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Dr. dr. Puspa Wardhani, SpPK
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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Profile of Pulmonary Tuberculosis Patients in Dr. Soetomo General Academic Hospital Muhammad Dany Ramadhan; Aryati Aryati; Laksmi Wulandari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2040

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, which mainly attacks the lungs but can also infect other body organs. Tuberculosis is a global health problem that causes the highest death after Human Immunodeficiency Virus (HIV). Indonesia ranks third highest in the world, with 420,994 cases in 2017. This study aims to determine the profile of pulmonary tuberculosis patients at Dr. Soetomo General Academic Hospital, Surabaya from January 1st to December 31st, 2019. The research was conducted using a descriptive method by collecting secondary data, through medical records of pulmonary tuberculosis patients at the Inpatient Unit of Dr. Soetomo General Academic Hospital during January 1st - December 31st, 2019. The data obtained were processed according to gender, age, education, occupation, comorbidities, clinical symptoms, history of TB treatment, sputum examination results, and GeneXpert. This study uses total sampling presented in the form of pictures. The results showed that most of the patients were male (61.92%), aged 45-54 years old (25.13%), high school education level (56.48%), and private employees (34.45%). The most common comorbidities were diabetes mellitus (35.07%), the most clinical symptoms found were shortness of breath (29.56%), the complete history of TB treatment was first-line OAT (42.22%), as many as (77.97%) sputum examinations showed no data. Many (7.77%) GeneXpert results showed resistance to rifampicin after six months of therapy.
Analysis of Alfa-Fetoprotein as A Staging Determiner of Hepatocellular Carcinoma Progresivity Dahvia Nursriyanti; Ani Kartini; Mutmainnah Mutmainnah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2044

Abstract

Hepatocellular carcinoma (HCC) is the most common malignant tumor with a poor prognosis and is known as the silent killer. The currently recommended HCC staging system is Barcelona Clinic Liver Cancer (BCLC). The Alpha-fetoprotein (AFP) test is still used to manage HCC patients. The purpose was to find out the AFP comparations and to decide cut-off values for each stage according to BCLC. Cross-sectional retrospective study using secondary data from medical records of Outpatients Clinic and Inpatients from January 2016 to October 2021 at Dr. Wahidin Sudirohusodo Hospital. A total of 432 samples based on BCLC were taken with AFP values and analyzed in this study. The male sample was 72.7%. The highest age is 46-65 years (62.7%). The etiology of HCC mostly is hepatitis B (72.5%). The most BCLC systems were BCLC B (53.7%), followed by BCLC A (25.9%), BCLC D (12.5%), and BCLC C (7.87%). There was a significant difference in AFP values between BCLC stages and the highest significance was BCLC D, followed by BCLC C, B, and A (p=0.05). The cut-off results values at the BCLC stage were BCLC A <21.84 ng/mL, BCLC B: 21.84 ng/mL (sensitivity 90.3%, specificity 85.7%), BCLC C: 478 ng/mL (sensitivity and specificity 100%), BCLC D: 7.693 ng/mL (sensitivity and specificity 100%). There was a significant difference in AFP values between BCLC stages and the highest is BCLC D. Based on the results of calculating the cut-off value, which has good sensitivity and specificity, AFP can be used as a determinant of stage progression of HCC.  
Analysis of the Relationship between Serum Magnesium Levels and Severity of COVID-19 Patients Muyadhil Nurindar; Ruland DN. Pakasi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2045

Abstract

Magnesium (Mg) plays an important role in the homeostasis functions of the lungs and heart for humankind. However, there is limited information concerning the importance of such an electrolyte mineral to COVID-19 pathogenesis. The Mg level is not primarily considered for the analysis of infectious diseases in the laboratory. The purpose of this study was to analyze the relationship between Mg levels and COVID-19 patient severity at Dr. Wahidin Sudirohusodo Hospital, Makassar. This research was a retrospective study with a cross-sectional design. Samples were prepared from 186 patients. Serum Mg levels were measured using an ABX Pentra 400C analyzer and the patients diagnosed with COVID-19 were then classified into abnormal and normal magnesemia. Based on the severity of COVID-19, patients were then categorized into severe and non-severe. The obtained data were then statistically analyzed using the Kolmogorov-Smirnov test, Mann-Whitney test, Chi-Square, and odd ratio with a significant level of p <0.05. The mean values of serum Mg levels of severe COVID-19 patients (2.53±2.03 mg/dL) were not significantly different compared to those of non-severe COVID-19 patients (2.12±0.83 mg/dL) with p=0.712. Patients with abnormal magnesemia had a 2.625 times higher risk of severe COVID-19 (95% CI = 1.499 – 4.757, p-value=0.001) compared to those with normal magnesemia. There was a significant relationship between serum Mg levels and the severity of COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital. Patients with abnormal Mg levels had a 2.625 times higher risk of severe COVID-19. Magnesium concentration is an important parameter, which must be monitored in the laboratory analyses of COVID-19 patients.  
Analysis of Serum Ghrelin Levels and BMI in Obese and Non-Obese Subjects Patachna Junita; Ruland DN. Pakasi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2047

