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Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 302 Documents
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The Effect of Bisoprolol on Heart Failure Preserved Ejection Fraction/HFpEF Patient’s Quality of Life Ayu Asri Devi Adityawati; Anna Fuji Rahimah; Mohammad Saifur Rohman; Setyasih Anjarwani; Djanggan Sargowo
Heart Science Journal Vol 2, No 4 (2021): Management of Thrombosis in Covid-19 Patient with Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2021.002.04.6

Abstract

Global Publich Health Burden of Heart Failure reported the growing prevalence of heart failure from 26 million people affected in 2017 to 64.3 million affected in 2020 worldwide with half of the case classified as heart failure preserved ejection fraction/HFpEF. It is well known that someone who have been diagnosed with heart failure will have a poorer quality of life/QoL. β-blocker is a heart rate lowering agent with a potency to improve the patient’s clinical outcome. One clinical outcome that should always be evaluated and become the main goal of the therapy is QoL of the patient. This study aimed to observe and evaluate the effect of Bisoprolol, a type of β-blocker, in the improvement of HFpEF patient’s QoL. This study is a retrospective cohort following HFpEF patients who received β-blocker and HFpEF patients who did not received β-blocker in a span of 6 months. The study participant selected by purposive sampling method. Our study found that from all HFpEF patients who received β-blocker 86 patients had a good QoL, 16 patients had a Mod QoL, and 2 patients had a poor QoL (p=0.000). Mean physical score in the patient who did not received β-blocker was 13.84±11.01 while the mean score of the patient who received β-blocker was 5.94±4.95 (p=0.000). Mean emotional score in the patient who did not received β-blocker was 6.02±6.61 while the mean score of patient who received β-blocker was 1.83±2.16 (p=0.000). We conclude that the use of Bisoprolol could improve the HFpEF patient’s QoL evaluated by total score, physical score, and emotional score.   
The Prothrombotic Predominance in Metabolic Syndrome: A Complex Patomechanism Fahmy Rusnanta; Mohammmad Saifur Rohman
Heart Science Journal Vol 2, No 4 (2021): Management of Thrombosis in Covid-19 Patient with Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2021.002.04.2

Abstract

Patients with metabolic syndrome (MS) have many cardiovascular complications related to atherothrombotic complications. MS contributes premature atherosclerosis, increase platelet activation, promote coagulation factors, and reduce fibrinolytic activity. The last step in the atherotrombotic cascade is blood clot formation, and altered clot structure is a key role to determine cardiovascular complications. This review discusses imbalance of hemostasis and eludicate their role of increased propensity to CVD. The correlation of MS and fibrinolysis is reviewed and complex mechanisms that promote coagulation are discussed. Understanding these effects on hemostasis pathway helps to build more effective treatment and preventive strategies to diminish the complication in this condition. 
D-dimer Levels as Novel Biomarker Predictor for All-cause Inhospital Mortality Risk in COVID-19 Patients Nisa Amnifolia Niazta; Muchammad Dzikrul Haq Karimullah; William Sulistyono Putra; Norma Khoirun Nisa'; Phamella Esty Nuraini; Shaffan Ula Prasetya
Heart Science Journal Vol 2, No 4 (2021): Management of Thrombosis in Covid-19 Patient with Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2021.002.04.4

