Articles
5,497 Documents
<![CDATA[Association of Autoimmune Thyroiditis and Type 1 Diabetes Mellitus With Severity of Children with Celiac Disease ]]>
<![CDATA[Bashar S Khalaf]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.145
<![CDATA[Purposes of study: analysis and measurement of incidence and association between autoimmune thyroiditis(AIT) and type 1 Diabetes mellitus(T1DM) with clinical and serological severity of patients with Celiac disease.Design and Methods: This is prospective study, All children (107 children with 41 male and 66 female ) with celiac disease are admitted and follow up in Hospital. Age groups ( 1-12 years) are arranged into two groups (1-6 and 7-12 years old). The celiac disease are divided into: Group1= 25-50 IU/ml, Group2 = 50-100 IU/ml, Group3 >100 IU/ml. All patients with celiac disease are follow up for AIT and type 1 T1DM.Results: (107) patients with celiac disease, mean age is 6.78±2.85, median age is 8, and female :male ratio are 1.6:1. All celiac patients are divided into: group 1 (43 patients), group 2 (50 patients), and group 3 (14 patients). Incidence of T1DM in all patients is 8.4% while AIT 2.8% . T1DM incidence in group 2 is 3.7% and in group 3 is 12.3%. But AIT incidence in group 3 is 4.6%. All cases with AIT have hypothyroidism with TSH > 100 ?U/ml. All diabetic patients have random blood sugar > 450 mg/dl. Age group are divided into two groups, 1-6 and 7-12 years old. Incidence of T1DM are 6.25% and 11.6% in these two age groups respectively, while AIT is 7% in age group 7-12 years. The association between celiac patients groups with T1DM and AIT is insignificant association ( (P value is 0.265 and 0.717 respectively). Also age groups have no significant association with T1DM and AIT ( (P value is 0.48 and 0.062 respectively) .Conclusion: follow up of celiac disease is important step for diagnosis AIT and T1DM . These two autoimmune diseases are increasing especially when there high concentration of IgA anti-tissue transglutaminase level ( >100 IU/ml) and advanced children age group . AIT may presented initially with hypothyroidism.]]>
<![CDATA[Role of PSA in Diagnosis of Chronic Prostatitis ]]>
<![CDATA[Yasir Abdulateef]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.146
<![CDATA[Background: Prostatitis is the poor cousin of prostatic cancer and Benign hyperplasia. The prevalence of prostatitis in general population was estimated to be 0.5 to 14.2% in developed countries. Publishing in Iraq was concern mainly with treatment of prostatitis.Objective: This work was carried out to comment on the concept of prostatitis in clinical practice.Method: A total of 275 males was included in this study. They were complaining of urinary symptoms (frequency, urgency, hesitancy, straining, difficulty in initiation urinary stream).All cases were confirmed to have chronic prostatic after excluding prostatic carcinoma by abdominal ultrasound, free to total PSA and urinary Prostatic carcino-antigen-3. Their age was 45.6 ± 9.6 year. Urine samples were proceeded immediately after collection. Centrifuged and non-centrifuged specimen were examined.Results: PSA was affected significantly by age (p = 0.002). A significant high level was observed among those complaining of pain during ejaculation (p = 0.0001).Those showed epithelial cells in urine had significant high level of PSA (p = 0.0001). Uric acid in urine was associated with significant high level of PSA (p = 0,03).Conclusion: The diagnosis of CP / CPPS might be outside the traditional urologic practice and might consider PSA level too.]]>
<![CDATA[Treatment and Experimental Infection with Klebsiella pneumoniae in Rats ]]>
<![CDATA[Aqeel A. Alsadawi1, Dhuhah Hayder Abdul-Jawad1, Noor Hani AL-Naji1]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.147
<![CDATA[So many diseases are caused by Klebsiella species including urinary tract infections (UTIs), pneumonia, sepsis, diarrhea and bacteremia. Also Klebsiella is responsible for a significant number of community-acquired infectionssuch as pneumonia that results in severe injury in the lung and responsible for a high death ratein children. The intranasal and left lung route of K. pneumoniae infection causes pathological change in the lungs tissues due to acute and chronic injury. Conducted to detect the histological and immunological changes in experimental rat’s lung infected by different routes with K.pneumoniae.Twenty-sevenAlbino Swiss male rats (Rattus rattus) were infected with 0.2ml