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Nursalam Hamzah
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universitas Islam Negeri Alauddin Makassar, Indonesia
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INDONESIA
ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
 1 
Search results for , issue "Vol 4 No 1 (2021)" : 6 Documents clear
Formation of Hydrochlorothiazide – Para-aminobenzoic Acid Cocrystals by Solvent Evaporation Method Haeria Doloking; Ayu Tri Sartika; Nurshalati Tahar
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21301

Abstract

Hydrochlorothiazide is a diuretic drug used for mild to moderate hypertension were classified in Class II BSC. The purpose of this study was to explore the formation of hydrochlorothiazide-para-aminobenzoic acid cocrystal by solvent evaporation method. Cocrystals are prepared with a molar ratio of 1:0; 1:1; 1:2; and 2:1 between hydrochlorothiazide and para-aminobenzoic acid. The cocrystals were characterized by Scanning Electron Microscopy (SEM), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) spectrophotometer. The hydrochlorothiazide-para-aminobenzoic acid cocrystal has new crystalline peaks at 2θ of 14.904o; 15.41o; 25.553o; 26.5o; 29.844o; 31.083o indicating the formation of a new crystalline phase. The cocrystal showed the melting point at 188.57oC which is different from the initial components. The FTIR spectra of cocrystal showed the shifting of absorption peaks of groups of initial components indicating of formation of hydrochlorothiazide-para-aminobenzoic acid cocrystal through intermolecular hydrogen bond interactions between amine/sulfonamide group and carboxyl group.
Antituberculosis Activity of Parang Romang (Boehmeria virgata (Forst.) Guill) Stem Extract Muhammad Rusdi; Muhammad Ikhlas; Nur Pratiwi Kartikasari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21359

Abstract

Parang Romang (Boehmeria virgata (Forst.) Guill) is one of the plants empirically used by the people of South Sulawesi. This study aimed to test the activity of Parang Romang Extract against Mycobacterium tuberculosis. The 96% ethanol extract obtained was fractionated by the liquid-solid extraction method: obtained n-Hexan soluble extract and n-Hexan insoluble extract. Samples of 96% ethanol extract, soluble extract of n-Hexan and insoluble extract of n-Hexan were made in series of concentrations of about 25, 50, 75, and 100 µg/ml. The inhibition test of Mycobacterium tuberculosis used the MODS method on the Mycobacterium tuberculosis strain H37RV. Color reagents then identify extracts that provide inhibition. The results of the minimum inhibition concentration of Mycobacterium tuberculosis showed that a 100 µg/ml of n-Hexan soluble extract was able to inhibit the growth of Mycobacterium tuberculosis strain H37RV.
Characterization and Screening Active Phytochemical Compounds of 70% Ethanol Extract of Mahogany Seed (Swietenia mahagoni Jacq.) I Putu Gede Adi Purwa Hita; Putu Eka Arimbawa; Ni Putu Aryati Suryaningsih
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21225

Abstract

One of the herbal medicinal plants in Indonesia with antidiabetic activity is mahogany (Swietenia mahagoni Jacq.). Differences in plant parts used, extraction methods, and solvents during the extraction process will result in different characterization, quantity, and active phytochemical compounds in the extract. This study aimed to determine the content of active phytochemical compounds and extract characteristics of mahogany seed that fit the standards. Extracts were made using the maceration method with 70% ethanol solvent, then extract was characterized, and phytochemicals of active compounds were screened using reagents according to each group of compounds' test method. 50.16 g of 70% ethanol extract of mahogany seeds produced in this study had a solid form, characteristic odor, bitter taste, and brown color. The extract has the characteristics of water content, total ash content, acid insoluble ash content, water-soluble extracts content, and soluble ethanol extracts content according to the standard. Several classes of active compounds were identified qualitatively in the extract, which are flavonoids, phenolics, terpenoids, steroids, glycosides, and saponins. It appears that 70% ethanol extract of mahogany seed has a characterize extract that meets the standards and contains several active phytochemical compounds as potential antidiabetic agents.
Pediculicidal Activity of Cem-ceman White Cempaka Flower (Michelia alba DC.) against Pediculus humanus capitis Ahmad Fadli Robby; Iman Surya Pratama; Galuh Tresnani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21154

Abstract

The prevalence of pediculosis reported in Asia has ranged from 0.7% to 59%. High resistance and side effects is a challenge in using the pediculicidal agents. The widely use and empirical as well as scientific studies of traditional plants for anti-lice were already done, one of them is cempaka. The aim of this study was to determine the pediculicidal activity of cem-ceman white cempaka flower (Michelia alba DC.) on Pediculus humanus capitis in vitro. The white cempaka flowers made into cem-ceman preparations by mixing and soaking in coconut oil until 3 days. Pediculisidal activity was tested by filter paper diffusion test method with 3 replications. Data were analyzed using Kruskal-Wallis followed by post hoc Mann-Whitney Method test with software SPSS v.16. The phytochemical screening showed that sample contains alkaloid, tannin, saponin, and triterpenoid. Pediculidal activity test showed that cem-ceman white cempaka flower has pediculicidal effect in 10% concentration (w/v) with 66.67% mortality and 15% concentration (w/v) with 77.33% mortality. In conclusion cem-ceman white cempaka flowers has pediculicidal activity at concentration 10% and 15% but lower than permethrin 1%  (p<0.05).
Effect of Kombucha Tea on Total Cholesterol Decreasing Levels in White Rats (Rattus norvegicus) Zulkifli Halid; Sulaiman Sulaiman; Rifka Irhamna
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21205

Abstract

The purpose of this study was to determine the type of content of 75% kombucha tea that is fermented for 12 days,  there are black tea, green tea, and the packaged tea. Fifteen Rattus norvegicus was randomized divided into 5 groups and each group consisted of 3 rats. Group I or the negative control was given aquadest, group II was given kombucha packaged tea, group III was given black tea kombucha, and group IV was given green tea kombucha. Group V as a positive control was given simvastatin. All groups were injected with the samples solution orally. Evaluation of effects was carried out by observed the cholesterol total level before and after treatment. The results showed that all kombucha tea can reduced the total cholesterol level on rats (Rattus norvegicus). Conclusion: Data were analyzed using ANOVA followed by Duncan test with 95% confidence level using SPSS 20.0 software, results showed that black tea kombucha 1.8 mL of 75% concentration has an optimal reduced total cholesterol levels in rats (Rattus norvegicus).
Antibacterial Activity Of Musa Paradisiaca Var. Sapientum Peel Extrak Cream And Ointments Dosage Form On Staphylococcus Aureus solikah ana estikomah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21303

Abstract

The aim of the present study was to determine the difference of antibacterial effectivity between ointment  and cream Musa paradisiaca var. Sapientum (MPvS) peel extract against bacteria Staphylococcus aureus. Objective: To prove the antibacterial effect of banana peel extract with 5%,10%,15% concentration cream and oitments on Staphylococcus aureus. Methods: This study was applying the true experimental design with analyzed statistically with the ANOVA test and continued with the Duncan test to determine the level of treatment that provided the difference and the T-test to determine the most effective differences between groups. The results of the antibacterial activity of cream with a concentration of 10% with an inhibition zone diameter of 12.80 mm and Ointment at a concentration of 15% with an inhibition zone value of 11.07 mm were able to inhibit antibacterial activity. Conclusion, banana peel MPvS extract Cream Formula is the most effective in inhibiting the growth of Staphylococcus aureus bacteria.

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