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International Journal of Nasopharyngeal Carcinoma

IJNPC
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Published by Universitas Sumatera Utara

ISSN : 26569027 EISSN : 26569035 DOI : https://doi.org/10.32734/ijnpc

Core Subject : Health,

Health Professions Medicine & Pharmacology

The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 10 Documents

Search results for , issue "Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma" : 10 Documents clear

EVALUATION OF RENAL FUNCTION BEFORE AND AFTER CHEMOTHERAPY IN NASOPHARYNGEAL CARCINOMA IN LOMBOK Hamsu Kadriyan; Muhammad Alfian Sulaksana; Nurhidayati; Baiq Endang Suprihartini
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Abstract Introduction: Combination of chemotherapy and radiation are the treatment of choice in advance stage of nasopharyngeal carcinoma. Cisplatin-based chemotherapy is a regiment of choice in those cases. Several studies show that cisplatin-based chemotherapy affect renal function. Objective: To evaluate and compare the renal function before and after chemotherapy through comparing the blood urea nitrogen and creatinine serum level in patients with nasopharyngeal cancer who receive cisplatin and paclitaxel chemotherapy. Method: Using Medical records data for study design. Design of this study is before and after using medical records data in West Nusa Tenggara General Hospital in Lombok. Result: There were 33 patients who fulfill the inclusion and exclusion criteria in this study. Most of the patients are male with male and female ratio 3:1. The youngest patient age is eight years old, on the other hand, the oldest is 70 years old with the average age 46.6 years old. According to histopathology finding, on this study researcher didn't found WHO type I and most the patients were WHO type III (89.9 %). The mean blood urea nitrogen concentration before chemotherapy is 25.00 and after the treatment 33.33 with the p-value 0.01 with the paired t-test. On the other hand, creatinine serum level before and after chemotherapy consecutively 0.99 and 1.10. P value 0.15, or there is no significant difference. Conclusion: Blood urea nitrogen and creatinine serum are increase after cisplatin-based chemotherapy. However, only BUN has a significant difference.

SURVIVAL ANALYSIS OF NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL Riska Adriana; Yussy Afriani Dewi; Dindy Samiadi; Edo Wira Candra
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is the fifth in range of malignancies in Indonesia and has high morbidity and mortality. A survival rate is a statistical index that summarizes the probable frequency of specific outcomes for a group of patients at a particular point in time. The survival of patients with nasopharyngeal carcinoma is influenced by several factors, such as the patient and tumor. Objective: The objective of this research is to determine survival analysis and factors that influence nasopharyngeal carcinoma which recorded at Hasan Sadikin Hospital. Methods: It is an analytic observational study. Data were analyzed with survival analysis using the Cox Regression test. Result: The subjects were 215 patients who were diagnosed NPC in first time at Hasan Sadikin Hospital from January 2006 until December 2009. There was a significant correlation between age, staging, histopathologic type and therapy with the survival (P=0.0001), (P=0.026), (P=0.0001), (P=0.024), (P=0.003); but no significant correlation between gender with the survival. Based on Cox proportional hazard, the male patients in over fifty years old have a risk of the death 7.724 and 1.113 times. The patients with nasopharyngeal carcinoma type I have a risk of the death 2.381 times. The patients with stage IVC have a risk of the death 3183.9 times. The patients who underwent chemoradiation have a risk of the death 2.761 times. Conclusion: The survival of patients with nasopharyngeal carcinoma is most influenced by prognostic factors such as age and therapy.

ASSOCIATION OF E-CADHERIN EXPRESSION TO CLINICAL STAGE OF NASOPHARYNGEAL CARCINOMA Felicia Melani Triastuti; Rizalina A. Asnir; Ashri Yudhistira; Sutoyo Eliandy
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Background: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis. Objective:To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma. Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block. Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of E-cadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%). Conclusion: No significant association was found between E-cadherin expression and tumor size (p = 1,000), lymph node metastasis (p = 1,000), histopathological type (p = 1,000) and tumor stage (p = 0.133).