of K. pneumonia suspension in different routes. After seven days from the last injection K.pneumoniae, the Lung and spleen are examined for histopathology changes. The blood vessels congestion with dispersed lymphocytic cells, infiltration throughout pulmonary parenchyma parts, edema formation along with hemorrhages Early neutrophils distribute into the Broncho-alveolar space, were detected. An acute splenitis was present in rat’s infection by left lung injection route after 10days, were observed in the Spleen tissue with mild white pulp within pulp hyperplasia.What makes K. pneumoniae infections more difficult to treat is that they gradually became more virulent and antibiotic resistant through time.The early K. pneumoniae infection -induced secretion of tumor necrosis factor alpha as pro-inflammatory cytokines.The level of cytokines has been related to severity of pulmonary inflammatory process.TNF-?is important for the acute phase response as proinflammatory responses.]]>
<![CDATA[Evaluation of Post Cementation Marginal Seating of Monolithic Zirconia Crown Restorations Using Different Preparation Designs (A comparative in vitro study) ]]>
<![CDATA[Adel F. Ibraheem1, Lena S. Abdullah2]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.148
<![CDATA[Objectives: The purpose of this in vitro study was to evaluate post-cementation vertical marginal seating of full contour zirconia crown restorations using different finish line designs (deep chamfer and shoulder) with different occlusal reduction schemes (planar and flat).Materials and Method: Thirty-two sound maxillary first premolar teeth freshly extracted for orthodontic purposes were collected to be used in this study. Teeth were divided into two main groups according to the design of finishing line used (n=16): Group A: Deep chamfer; Group B: Shoulder. Each group was then subdivided into two subgroups according to the scheme of occlusal reduction used (n=8): (A1, B1) Planar; (A2, B2) Flat. Standardized preparation for full contour zirconia crown restorations was carried out with finishing lines depth 1.0 mm, total convergence angle of 6 degrees and axial height 4 mm (buccally and palatally).Results: The results of this study showed that there were statistically highly significant differences among different groups (p < 0.01) using one-way ANOVA analysis and Student’s t-test. Additionally, comparison of significance between each pair of subgroups at pre and post-cementation intervals using Paired-Samples t-test showed a statistically highly significant differences.Conclusions: Deep chamfer with planar occlusal reduction scheme provided better marginal fit compared to that obtained with shoulder. On the other hand, shoulder with flat occlusal reduction scheme provided better marginal fit compared to that obtained with deep chamfer. Concerning the effect of the cementation procedure, the marginal gap was increased post-cementation as compared with the pre-cementation gap for all subgroups, but still within the clinically acceptable limit.]]>
<![CDATA[Effect of the Different Disinfectants on the Microbial Contamination of Alginate Impression Materials ]]>
<![CDATA[Haider M. A. Ahmed1, Rawof Rasheed Jawad2, Mohammed Nahidh1]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.149
<![CDATA[Objectives: This study aimed to evaluate the efficacy of different solutions used to disinfect Alginate impression material.Materials and Method: Twenty Alginate impressions for the maxillary arch of five patients recently completed their treatment (four impressions for each patients) were taken swabbed before and after disinfecting them with Chlorhexidine, Desident CaviCide and Alcohol and one just washed with tap water as a control. Swabs were cultured to detect bacteria and fungi and count them.Results: Only Streptococcus bacteria were detected with no fungal contamination. Tap water reduced the bacterial count while other disinfectants killed the bacteria completely.Conclusions: Chlorhexidine, Desident CaviCide and Alcohol can be used to disinfect the dental impression effectively.]]>
<![CDATA[Role of Respiratory Syncytial Virus and Some Bacteria Causes Tonsillitis among Children Under 5 Years Old in Duhok City ]]>
<![CDATA[Najat Abdeal-Qadir Zaman1, Asma Sumiea Karomi1, Nora Esam Aldeen Mahmood1]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.150