Abstract

BACKGROUND: COVID-19 has infected the world on a wide spectrum, from mild to severe and causing death. As of January 1st 2021, global case fatality rate (CFR) was 2.2 % due to COVID-19. CFR in Kediri district is 7.7 %, higher than Nasional CFR which is only 3 %. We analysed elevated D-dimer as one of predictor inhospital mortality in COVID-19OBJECTIVES: To determine the association and evaluate the optimal cut off point D-dimer level as predictor for all-cause inhospital mortality of COVID-19 patients.METHODS: This is a single center cross sectional. A total of 185 COVID-19 patients confirmed positive by RT-PCR were hospitalized at Kediri General Hospital since March to December 2020 met the inclusion criteria. D-dimer levels were categorized into 2 groups, above and below the cut of point. We analyzed 4 cut of points, D-dimer ≥ 0.5 µg/ml, D-dimer ≥ 2 µg/ml, D-dimer ≥ 3 µg/ml, and D-dimer ≥ 4 µg/ml. The primary endpoint was all-cause inhospital mortality. Data were collected retrospectively and processed using SPSS version 25.0.RESULTS:During hospitalization, 45 patients (24.3%) were died. Elevated D-dimer ≥ 4 µg/ml was statistically significant associated with all-cause inhospital mortality (adjusted OR95%CI = 3.46 [1.41 – 8.49], p = 0.007), with a sensitivity of 82.1% and a specificity of 42.2% (AUC, 0.628; 95% CI, 0.527 – 0.728, p = 0.012).CONCLUSION: Elevated D-dimer level were associated statistically significant with all-cause inhospital mortality. In our study, optimal cut of point D-dimer value was 4 µg/ml.
The Role of STEMI Communication Network in Malang with Major Adverse Cardiac Event (MACE) Incidence in STEMI Patients Hospitalized in Saiful Anwar General Hospital Malang Adhika Prastya Wikananda; Lenny Kartika; Dadang Hendrawan; Heny Martini; Mohammad Saifur Rohman
Heart Science Journal Vol 2, No 4 (2021): Management of Thrombosis in Covid-19 Patient with Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2021.002.04.3

Abstract

Background: Patient with STEMI requires urgent reperfusion either with fibrinolytic or primary PCI. In Malang, a communication network of STEMI has been developed. It connects Saiful Anwar General Hospital with all of the PHC in Greater Malang to shorten system delay since 2015.Objective: To elucidate Malang’s communication network’s role in decreasing MACE (Major Adverse Cardiac Event) in STEMI patients.Methods : This is a retrospective cohort study. Study sample was taken from medical record. Non-network: 96 patients and 88 network patients. Statistical tests using SPSS and PLS, α value 0.05 and t-test is significant if more than 1.96.Results: Bivariate analysis shows network-group has a significantly lower MACE (p=0.001). Door-to-balloon time is also lower in network-group (p=0.026). Multivariate analysis without confounder shows that network-group has significantly shorter door-to-reperfusion time (p=0.032) and lower MACE (p=0.035) compared to non-network group. But multivariate analysis with confounder door-to-balloon and door-to-needle fails to explain lower MACE incidence. Network-group (p=0.005) and reperfusion with primary PCI (p=0.05) significantly decrease MACE incidence.Conclusion: Malang’s STEMI communication network and reperfusion with primary PCI reduce MACE in STEMI patients in Saiful Anwar General Hospital Malang.
Premature Coronary Artery Disease in Young Male Patient with Strong Family History Dea Arie Kurniawan; Mohammad Saifur Rohman; Anna Fuji Rahimah; Budi Satrijo
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.8

Abstract

BACKGROUND: Coronary artery disease (CAD) occurring in less than 45 years of age is termed as premature CAD (PCAD). Recent studies showed a prevalence of 4-10 % of PCAD. PCAD is associated with unfavorable outcomes for the patients and had a greater impact on the quality of life. Family History is the best method to explained complex interaction between shared risk factor.CASE ILLUSTRATION: A 37-years old male admitted to Saiful Anwar Hospital for further evaluation of anginal pain. The patient complains of recurrent chest pain since 5 months ago but still relieved by rest. The electrocardiogram showed Wellens Type B which is specific for critical stenosis of the left anterior descending artery (LAD). Then the patient undergoing DCA Ad Hoc. The implantation of a 46 mm DES at proximal until distal LAD was performed. The patient discharged after a day observation.DISCUSSION: The challenging point, in this case, was it happen at a young age with strong family history. There was positive family history of PCAD in 1st degree relative on her brother and mother, despite several risk factors were identified in this case consist of smoking, and dyslipidemia, which make CAD risk higher. Despite adequate control of risk factors, family screening is important to reveal subclinical atherosclerosis.CONCLUSION: Approach to a patient with PCAD comprises of management of traditional risk factors and careful investigation of Family History. Individual with positive family history of PCAD should be treated more cautiously
Factors Associated with In-hospital Mortality in Patients with Acute Coronary Syndrome Hiradipta Ardining; Nisa Amnifolia Niazta; Muchammad Dzikrul Haq Karimullah
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.6

