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Mohammad Saifur Rohman
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Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 325 Documents
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Early Detection of Congenital Heart Disease in Pregnant Young Women at Risk Putri, Valerinna Yogibuana Swastika
Heart Science Journal Vol. 3 No. 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.1

Abstract

Cardiovascular disease (CVD) is one of the non-communicable diseases in which the leading cause of death worldwide at 48%1. CVD contains a spectrum of diseases, one of which is Congenital Heart Defect (CHD). CHD is one of the contributors to morbidity from young until adulthood. The advancement of surgical correction and medical therapy made it possible for early structural correction, as uncorrected CHD while patients were still young posed a risk of health outcome deterioration later in life. CHD affected especially pregnant individuals. A pregnant woman diagnosed with CHD would often complain of significantly significant deterioration of health condition and quality of life as they have a higher susceptibility to cardiovascular complications than women in general. Pregnant women diagnosed with CHD in developing countries more often presented with signs indicating complications of CHD, such as Eisenmenger syndrome, signs of heart failure, Pulmonary Hypertension (PH), cyanosis, and NYHA functional classes II and III, which indicate later diagnosis and treatment further into adulthood in these patients. Lack of expertise and facility for diagnosis of CHD posed a major challenge in reducing mortality related to CHD in these countries. Therefore the need for a screening method at least for directing further referral to major health centers is still in high demand.
Idiopathic Pulmonary Arterial Hypertension Newly Diagnosed in Pregnancy with Anemia and Threatened Preterm Labor Harumsari, Stefani; Rahardjo, Bambang; Prasetyorini, Nugrahanti; Dwijayasa, Pande Made; Yogibuana, Valerinna; Rohman, Mohammad Saifur
Heart Science Journal Vol. 3 No. 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improv
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.04.7

Abstract

Background: Pulmonary hypertension (PH) is a rare cardiovascular disorder that leads to right heart failure (RHF). Although most PH occurs secondary to congenital heart disease (CHD), PH can occur primarily due to pulmonary arterial vasculature abnormalities, known as Idiopathic pulmonary arterial hypertension (IPAH). In addition, the physiologic changes during pregnancy can potentially lead to worsening PAH and confer a poor prognosis. Therefore, when the mother refuses termination, a multidisciplinary team should manage the pregnancy and delivery to improve maternal and fetal outcomes.Objectives: This case report aimed to describe the importance of early diagnosis and treatment in PAH.Case reports: We reported a case of a 24-year-old woman with idiopathic pulmonary arterial hypertension (IPAH) that was newly diagnosed at 25 weeks of pregnancy and previously misdiagnosed with patent ductus arteriosus (PDA). This pregnancy was complicated with anemia and threatened preterm labor. Sildenafil was used as a vasodilator to reduce the symptoms of PAH. Unfortunately, the pregnancy was terminated at 29 weeks because of PPROM after considering giving lung maturation and neuroprotectant to the fetus. The patient was discharged without complication, but the baby died after eight days of intensive care due to HMD II, which led to respiratory failure.Conclusion: PAH in pregnancy is a life-threatening condition if untreated. Continuous treatments can help control the symptoms and avoid further complications for both mother and baby.
The Nightmare in Defect Occlusion by Transcatheter: A Case Report Iskandar Iskandar; Seprian Widasmara; Ratna Pancasari; Heny Martini
Heart Science Journal Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.7

