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Journal of Stem Cell Research and Tissue Engineering
Published by Universitas Airlangga
ISSN : 26141264     EISSN : 26141256     DOI : https://dx.doi.org/10.20473/jscrte
Core Subject : Health, Science, Engineering,
Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary
Journal of Stem Cell Research and Tissue Engineering (JSCRTE) is published by Stem Cell Research and Development Center, Airlangga University. Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancerstem cells, developmental studies, genomics and translational research. Special focus of JSCRTE is on mechanisms of pluripotency and description of newly generated pluripotent stem cell lines. Articles that go through the selection process will be review by peer reviewer or editor. The journal is published regularly twice a year in December and May. Every publication consists of 60-70 pages and 5 scientific articles in the form of research, study literature, and the case study in English. The contributors Journal of Stem Cell Research and Tissue Engineering are Stem Cell researchers, lecturers, student and practitioners that came from Indonesia and abroad.
Arjuna Subject : Kedokteran - Imonologi dan Alergi
Articles 90 Documents
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METABOLIC REGULATION AND EPIGENETIC CONTROL: UNRAVELING THE COMPLEXITY OF SKELETAL STEM CELL FATE AND BONE HEALTH Wahyuni, Afrinda Dwi
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 1 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i1.58141

Abstract

Skeletal stem cells (SSCs) are essential for bone formation and tissue regeneration within the skeletal system. These self-regenerating cells differentiate into various skeletal cell types, maintaining skeletal health. However, aging diminishes SSC capacity, impacting skeletal integrity. Epigenetics, the study of heritable changes in gene expression, plays a crucial role in stem cell regulation. Mechanisms like DNA methylation and histone modifications control gene expression without altering the DNA sequence. Dysregulation of epigenetic processes in transplanted cells may lead to immunological rejection or functional impairment. Understanding epigenetic regulation in stem cells is vital for tissue regeneration strategies. This narrative review focuses on summarizing existing scientific literature on epigenetic regulation within stem cells, particularly skeletal stem cells. The study utilized Google Scholar to search for relevant articles using keywords like "epigenetic", "stem cell", and "skeletal stem cell". Selection criteria included publication year, article title, abstract, Scopus ranking, and accessibility. Four articles were chosen as reference sources for the review. Recent research emphasizes cellular metabolism's role in regulating skeletal functions through skeletal stem cells (SSCs), crucial for skeletal health and potential regenerative therapies. Transcriptomic and epigenetic analysis of human SSCs reveal species-specific pathways. Metabolic pathways are vital for SSC selfrenewal and multipotency, with glycolysis being the primary energy source for human bone marrow stem cells. Aging affects bone cells and inherited epigenetic changes significantly influence cell fate. Recent studies identify Ptip as a key epigenetic regulator of glycolysis in SSCs, impacting growth plate activity.
REGULATORY ROLE OF ETV4 IN EMBRYONIC STEM CELL FATE: INSIGHTS INTO MECHANOTRANSDUCTION AND LINEAGE DETERMINATION Ardiana, Asa
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 1 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i1.58143

Abstract

Conventional cell biology studies focus on cellular responses to chemical signals, but cells also react to mechanical cues like density, size, and substrate rigidity, activating specific gene expression. Embryo development leads to the formation of a gastrula, establishing body structure and germ layers (endoderm, ectoderm, mesoderm) via diverse mechanisms. In humans, gastrulation begins with the Primitive Streak (PS) and T gene expression, guiding epiblast cell migration. Self-regulation occurs in gastruloid models, derived from human embryonic stem cells, capable of differentiation. Mediators like YAP/TAZ and PIEZO1 link density to cellular responses, with ETV4 serving as a link between mechanical environment and gene expression. This research employed a systematic literature review to synthesize relevant studies. Inspired by stem cell advancements, particularly ETV4's role, searches on PubMed yielded three articles meeting inclusion criteria. ES cells maintain undifferentiated states via ETV4 and ETV5. Rapid cell growth deactivates ETV4, prompting differentiation, influenced by mechanical cues. ETV4, ETV5, and SPRY4 regulate the FGF/ERK pathway, modulating sensitivity. High density initiates neuroectodermal cell formation, impacting integrin-actomyosin and FGFR pathways, via ETV4. Fluctuations in density dictate lineage fate, with ETV4 as a key sensor, linking density shifts to lineage determination via the ERK pathway.
THE INFLUENCE OF MARKERS IN THE DIFFERENTIATION PROCESS OF STEM CELLS INTO ENDOTHELIAL CELLS TO SUPPORT TREATMENT TESTING EXPERIMENTS Nurdiyati, Nanis
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 1 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i1.58146