THE CHARACTERISTICS OF ADOLESCENTS NASOPHARYNGEAL CARCINOMA PATIENTS IN MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013-DECEMBER 2017 Melania; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Abstract Introduction: Nasopharyngeal carcinoma is (NPC) mostly found in men of productive age with a ratio of men and women 2,18: 1 and 60% of patients age between 25 and 60 years. NPCs are very rarely found in adolescents, namely age 11 to 21 years. Objective: To determine the characteristics of nasopharyngeal carcinoma in adolescent patients at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang. Method: This is a descriptive retrospective study. The sample is all patients diagnosed with NPC in adolescence at ORL-HNS Department of Dr. Mohammad Hoesin General Hospital Palembang in January 2013 to December 2017 period. Results: In this study, the number of adolescent NPC patients from January 2013 to December 2017 was 12 patients. The majority of adolescent NPC patients were male (66,6%). The most common histopathological finding was WHO 2B (50%). Based on the T category, largely, the patients were T4 (41,6%). Most patients with Nodules were N3 (58,3%) and came to the ENT clinic were already in stage IV (41,6%). Conclusion: Adolescent nasopharyngeal carcinoma is more common in men than women (2: 1), and shows a response to proper therapy.

POST-TREATMENT FOLLOW-UP OF NASOPHARYNGEAL CARCINOMA PATIENTS: A REVIEW Ika Dewi Mayangsari
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Locoregional failure of nasopharyngeal carcinoma (NPC) occurs despite the aggressive treatment that has been done. Optimal and accurate follow-up schedule after the radiotherapy or chemoradiotherapy sessions could improve the patient's quality of life (QoL). Discussion Kwong et al. reported complete histological remission within 3 months after therapy and positive histological signs at >12 weeks considered a persistent disease. Kong et al. (2017) showed that the pathological treatment response using CT scan and MRI and stated that the median time to full regressions is 4.9 months. Some studies also reported that primary tumor continuously regressed >4 months after treatment and delayed remission >12 weeks is not a prognostic factor for poor survival. The use of MRI is superior to CT scan to detect residual or recurrent NPC. MRI showed good results in differentiating mature scar and tumor, whereas CT scan could not differentiate fibrosis and tumor because of the radiation therapy-induced inflammation. On the other hand, PET-CT has higher sensitivity compared to CT scan and MRI, but poor cost-effectiveness. Various studies and NCCN 2018 guidelines recommend the use of imaging between the third and sixth months after therapy to evaluate treatment response. Conclusion Assessment of treatment-related late toxicities also an important factor to improve patient’s QoL. Evaluation of nutrition, speech difficulties, swallowing, hearing, dental care should be done annually and peer support groups can help improve patient’s QoL. Assessment of residual disease should be done at the minimum of 10 weeks after the completion of the therapy and long-term follow-up is a must because locoregional recurrences of NPC are common within the first two to three years after the treatment.

CHARACTERISTIC OF NASOPHARYNGEAL CARSINOMA IN ACEH 2016-2017 Benny Kurnia; Reno Keumalazia Kamarlis; Fera Kamila Kamal
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is among five major malignancies in Indonesia and the primary malignant tumor in men. Among all head and neck (H&N) cancers, nasopharyngeal carcinoma (NPC) is endemic in certain regions of the world, especially in Southeast Asia, and has a poor prognosis. In Indonesia, the recorded mean prevalence is 13 000 yearly new NPC cases, but otherwise little is documented on NPC in Indonesia. Objectives We collected all cases of nasopharyngeal carcinoma diagnosed by histopathological examination during the period of 2016-2017 from archives of the registry in the Ear, Nose, and Throat department and Patologi Anatomy laboratory Dr. Zainoel Abidin General Hospital. We did this research to presenting the basic data of NPC in Aceh according to gender, age, geographic site and WHO histopathology criteria. Method All the data we counted by using Microsoft Excel 2016 by grouping it according to the variable that we want to grade. We made it into a table and graphic presentation to explain each item of the variable. Result Here, in Aceh, we reported 46 cases in the year 2016 and 26 cases in the year 2017, a total of 72 patients during 2 years. We studied NPC incidence in Aceh among all H&N cancer cases focusing on age, gender, the ethnic background, and the disease histopathology. In this study population, from a total of 72 patient we found 44 male (61.1%) and 28 female (38.9%), with a male to female ratio is 1.57:1. According to the geographic site, NPC in Aceh was the most endemic in the Banda Aceh population (15.3%) followed by Southwest Aceh (12.5%) as a second one. From the age range, NPC most frequent to affect patients at the age range 41-60 years (44.44%), besides that we found 8 (11.11%) cases NPC in Aceh at the age 0- 20 years with 13 years old patient was the younger one. Here, we found that Undifferentiated NPC is the most frequent histological type (44.4%). We continued the study by analyzed NPC patient according to WHO criteria, type I WHO most frequent from the Great Aceh. Type II and Type III WHO we found most frequent from Banda Aceh. Conclusion: Our data NPC incidence did not differ significantly among the literature. Mostly NPC patients over the world at the old adult age, even all of the age range can be affected by NPC. There are similar histopathological features results here compare to the Southeast Asian country.