<![CDATA[Background: Acute infection of the respiratory tract is a prevalent cause of death in children under the age of 5 years, particularly in developing nations. Infection with respiratory syncytial virus is a causative factor for bacterial co-infection with an increase in the incidence of respiratory disease.Objective: This research was intended to clarify the connection between the Respiratory Syncytial Virus RSV and the tonsillitis-causing bacteria.Method: In 120 patients with acute and chronic tonsillitis, swabs were obtained from the tonsils to detect pathogenic and commensal bacteria in the throat, and blood samples collected to identify RSV infection by identifying the antibody value in the serum.The results: Culture results showed that 78.53% of the bacteria isolated belonged to the Gram-positive group and that only 21.47% belonged to the Gram-negative group, (51.98%) were positive for pathogenic bacteria while (48.02%) were positive for commensal bacteria and showed the highest rate of pathogenic bacteria isolated from tonsillitis patients was to Staph. aureus and Strep. pyogenes. Serological testing using ELISA showed that respiratory syncytial virus infection increases tonsillitis co-infection. Type of antibodies showed a change depending on the sex group and the stages of immune response maturity.]]>
<![CDATA[Broad-Spectrum Cytotoxic Effect of Calendula officinalis L Against Breast Cancer Cells ]]>
<![CDATA[Khulood M. Alsaraf1, Maeda H. Mohamed1, Ahmed Majeed Al-Shammari2, Ibrahim S. Abbas3]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.151
<![CDATA[Background: Calendula officinalis L used in Iraqi folklore medicine for several medical applications. This research evaluated the leaves extract as an anti-breast cancer agent in in-vitro cancer cell line systems and studies its active compounds. Crystal violet viability assay was used to determine the cytotoxicity of the leave methanolic extract of Calendula officinalis L against diverse breast cancer cell lines. Human breast cancer MCF7, AMJ13, MDAMB, and CAL51 cells were treated with different concentrations of extract for 72 hours. Morphological study for the exposed cell was done by examination under a phase-contrast inverted microscope. High-performance liquid chromatography (HPLC) analysis was performed to measure the concentrations of each component of phenols and flavonoids in the Calendula officinalis L extract. Results: It was found that methanolic extract of Calendula officinalis L inhibits the proliferation of all breast cancer cells significantly at the meantime; it does not affect normal embryonic cells. Additionally, it induced the cytopathic morphological changes in cancer cells. Furthermore, HPLC study revealed that Calendula officinalis L extract contained an important component of flavonoids. Conclusions: Calendula officinalis L leaves extract inhibited the proliferation of breast cancer cells especially MDAMB cells with no effect on normal cells. This work showed that Calendula officinalis L is a possible natural source as broad-spectrum anti-breast cancer drug.]]>
<![CDATA[The Role of c-ERBB2(Her-2) and P53 in Differentiating Low Grade from High Grade Urothelial Carcinoma of Urinary Bladder ]]>
<![CDATA[Roaa Salih Mahdi]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.152
<![CDATA[Background: Urothelial carcinoma of the urinary bladder, represents 90% of all primary tumors of this organ, and one of the most common ten malignancy in Iraq and world wide. These tumors can range from low grade papillary neoplasms to less frequent more aggressive and invasive solid tumors. More than 70% of superficial tumors recur, and about one-third of the patients have tumor progression, which can affect the quality of their life HER-2\neu receptor as an important growth factor . This receptor possesses intrinsic tyrosine kinase activity and all members of this family are frequently overexpressed and \or their respective genes are amplified in human neoplastic tissue . Its overexpression has been associated with high grade and advanced stage of bladder carcinoma specially TCC. Altered expression of the p53 gene has also been associated with transitional cell carcinoma. Materials and Methods: 62 patients with TCC were included in this study and conducted in the Department of Pathology, Faculty of Medicine, Kufa University during the period from January 2012 through April 2013. EnVision method (polymer based immunohistochemistry) was used for the immunohistochemical detection of p53 and Her_2/neu. Results: HER-2\neu overexpression was found in 62.9% of bladder carcinoma , and no expression