Abstract

Research on stem cells, particularly their differentiation into endothelial cells, is highly significant in the field of biomedical science and regenerative therapy. Endothelial cells are crucial for blood vessel formation, wound healing, tissue regeneration, and the treatment of degenerative diseases. Human pluripotent stem cells can differentiate into various cell types, making them valuable for repairing or replacing damaged tissue. This study reviews the role of markers in distinguishing human stem cells into endothelial cells. A comprehensive literature search was conducted, and out of 428 screened articles, only 4 met the inclusion criteria. SOXF proteins were analyzed using scRNA-seq analysis, focusing on their role in enhancing stem cell differentiation. SOX17 was found to significantly increase the percentage of cells expressing CD34+ and Vascular Endothelial Cadherin (VEC), consistent with its known role in endoderm differentiation and endothelial cell specification. SOX17 can override pluripotency signals in human stem cells, triggering their differentiation into endothelial cells. Overexpression of SOX17 in human stem cells resulted in cells with endothelial characteristics, and combining SOX17 with FGF2 enhanced this effect, resulting in more than 90% of cells expressing endothelial stem cell markers (CD34+, VEC+, CD31+). SOXF was applied to prompt stem cell differentiation, with only SOX17 demonstrating notable effectiveness.
CHARACTERIZATION OF AUTOFLUORESCENCE AS AN INDICATOR OF ACTIVATION STATE IN NEURAL STEM CELLS Nisaa, Rachma Khairun
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 1 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i1.58150

Abstract

Recent advancements in stem cell research have uncovered a novel autofluorescence marker pivotal for investigating the dormant state of stem cells. This marker presents a groundbreaking opportunity to monitor the transition of stem cells from a quiescent to an active state, facilitating the identification of cells entering the cell cycle. The primary objective of this research is to comprehensively review this marker's efficacy with the aim of developing therapeutic strategies for generating human nerve cells. A systematic literature search initially yielded 2297 articles on autofluorescence characterization as an indicator of activation state in neural stem cells (NSCs). However, only three articles met the stringent inclusion criteria, underscoring the novelty and scarcity of research in this domain. Autofluorescence, particularly in NSCs, offers a non-invasive approach to studying molecular processes and discerning various activation states, obviating the need for external labels. This technique not only preserves the intrinsic properties of cells but also circumvents biases inherent in traditional labeling methods. Moreover, when coupled with cutting-edge technologies such as Optical Coherence Tomography with Spectral Inverse Analysis (OCSI), it enables precise, real-time monitoring of metabolic alterations in NSCs during their transition from dormancy to activity.
TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION: TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION Kamadjaja, David
Journal of Stem Cell Research and Tissue Engineering Vol. 1 No. 1 (2017): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v1i1.60445

Abstract

Maxillofacial bone defects due to tumor resection, trauma or infections should be reconstructed to maintain the bone continuity in order to preserve its masticatory, speech and esthetic functions. Autogenous bone graft have been the gold standard for mandibular defects reconstruction, however, it is associated with limitation in volume and availability as well as the donor site morbidities. Tissue engineering approach has been proved to be a good alternative to overcome the limitation of autogenous bone graft. Tissue engineering studies have been conducted combining various sources of mesenchymal stem cell, scaffolds, and or signaling molecules. The paper aims to provide information on the development of bone tissue engineering researches to reconstruct bone defects through results of numerous studies obtained in the English literature. As the conclusion, bone tissue engineering is a potential approach to reconstruct maxillofacial bone defects.
UTILIZATION OF STEM CELL THERAPY AS A NEW APPROACH TO OVERCOME REPRODUCTIVE DISEASES IN WOMEN Warda, Rizki Zeillatul; Sumadi
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67758