Abstract

Background : ASD closure ASD closure with a transcatheter is the first choice in patients who meet the criteria for insertion. Closure using this method is relatively safe, and has low complications. Several factors must be considered so that this closure action can be optimal. Case illustrations:A 24-year-old woman with complaints of shortness of breath during strenuous activities since 3 years ago. Transthroracal echocardiography showed a gap in the IAS of 1.7-1.9 cm. The patient then underwent TEE and DXRL. The patient was planned for percutaneous ASD closure with zero fluoroscopy. The patient was punctured on the right femoral, and entered into the occluder memopart no 24 mm. Do a wriggle test, the occlude tool is installed properly. When the device was pulled out, the patient's blood pressure dropped to 75/52. On TEE examination, pericardial effusion was found and pericardiocentesis was performed, obtained 600 cc of fluid. The patient was then observed in the ICVCU, and there was no additional free fluid in the pericardial cavity. Discussions:ASD closure can be done through percutaneous and surgery. Closure via percutaneous is the main option. Complications and treatment period is shorter than surgery. Preparation and timing of appropriate action is closely related to clinical outcomes. Observation and knowledge of the risks of the procedure are very important to be able to detect complications and optimize clinical outcomes.  
Type 1 Diabetes Mellitus and Premature Coronary Artery Disease Dyah Ayu Ikeningrum; Djanggan Sargowo; Novi Kurnianingsih; Anna Fuji Rahimah
Heart Science Journal Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.2

Abstract

Cardiovascular disease, which affects more than half of all diabetics, is the leading cause of morbidity and mortality in patients with type 1 and type 2 Diabetes Mellitus (DM). Around 55% of diabetes patients are thought to have it, in comparison to 2-4% of the general population. A significant risk factor for the development of Coronary Artery Disease (CAD) exists in people with Type 1 Diabetes Mellitus (T1DM). However, it is worth noting that the present Models of risk prediction for T1DM have a variety of flaws. CAD risk is expected to double or quadruple over the next two to four decades, and diabetes mellitus is the third most significant risk factor for the etiology of illness. As a result, diabetes increases the chance of developing Acute Coronary Syndromes (ACS), whose incidence surpasses 20% after seven years, compared to a rate of 3.5 percent in non-diabetics – a rate comparable to individuals who have already experienced an Acute Myocardial Infarction (AMI). Additionally, it is crucial to identify any well-defined specific risk factors for T1DM as well as any extra subclinical atherosclerosis that may influence these patients at an advanced stage of disease progression. T1DM patients have more severe lesions, a lower left ventricle (LV) ejection fraction, a higher risk of cardiac events, and a higher rate of silent ischemia when compared to non-diabetics. They continue to have impaired microcirculation and endothelial function, both of which contribute to tissue perfusion problems.
Central Vein Stenosis in Patient with Routine Haemodialysis: From Diagnosis and Prompt Treatment A Case Report Yudi Putra Apriditya; Novi Kurnianingsih; Djanggan Sargowo; Indra Prasetya
Heart Science Journal Vol 3, No 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improve
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.04.8

Abstract

Central vein stenosis (CVS) is common in hemodialysis patients caused by the implantation of cardiac intravascular devices, venous access, and limited vascular access. Until an arteriovenous fistula (AVF) or graft is established in the ipsilateral arm or forearm for hemodialysis, the effect may develop. Arm edema, significant venous dilatation, and recurring infections are common complications of having an ipsilateral arteriovenous fistula or graft. We present the case of a 50-year-old female who developed symptomatic CVS while being on regular hemodialysis. A venography using a catheter revealed a significant stenosis of the subclavian vein. Due to central venous stenosis, this patient had substantial edema of her left arms after undergoing an ipsilateral arteriovenous graft. Multiple endovascular treatments have failed to alleviate the symptoms. The incidence and danger of central vein stenosis in hemodialysis patients are discussed, as well as the success of endovascular therapies. The initial line of therapy should be percutaneous balloon angioplasty. Unfortunately, after angioplasty or stenting, primary patency is poor. If there is recurring stenosis, the procedure can be repeated.
Cardiomyopathy and Frequent Monomorphic PVC : Which One Comes First? Anita Surya Santoso; Djanggan Sargowo; Ardian Rizal
Heart Science Journal Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.8

