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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Platelet Large Cell Ratio as a Prothrombotic Biomarker to Predict the Severity of COVID-19 Rikarni, Rikarni; Najirman, Najirman; Yulia, Dwi; Burhan, Ida Rahmah; Amalina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2622

Abstract

 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the lungs causes alveolar cell inflammation and disruption, leading to increased levels of proinflammatory cytokines that stimulate platelet activation and consumption. In response, megakaryocytes will increase the production of large, immature platelets. Large platelets bind more to fibrinogen than small platelets, increasing the potential for thrombus formation. This study aims to analyze the platelet large cell ratio as a prothrombotic biomarker to predict the severity of thrombosis in patients. A prospective cohort study was conducted in May-November 2021 at M. Djamil Hospital involving 206 samples of confirmed coronavirus disease 2019 (COVID-19) patients. The examinations included platelet count, P-LCR, and D-dimer. Large platelet counts were calculated using the Platelet Large Cell Ratio (P-LCR) parameter with an automated hematology analyzer. Clinical manifestations of disease severity were monitored based on WHO criteria, grouped into non-severe and severe disease. The 3 results showed a mean age of 47.41 (SD = 17.82). Platelet count was 263,690 (116,995)/mm , P-LCR was 30.86 (6.63)%, and D-dimer value was 2,215.97 (2,590.86) ng/mL. The P-LCR in the severe group was 35.08 (8.21)%, and the non-severe group was 26.64 (6.81)%, with p <0.001. D-dimer in the severe group was 3,680.36 (3,006.23) ng/mL, and in the non-severe group, 869.12 (977.03) ng/mL, with p <0.001. The relative risk of a high P-LCR causing severe COVID-19 is 2.35 compared to a low P-LCR, with p <0.001. The relative risk of a high D-dimer value causing severe COVID-19 is 6.80 compared to a low D-dimer, with p <0.001. The conclusion is  that a greater increase in large platelet production occurs in severe COVID-19 disease. P-LCR is a crucial biomarker for evaluating platelet activity. A high P-LCR value is a risk factor for predicting the severity of COVID-19. Suggestions for the use of PLCR. Increased risk of thrombotic events in COVID-19 patients can be identified by P-LCR examination upon admission to the hospital, allowing for preventive treatment.
Platelet Aggregation Test on Different Dual Antiplatelet Strategies in Acute Coronary Syndrome Amalia, Yustisia; Hernaningsih, Yetti; Yusuf, Moch; Indrasari, Yulia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2675

Abstract

Acute coronary syndrome (ACS) is frequently accompanied by platelet hyper-aggregation, which requires percutaneous coronary intervention (PCI) as definitive management, as it has the side effect of thrombosis, so platelet function must be monitored. This study aimed to evaluate platelet aggregation between the loading and maintenance doses of different DAPT combinations in patients with ACS undergoing PCI. This study employed a prospective cohort design with consecutive sampling, conducted at Dr. Soetomo General Academic Hospital in Surabaya and Universitas Airlangga Hospital in Indonesia. Patients with active bleeding, hemodynamic instability, or contraindications to antiplatelet agents were excluded. Patients were divided into a high-risk bleeding ACS group treated with aspirin–clopidogrel and a low-risk bleeding ACS group treated with aspirin–ticagrelor or aspirin–prasugrel according to the ARC-HBR score. Platelet aggregation tests (% maximum aggregation) were performed using the light transmission aggregometry method with adenosine diphosphate (ADP), collagen (COL), and epinephrine (EPI) agonists. Statistical analysis was performed to compare the differences between groups.The study included a total of 68 ACS patients with PCI: aspirin–clopidogrel (22.1%), aspirin–ticagrelor (44.1%), and aspirin–prasugrel (33.8%). There was no significant difference in platelet aggregation between groups with EPI and COL agonists. ADP agonists showed a significant difference between the loading and maintenance doses in the aspirin–ticagrelor and aspirin–prasugrel groups. The most important difference was observed in the aspirin–prasugrel group (95% CI: -22.68, -9.00; p = 0.000). Aspirin–prasugrel is the most potent inhibitor of platelet aggregation in patients with ACS undergoing PCI.
The Correlation between HbA1c and MCP-1 Levels in Diabetic Retinopathy Patients Lestari, Anak Agung Wiradewi; Nabu, Ekarini Katharina Yunarti; Triningrat, Anak Agung Mas Putrawati; Wande, I Nyoman; Wirawati, Ida Ayu Putri; Mahartini, Ni Nyoman; Cong, Tzeto Han; Prabawa, I Putu Yuda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2678