Abstract

BACKGROUND: Acute coronary syndrome (ACS) remains major cause of death worldwide, therefore it is important to determine factors associated with worse outcomes to better elucidate which patients deserve a more aggressive approach for management. OBJECTIVES: To describe the characteristics of patients admitted with ACS to Kediri General Hospital and factors associated with in-hospital mortality in ACS patients.METHODS: In this cross-sectional study, 117 patients who admitted with ACS to Kediri General Hospital between January and June 2020 were included. Data were collected retrospectively from medical records and analyzed using SPSS software v25.RESULTS: During hospitalization, 18 (15,4%) died. The bivariate analysis showed the patients who died were predominantly female, had higher prevalence of Killip IV, higher prevalence of clinical signs of heart failure, lower admission systolic and diastolic blood pressure, and higher heart rate. From multivariable analysis, variables which were significantly associated with in-hospital mortality were decreased consciousness (OR 11, 95% CI 1.327-92.4, p=0.026), and Killip class IV (OR 9.558, 95% CI 2.016-45.317). CONCLUSION: Decreased consciousness and Killip class IV were associated with increased inhospital mortality in ACS.KEYWORDS:In-hospital mortality, acute coronary syndrome, Killip class, Decrease of Conciousness
Reperfusion Arrhythmia in Acute Myocardial Infarction: Clinical Implication and Management Harris Kristanto; Budi Satrijo; Sasmojo Widito; Ardian Rizal
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.2

Abstract

Reperfusion is a critical component of myocardium survival in acute myocardial infarction to minimize infarct size and improve clinical prognosis. Reperfusion, on the other hand, may result in increased and accelerated myocardial injury, a condition known as reperfusion injury. Following reperfusion, several arrhythmias are observed, and it is called reperfusion arrhythmia. Reperfusion arrhythmia is one manifestation of reperfusion injury. Numerous modest studies have evaluated what reperfusion arrhythmias are defined. It is described as an arrhythmia that occurs immediately or within the first minutes after coronary blood flow is restored. Traditionally, Accelerated Idioventricular Rhythm (AIVR) has been seen as a reperfusion arrhythmia. However, reperfusion may reveal any arrhythmia (or none at all); conversely, AIVR may occur in the absence of reperfusion. Calcium excess within the cells is thought to be a significant factor in the development of reperfusion arrhythmias. This may affect the significant delay following depolarization and the regional heterogeneity of regional blood flow restoration inside the ischemic zone, resulting in reperfusion arrhythmia. In some studies, it was mentioned that these arrhythmias may be due to ongoing myocardial cell damage and ischemia. Arrhythmias associated with reperfusion require special attention since hemodynamics can deteriorate quickly. In this review, clinical significance and management of reperfusion arrhythmia, as well as its link with reperfusion injury will be discussed.   
Periprocedural Myocardial Infraction: A Review Article Irma Kamelia Pratiwi; Fandy Hazzy Alfatta; Teguh Aryanugraha; Muhamad Bayu Aji; Putri Annisa Kamila; Ratna Pancasari; Ayu Asri Devi; Krishna Ari Nugraha; Mohammad Saifur Rohman
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.3

Abstract

Percutaneous coronary intervention can be associated with several complications such as periprocedural myocardial infarction (PPMI) that was defined as an elevation of CK-MB >3 times the upper limit of the normal range in at least two blood samples with a normal range of baseline value, prolonged ischemia as demonstrated by persistent chest pain (>20 min), or new pathological Q waves seen on the electrocardiogram.By epidemiology, periprocedural myocardial infarction was happen in about 6 – 7% patient underwent PCI and associated with adverse outcome. Therefore it is important to identify the possible factors to detect, prevent and manage this event.
Prognostic Value of Residual Syntax Score Combined with Acef Score in Acute Coronary Syndrome Patient After Percutaneus Coronary Intervention in Saiful Anwar Hospital, Malang Adhika Prastya Wikananda; Mohammad Saifur Rohman; Novi Kurnianingsih; Sasmojo Widito; Ardian Rizal
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.4

