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Neurologico Spinale Medico Chirurgico
Published by Universitas Udayana
ISSN : -     EISSN : 26212064     DOI : https://doi.org/10.36444/nsmc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Neurologico Spinale Medico Chirurgico (NSMC) is an open-access, single-blind peer-reviewed journal, published by Indonesian Neurospine Society (INSS) under the flag of Indonesian Neurosurgery Society (INS) and Faculty of Medicine, Udayana University. NSMC publishes articles which encompass all aspects of basic research/clinical studies. The journal facilitates, bridge and integrate the intellectual, methodological, and substantive diversity of medical knowledge, especially in the field of surgery, neurology, neurosurgery, spine, neuroanesthesia, medicine, and health. The journal appreciates any contributions which promote the exchange of ideas between practising educators and medical researchers all over the world.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 134 Documents
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Topical administration of Tamanu Oil (Calophyllum inophyllum) inhibited the increase of matrix metalloproteinase-1 (MMP-1) expressions and decrease of collagen dermis amount in male wistar rats exposed to ultraviolet B Yoselyn Gunawan; Alex Pangkahila; Agus Eka Darwinata
Neurologico Spinale Medico Chirurgico Vol 4 No 3 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i3.186

Abstract

Background: UV-B irradiation is the major causative factor in photoaging. Photoaging increases MMP-1 significantly and cause damage to collagen by forming ROS. The monounsaturated free fatty acids and antioxidant compounds in Tamanu oil have been studied to inhibit the emergence of MMP-1 and maintain collagen amount. The study aimed to investigate topical Tamanu oil in inhibiting MMP-1 expressions and collagen decrease in male Wistar rats’ skin exposed to UV-B. Methods: A randomized post-test-only control group design was performed on 36 male Wistar rats, aged 2-3 months old with 180-220 grams body weight. They were assigned to two groups: the placebo group and the Tamanu oil group. Both groups were given the same amount of UV-B exposure for four weeks totalling in 840 mJ/cm2 of dosage radiation. Their dermis was examined for MMP-1 using Immunohistochemistry and collagen amount using Picro Sirius Red staining. Results: A comparative analysis was done to show the difference between groups. The mean expression of MMP-1 in the control group was 34,03±2.97 cell/HPF and the Tamanu oil group was lower at 22.73±2.68 cell/HPF. The mean amount of collagen dermis in the control group was 38.90±11.64 % and the Tamanu oil group was higher at 65.66±8.13 %. A significant difference was shown in the two groups (p<0.05). Conclusion: Topical Tamanu oil has proven to hinder the increase of MMP-1 expressions and collagen amount in male Wistar rats’ skin exposed to UV-B.
Eucalyptus globulus essential oil increased neovascularization and vascular endothelial growth factor expression in male wistar rats exposed to UVB Noviana Indrawati; Ida Sri Iswari; Ni Wayan Winarti
Neurologico Spinale Medico Chirurgico Vol 4 No 3 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i3.187

Abstract

Background: Eucalyptus globulus essential oil contained 1,8-cineol, which may accelerate wound healing. This study aimed to prove Eucalyptus globulus essential oil's effect on increasing neovascularization and Vascular Endothelial Growth Factor (VEGF) expression in Wistar rats skin exposed to ultraviolet B (UVB). Methods: A Post-test only controls group study design was applied on 36 male Wistar rats, aged 3-4 months old, weighing 150-200 grams. The animal subject was exposed to UVB (65 mJ/cm2, 65 seconds for seven days), injured on their back using a punch biopsy with a diameter of 10 mm, and divided into two groups. For seven days, on the wound, the control group was given 2 cc of 0.9% NaCl twice a day, while the treatment group was given Eucalyptus globulus essential oil (2 cc). Both groups were given oral Amoxicillin three times a day. The skin tissue was taken on day eight to assess neovascularization and VEGF expression. Results: The results show that neovascularization in the treatment group was higher than in the control group (p < 0.05). Meanwhile, the median VEGF expression in the treatment group was also higher than in the control group (p < 0.05). Conclusions: Topical administration of Eucalyptus globulus essential oil increased neovascularization and VEGF expression in the skin of male Wistar rats injured and exposed to UVB. Further research is needed to assess the effectiveness of the essential oil in enhancing neovascularization and VEGF expression in humans with multiple exposures at different doses to optimize the wound-healing effect.
Occipito-cervical fusion approach to Hangman’s fracture on osteoporosis patient Glen Sandi Saapang; I Gusti Ketut Agung Surya Kencana; Tjokorda Gde Bagus Mahadewa
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.163