Abstract

Diabetic Retinopathy (DR) is a common microvascular complication of diabetes mellitus and a leading cause of vision loss. Persistent hyperglycemia plays a central role in the pathogenesis of DR by promoting chronic inflammation. Monocyte Chemoattractant Protein-1 (MCP-1), a key pro-inflammatory chemokine, is believed to mediate this process. This study aimed to investigate the correlation between glycemic control, as reflected by glycated hemoglobin (HbA1c) levels, and serum MCP-1 concentrations in patients with DR. A cross-sectional analysis was conducted involving 45 DR patients at Prof. dr. I. G. N. G. Ngoerah General Hospital. HbA1c levels were assessed enzymatically and reported in NGSP units, while serum MCP-1 concentrations were measured through ELISA and expressed in pg/mL. The correlation between the two parameters was evaluated using Spearman's rank correlation test, with significance determined at p <0.05.The participants consisted of 64.4% males and 35.6% females, with a mean age of 55.0±6.6 years. The median HbA1c was 9.5% (range: 5.9–12.3%), and the median MCP-1 level was 320.57 pg/mL (range: 32.34–605.41 pg/mL). A moderate positive correlation was identified between HbA1c and MCP-1 levels r = 0.45; p = 0.007). These findings indicate that increased blood glucose levels may coincide with elevated MCP-1, suggesting an ongoing inflammatory response contributing to DR progression. This study demonstrates a significant moderate positive correlation between HbA1c and serum MCP-1 in DR patients, suggesting that elevated blood glucose levels may contribute to increased MCP-1 expression. These findings support the potential role of MCP-1 as a biomarker of both poor glycemic regulation and inflammation in the progression of diabetic retinopathy.
Albumin-Bilirubin Score as A Predictor of Mortality in Patients with Hepatocellular Carcinoma -, Sagita Adventia; -, Umi Solekhah Intansari; Sianipar, Osman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2710

Abstract

 An Albumin-Bilirubin (ALBI) score was developed as a tool to assess liver function. Still, its application in clinical practice particularly as a predictor of mortality in hepatocellular carcinoma (HCC)—remains limited. This study aimed to evaluate the ALBI score as a prognostic factor for mortality in patients with HCC. A retrospective cohort study was conducted, involving HCC patients treated at Dr. Sardjito General Hospital, Yogyakarta, from January 2017 to December 2021. Patients with HCC who had an Eastern Cooperative Oncology Group (ECOG) performance status score of 0–2 and available albumin and bilirubin data at the time of diagnosis were included. Subjects were classified into three groups based on ALBI grade: grade I (score ≤ -2.60), grade II (score> -2.60 to ≤ -1.39), and  grade III (score > -1.39). The exposed group consisted of subjects with ALBI grade II and grade III, while those with ALBI grade I were classified as the unexposed group. Follow-up was conducted for two years after diagnosis, with death as the primary outcome. Survival analysis was performed using the Kaplan-Meier method and the log-rank test. Hazard ratios (HRs) were analyzed using Cox regression.  A p-value of <0.05 was considered statistically significant. The study included 35 subjects with ALBI grade I, 78 with ALBI grade II, and 54 with ALBI grade III. The risk of mortality for subjects with ALBI grade II and grade III was 2.27 and 2.32 times higher, respectively, compared to those with ALBI grade I.
Blood Q Creatinine Based on Sex and Age in Healthy Indonesian Geriatrics Marpaung, Ferdy Royland; Santoso, Djoko; Cavalier, Etienne; Aryati, Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2726

Abstract

Median blood creatinine (Qcr) is necessary for an accurate evaluation of geriatric renal function. Nonetheless, there is a significant void in existing literature concerning creatinine reference data unique to the elderly. To improve diagnostic precision and clinical decision making in this susceptible group, this study developed a corresponding Q model for serum creatinine in geriatric patients stratified by age and sex. To determine the Qcr serum and reference range creatinine concentrations, 913 healthy elderly patients (452 males and 461 females) undergoing routine examinations at clinical laboratories were studied. Creatinine concentration reference intervals were divided into 3 age groups, namely: 60-69 years, 70-79 years, and >80 years. The median and percentiles p2.5 (lower reference limit/LRL) and p97.5 (upper reference limit/URL) were determined by the study. The study determined the Qcr serum creatinine and reference values for the elderly, stratified by age and sex. There were no significant differences observed in creatinine level across the age group, either in males or females. Males exhibited higher creatinine compared to females (p <0.05). These recently developed, age and sex stratified Qcr values are an invaluable tool for clinical laboratories, enabling more precise, tailored care for elderly patients with renal issues and enabling clinicians to more accurately assess geriatric renal function.
RF AND ANTI-CCP POSITIF IN ANKYLOSING SPONDYLITIS(AS) PATIENT WITH RHEUMATOID ARTHRITIS(RA): TRUE OR FALSE POSITIVE? TRUE OR FALSE POSITIVE? Margalin, Brilliant; Aryati, Aryati; Yuliasih, Yuliasih; R Raharjo, Paulus
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2765

Abstract

Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA) are different autoimmune arthritis diseases but have overlapping clinical manifestations. Rheumatoid Factor (RF) and Anti-Cyclic-Citrulinated-Peptide (anti-CCP) serological examinations have an important role because they are seropositive in RA and seronegative in AS. This case report is interesting because it discusses a patient with AS who was unexpectedly negative for HLA-B27, positive for RF and anti-CCP, raising doubts about clinical and laboratory discrepancies. Patients with AS and RA disease can occur simultaneously, although it is very rare. This case report analyzes the diagnostic role of RF and Anti-CCP examinations, whether they are true positive or false positive.
Cover and Content Frisqila Amalia Rizka
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Erratum to “The Difference between Coagulation Profile and Fibrinolysis in Acute and Chronic Leukemia Patients”[Published Issue of Indonesian Journal of Clinical Pathology and Medical Laboratory March 2025, 31(2) : p. 136] Limijadi, Edward Kurnia Setiawan; Devi, Wivina Riza; Tjitradinata, Cynthia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2873

Abstract

This erratum is to explain a typographical error in Table 2 occurred in the published issue of Indonesian Journal of Clinical Pathology and Medical Laboratory Volume 31, Number 2 in March 2025, pages 136. The error was in writing the Fibrinogen level which should be a period, not a comma and D-dimer level in the table, which should be a comma, not a period.

Page 133 of 133 | Total Record : 1328

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