Abstract

Obesity is excessive body fat and was associated with the importance of metabolic and endocrine problems in somatotropic secretion in functional obesity. Ghrelin is an acylated peptide hormone produced by the stomach, which is a mediator of the growth hormone secretory receptor. The activity of ghrelin stimulates the release of growth hormone, and appetite and stimulates the metabolism of carbohydrates. Circulating ghrelin levels in healthy people increase during fasting and decrease after meals. This study aims to analyze the difference in ghrelin levels among obese and non-obese subjects. A cross-sectional design research was conducted in August 2022. The samples consisted of obese and non-obese subjects based on Body Mass Index (BMI). Ghrelin levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were statistically analyzed using the Mann-Whitney and Spearman tests. p<0.05 was reported significant. The samples consisted of 80 obese and non-obese subjects, 39 males and 41 females. There was no difference in ghrelin serum levels in the obese group (1.45±2 ng/mL) compared to the non-obese group (0.67±0.25 ng/mL) with p =0.233 (p>0.05). There was a positive correlation between ghrelin levels and BMI (r=0.247). There was no difference in ghrelin levels between the obese group and the non-obese group, and there was a positive correlation between ghrelin levels and BMI. A higher BMI would lead to higher ghrelin levels.
Correlation Analysis of Galectin-3 Serum Level in Obesity with and without Obesity Nurjannah Nurjannah; Nurahmi Nurahmi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2048

Abstract

There are more than 3.4 million deaths every year in the world due to overweight and obesity. Obesity is a chronic proinflammatory condition marked by increased lipid and adipose tissues, leading to ectopic fat accumulation with increased levels of proinflammatory cytokines. Obesity causes a progressive increase in galectin-3 expression, especially in visceral and subcutaneous adipose tissue in experimental animals. Galectin-3 is upregulated in obesity and is defined as a proinflammatory molecule that can cause insulin resistance. This study aims to analyze differences in galectin-3 levels between obese and non-obese subjects. This was a cross-sectional study, using a total of 80 subjects. The study was conducted throughout August 2022. The samples were grouped into obese and non-obese based on Body Mass Index (BMI). The galectin-3 measurement used the Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical tests used the Mann-Whitney test and Spearmen rho; the test results were significant if the p-value <0.05. The samples were divided into obese and non-obese groups, each group had 40 people. Galectin-3 levels in the obese group were 0.9±0.36 ng/mL significantly higher than the non-obese group’s 0.43±0.11 ng/mL, (p<0.001). There was a strong positive correlation between levels of galectin-3 and BMI, (r=0.866, p<0.001). There is a positive correlation between serum galectin-3 levels and BMI. The greater value of the BMI, the higher levels of galectin-3.
Analysis of the Relationship between HbA1c and Serum IGF-1 Levels in Patients with T2DM Alya Rahmaditya Arfan; Liong Boy Kurniawan; Mansyur Arif; Husaini Umar; Nurahmi; Burhanuddin Bahar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2151

Abstract

Type 2 Diabetes Mellitus (T2DM) is characterized by the reduced ability of insulin responses, leading to difficulty in processing blood sugar. It is caused by a combination of two main factors: damaged insulin secretion by pancreatic beta-cells and the inability of insulin-sensitive tissues to respond to insulin. Blood sugar monitoring in T2DM is done by measuring glycated hemoglobin or Hemoglobin A1c (HbA1c). Insulin Like Growth Factor-1 (IGF-1) is the primary mediator of growth hormone known to play a pivotal biological role in growth and metabolism. This study aims to analyze the relationship between HbA1c levels and serum IGF-1 levels in T2DM patients. The method used was observational analytic with a cross-sectional design. There were 60 T2DM patients involved as research subjects consisting of 26 males and 34 females. HbA1c examination was carried out using the Boronete Affinity Assay, while IGF-1 examination was performed using the Enzyme-Linked Immunosorbent Assay (ELISA) sandwich method. The statistical analysis results showed that the average value and standard deviation of serum IGF-1 levels in controlled T2DM was higher (5740.23±4320.60 pg/mL) than that of uncontrolled T2DM (4843.18±3375.63 pg/mL), showed no significant difference (p=0.462) and no correlation between HbA1c and serum IGF-1 levels in T2DM subjects (r=-0.005 p=0.972). It was concluded that there was no significant relationship between HbA1c levels and serum IGF-1 levels in patients with T2DM.
Cover and Contents Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

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Abstract

Cover and Contents
Author Guideline and Subcribes Form Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

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Abstract

Author Guideline and Subcribes Form
Author and Subjects Indexs Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

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Abstract

Author and Subjects Indexs
Convalescent Plasma Therapy for COVID-19 with Pregnancy in Sanglah Hospital, Denpasar Ni Luh Ayu Suwandari; Ni Kadek Mulyantari; Ida Ayu Putri Wirawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 1 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i1.1837

Abstract

The Coronavirus Disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). Pregnant females are a vulnerable population to contract COVID-19. The most promising therapies for COVID-19 infection are Remdesivir and Convalescent Plasma Therapy (CPT). Convalescent plasma therapy in COVID-19 with pregnancy is rare. A 26-year-old female with 29-30 weeks pregnancy with complaints of shortness of breath and cough was referred. Physical examination showed an increase in respiratory rate. Laboratory tests showed increased WBC (leukocytosis), anemia, thrombocytosis, Neutrophil-Lymphocyte Ratio (NLR), SGOT, and C-reactive protein. The results of the RT-PCR molecular biology test showed confirmed COVID-19. In treatment, complaints worsened with a respiratory rate of 32 beats/minute and oxygen saturation of 93%. The patient was treated with CPT and showed clinical improvement. Convalescent plasma therapy in pregnancy with COVID-19 aims to prevent the binding of spike protein (S) in the virus with the ACE-2 receptor in the host. Convalescent plasma therapy should be carried out in the right conditions according to the agreed criteria. Because clinical and laboratory improvements were observed in this study after convalescent plasma therapy was administered, it can be considered as an alternative therapy in severe clinical conditions.

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