THE CHARACTERISTICS OF NASOPHARYNGEAL CARCINOMA PATIENTS IN MOEHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013 - DECEMBER 2017 Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is a malignant tumor that grows in nasopharyngeal area with a predilection in fossa of Rossenmuller and roof of nasopharynx. Nasopharyngeal carcinoma is the most common malignant tumor in the neck and head area. This research is to determine the characteristics of nasopharyngeal carcinoma at Moehammad Hoesin General Hospital Palembang. Methods This study design is restrospective descriptive and took the sample from medical records in department of ORL-HNS Moehammad Hoesin General Hospital Palembang between January 2013 until December 2017. Results In this study, the number of nasopharyngeal carcinoma patients January 2013 to December 2017 was 284 patient. Most of them were male (72.86%). The age of most patients ranges from 41-50 years (33.20%). The highest histopathological description of patients was WHO 2B (54.9%). Most patients were T4 (36.29%). Most patients nodules were N3 (34.09%). As many as 93.88% of patients have not experienced distant metastasis. Most patients came to the department of ORL-HNS had already been in stage IV (63.84%). The most chemotherapy regimens given were carboplatin and docetaxel. Conclusions Nasopharyngeal carcinoma is still a problem in many countries. The main management is radiotherapy with or without chemotherapy.

THE ASSOCIATION BETWEEN EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR WITH PRIMARY TUMOR VOLUME OF NASOPHARYNGEAL CARCINOMA Audi Wahyu Utomo; Indah Asmara Gustarini
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Objective: Tumor development was triggered by the excess population of the Epidermal Growth Factor Receptor (EGFR). Expression of EGFR with primary tumor volume of in patients with NPC. Expression of EGFR has a role in the increasing of metastasis, self-renewal, drug resistance and anti-apoptosis. EGFR expression associated with tumors size, positively nodules and advanced tumor stage in NPC patients. High level of EGFR expression by immunohistochemical examination associated with the development, progression and differentiation cell of tumors. Methods: Using Cross-sectional as study design. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The expression of EGFR was studied with immunohistochemistry using EGFR polyclonal antibody (Bioss, USA). Assessment of the staining was performed by pathologist consultant used histoscore. The Pearson’s correlation test was used to determine the correlation between expression of EGFR and primary tumor volume of nasopharyngeal carcinoma. Statistical significance was defined as p <0.05. Result: Total samples are 19 patients. The result of EGFR expression in NPC patients with a primary tumor volume of 1-50 ml is 5 samples with a weak positive expression and 4 samples with moderate positive expression. NPC with a primary tumor volume of 51-100 ml is 2 samples of negative expression, 1 sample of weak positive expression, 3 samples with moderate positive expression and 2 samples with strong positive expression. NPC with primary tumor volume >100 ml is 1 sample weak positive expression and 1 sample strong positive expression. Statistical analysis using Pearson’s exact test was obtained p=0.047 with a correlation coefficient 0.461. EGFR expression from all of the patients there was 2 samples (10.53%) negatives, 7 samples (36.84%) weak positive, moderate positive was 7 samples (36.84%), and strong positive 3 samples (15.79%). Conclusion: There was an association between the expression of EGFR with the primary tumor volume of nasopharyngeal carcinoma.