Abstract

The human body contains approximately 37.2 trillion cells, each specialized to perform specific functions within tissues and organs. Stem cells, particularly mesenchymal stem cells (MSCs), have emerged as a promising therapeutic option for various medical conditions due to their regenerative and differentiation capabilities. Female infertility, which significantly impacts quality of life, often results from reproductive disorders such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. Conventional treatments like hormone therapy are limited by long-term risks, including heart disease and cancer, while assisted reproductive technologies are hindered by ethical, safety, and financial concerns. This review explores MSC-based therapies as innovative alternatives for addressing female reproductive disorders. MSCs demonstrate potential in regenerating ovarian cells, restoring hormonal balance, and repairing uterine tissue. For POF, MSC therapy replenishes ovarian cells, improves hormone levels, and restores function. In PCOS, MSCs reduce inflammation and fibrosis while enhancing ovarian function. Endometriosis management benefits from MSCs' ability to repair endometrial damage and improve uterine receptivity. MSCs also show efficacy in reducing fibrosis and increasing vascularization in Asherman syndrome and repairing placental damage in preeclampsia by mitigating oxidative stress and inflammation. This review synthesizes findings from recent studies to highlight MSCs' role in advancing gynecological medicine, presenting them as a safe, effective, and sustainable therapeutic approach for treating infertility and enhancing reproductive health.
DEVELOPMENT OF STEM CELL-BASED CANCER THERAPY STRATEGIES Sumadi; Warda, Rizki Zeillatul
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67760

Abstract

Cancer remains one of the leading causes of death worldwide, with various treatment options available depending on the type and stage of the disease. Traditional therapies, such as surgery, radiotherapy, chemotherapy, and immunotherapy, have shown varying degrees of success, but each has its limitations. Recently, stem cell therapies have emerged as a promising alternative, offering more targeted treatments with fewer side effects. Stem cells, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs), have demonstrated potential in cancer therapy through mechanisms like tumor site targeting, paracrine signaling, and gene delivery. MSCs, in particular, are of interest due to their ability to migrate to tumor sites and release exosomes that can influence tumor growth, angiogenesis, and metastasis. Modified MSCs have been engineered to deliver anticancer agents or "suicide" genes, providing a more focused approach to tumor treatment. Moreover, MSCs have shown promise in addressing challenges like drug resistance and recurrence in cancer. However, their effectiveness depends on factors such as exosome composition and the tumor microenvironment. Despite the challenges, stem cell-based therapies, including MSC-derived exosomes, represent a novel strategy to enhance the specificity and efficacy of cancer treatments. This review explores current advances in stem cell-based cancer therapies, highlighting their potential, ongoing research, and the need for further studies to optimize these approaches for clinical application.
AUTOLOGOUS STEM CELL-BASED GENE THERAPY OFFERS AN INNOVATIVE SOLUTION FOR TREATING INHERITED BLOOD CELLS DISORDERS Faudhan, Nurul; Aisida, Yayu
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67762

Abstract

Recent advancements in medical treatments, particularly gene therapy using hematopoietic stem cells (HSCs), have significantly impacted the treatment of inherited blood disorders. HSCs can self-renew and differentiate into blood cells, making them essential for treating conditions like sickle cell anemia, thalassemia, and severe combined immunodeficiency (SCID). This study conducted a literature review on autologous stem cell therapy for genetic blood disorders, analyzing studies from databases such as PubMed and Scopus. Gene therapy corrects genetic defects in HSCs, offering an alternative to allogeneic transplantation by avoiding immune rejection. The therapy involves modifying stem cells in the lab, often through viral vectors or gene-editing tools, and reinfusing them into the patient to produce healthy blood cells long-term. Lentiviral vectors, considered safer than retroviruses, have been particularly effective in treating various conditions, including immunodeficiencies and hemoglobinopathies. The ex vivo gene transfer approach, commonly used for genetic disorders, has shown promise for one-time curative treatments, especially for pediatric diseases. However, early gene therapy efforts, such as the use of gamma-retroviral vectors for SCID, faced complications like leukemia, leading to a shift towards safer lentiviral vectors. Despite its complexity, the procedure has a low failure rate and provides a less risky alternative to traditional allogeneic stem cell transplants. Ultimately, HSC gene therapy holds significant potential for curing genetic blood disorders by permanently altering the stem cells, ensuring long-term benefits and improved treatment outcomes, with ongoing advancements in safety and efficacy.
UTILIZATION OF STEM CELL RESEARCH IN MICROGRAVITY FOR INNOVATION IN CELLULAR THERAPY ON EARTH Hendrizal; Dahlan; Gower
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67764

