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Budapest International Research and Critics in Linguistics and Education Journal (Birle Journal)
Published by Budapest International Research and Critics University Journal
ISSN : 26552647     EISSN : 26551470     DOI : DOI: https://doi.org/10.33258/birle
Core Subject : Humanities, Education, Social,
Humanities Education Languange, Linguistic, Communication & Media Social Sciences Other
Budapest International Research and Critics in Linguistics and Education (BirLE-Journal) is a peer reviewed journal published in February, May, August, November welcome research paper in language, linguistics, oral tradition, literature, arts, education and other related fields which is published in both online and printed versions.
Arjuna Subject : Ilmu Sosial - Linguistik dan Bahasa
Articles 681 Documents
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Refining Biological Aging Clocks: Harnessing Multi-Organ, Multi-Omics Data with Machine Learning Goshu, Belay Sitotaw
Budapest International Research and Critics in Linguistics and Education (BirLE) Journal Vol 8, No 4 (2025): Budapest International Research and Critics in Linguistics and Education, Novemb
Publisher : BIRCU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birle.v8i4.8151

Abstract

The image aging as a deeply personal story, where a gentle mirror reflects not just the years you’ve lived but the vibrant health pulsing through you, guided by cutting-edge aging clocks. This study dives into crafting and testing two aging clocks, basic and refined, using synthetic data from 1,200 unique souls across Groups A, B, and C. With 12 biomarkers as our guide, we shaped these clocks with linear and Ridge regression, achieving a heartwarming near-perfect match to biological age, missing by just 1.81 years on average, with an R² of 0.99 for both. In imagined clinical moments, a 30% dip in Delta Age after intervention and a strong bond between faster aging and lower therapy adherence (r = -0.587, p = 4.558e-112) showed these clocks’ promise. Response to help varied warmly, 68.6% for Group A, 67.4% for Group B, and 62.5% for Group C, hinting at our diverse human hues. The pre- and post-intervention shifts and adherence shaping age, while Table 1 unpacks a logistic model where chronological age (coefficient 0.0941, p < 0.001) steals the spotlight. Though our synthetic world softens life’s rough edges, these clocks offer a tender start for personalized care. They whisper hope for tailoring treatments and watching progress, though real-life validation will bring the full story to light.

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