RELATIONSHIP BETWEEN CIGARETTE SMOKING AND NASOPHARYNGEAL CARCINOMA Ibrahim Irsan Nasution; Ramsi Lutan; Delfitri Munir; Arlinda Sari Wahyuni
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduciton Since then the pathogenesis of NPC has been intensively studied, specifically aimed at geography and racial variation. In recent years many environmental and biological factors have shown a risky relationship to the occurrence of NPC and the latest research results indicate the role of genetic and viral factors in the development of this disease Objectives Etiology of nasopharyngeal cancer (NPC) is multifactorial, and many of these factors overlap where one factor may occur together with other elements as a cause. Cigarette smoking is thought to also play a role in the development of NPC. Methods The study design was in case of control with an analytical approach during February-October 2007. To find out the relationship between Cigarette smoking NPC, a case-control study was conducted, with a sample of 96 patients with NPC as case and 96 people as a control. Case group and control samples were taken from RSUP H. Adam Malik Medan and RSU Dr. Pirngadi Medan. Results The majority of NPC patients are: Men (compared with women 2.84: 1), 50-59 years (29.2%), and farming (32.3%). The Batak ethnic is the largest ethnic group suffering from NPC 54 people (56.3%) and followed in the second place the most are Javanese (29.2%). The most histopathological type is WHO type 3 (38.6%). Most stages were III (58.4%), followed by stage IV (40.6%), stage II (1%), and there was none of stage I.In univariate logistic regression showed a significant relationship between smokers with consumption of cigarettes 11-20 cigarettes per day with OR=2.530 (p=0.021) with the occurrence of NPC. However, in the multivariate logistic regression analysis, the number of cigarettes per day did not show a significant relationship (p=0.587). The results of multivariate logistic regression analysis, nasopharyngeal carcinoma were significantly associated with people who had started smoking before the age of 20 years (p=0.000; OR 5.35 and CI 95% 2.290-12.499), consuming habits of salted fish before 10 years of age with sometimes frequency consumption of salted fish p=0.000; OR 7.766 (95% CI 2.937-20.538), often p=0.000; OR 16.515 (95% CI 5.3000-51.463), and the habit of using firewood p=0.014; OR 3.147 (95% CI 1.260-7.860). There was no significant relationship between the duration of cigarette smoking (p=0.293), a number of cigarettes (p=0.021) and the types of cigarettes smoked (p=0.081) with the incidence of NPC. Conclusion Cigarette smoking as a risk factor for NPC cannot act stand-alone as a risk factor, but there is a role for other factors that also influence as a risk factor.

INCIDENCE OF ANEMIA IN PATIENT WITH NASOPHARYNGEAL CARCINOMA AT ENT-HNS DEPARTMENT WEST NUSA TENGGARA Ni Ketut Susilawati; Hamsu Kadriyan
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is common in China and Southeast Asia, includingIndonesia. The cases are often diagnosed in an advanced stage with a poor prognosis. Objective The purpose of this study was to determine the incidence of anemia in nasopharyngeal carcinoma patients in the ENT-HNS Department West Nusa Tenggara Hospital. Methods The methods of this research are a descriptive study that used data from the medical record of West Nusa Tenggara Hospital. The data were obtained between April 2017 to September 2017. Result During the study periods, we obtained 32 cases. 75% of patients were male and 25% female, with ratio 3: 1. According to the age, patients were distributed from 28 to 69 years old with peak incidence at 41-60 years old. Most patients were stage IV (68.75%). There was 87.51% patient with anemia in this research. However,the highest number was found mild anemia 59.38% and the most types of anemia were hypochromic microcytic. Conclusion The incidence of anemia in a patient with nasopharyngeal cancer in West Nusa Tenggara Hospital is 87.51%. Most of them were mild grade and hypochromic microcytic type

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Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)

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Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)

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Journal Mail Official ijnpc@usu.ac.id

Editorial Address Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)

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Journal Mail Official
ijnpc@usu.ac.id

Editorial Address
Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara

Location
Kota medan,

Sumatera utara

INDONESIA