in benign bladder lesions (cystitis) was detected , (P value < 0.05) . HER-2\neu overexpression and its intensity were well correlated to grade of tumor indicating that HER-2\neu positive bladder carcinoma are biologically aggressive and detected more frequent in grade III than grade I or grade II (P value < 0.05, R = 0.0181).P53 was expressed in (66.12%) of bladder carcinoma , and no expression in benign bladder lesions (cystitis) was detected , (P value < 0.05) . P53 overexpression and its intensity were well correlated to grade of tumor indicating that P53 positive bladder carcinoma are biologically aggressive and detected more frequent in grade III than grade I or grade II (P value < 0.05, R = 0.0821). Conclusions: From the above results we concluded that p53 and Her_2/neu over-expression play an important role in pathogenesis of urothelial carcinoma evolution, as their positivity associated with higher tumor grade.]]>
<![CDATA[Serum Secretagogin and Focal Adhesion Kinase as Markers for Type 2 Diabetes Mellitus and Beta Cells Function ]]>
<![CDATA[Shahad Ali Al-Eqabi1, Zeena Abdul llah1, Mahmood Shakir Khudhair2]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.153
<![CDATA[Diabetes mellitus (DM) is one of the world’s major public health problems. The increasing incidence of DM worldwide makes it a leading cause of morbidity and mortality for the anticipated future. Secretagogin (SCGN) is a protein enriched and secreted from pancreatic islets, it demonstrates protective effects on ?-cell function. Focal adhesion kinase (FAK) plays a critical role in ?-cell survival and is a vital regulator of insulin secretion. In this research, serum SCGN, FAK, fasting blood glucose (FBG), HbA1c, C-peptide, lipid profile, blood urea nitrogen (BUN) and creatinine were measured in patients diagnosed with type 2 diabetes mellitus (T2DM) and in healthy volunteers. The results showed that there was a significant increase in the levels of serum SCGN in patients with T2DM compared to the control group. There was a significant decrease in levels of FAK and C-peptide in T2DM patients compared to the control group. In addition, a significant increase was seen in FBG and HbA1c levels in T2DM patients compared to the control group. The lipid profile of T2DM patients was altered compared to the control group. There was no significant difference in the levels of BUN and creatinine among the study subjects. The results of this study suggest that both SCGN and FAK may serve as potential biomarkers reflecting the state of islet cells dysfunction in T2DM patients which may present additional markers for the diagnosis of T2DM.]]>
<![CDATA[Thyroid Nodules of Iraqi Patients with Acromegaly ]]>
<![CDATA[Nihad Abdallah Selman1, Abbas Mahdi Rahma2, Atheer Yass Ali3, Hayder K. Abed4]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.37506/ijfmt.v14i1.154
<![CDATA[Acromegaly is a chronic endocrine disorder caused by excessive secretion of growth hormone. The incidence of malignancy like colorectal carcinoma is well documented to increase in patients with acromegaly. While the real incidence of thyroid neoplasm in these patients are not well known.Aims: Find out the rate of structural thyroid disorders in a sample of Iraqi patients with acromegaly; Identify the rate of thyroid malignant transformation in patients with acromegaly.Settings and Design: A case control studyMethods and Material: seventy patients with acromegaly were enrolled compared with 70 controls from 2 endocrinology centers from Jan. -Dec. 2017. Their mean age 46+/-11years ;41(58.5%) males. Thyroid ultrasound was conducted for all participants while fine needle aspirate conducted for those with nodule diameter ?1cm.Results: . Goiter was founded more in patients with acromegaly versus control group (81.4% vs 18.5% respectively ;P<0.0001) .The overall nodular thyroid disease were found in (61.4%) acromegalic patients(of those : (11.4%) had single thyroid nodule and (50%) had multiple thyroid nodules. The ultrasonic feature of thyroid nodule were suspicious in (13.9%) of acromegaly group and none in control; P<0.0001). The fine needle aspirate results were suspicious in(9.3%) acromegaly group versus none in control group, P<0.05). One patient (2.3%) with acromegaly had papillary thyroid carcinoma and none in control; P=0.31).Conclusions: Nodular thyroid disease were more prevalent in Iraqi patients with acromegaly but the risk of malignancy is not significantly different from normal population.]]>