Abstract

An unstable Hangman fracture in an elderly patient is a condition that requires special consideration in selecting a surgical approach. In a healthy sixty-year-old man with a good Karnofsky score, a cervical X-ray and non-contrast CT-scan (NCCT) were performed to confirm the diagnosis. Installation of cervical traction with light weights first followed by occipito-cervical fusion has shown improvement in fracture alignment without complications, even with limited resources. Postoperative radiological examination showed good realignment with lateral mass screw fixation. From this case, it can be seen that the selection of the right surgical procedure in elderly patients is important, especially for those who do not have significant comorbidities.
Surgery on displaced depressed skull fracture overlying sigmoid sinus: Rationale, techniques, and risk management Kadek Biondi; Tjokorda Gde Bagus Mahadewa; Marleen
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.164

Abstract

Skull fracture may occur at all parts of the skull after direct trauma. Skull fragment overlying dural venous structure, may inherit the risk of infection, thrombosis, and massive bleeding. Controversy arises among institutions whether the surgical measure is superior to the conservative option. The occurrence of depressed skull fracture overlying sigmoid sinus is seldom discussed in trauma literature, but some authors reported that the risk of infection and sepsis might occur in a delayed fashion in this group of patients. Several reports on the radiological study in depressed skull fracture overlying venous sinus found that fracture may predispose to venous sinus thrombosis. However, the risk of profuse bleeding when attempting to elevate bone fragments could place the patient into serious and devastating conditions, which need aggressive and effective bleeding control. We report a case of a middle-aged man who had a displaced depressed skull fracture overlying the right sigmoid sinus after falling from height. Surgery was performed in order to decompress the right sigmoid sinus structure and repair the cerebrospinal fluid leak at the overlying duramater. The patient was discharged from the hospital with minimal conductive hearing disturbance, with no sign of infection and neurologic deficits.
Perioperative management of a morbidly obese patient with Pickwickian syndrome who underwent herniotomy herniorrhaphy surgery Reynaldi Reiky Hadiwijaya; I Made Gede Widnyana; Tjokorda Gde Agung Senapathi
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.170

Abstract

Administering anesthesia in obese patients has its challenges. Most obese patients have multiple comorbidities with a higher risk for perioperative complications. Obese patients also have several physiological changes, including respiratory changes that could affect anesthesia. With the increasing number of obesity rates worldwide, the possibility of obese patients who need anesthesia increases, thus providing challenges for anesthetists in treating obese patients. This case described a 62-year-old male who underwent herniotomy and herniorrhaphy under general anesthesia. The patient was morbidly obese with a BMI of 54.68 kg/m2 and found to have Pickwickian Syndrome. The patient was assessed with physical state ASA III and underwent general anesthesia. The patient recovered with no complications and was discharged from the hospital three days after the surgery. In obese patients, several physiological changes could be a challenge for administering anesthesia. The choice of anesthetic agent for obese patients with Pickwickian Syndrome should be carefully selected, considering it can significantly impact the patient. The perioperative period should be focused on careful monitoring and improvement of comorbid diseases.
Is there any benefit from surgery for giant-dumbbell spinal tumors with prolonged paraplegia and joints contractures? a rare case report Mohamad Saekhu; Eka Susanto; Samsul Ashari; Setyowidi Nugroho
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.174

Abstract

The lack of clarity about the opportunities for significant neurologic improvement, coupled with the risk of severe postoperative complications, decompression surgery for patients with giant tumors in the cervical spine accompanied by long-lasting advanced neurological deficits places a heavy moral burden on surgeons. Here we report a three-year follow-up after surgery for an immense spinal neurofibroma in which the patient was bedridden for the past fifteen years. Our findings suggest surgery remains beneficial for patients without major postoperative complications.
Endovascular coiling procedure for saccular multilobulated anterior communicating artery aneurysm associated with contralateral A1 segment aplasia Bilzardy Ferry Zulkifli; Achmad Adam; Christian Beta Kurniawan; Yustinus Robby Budiman Gondowardojo
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.176

Abstract

The anterior communicating artery complex anatomy is very important in treating anterior cerebral circulation aneurysms surgically. About a quarter of all intracranial aneurysms are anterior communicating artery (AcomA) aneurysms. Aneurysm formation may be influenced by anatomic risk factors, with a co-occurring incidence of anterior cerebral artery trunks (A1) asymmetry. Patients with AcomA aneurysm are often presented with anterior cerebral artery A1 segment aplasia/hypoplasia. In this study, we will report a case of A1 hypoplasia in a 42-year-old female with a history of headache 3 days prior to admission which worsened overtime. Traditionally, coiling of A1 hypoplasia was not needed, however due to the neurological deficit, coiling was performed. This case report addresses the comparison between patient’s pre-operative and post-operative results from angiography and coiling.
Centella asiatica extract cream inhibited microphthalmia-associated transcription factor (MITF) expression and prevented melanin amount increase in Guinea pig skin exposed to ultraviolet-B Fatri Idana; Anak Agung Gde Putra Wiraguna; Ni Wayan Winarti
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.177