Abstract

Background : Percutaneous coronary intervention (PCI) is one of the revascularization options in patients with clinical acute coronary syndrome (ACS) who often have multiple and complex vascular lesions. So, the decision to complete revascularization is still a topic that is widely explored to reduce the rate of rehospitalization and reinfarction. This study aims to determine the predictor value of rehospitalization and reinfarction events that can be used in ACS patients undergoing IKP using coronary angiography parameters with residual SYNTAX scores and clinical parameters using ACEF scores.  Method : The study was cohort prospective with the inclusion criteria being all ACS patients who underwent PCI in RSUD Dr. Saiful Anwar Malang from January 2017 to July 2021. All patients underwent IKP and underwent coronary angiography evaluation after IKP with a residual SYNTAX score (rSS) and divided into categories into rSS≤8 and rSS>8. All patients underwent laboratory examination of serum creatinine and post-PCI echocardiography, and an ACEF score was obtained (ACEF score = age/left ventricular ejection fraction + 1 [if serum creatinine >2 mg/dl]). Research subjects will be followed up for at least 1 year related to the incidence of post-PCI rehospitalization and reinfarction.  Results : From a total sample of 209 patients, it was found that the residual SYNTAX score data had the most significant predictive factor for the occurrence of rehospitalization at 1 year after PCI (OR 6.14 [95% CI, 1.92-1967]). At the value of rSS > 8, (AUC 0.750 [95% CI, 0.682-0.818], p 0.001) has a good predictive value for the occurrence of rehospitalization. However, combining with clinical parameters using the ACEF score provides a better predictive value. This study shows that the combination of rSS>8 and ACEF score>1.2 provides a better predictive value (AUC 0.884 [95%CI, 0.832-0.936) for the incidence of rehospitalization in post-PCI ACS patients. Conclusion : Acute coronary syndrome patients with residual SYNTAX scores > 8 and ACEF scores > 1.2 had a strong predictive value for rehospitalization events 1 year after PCI. The use of the combination of these two scores is expected to be a clinical guide to obtain the degree of completeness of revascularization in ACS patients.
Multimodality Imaging Evaluation in Coronary Artery Disease Anna Fuji Rahimah
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.1

Abstract

Non-invasive imaging modalities are fundamental in evaluating and managing patients with known or suspected coronary artery disease (CAD). Multimodality cardiac imaging procedures detect the presence of CAD and guide clinical decision-making. Combining anatomical and functional imaging modalities would enable a more thorough characterization of obstructive CAD. When selecting an imaging test, one must consider the many factors that interact in the development of chronic CAD and acute coronary syndrome (ACS). The clinical presentation, baseline characteristics of the patient, as well as the clinical center's local availability and expertise will determine the preferred imaging technique to confirm the diagnosis of ACS or chronic CAD. Diagnostic testing is most useful and recommended in patients with chronic coronary syndromes (CCS) when the likelihood is intermediate. The preferred options are coronary computed tomography angiography (CTA) or stress tests, but patients may be referred directly for invasive coronary angiography (ICA) if the likelihood of CAD is very high. The primary goal of the initial diagnostic evaluation in patients with suspected ACS is to confirm ACS and rule out the other most common life-threatening conditions, such as acute pulmonary embolism (PE) or acute aortic syndromes (AAS). Non-invasive imaging is essential in the differential diagnosis of ACS and frequently necessitates multimodality imaging. Cardiac magnetic resonance (CMR) is the most helpful imaging test in diagnosing myocardial infarction with non-obstructed coronary arteries (MINOCAs), and it can detect or rule out other cardiac causes of troponin rise.

Page 7 of 31 | Total Record : 302

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