Abstract

A 28-year-old male wasaadmittedto hospitalwwith chief complaint chestadiscomfort. There were symptoms of dyspnea on effort and palpitation before. He had a history of alcoholics for more than five years. The ECG showed frequent Premature Ventricular Complex (PVC) and recommended to have ambulatory Holter monitoring with conclusion frequent monomorphic right ventricle outflow tract (RVOT) origin PVC. Echocardiography indicated a decrease in left ventricular (LV) function, LV dilatation, and global hypokinetic. Cardiac Magnetic Resonance Imaging (CMR) was performed, and there was no “edema”and myocardium fibrosis. It is essential to analyze which comes first, arrhythmia induced cardiomyopathy (AIC), or cardiomyopathy induced arrhythmia to have direct treatment. From the collected data, we conclude that the frequent RVOT origin PVC induced cardiomyopathy and catheter ablation is the definitive therapy.
Atherosclerosis Early Detection In Type 1 Diabetes Mellitus Seprian Widasmara; Novi Kurnianingsih; Mohammad Saifur Rohman; Anna Fuji Rahimah
Heart Science Journal Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.3

Abstract

Atherosclerosis continues to be a significant consequence in type I diabetes mellitus (T1DM). Cardiovascular disease, caused by accelerated atherosclerosis, is the leading cause of illness and often premature death in patients with T1DM. Risk management is critical. Patients with T1DM who are at an increased risk include those who are less than 10 years old at the time of diagnosis, have a longer history of diabetes, have microvascular problems, or have several risk factors. It is frequently difficult to evaluate vascular hazard and the degree of atherosclerosis on an individualized level, especially early on.
Provisional Technique for Bifurcation Left Main In-Stent Restenosis Lesion: A Case Report Krishna Ari Nugraha; Sasmojo Widito; Budi Satrijo; Novi Kurnianingsih
Heart Science Journal Vol 3, No 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improve
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.04.5

Abstract

BackgroundPercutaneous coronary intervention for bifurcation lesions remains challenging because of its complexity and the lack of trials to guide decision-making. Interventional cardiologists are forced to make decisions based on their own judgment and experience rather than the results of rigorously randomized trials.Case SummaryA 64-year-old male with some coronary risk factors of hypertension, passive smoker, and family history of CAD presented with recurring exertional chest pain for the last 4 months. He was hospitalized to undergo DCA-Adhoc after the ECG stress test revealed a positive result. The coronary angiography revealed a 95% ISR in the osteal LAD and 20% ISR of the proximal LCx. Since the patient refused to undergo coronary bypass surgery, the team decided to perform catheter intervention to the LM bifurcation of LAD-LCx. The procedure begins with the insertion of IABP through the access of the left femoral artery. We performed a provisional approach with the main vessel stenting of LM-LAD. At the end of the procedure, we performed simultaneous kissing balloon inflation of LAD-LCx followed by POT in LM stent as the post-dilation procedure.DiscussionWhen considering intervention on a bifurcation lesion, there are two general strategies i.e the more conservative or provisional technique that intent to only use one stent and the two-stent approach. The provisional technique is considered to offer advantages in terms of reducing procedure complexity, reducing fluoroscopic time, requiring less contrast volume, and reducing resource (stent) use compared by 2 stent strategy.
Correlation of Urine Albumin Creatinine Ratio And C-Reactive Protein Levels on Carotid Artery Intima-Media Thickness And Flow-Mediated Dilatation Response In Children and Adolescent with Type 1 Diabetes Mellitus At Dr Saiful Anwar Hospital Malang Seprian Widasmara; Novi Kurnianingsih; Indra Prasetya; Cholid Tri Tjahjono; Budi Satrijo
Heart Science Journal Vol 3, No 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improve
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.04.3