Abstract

Recent advancements in stem cell biology, coupled with developments in space exploration, have opened new avenues for regenerative medicine. Microgravity environments in space induce significant physiological changes in the human body, such as muscle atrophy, decreased bone density, and immune system impairments, mimicking accelerated aging and chronic disease progression. These conditions offer a unique opportunity to study stem cell behavior, proliferation, and differentiation, which occur at a faster pace in space compared to Earth. The three-dimensional (3D) microgravity environment provides a more accurate representation of the human body’s natural state than traditional two-dimensional culture systems, fostering enhanced stem cell development. Among the various stem cells studied in space, mesenchymal stem cells (MSCs) have shown promise for therapeutic applications, including the treatment of stroke, cancer, and neurodegenerative diseases. Research aboard the International Space Station (ISS) has demonstrated that MSCs maintain their properties, proliferate, and differentiate under microgravity conditions, offering potential for future therapies. Additionally, MSCs exhibit resistance to space radiation, protecting astronauts from its harmful effects by promoting tissue repair and releasing regenerative factors. This radiation resistance, coupled with cryopreservation techniques, enables MSCs to be used in long-duration space missions. The ongoing research on MSCs in space not only supports astronaut health but also holds the potential to revolutionize regenerative medicine on Earth. By understanding how microgravity influences stem cell behavior, scientists are uncovering critical insights into tissue repair and cell function, paving the way for innovative treatments for aging-related diseases and other medical conditions. These findings highlight the broader implications of space-based stem cell research for advancing human health both in space and on Earth.
THE POTENTIAL OF PLURIPOTENT STEM CELL-BASED THERAPY AND EXTRACELLULAR VESICLES IN PROMOTING TISSUE REGENERATION Fitria; Muslimah; Zulnandar
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67765

Abstract

Stem cell research has paved the way for revolutionary regenerative therapies targeting damaged and diseased tissues. Beyond traditional cell transplantation, current evidence suggests that therapeutic benefits are primarily mediated through paracrine effects. Extracellular vesicles (EVs), which can traverse biological barriers and deliver bioactive molecules, represent a promising avenue for cell-free therapy. Tissue engineering, as the second-generation regenerative innovation, integrates biodegradable 3D scaffolds with cells to mimic natural extracellular matrices, enhancing therapeutic outcomes. This study examines the potential of EVs across diverse applications. In ocular regeneration, neural progenitor-derived EVs preserve photoreceptor cells and mitigate retinal inflammation in retinitis pigmentosa. For skin repair, EVs derived from mesenchymal stem cells (MSCs) support key phases of wound healing by modulating macrophage polarization and activating molecular pathways like RAC-alpha and Notch signaling. In cardiovascular therapy, EVs contribute to heart tissue recovery, reduce myocardial apoptosis, and combat fibrosis through targeted gene modulation. Skeletal muscle regeneration benefits from EVs enhancing myogenic differentiation, decreasing fibrosis, and addressing excessive extracellular matrix accumulation common in disorders like muscular dystrophy. The ability of EVs to emulate paracrine signaling processes expands the horizons of regenerative medicine, offering a scalable and efficient alternative to cell-based therapies. Literature highlights the critical role of high-quality, large-scale production under stringent standards to ensure therapeutic consistency. These findings underscore EVs as potent, cell-free agents capable of driving tissue repair and regeneration. Further investigations are encouraged to optimize production, application, and integration with advanced biomaterials for clinical efficacy.

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