Abstract

Background: Centella asiatica has been popularly used in cosmetic products, especially due to its antioxidant benefits in soothing and healing wounds. However, the inhibition of melanogenesis in the content of Centella asiatica has not been widely studied. This study aimed to prove the effectiveness of 10% Centella asiatica cream on male Guinea pig (Cavia porcellus) skin exposed to UVB. Methods: The randomized posttest-only control group study was conducted on 36 Guinea pigs aged 3-months, body weight 300-350 grams with a healthy skin condition. They were randomly divided into two groups; each consists of 18 Guinea pigs. The first group was a control group given base cream 20-minutes before and 4-hours after UVB exposure, 3-times-a-week for two weeks. The second group was the treatment group given 10% Centella asiatica cream and expose to UVB with the same procedure. The histopathological preparations were made using a punch biopsy after intervention was completed. Immunohistochemical staining was performed to measure the expression of microphthalmia-associated-transcription-factor (MITF) and Masson-Fontana to measure the amount of melanin. Data analysis was conducted to compare the results in both groups. Results: The treatment group had a significantly lower mean MITF expression (13.61 ± 5.36 vs. 27.24 ± 6.50%) and melanin amount (5.95 ± 3.81 vs. 16.59 ± 5.77%) (p < 0.001) compared to the control group. Conclusion: The administration of cream consists of Centella asiatica extract 10% effectively inhibits the expression of MITF and prevented the increase of melanin amount in male guinea pigs (Cavia porcellus) exposed to UVB.
Characteristics and outcome of traumatic brain injury in Nabire General Hospital, Papua, Indonesia I Nyoman Surya Negara; Joni Ribo Tandisau; Amos Nomba
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.185

Abstract

Background: Traumatic brain injury (TBI) is a disruption in the normal function of the brain that can be caused by a bump, blow, or jolt to the head, or penetrating head injury. TBI is a major public health problem that can lead to long-term disability. This study was performed to cognize the clinical characteristic and parameters that could predict the outcome of TBI patients and become the foundations for public health interventions to help prevent and lower the mortality rates of TBI in other rural and remote areas. Methods: This research is a retrospective study. Our patient data were collected from Nabire General Hospital medical records from 1 January 2020 to 31 December 2020. This study included all patients who were diagnosed with TBI and excluded the incomplete data. The study was analyzed using chi-square. Results: This study shows TBI mostly occurs in men and the peak incidence in aged 17-65 years old and mainly caused by road traffic accidents. Some factors significantly shows correlation to predict worse outcomes in TBI patients are impaired oxygen distribution, low GCS score, history of consuming anticoagulant and antiplatelet, and the different types of brain hemorrhage. Conclusion: TBI in Papua mostly occurs in men aged between 17-65 years old and road traffic accidents are the main cause. The impaired oxygen distribution, low GCS score, history of consuming anticoagulant and antiplatelet, and the different types of brain hemorrhage were associated with unfavorable outcomes.
Correlation between knowledge, attitude, practice toward anxiety, and perception of the need for mental health services in Bali communities during the COVID-19 pandemic Putu Satyakumara Upadhana; I Gede Gita Sastrawan; I Gusti Agung Ayu Chintya Cahyarini; Ni Putu Gita Raditya Sanjiwani; Ida Ayu Kanaka Puspita; Wayan Citra Wulan Sucipta Putri; Ida Aju Kusuma Wardani
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.189

Abstract

Background: The level of knowledge, attitudes, and practices of a person in dealing with the COVID-19 pandemic can be a factor that influences the emergence of anxiety disorders. The study aims to determine the correlation between knowledge, attitude, practice toward anxiety, and perception of the need for mental health services in Bali communities during the COVID-19 pandemic. Methods: This study was a cross-sectional observational analytical study with a consecutive sampling method. An online questionnaire was distributed in all provinces by the enumerator from 1 November to 30 November 2020. The inclusion criteria are respondents that lived in Bali and were aged between 18 to 65 years old. Results: There were 356 respondents included in this study. Most of them were female (n = 227, 63.8%), and not married (n = 251, 70.5%), with a median age of 25 years old (18-64 years old). There was a significant correlation between attitude and perception of the need for mental health service (p = 0.028, R = 0.177) and anxiety of the respondent (p = 0.004, R = 0.151). Also, the correlation between practice and perception of the need for mental health (p = 0.039, R = 0.109) and anxiety with the perception of the need for mental health (p = 0.039, R = 0.109) were found to be statistically significant. Conclusion: There is a correlation between knowledge, attitude, practice toward anxiety, and perception of the need for mental health services in Bali communities during the COVID-19 pandemic.

Page 13 of 14 | Total Record : 134

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