the levels of Galectin-3 between those who had a smoking risk factor (17.79 ng/mL) and those who did not (26.12 ng/mL). Galectin-3 levels were found to be elevated among those suffering from CAD. However, this investigation did not find any significant variations in Galectin-3 levels in STEMI and NSTEMI patients.
Analysis of Immature Platelet Fraction in Patients with Solid Tumors Undergoing Chemotherapy Runtuwene, Aliza Virginia Eunike; Abdullah, Agus Alim; Arif, Mansyur
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2277

Abstract

Thrombocytopenia is a common side effect in patients undergoing chemotherapy. Examination of platelet count parameters alone cannot predict the platelet recovery response. Immature Platelet Fraction (IPF) can be used as an additional parameter to determine the etiology of thrombocytopenia. This study aimed to analyze IPF, and other platelet-related parameters related to the effects of chemotherapy on solid tumor patients. A prospective observational study design involving 35 solid tumor patients undergoing chemotherapy at Dr. Wahidin Sudirohusodo Hospital, Makassar, was carried out from August to September 2023. Platelet-related parameters (PLT, PDW, IPF, AIPF, and MPV) were measured using an automatic hematology analyzer. Kolmogorov-Smirnov, paired T-test, Wilcoxon, and Spearman test were used for statistical analysis. There was a significant difference in mean PLT, IPF, PDW, and MPV (p < 0.05) before and after chemotherapy. There was a positive correlation in differences in IPF, MPV and PDW (p < 0.001) with a strong correlation (r =0.6-0.8). There was a negative difference in IPF and PLT (p=0.068) with moderate correlation (r =0.312). Chemotherapy causes a significant decrease in platelets and a significant increase in IPF. Routine blood tests and IPF are useful for monitoring thrombocytopenia due to the effects of chemotherapy.
Correlation High-Sensitivity Troponin-I and Length of Stay Acute Myocardial Infarction Patients Dr. Wahidin Sudirohusodo Hospital Sari, Ni Putu Yunita Puspitra; Wibawa, Sulina Yanti; T. Lopa, Amaliyah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2278

Abstract

  Acute myocardial infarction is a part of acute coronary syndrome, which is characterized by reduced coronary blood flow causing no oxygen supply for more than 20 minutes. High-sensitivity Troponin-I test detects heart abnormalities with minimal injury to the heart muscle. The length of stay indicates the number of days a patient is hospitalized in one treatment period. This study aims to analyze the correlation between high-sensitivity Troponin-I levels and the length of stay of acute myocardial infarction patients. A retrospective analytic observational study using medical records data with a cross-sectional design. A total of 111 patients were involved in the period of January 01 to December 31, 2022. Statistical analysis using Kolmogorov-Smirnov test and Spearman's correlation test. A correlation test showed a significant correlation between high-sensitivity Troponin-I and length of stay in NSTEMI and STEMI patients with p=0.131 (p>0.05) and p=0.415 (p>0.05), respectively. This study found no significant correlation between high-sensitivity Troponin-I levels and the length of stay of acute myocardial infarction patients.
An Atherogenic Index of Plasma in Type 2 Diabetes Mellitus with and without Coronary Artery Disease Oktarina, Nur Hasni; Kurniawan, Liong Boy; Nurahmi, Nurahmi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2280

Abstract

Chronic hyperglycemia causes an increase in glycosylation products that induce inflammation and injury to the arterial wall, which will cause changes in the vascular tissue resulting in atherosclerosis. The Atherogenic Index of Plasma (AIP) has been suggested as a biomarker for atherosclerosis and has demonstrated a strong correlation with other atherosclerosis indices, including small dense LDL and LDL cholesterol. This study aimed to determine the AIP in Type 2 Diabetes Mellitus (T2DM) patients with and without Coronary Artery Disease (CAD) complications. A retrospective cross-sectional study using medical record data of 73 T2DM patients without CAD complications and 73 T2DM patients with CAD complications at Dr. Wahidin Sudirohusodo General Hospital was carried out from January to December 2022. The diagnosis of T2DM and CAD was based on the clinician's diagnosis. An atherogenic index of plasma was calculated as log (triglyceride/HDL cholesterol). Samples were analyzed using SPSS version 25, using the Kolmogorov-Smirnov statistical test to assess data normality, Mann-Whitney test, the Receiver Operating Characteristics (ROC) curve to assess Area Under Curve (AUC), and a determination of cut-off values. Statistical test results with p-values <0.05 were reported as significant. Atherogenic index of plasma values was significantly higher in T2DM with CAD complications than without CAD complications (0.51±0.25 vs. 0.30±0.11, p<0.001). The ROC curve analysis showed an optimal cut-off value of 0.36 to predict T2DM with CAD with 71% sensitivity, 62% specificity, and 66% accuracy. There was a significant association between high AIP values and CAD complications in T2DM. An atherogenic index of plasma value can be used to predict T2DM with CAD.

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