Abstract

Background:Early and accelerated atherosclerosis is a major cause of cardiovascular disease and often causes premature death in T1DM patients. In DMT1, atherosclerosis can be detected since adolescence. The initial association between urinary albumin to creatinine ratio (ACR) and c-reactive protein (hs-CRP) with subclinical cardiovascular disease in children and adolescents with T1DM supported findings from previous studies. Imaging tests using ultrasound can detect subclinical atherosclerosis in this patient population. Carotid artery intima-media thickness (cIMT) and flow-mediated dilatation response (FMD) have been frequently used to detect subclinical atherosclerosis.Objective: To find correlation between ACR and hsCRP on the thickness values of cIMT and FMD in children and adolescent DMT1 patients at Dr Saiful Anwar Hospital MalangMethods: This is a cross-sectional study with 82 subjects of DMT1 patients who routinely control the pediatric outpatient clinic of RSUD Dr. Saiful Anwar Malang, with the research period January – July 2019 and December 2021 – March 2022.Results: There was correlation between ACR with FMD and cIMT (r=-0.593; p=0.000 and r=0.339; p=0.002, respectively). There was also correlation between hsCRP with FMD and cIMT (p=-0.375; p=0.001 and r= 0.414; p=0.023, respectively).Conclusion: ACR and hsCRP have a correlation with increasing CIMT values and decreasing FMD values in children and adolescents with DMT1 patients.
The Effect of HbA1C Variability and Lipid Profile on Carotid Intima-Media Thickness (cIMT) and Flow-mediated Dilatation (FMD) in children and adolescent with Type 1 Diabetes Mellitus at Saiful Anwar Hospital Malang Ikeningrum, Dyah Ayu; Tjahjono, Cholid Tri; Kurnianingsih, Novi; Widito, Sasmojo; Putri, Valerina Yogibuana Swastika
Heart Science Journal Vol. 3 No. 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.03.4

Abstract

BackgroundThere is a correlation between diabetes mellitus type 1 (T1DM) and a higher risk of heart disease. Atherosclerosis, which can be discovered early with cIMT (Carotid Intima-Media Thickness) and Flow Mediated Dilation (FMD) tests, contributes to the development of cardiovascular disease. HbA1c fluctuation and lipid profile can have an impact on cIMT and FMD.AimThe aim of this study is to determine the influence of HbA1c variability and lipid profile on cIMT and FMD levels in children T1DM patients treated at Dr Saiful Anwar Hospital Malang.MethodsThe study utilized a cross-sectional design and included 82 participants with Type 1 Diabetes Mellitus who were routinely treated at the Dr. Saiful Anwar Hospital Malang's pediatric outpatient clinic between January - July 2019 and December 2021 and- January 2022.ResultsThe correlation test revealed no significant connection between HDL (ρ=-0,029; p=0,796), LDL (ρ=-0.213; p=0.055), TG (ρ= -0.179; p= 0.107), and total cholesterol (ρ=-0.182; p= 0.101). Association tests revealed a positive correlation between LDL (ρ=0,318; p=0,004) and total cholesterol (ρ=0,230; p=0,038) levels and IMT. The correlation coefficient between HbA1C variability and FMD as evaluated by HVS was -0.498 (ρ=0.000; p=0.05), as was the correlation coefficient between HbA1c-SD (ρ=-0.467; p=0.000) and HbA1c-CV (ρ=-0.400; p=0.000). Additionally, a significant positive connection was discovered between IMT and the value of HbA1c variability utilizing HVS (ρ=0.455; p=0.000), HbA1c-SD (ρ=0.434; p=0.000), and HbA1c-CV (ρ=0.325; p=0.003). The linear regression analysis revealed that the three variables with the greatest influence on FMD were HVS (R=0.398), LDL (R=0.316), and HbA1c-SD (R=0.293). HVS (R=0.468), LDL (R=0.268), and total cholesterol (R=0.198) were the three most impactful variables on IMT. It is known that the combination of lipid profile and HbA1c fluctuation contributes 25.1% to FMD using this model. Meanwhile, the lipid profile and HbA1c variability together accounted for 34.5% of the variance in IMT.ConclusionVariability in HbA1c and lipid profile (LDL and total cholesterol) can contribute to an increase in intima-media thickness and a decrease in brachial artery FMD in children with T1DM.  

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